Long-term combined inhaled therapy with ipratropium bromide and ambroxol of heavy smoking patients with chronic obstructive lung disease
https://doi.org/10.18093/0869-0189-2005-0-5-102-106
Abstract
The study was aimed to investigate the efficiency of long-term combined inhaled therapy with ipratropium bromide and ambroxol via compressor pneumatic nebulizer in 86 COPD patients. Significant improvement in clinical status, physical tolerance and cell content (macrophages, neutrophils) of induced sputum was revealed in all the patients in comparison with a control group. Mild to moderate COPD patients had considerable improvement in FEV1. The authors concluded that the proposed treatment had resulted in the positive effects.
About the Authors
A. R. Tatarsky
ФГУ НИИ пульмонологии Росздрава
Russian Federation
Russian Federation
E. V. Sukhanova
ФГУ НИИ пульмонологии Росздрава
Russian Federation
Russian Federation
E. V. Bobkov
ФГУ НИИ пульмонологии Росздрава
Russian Federation
Russian Federation
A. B. Kiryukhin
ФГУ НИИ пульмонологии Росздрава
Russian Federation
Russian Federation
References
1. Доклад рабочей группы GOLD (Global Initiative for Chronic Obstructive Lung Disease) — пересмотр 2003 г. — http://www.goldcopd.com.
2. Хронические обструктивные болезни легких. Федеральная программа. М.; 1999.
3. Postma D.S. Epidemiology of COPD risk factors IICOPD: Diagnosis and treatment. Excerpta Medica, 1996, 17 Report. Chronic bronchitis in Great Britain. Br. Med. J. 1961; 2: 973.
4. Burge P.S. Occupation and chronic obstructive pulmonary disease (COPD). Eur. Respir. J., 1994; 7: 1032–1034.
5. Бакенова Р., Сейсембекова Т., Чернова Н, Кенжина 3. Использование небулайзера в лечении бронхиальной астмы и хронического обструктивного бронхита. Пульмонология 1998; Прил.: Сборник резюме 8-го Национально конгресса по болезням органов дыхания: 10.
6. Гельцер Б.И., Майданов Ю.Б. Функциональная активность сурфактанта легких при хроническом бронхите. Тер. арх. 1997; 3: 9–12.
7. Овчаренко С.И. Хронические обструктивные заболевания легких (современные концепции и перспективные направления). Тер. арх. 1996; 8: 86–88.
8. Игнатьев В., Заблоцкая П., Алкацева И. Эффективность небулайзерной терапии беродуалом. Пульмонология 1998; Прил.: Сборник резюме 8-го Национального конгресса по болезням органов дыхания: 440.
9. Knoch M., Sommer E. Jet nebulizer design and function. Eur. Respir. Rev. 2000; 10: 183–186.
10. Task Group on Lung Dynamics. Deposition and retention models for internal dosimetry of the human respiratory flow; tract. Hlth Phys. 1966; 12:173–208.
11. Barry P., O'Callaghan C. Therapeutic aerosols. Medicine (Lond.) 1995; 23: 270–273.
12. Smith L.J. Aerosols. In: Baum G.L., Grapo J.D., Celli B.R., Karlinsky J.B., eds. Textbook of pulmonary diseases. Philadelphia; New York, Lippincott-Raven Publishers; 1998. 313–320.
13. O'Callaghan С., Barry P. The science of nebulized drug delivery. Thorax 1997; 52 (suppl. 2): S31–S44.
14. Bowler S.D., Mitchell C.A., Armstrong J.G., Scicchitano R. Nebulized fenoterol and i.v., aminophylline in acute severe asthma. Eur. J. Respir. Dis. 1987; 70 (5): 280–283.
15. Matthys H. CFCs and their effect on the ozone layer: the Montreal Protocol and consequences for physicians. Eur. Respir. Rev. 1997; 7: 29–31.
16. Idris A.H., McDermott M.F., Raucci J.C. et al. Emergency department treatment of severe asthma. Metered-dose inhaler plus holding chamber is equivalent ineffectiveness to nebulizer. Chest 1993; 103: 665–672.
17. Rodrigo C., Rodrigo G. Salbutamol treatment of acute severe asthma in the ED: MDI versus handiheld nebulizer. Am. J. Emerg. Med. 1998; 16: 637–642.
18. Maguire G.P., Newman Т., DeLorenzo L.J. et. al. Comparison of a hand-held nebulizer with a metered dose inhalerspacer combination in acute obstructive pulmonary disease Chest 1991; 100: 1300–1305.
19. Gates С J, Rowe BH. Holding chambers versus nebulisers for beta-agonist treatment of acute asthma (Cochrane Review). In: The Cochrane library, Oxford: Update Software; 2000; Issue 3.
20. Pin I., Gibson P.G., Kolendovicz R. et al. Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax 1992; 47: 25–29.
21. Popov T.A.. Pizzichini MM., Pizzichini E., et al. Some technical factors influencing the induction of sputum for cell analysis. Eur. Respir. J. 1995; 8: 559–565.
22. Авдеев С.Н., Анаев Э.Х., Чучалин А.Г. Применение метода индуцированной мокроты для оценки интенсивности воспаления дыхательных путей. Пульмонология 1998; 2: 81–87.
Review
For citations:
Tatarsky A.R., Sukhanova E.V., Bobkov E.V., Kiryukhin A.B. Long-term combined inhaled therapy with ipratropium bromide and ambroxol of heavy smoking patients with chronic obstructive lung disease. PULMONOLOGIYA. 2005;(5):102-106. (In Russ.) https://doi.org/10.18093/0869-0189-2005-0-5-102-106
Views:
414
Email this article 