The experimental model of noninfectional granulomatosis in lungs

Abstract

Experimental model of noninfectional granulomatosis in lungs was elaborated by the authors. The lung granulomatosis was induced by Sefadex A-25 aerosol inspiration in Wistar rats. It was characterised by the mature macrophagal granulomas appearance in couple with acute bronchitis and alveolitis. Granulomatous reaction in lungs was accompanied by extreme hyperplasia of lymphoid bronchial folliculi. The bronchial alveolai lavage cell count, especially neutrophil, lymphocyte, and polynuclear macrophage counts, increased during the experiment. Maximally manifestated changes of the mentioned parameters were noted after 7 days since Sefadex A-25 aerosol inhalation. Using the elaboreted model of noninfectional pulmonary granulomatosis, it was demonstrated that the model can be used to estimate the efficiency of antiinflammatory and immunomodulating pharmacological products, as well Budesonide, which are used in pulmonology.