Comparative estimation of surfactant system state during pneumonia and lung cancer
Abstract
Functional activity of pulmonary surfactant was studied in patients with malignant tumors and nonspecific inflammatory process in the lung tissue. Minimal and maximal surface tension (ST), hysteresis form, and stability index (SI) of bronchial lavage fliud were estimated with Willihelmi’s surface balance. The static surface tension of expirated condensate was studied too. The study resuts showed the significant decrease of surface active property of bronchial alveolar lavage fluids during pneumonia (SI=0.58±0.04, p<0.001). During the examination in patients with cancer progression, differences in ST and SI parameters were noted. The extreme depression of surface active properties (SI = 0.41±0.03, p<0.001) was noted in patients with the III–IV stage of lung cancer with expressed tumor germinatings into lung tissue and with atelectasis, while in earler stages of cancer, these ST parameters did not differ from those ones in pneumonia (S1=0.62+0.06 and S1=0.58+0.04 respectively). That points on the nonspccifics of functional surfactant activity depression during the tumor progression. During the expirate study, the insufficient increase of static ST was noted in pneumonia and cancer patients in comparison with controls.
About the Authors
V. M. Provotorov
Воронежская государственная медицинская академия им. Н.Н. Бурденко
Russian Federation
Russian Federation
V. I. Busurtanov
Воронежская государственная медицинская академия им. Н.Н. Бурденко
Russian Federation
Russian Federation
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For citations:
Provotorov V.M., Busurtanov V.I. Comparative estimation of surfactant system state during pneumonia and lung cancer. PULMONOLOGIYA. 1996;(1):32-35. (In Russ.)
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