Clinical aspects of the use of macrolide antibiotics
Abstract
The conclusive evidence in support of the efficacy of macrolide antibiotics against introcellular infection causing pathogens and Helicobacter pylori on one side and the development of new macrolide antibiotics (midecamycin, clarithromycin, azithromycin, roxithromycin) on the other reversed the increased interest in this group of antibiotics and revived their popularity. Macrolides present an effective alternative to penicillins in patients with allergy to penicillin, hey are characterized by an exellent tissue and body fluids penetration. Following reabsorption, their main route of excretion is trough the liver, therefore no reduction in dosage is required in patients with impaired renal function. Compared with erythromycin, the newer macrolides possess a more favorable pharmacokinetic profile and are associated with less side effects. In the near future, not only further development of new forms of macrolide antibiotics may be expected but also a proof of their efficacy against varios pathogens in a range of clinical conditions.
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Review
For citations:
Jerman A., Drinovets J. Clinical aspects of the use of macrolide antibiotics. PULMONOLOGIYA. 1996;(3):90-94. (In Russ.)
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