pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2018-28-2-217-233pulmo-988Research ArticleОБЗОРЫREVIEWМагнитно-резонансная томография в диагностике заболеваний легкихMagnetic resonance imaging for diagnostics of lung diseasesКотляровП. М.KotlyarovP. M.

д. м. н., профессор, заведующий научно-исследовательским отделом новых технологий и семиотики лучевой диагностики заболеваний органов и систем

Affiliation ID: 60105123

Doctor of Medicine, Professor, Head of Research Department of Novel Technologies and Radiological Diagnosis of Diseases

Affiliation ID: 60105123

marnad@list.ruЛагкуеваИ. Д.LagkuyevaI. D.

м. н. с. научно-исследовательского отдела новых технологий и семиотики лучевой диагностики заболеваний органов и систем

Junior Research, Research Department of Novel Technologies and Radiological Diagnosis of Diseases

ilagkueva@mail.ruСергеевН. И.SergeyevN. I.

д. м. н., ведущий научный сотрудник научно-исследовательского отдела новых технологий и семиотики лучевой диагностики заболеваний органов и систем

Doctor of Medicine, Leading Researcher, Research Department of Novel Technologies and Radiological Diagnosis of Diseases

marnad@list.ruСолодкийВ. А.SolodkiyV. A.

д. м. н., профессор, академик Российской академии наук, директор

Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Director

direktor@rncrr.ruФедеральное государственное бюджетное учреждение «Российский научный центр рентгенорадиологии» Министерства здравоохранения Российской ФедерацииРоссияFederal Russian Scientific Radiology Center, Healthcare Ministry of RussiaRussian Federation201830062018282217233Copyright © Котляров П.М., Лагкуева И.Д., Сергеев Н.И., Солодкий В.А., 20182018Котляров П.М., Лагкуева И.Д., Сергеев Н.И., Солодкий В.А.Kotlyarov P.M., Lagkuyeva I.D., Sergeyev N.I., Solodkiy V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/988

Представлены анализ литературных данных, посвященных магнитно-резонансной томографии (МРТ) при заболеваниях легких, а также методики исследования, семиотика воспалительных и онкологических заболеваний, их дифференциальная диагностика на основании данных МРТ. Приводится сравнительная характеристика роли МРТ и компьютерной томографии (КТ). Сделано заключение об актуальности использования МРТ как метода, существенно дополняющего данные КТ при диагностике и дифференциальной диагностике заболеваний легких.

Published data on a role of magnetic resonance imaging (MRI) in diagnosis of lung disease are reviewed in the article. Methodology, signs of inflammatory and malignant diseases, and differential diagnosis are also described. The authors compared a role of MRI and computed tomography (CN) for diagnosis of lung diseases. In conclusion, MRI is a useful method for diagnosis and differential diagnosis which could complement CT findings.

магнитно-резонансная томографиядиагностиказаболевания легкихmagnetic resonance imagingdiagnosislung diseasesReferencesИванова Е.В., Биличенко Т.Н., Чучалин А.Г. Заболеваемость и смертность населения трудоспособного возраста России по причине болезней органов дыхания в 2010–2012 гг. Пульмонология. 2015; 25 (3): 291–297. DOI: 10.18093/0869-0189-2015-25-3-291-297.Ivanova E.V., Bilichenko T.N., Chuchalin A.G. Morbidity and mortality from respiratory diseases in employable population of Russia in 2010 – 2012. Pul’monologiya. 2015; 25 (3): 291–297. DOI: 10.18093/0869-0189-2015-25-3-291-297 (in Russian).Каприн А.Д., Старинский В.В., Петров Г.В. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). M.: МНИОИ им. П.А. Герцена филиал ФГБУ «НМИРЦ» Минздрава России; 2017.Kaprin A.D., Starinskiy V.V., Petrov G.V. Malignancy in Russia, 2015 (morbidity and mortality). Moscow: MNIOI im. P.A. Gertsena filial FGBU «NMIRTS» Minzdrava Rossii; 2017 (in Russian).Tuddenham W.J. Glossary of terms for thoracic radiology: recommendations of the Nomenclature Committee of the Fleischner Society. Am. J. Roentgenol. 1984; 143 (3): 509–517. DOI: 10.2214/ajr.143.3.509.Tuddenham W.J. Glossary of terms for thoracic radiology: recommendations of the Nomenclature Committee of the Fleischner Society. Am. J. Roentgenol. 1984; 143 (3): 509–517. DOI: 10.2214/ajr.143.3.509.Baert A. L., Knauth M., Sartor K. et al. Diagnostic Imaging. Computed Tomography of the Lung a Pattern Approach. M.: Springer-Verlag Berlin Heidelberg; 2007.Baert A. L., Knauth M., Sartor K. et al. Diagnostic Imaging. Computed Tomography of the Lung a Pattern Approach. M.: Springer-Verlag Berlin Heidelberg; 2007.Котляров П.М. Многосрезовая компьютерная томография легких – новый этап развития лучевой диагностики заболеваний легких. Медицинская визуализация. 2011; (4): 14–20.Kotlyarov P.M. Multislice CT as a novel imaging diagnostic method in lung diseases. Meditsinskaya vizualizatsiya. 2011; (4): 14–20. (in Russian).Котляров П. М. Постпроцессинговая обработка данных мультиспиральной компьютерной томографии в уточненной диагностике патологических изменений при диффузных заболеваниях легких. Пульмонология. 2017; 27 (4): 472–477. DOI: 10.18093/0869-0189-2017-27-4-472-477.Kotlyarov P.M. Multispiral computed tomography post-processing for refining diagnosis of diffuse lung diseases. Pul’monologiya. 2017; 27 (4): 472–477. DOI: 10.18093/0869-0189-2017-27-4-472-477. (in Russian).Котляров П.М. Лучевые методы в диагностике заболеваний органов дыхания. Российский медицинский журнал. 2001; 9 (5): 197–207.Kotlyarov P.M. Image methods in diagnosis of respiratory disease. Rossiyskiy meditsinskiy zhurnal. 2001; 9 (5): 197–207. (in Russian).Котляров П.М., Гамова Е.В., Нуднов Н.В. и др. Магнитно-резонансная томография в визуализации органов дыхания, средостения и при некоторых патологических состояниях. Пульмонология. 1999; (4): 26–30.Kotlyarov P.M., Gamova E.V., Nudnov N.V., et al. Magnetic resonance imaging in visualization of respiratory system, mediastinum and in some diseases. Pul’monologiya. 1999; (4): 26–30. (in Russian).Wielpütz M., Kauczor H.U. MRI of the lung: state of the art. Diagn. Interv. Radiol. 2012; 18 (4): 344–353. DOI: 10.4261/1305-3825.DIR.5365-11.0.Wielpütz M., Kauczor H.U. MRI of the lung: state of the art. Diagn. Interv. Radiol. 2012; 18 (4): 344–353. DOI: 10.4261/1305-3825.DIR.5365-11.0.Biederer J., Beer M., Hirsch W. et al. MRI of the lung (2/3). Why … when … how? Insights Imaging. 2012; 3 (4): 355–371. DOI: 10.1007/s13244-011-0146-8.Biederer J., Beer M., Hirsch W. et al. MRI of the lung (2/3). Why … when … how? Insights Imaging. 2012; 3 (4): 355–371. DOI: 10.1007/s13244-011-0146-8.Biederer J., Ohno Y., Hatabu H. et al. Screening for lung cancer: Does MRI have a role? Eur. J. Radiol. 2017; 86: 353–360. DOI: 10.1016/j.ejrad.2016.09.016.Biederer J., Ohno Y., Hatabu H. et al. Screening for lung cancer: Does MRI have a role? Eur. J. Radiol. 2017; 86: 353–360. DOI: 10.1016/j.ejrad.2016.09.016.Kurihara Y., Matsuoka S., Yamashiro T. et al. MRI of pulmonary nodules. Am. J. Roentgenol. 2014; 202 (3): 210–216. DOI: 10.2214/AJR.13.11618.Kurihara Y., Matsuoka S., Yamashiro T. et al. MRI of pulmonary nodules. Am. J. Roentgenol. 2014; 202 (3): 210–216. DOI: 10.2214/AJR.13.11618.Mori T., Nomori H., Ikeda K. et al. Diffusion weighted magnetic resonance imaging for diagnosing malignant pulmonary nodules/masses: comparison with positron emission tomography. J. Thorac. Oncol. 2008; 3 (4): 358–364. DOI: 10.1097/JTO.0b013e318168d9ed.Mori T., Nomori H., Ikeda K. et al. Diffusion weighted magnetic resonance imaging for diagnosing malignant pulmonary nodules/masses: comparison with positron emission tomography. J. Thorac. Oncol. 2008; 3 (4): 358–364. DOI: 10.1097/JTO.0b013e318168d9ed.Eibel R., Herzong P., Dietrich O. et al. Magnetic resonance imaging in the involution of pneumonia. Radiologe. 2006; 46 (4): 267–274. DOI: 10.1007/s00117-005-1326-7.Eibel R., Herzong P., Dietrich O. et al. Magnetic resonance imaging in the involution of pneumonia. Radiologe. 2006; 46 (4): 267–274. DOI: 10.1007/s00117-005-1326-7.Kim M.J., Lee K.S., Kim J. et al. Crescent sign in invasive pulmonary aspergillosis: frequency and related CT and clinical factors. J. Comput. Assist. Tomogr. 2001; 25 (2): 305–310.Kim M.J., Lee K.S., Kim J. et al. Crescent sign in invasive pulmonary aspergillosis: frequency and related CT and clinical factors. J. Comput. Assist. Tomogr. 2001; 25 (2): 305–310.Blum U., Windfuhr M., Buitrago-Tellez C. et al. Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest. 1994; 106 (4): 1156–1161.Blum U., Windfuhr M., Buitrago-Tellez C. et al. Invasive pulmonary aspergillosis. MRI, CT, and plain radiographic findings and their contribution for early diagnosis. Chest. 1994; 106 (4): 1156–1161.Binghu J., Huaijun L., Dan Z. Diagnostic and clinical utility of dynamic contrast-enhanced MR imaging in indeterminate pulmonary nodules: a metaanalysis. Clin. Imaging. 2016; 40 (6): 1219–1225. DOI: 10.1016/j.clinimag.2016.08.017.Binghu J., Huaijun L., Dan Z. Diagnostic and clinical utility of dynamic contrast-enhanced MR imaging in indeterminate pulmonary nodules: a metaanalysis. Clin. Imaging. 2016; 40 (6): 1219–1225. DOI: 10.1016/j.clinimag.2016.08.017.Лукьяненок П.И., Усов В.Ю., Коломиец С.А. и др. Возможности магнитно-резонансной томографии с контрастированием в диагностике рака легкого. Международный журнал прикладных и фундаментальных исследований. 2014; 11 (3): 455–459.Luk’yanеnok P.I., Usov V.YU., Kolomiyets S.A., et al. A role of contrast-enhanced magnetic resonance imaging for diagnosis of lung carcinoma. Mezhdunarodnyy zhurnal prikladnykh i fundamental’nykh issledovaniy. 2014; 11 (3): 455–459 (in Russian).Khalila A., Majlatha M., Gounantc V. et al. Contribution of magnetic resonance imagingin lung cancer imaging. Diagnostic and Interventional Imaging. 2016; 97 (10): 991–1002. DOI: 10.1016/j.diii.2016.08.015.Khalila A., Majlatha M., Gounantc V. et al. Contribution of magnetic resonance imagingin lung cancer imaging. Diagnostic and Interventional Imaging. 2016; 97 (10): 991–1002. DOI: 10.1016/j.diii.2016.08.015.Сергеев Н.И., Котляров П.М., Нуднов Н.В. Оценка результатов химиолучевого лечения вторичного поражения костей по данным магнитно-резонансной томографии с динамическим контрастным усилением. Лучевая диагностика и терапия. 2013; 3 (4): 89–92.Sergeyev N.I., Kotlyarov P.M., Nudnov N.V. Results of chemotherapeutic and radiation treatment of secondary bone lesions according to data of dynamic contrast-enhanced magnetic resonance imaging. Luchevaya diagnostika i terapiya. 2013; 3 (4): 89–92 (in Russian).Yang R.M., Li L., Wei X.H. et al. Differentiation of Central Lung Cancer from Atelectasis: Comparison of Diffusion-Weighted MRI with PET/CТ. PloS One. 2013; 8 (4): e60279. DOI: 10.1371/journal.pone.0060279.Yang R.M., Li L., Wei X.H. et al. Differentiation of Central Lung Cancer from Atelectasis: Comparison of Diffusion-Weighted MRI with PET/CТ. PloS One. 2013; 8 (4): e60279. DOI: 10.1371/journal.pone.0060279.Ohno Y., Koyama H., Yoshikawa T. et al. Diffusion weighted MRI versus 18F-FDG PET/CT: performance as predictors of tumor treatment response and patient urvival in patients with non-small cell lung cancer receiving chemoradiotherapy. Am. J. Roentgenol. 2012; 198 (1): 75–82. DOI: 10.2214/AJR.11.6525.Ohno Y., Koyama H., Yoshikawa T. et al. Diffusion weighted MRI versus 18F-FDG PET/CT: performance as predictors of tumor treatment response and patient urvival in patients with non-small cell lung cancer receiving chemoradiotherapy. Am. J. Roentgenol. 2012; 198 (1): 75–82. DOI: 10.2214/AJR.11.6525.Hausmann D., Jochum S., Utikal J. et al. Comparison of the diagnostic accuracy of whole-body MRI and whole-body CT in stage III/IV malignant melanoma. J. Dtsch. Dermatol. Ges. 2011; 9 (3): 212–222. DOI: 10.1111/j.1610-0387.2011.07614.x.Hausmann D., Jochum S., Utikal J. et al. Comparison of the diagnostic accuracy of whole-body MRI and whole-body CT in stage III/IV malignant melanoma. J. Dtsch. Dermatol. Ges. 2011; 9 (3): 212–222. DOI: 10.1111/j.1610-0387.2011.07614.x.Liu H., Liu Y., Ye N. Usefulness of diffusion weighted MR imaging in the evaluation of pulmonary lesions. Eur. Radiol. 2010; 20 (4): 807–815. DOI: 10.1007/s00330-009-1629-6.Liu H., Liu Y., Ye N. Usefulness of diffusion weighted MR imaging in the evaluation of pulmonary lesions. Eur. Radiol. 2010; 20 (4): 807–815. DOI: 10.1007/s00330-009-1629-6.Alexopoulou E., Economopoulos N., Priftis K.N. et al. MR imaging findings of an atypical pulmonary hamartoma in a 12-year-old child. Pediatr. Radiol. 2008; 38 (10): 1134–1137. DOI: 10.1007/s00247-008-0938-2.Alexopoulou E., Economopoulos N., Priftis K.N. et al. MR imaging findings of an atypical pulmonary hamartoma in a 12-year-old child. Pediatr. Radiol. 2008; 38 (10): 1134–1137. DOI: 10.1007/s00247-008-0938-2.Fujimoto K. Usefulness of contrast-enhanced magnetic resonance imaging for evaluating solitary pulmonary nodules. Cancer Imaging. 2008; 8 (1): 36–44. DOI: 10.1102/1470-7330.2008.0009.Fujimoto K. Usefulness of contrast-enhanced magnetic resonance imaging for evaluating solitary pulmonary nodules. Cancer Imaging. 2008; 8 (1): 36–44. DOI: 10.1102/1470-7330.2008.0009.Котляров П.М., Сергеев Н.И. Лучевые методы исследования в дифференциальной диагностике паразитарных и опухолевых поражений легких. Сибирский онкологический журнал. 2016; 15 (4): 33–39. DOI: 10.21294/1814-4861-2016-15-4-33-39.Kotlyarov P.M., Sergeyev N.I. Imaging methods in differential diagnosis of parasitic and malignant lesions of the lungs. Sibirskiy onkologicheskiy zhurnal. 2016; 15 (4): 33–39. DOI: 10.21294/1814-4861-2016-15-4-33-39 (in Russian).Nakanishi K., Kozaki S., Fujimoto S. et al. Pulmonary sclerosing hemangioma: report of a case with emphasis on dynamic MR imaging findings. Radiat. Med. 1997; 15 (2): 117–119.Nakanishi K., Kozaki S., Fujimoto S. et al. Pulmonary sclerosing hemangioma: report of a case with emphasis on dynamic MR imaging findings. Radiat. Med. 1997; 15 (2): 117–119.Ерохин В. В., Земскова С. С. Современные представления о туберкулезном воспалении. Проблемы туберкулеза. 2003; (3): 11–21.Erokhin V. V., Zemskova S. S. Current approach to tuberculous inflammation. Problemy tuberkuleza. 2003; 3: 11–21 (in Russian).Холодок О.А., Григоренко А.А., Черемкин М.И. Туберкулема легкого как форма туберкулезного процесса. Бюллетень физиологии и патологии дыхания. 2014; 53: 126–131.Kholodok O.A., Grigorenko A.A., Cheremkin M.I. Pulmonary tuberculoma as a variant of pulmonary tuberculosis. Byulleten’ fiziologii i patologii dykhaniya. 2014; 53: 126–131 (in Russian).Chung M.H., Lee H.G., Kwon S.S. et al. MR imaging of solitary pulmonary lesion: emphasis on tuberculomas and comparison with tumors. J. Magn. Reson. Imaging. 2000; 11 (6): 629–637.Chung M.H., Lee H.G., Kwon S.S. et al. MR imaging of solitary pulmonary lesion: emphasis on tuberculomas and comparison with tumors. J. Magn. Reson. Imaging. 2000; 11 (6): 629–637.Sakai F., Sone S., Maruyama A. et al. Thin-rim enhancement in Gd-DTPA-enhanced magnetic resonance images of tuberculoma: a new finding of potential differential diagnostic importance. J. Thorac. Imaging. 1992; 7 (3): 64–69.Sakai F., Sone S., Maruyama A. et al. Thin-rim enhancement in Gd-DTPA-enhanced magnetic resonance images of tuberculoma: a new finding of potential differential diagnostic importance. J. Thorac. Imaging. 1992; 7 (3): 64–69.Котляров П.М., Гамова Е.В., Нуднов Н.В. Возможности магнитно-резонансной томографии в диагностике периферического рака легкого. Медицинская визуализация. 2002; 4: 35–39.Kotlyarov P.M., Gamova E.V., Nudnov N.V. Possibilities of magnetic resonance imaging in diagnosis of peripheral lung carcinoma. Meditsinskaya vizualizatsiya. 2002; 4: 35–39 (in Russian).Карташов М.В., Карташова О.М., Котляров П.М. Первый опыт применения диффузионно-взвешенной магнитно-резонансной томографии при мелкоклеточном раке легкого. Медицинская визуализация. 2011; (4): 28–33.Kartashov M.V., Kartashova O.M., Kotlyarov P.M. The first experience of diffusion weighted magnetic resonance imaging for diagnosis of small-cell lung cancer. Meditsinskaya vizualizatsiya. 2011; 4: 28–33 (in Russian).Yoon S.H., Park C.M., Park S.J. et al. Tumor heterogeneity in lung cancer: assessment with dynamic contrast-enhanced MR imaging. Radiology. 2016; 280 (3): 940–948. DOI: 10.1148/radiol.2016151367.Yoon S.H., Park C.M., Park S.J. et al. Tumor heterogeneity in lung cancer: assessment with dynamic contrast-enhanced MR imaging. Radiology. 2016; 280 (3): 940–948. DOI: 10.1148/radiol.2016151367.Gaustad J.V., Simonsen T.G., Smistad R. et al. Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging. BMC Cancer. 2015; 15: 900. DOI: 10.1186/s12885-015-1918-1.Gaustad J.V., Simonsen T.G., Smistad R. et al. Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging. BMC Cancer. 2015; 15: 900. DOI: 10.1186/s12885-015-1918-1.Chen Y.F., Yuan A., Cho K.H. et al. Functional evaluation of therapeutic response of HCC827 lung cancer to bevacizumab and erlotinib targeted therapy using dynamic contrast-enhanced and diffusion-weighted MRI. PLoS One. 2017; 12 (11): e0187824. DOI: 10.1371/journal.pone.0187824.Chen Y.F., Yuan A., Cho K.H. et al. Functional evaluation of therapeutic response of HCC827 lung cancer to bevacizumab and erlotinib targeted therapy using dynamic contrast-enhanced and diffusion-weighted MRI. PLoS One. 2017; 12 (11): e0187824. DOI: 10.1371/journal.pone.0187824.

The authors declare that there are no conflicts of interest present.