The efficiency of chronic treatment with salmeterol in patients with bronchial asthma
Abstract
The efficiency of chronic treatment with salmeterol was estimated in 11 patients with mild and moderate bronchial asthma in remission stage. Salmeterol was unhaled via a diskhaler (Glaxo Gmbh, Bad Oldesloe, Germany) in dose of 50 mkg/puff twice a day during 4 weeks.
After regular treatment with salmeterol in patients with asthma, it was found significant increase in pulmonary function parameters (6.0% in FVC, 6.5% in FEV1, 9.0% in FEF25, 40.9% in sGaw, and 20.8% decrease in RV) and airways hystamin sensitivity decrease (the increase of PD20 logarithmic value in 0.6 mg/ml, p<0.05). That corresponds to the PD20 increase at 2.87 times in average. During the whole treatment period, the stable remission was noted in the patients.
During the prolonged use, salmeterol is high effective remedy for patients with mild and moderate bronchial asthma.
About the Authors
A. V. Cherniack
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
N. P. Kniazheskaya
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
N. A. Boloshina
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
A. S. Sokolov
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
T. L. Pashkova
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии М3 и МП РФ
Russian Federation
Russian Federation
References
1. Kирушаa В.П., Трубкина Н.Н., Вишняков И.И. Организация и некоторые результаты лечения больных бронхиальной астмой в Вологодской области // Тер. арх. — 1988. — № 3. — С. 81—84.
2. Масуев К.А. Эйкозаноиды и бронхиальная астма // Пульмонология. — 1993. — № 1. — С. 78.
3. Официальный бюллетень Европейского респираторного общества. Легочные объемы и форсированные вентиляционные потоки // Там же. — 1993. — Приложение. — С. 6—44.
4. Официальный бюллетень Европейского респираторного общества. Восприимчивость дыхательных путей. // Там же. — С. 60—86.
5. Федосеев Г.Б., Емельянов А.В. Бронхиальная астма: трудные и нерешенные проблемы // Тер. арх. — 1991. — № 5. — С. 74—78.
6. Чучалин А.Г. // Бронхиальная астма. Сальбутамол / Под ред. А.Г.Чучалина, И.Хамида. — М.: ФАРМЕДИНФО, 1992. — С. 4—66.
7. Abramson М., Bowes G. Asthma death: Where now? // Med. J. Austr. — 1991. — Vol. 154. - № 1. — P. 12—13.
8. Baker A.J., Fuller RAV. Anti-inflammatory effect of salmeterol on human alveolar macrophages // Am. Rev. Respir. Dis. — 1990. — Vol. 141. - № 4. — P. A394.
9. Barnes P.J. New concepts in the pathogenesis of bronchial responsiveness and asthma // J. Allergy Clin. Immunol. — 1989. — Vol. 83. — P. 1013—1026.
10. Benatar S.R. Fatal asthma // N. Engl. J. Med. — 1986. — Vol. 314. — P. 423—429.
11. Burney P.G.I. Asthma mortality in England and Wales: evidence for a further increase // Lancet. — 1986. — Vol. 2. — P. 323—326.
12. Butchers P.R., Vardey C.J., Johnson M. Salmeterol: a potent and long acting inhibitor of inflammatory mediator release from human lung // Br. J. Pharmacol. — 1991. — Vol. 104. — P. 672—676.
13. Church M.K., Hiroi J. Inhibition of IgE-dependent histamine release from human dispersed lung mast cells by antiallergic drugs and salbutamol // Ibid. — 1987. — Vol. 90, № 2. — P. 421—429.
14. Church M.K., Young K.D. The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromasine // Br. J. Pharmacol. — 1983. — Vol. 78, № 4. — P. 671—769.
15. Cochrane G.M. Bronchial asthma and the role of ß2-agonists // Lung. — 1990. — Vol. 168, Suppl. — P. 66—70.
16. Cockcroft D.W., Murdock K.Y. Comparative effects of inhaled selbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen-induced early asthmatic responses, late asthmatic responses and increased bronchial responsiveness to histamine // J. Allergy Clin. Immunol. — 1987. — Vol. 79. - № 5. — P. 734—740.
17. Derom E.Y., Pauwels R., Van der Straeten M. The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hours // Ibid. — 1992. — Vol. 89. — P. 811—815.
18. Holgate S.T., Kay A.B. Mast cells, mediators and asthma // Clin.Allergy. - 1985. — Vol. 15. - № 3. — P. 221—234.
19. Juniper E.F., Cockcroft D.W., Hargreave F.E. Histamine and Methacholine Inhalation Tests: Tidal Breathing Method (Laboratory Procedure and Standardisation. AB Draco) — Lund, 1991.
20. Kerrebijn K.F., Van Essen-Zandvliet E.E.M., Neijens H.J. Effect of long-term treatment with inhaled corticosteroids and P-agonists on the bronchial responsiveness in children with asthma // J. Allergy Clin. Immunol. — 1987. — Vol. 79. — P. 653—659.
21. Kraan J., Koeter G.H., Van der Mark T.W., Sluiter H.J., de Vries K. Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: a comparison between budesonide and terbutaline // Ibid. — 1985. — Vol. 76. — P. 628—636.
22. Malo J.I., Cartier A., Ghezzo H., Trudeau C., L’Archeveque J. Duree de l’effet bronchoprotecteur du salmeterol dans Fasthme induit par l’hyperventilation d’air froid sec // Rev. Mai. Respir. - 1992. — Vol. 9. — P. R19—R21.
23. Quanjer Ph.H., Tamrneling G.I., Cotes J.E., Pedersen Of Peslin R. Lung volumes and ventilatory flows // Eur. Respir. J. - 1993. — Vol. 6. — P. 4—40.
24. Sterk P.J., Fabbri L.M., Quanjer Ph.H., Cockcroft D. W., О'Вупц P.M., Anderson S.D., Juniper E.F., Malo J.-L. Airway responsiveness // Ibid. — Suppl. 6. — P. 55—64.
25. Thom T.I. International Comparisons in COPD Mortality // AM Rev. Respir. Dis. — 1989. — Vol. 140, № 3. — P. 27—34.
26. Twentyrnan O.P., Finnerty J.P., Harris A. et at. Protection against allergen-induced asthma by salmeterol // Lancet. - 1990. — Vol. 336, № 8727. — P. 1338—1342.
27. Urbanek R. Allergy and asthma // Lung. — 1990. — Vol. 168, Suppl. — P. 263—267.
28. Van Bever H.P., Desage K.M., Steuena W.I. The effect of inhaled fenoterol, administered during the late asthmatic reaction to house dust mite // J. Allergy Clin. Immunol. — 1990. — Vol. 85, №4. - P. 700—703.
29. Viegi G., Paoletti P., Prediletto R. et at. Prevalence of respirator) symptoms in an upolluted area of Northern Italy // Eur. Respir J. _ 1988. — Vol. 1. — P. 311—318.
30. Williams I.P., Phipps R.J., Wright N.I. et at. Sympathomimetic agonists stimulate mucus secretion into human bronchi // Thorax. — 1981. — Vol. 36, № 3. — P. 231.
31. Ziment J. Risk/benefit ratio of long-term treatment with po-adrenoceptor agonists // Lung. — 1990. — Vol. 168, Suppl. — P. 168—176.
Review
For citations:
Cherniack A.V., Kniazheskaya N.P., Boloshina N.A., Sokolov A.S., Pashkova T.L., Chuchalin A.G. The efficiency of chronic treatment with salmeterol in patients with bronchial asthma. PULMONOLOGIYA. 1996;(1):47-50. (In Russ.)
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