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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2017-27-2-274-282</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-850</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>GOLD  (2017): что и почему изменилось в глобальной  стратегии лечения хронической обструктивной болезни легких</article-title><trans-title-group xml:lang="en"><trans-title>GOLD  2017: what change were made in global strategy of treatment of chronic obstructive pulmonary disease and why?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барабанова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Barabanova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барабанова Екатерина Николаевна – кандидат медицинских наук, менеджер по медицинским и научным коммуникациям </p><p>121614, Москва, ул. Крылатская, 17, корп. 3</p></bio><bio xml:lang="en"><p>Ekaterina N. Barabanova, Candidate of Medicine, Manager on Medical and Scientific Communication </p><p>ul. Krylatskaya 17, build. 3, Moscow, 121614</p></bio><email xlink:type="simple">ekaterina.n.barabanova@gsk.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ЗАО «ГлаксоСмитКляйн Трейдинг»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>GlaxoSmithKline Trading PLC</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>05</day><month>07</month><year>2017</year></pub-date><volume>27</volume><issue>2</issue><fpage>274</fpage><lpage>282</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Барабанова Е.Н., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Барабанова Е.Н.</copyright-holder><copyright-holder xml:lang="en">Barabanova E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/850">https://journal.pulmonology.ru/pulm/article/view/850</self-uri><abstract><p>В1997 г. Международной группой экспертов в области хронической обструктивной болезни легких (ХОБЛ) принято соглашение о необходимости создания Глобальной инициативы по ХОБЛ (GOLD). Первый доклад рабочей группы GOLD, ставший основой для создания в ряде стран национальных программ диагностики и лечения ХОБЛ, опубликован в2001 г. С учетом данных, накопленных за прошедшее десятилетие, в 2011–2013 гг. проведен пересмотр глобальной стратегии, в котором при оценке прогноза и выборе терапии ХОБЛ предусмотрен персонализированный подход. В конце2016 г. опубликован очередной крупный пересмотр доклада GOLD. Изменена схема категоризации пациентов ABCD, а степень ограничения воздушного потока по спирометрической классификации GOLD исключена из алгоритма выбора медикаментозной терапии. Подчеркнуто влияние правильной техники ингаляции на контроль над симптомами ХОБЛ и важность ее регулярной оценки. Добавлены новые данные по использованию комбинаций длительно действующих β2-агонистов и длительно действующих антихолинергических препаратов, а также тройной терапии. Приведена классификация обострений ХОБЛ по степени тяжести, отмечено влияние сопутствующих заболеваний на течение обострения. Расширен раздел, относящийся к пульмонологической реабилитации.</p></abstract><trans-abstract xml:lang="en"><p>In 1997, the International Expert group on chronic obstructive pulmonary disease (COPD) has come to decision to initiate the Global Initiative for COPD (GOLD). The first GOLD report was published in 2001 and provided the basis for many national programs for COPD diagnosis and management. Research data accumulated in the next decade allowed to perform complete revision of global strategy in 2011 (updated 2013), considering personalized approach to prognosis and treatment selection in an individual patient. At the end of2016, anew comprehensive reassessment of GOLD report was released. The ABCD assessment tool has been refined; the role of spirometry in COPD management has been updated. Regular assessment of inhaler technique to improve the disease control has been emphasized. New data on therapy with long-acting β2-agonists/long acting anticholinergic combinations and «triple therapy» have been added. Classification of severity of COPD exacerbations was provided and impact of concomitant diseases was stressed. The section on pulmonary rehabilitation has been amplified.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая обструктивная болезнь легких</kwd><kwd>Глобальная инициатива по хронической обструктивной болезни легких</kwd><kwd>спирометрия</kwd><kwd>фармакотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic obstructive pulmonary disease</kwd><kwd>Global Initiative for chronic obstructive pulmonary disease</kwd><kwd>spirometry</kwd><kwd>pharmacotherapy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ЗАО «ГлаксоСмитКляйн Трейдинг»</funding-statement><funding-statement xml:lang="en">GlaxoSmithKline PLC</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lange P., Celli B., Agusti A. et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N. Engl. J. Med. 2015; 373 (2): 111–122. DOI: 10.1056/NEJMoa1411532.</mixed-citation><mixed-citation xml:lang="en">Lange P., Celli B., Agusti A. et al. Lung-function trajectories leading to chronic obstructive pulmonary disease. N. Engl. J. Med. 2015; 373 (2): 111–122. DOI: 10.1056/NEJMoa1411532.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Vas Fragoso C.A., McAvay G., Van Ness P.H. et al. Phenotype of normal spirometry in an aging population. Am. J. Respir. Crit. Care Med. 2015; 192 (7): 817–825. DOI: 10.1164/rccm.201503-0463OC.</mixed-citation><mixed-citation xml:lang="en">Vas Fragoso C.A., McAvay G., Van Ness P.H. et al. Phenotype of normal spirometry in an aging population. Am. J. Respir. Crit. Care Med. 2015; 192 (7): 817–825. DOI: 10.1164/rccm.201503-0463OC.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Vas Fragoso C.A., McAvay G., Van Ness P.H. et al. Phenotype of spirometric impairment in an aging population. Am. J. Respir. Crit. Care Med. 2016; 193 (7): 727–735. DOI: 10.1164/rccm.201508-1603OC.</mixed-citation><mixed-citation xml:lang="en">Vas Fragoso C.A., McAvay G., Van Ness P.H. et al. Phenotype of spirometric impairment in an aging population. Am. J. Respir. Crit. Care Med. 2016; 193 (7): 727–735. DOI: 10.1164/rccm.201508-1603OC.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lee P.N., Fariss M.W. A systematic review of possible serious adverse effects of nicotine replacement therapy. Arch. Toxicol. 2017; 91 (4): 1565–1594. DOI: 10.1007/s00204-016-1856-y.</mixed-citation><mixed-citation xml:lang="en">Lee P.N., Fariss M.W. A systematic review of possible serious adverse effects of nicotine replacement therapy. Arch. Toxicol. 2017; 91 (4): 1565–1594. DOI: 10.1007/s00204-016-1856-y.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McNeill A., Brose L.S., Calder R.I. et al. E-cigarettes: an evidence update. A report commissioned by Public Health England: Public Health England, 2015. Available at: https:// www.gov.uk/government/uploads/system/uploads/attach-ment-data/file/457102/Ecigarettes-an-evidence-update-A-report-commissioned-by-Public-Health-England-FINAL.pdf</mixed-citation><mixed-citation xml:lang="en">McNeill A., Brose L.S., Calder R.I. et al. E-cigarettes: an evidence update. A report commissioned by Public Health England: Public Health England, 2015. Available at: https:// www.gov.uk/government/uploads/system/uploads/attach-ment-data/file/457102/Ecigarettes-an-evidence-update-A-report-commissioned-by-Public-Health-England-FINAL.pdf</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">McRobbie H., Bullen C., Hartmann-Boyce J., Hajek P. Electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst. Rev. 2014; (12): CD010216. DOI: 10.1002/14651858.CD010216.pub2.</mixed-citation><mixed-citation xml:lang="en">McRobbie H., Bullen C., Hartmann-Boyce J., Hajek P. Electronic cigarettes for smoking cessation and reduction. Cochrane Database Syst. Rev. 2014; (12): CD010216. DOI: 10.1002/14651858.CD010216.pub2.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kalkhoran S., Glantz S.A. E-cigarettes and smoking cessation – Author’s reply. Lancet Respir. Med. 2016; 4 (6): e26–27. DOI: 10.1016/S2213-2600(16)30025-X.</mixed-citation><mixed-citation xml:lang="en">Kalkhoran S., Glantz S.A. E-cigarettes and smoking cessation – Author’s reply. Lancet Respir. Med. 2016; 4 (6): e26–27. DOI: 10.1016/S2213-2600(16)30025-X.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Malas M., van der Tempel J., Schwartz R. et al. Electronic cigarettes for smoking cessation: A systematic review. Nicotine Tob. Res. 2016; 18 (10): 1926–1936. DOI: 10.1093/ntr/ntw119.</mixed-citation><mixed-citation xml:lang="en">Malas M., van der Tempel J., Schwartz R. et al. Electronic cigarettes for smoking cessation: A systematic review. Nicotine Tob. Res. 2016; 18 (10): 1926–1936. DOI: 10.1093/ntr/ntw119.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Souza M.L., Meneghini A.C., Ferraz E. et al. Knowledge of and technique for using inhalation devices among asthma patients and COPD patients. J. Braz. Pneumol. 2009; 35 (9): 824–831.</mixed-citation><mixed-citation xml:lang="en">Souza M.L., Meneghini A.C., Ferraz E. et al. Knowledge of and technique for using inhalation devices among asthma patients and COPD patients. J. Braz. Pneumol. 2009; 35 (9): 824–831.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Melani A.S., Bonavia M., Cilenti V. et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir. Med. 2011; 105 (6): 930–938. DOI: 10.1016/j.rmed.2011.01.005.</mixed-citation><mixed-citation xml:lang="en">Melani A.S., Bonavia M., Cilenti V. et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir. Med. 2011; 105 (6): 930–938. DOI: 10.1016/j.rmed.2011.01.005.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchis J., Gich I., Pedersen S. Systematic review of errors in inhaler use: Has patient technique improved over time? Chest. 2016; 150 (2):394–406. DOI: 10.1016/j.chest.2016.03.041.</mixed-citation><mixed-citation xml:lang="en">Sanchis J., Gich I., Pedersen S. Systematic review of errors in inhaler use: Has patient technique improved over time? Chest. 2016; 150 (2):394–406. DOI: 10.1016/j.chest.2016.03.041.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sulaiman I., Cushen B., Greene G. et al. Objective assessment of adherence to inhalers by COPD patients. Am. J. Respir. Care Med. 2017; 195 (10): 1333–1343. DOI: 10.1164/rccm.201604-0733OC.</mixed-citation><mixed-citation xml:lang="en">Sulaiman I., Cushen B., Greene G. et al. Objective assessment of adherence to inhalers by COPD patients. Am. J. Respir. Care Med. 2017; 195 (10): 1333–1343. DOI: 10.1164/rccm.201604-0733OC.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rootmensen G.N., van Keimpena A.R., Jansen H.M., de Haan R.J. Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped method. J. Aerosol Med. Pulm. Drug Deliv. 2010; 23 (5): 323–328. DOI: 10.1089/jamp.2009.0785.</mixed-citation><mixed-citation xml:lang="en">Rootmensen G.N., van Keimpena A.R., Jansen H.M., de Haan R.J. Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped method. J. Aerosol Med. Pulm. Drug Deliv. 2010; 23 (5): 323–328. DOI: 10.1089/jamp.2009.0785.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Wedzicha J.A., Decramer M., Ficker J.H. et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomized, doubleblind, parallel-group study. Lancet Respir. Med. 2013; 1 (3): 199–209. DOI: 10.1016/S2213-2600(13)70052-3.</mixed-citation><mixed-citation xml:lang="en">Wedzicha J.A., Decramer M., Ficker J.H. et al. Analysis of chronic obstructive pulmonary disease exacerbations with the dual bronchodilator QVA149 compared with glycopyrronium and tiotropium (SPARK): a randomized, doubleblind, parallel-group study. Lancet Respir. Med. 2013; 1 (3): 199–209. DOI: 10.1016/S2213-2600(13)70052-3.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wedzicha J.A., Banerji D., Chapman K. et al. Indacaterolglycopyrronium versus salmeterol-fluticasone for COPD. N. Engl. J. Med. 2016; 374 (23): 2222–2234. DOI: 10.1056/NEJMoa1516385.</mixed-citation><mixed-citation xml:lang="en">Wedzicha J.A., Banerji D., Chapman K. et al. Indacaterolglycopyrronium versus salmeterol-fluticasone for COPD. N. Engl. J. Med. 2016; 374 (23): 2222–2234. DOI: 10.1056/NEJMoa1516385.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Brusselle G., Price D., Gruffydd-Jones K. et al. The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK. Int. J. Chron. Obstruct. Pulmon. Dis. 2015; 10 (1): 2207–2217. DOI: 10.2147/COPD.S91694.</mixed-citation><mixed-citation xml:lang="en">Brusselle G., Price D., Gruffydd-Jones K. et al. The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK. Int. J. Chron. Obstruct. Pulmon. Dis. 2015; 10 (1): 2207–2217. DOI: 10.2147/COPD.S91694.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Singh D., Brooks J., Hagan G. et al. Superiority of “triple” therapy with salmeterol-fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax. 2008; 63 (7): 592–598. DOI: 10.1136/thx.2007.087213.</mixed-citation><mixed-citation xml:lang="en">Singh D., Brooks J., Hagan G. et al. Superiority of “triple” therapy with salmeterol-fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax. 2008; 63 (7): 592–598. DOI: 10.1136/thx.2007.087213.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Frith P.A., Thompson P.J., Ratnavadivel R. et al. Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD – a randomized controlles trial. Thorax. 2015; 70 (6): 519–527. DOI: 10.1136/thoraxjnl2014-206670.</mixed-citation><mixed-citation xml:lang="en">Frith P.A., Thompson P.J., Ratnavadivel R. et al. Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD – a randomized controlles trial. Thorax. 2015; 70 (6): 519–527. DOI: 10.1136/thoraxjnl2014-206670.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Siler T.M., Kerwin E., Singletary K. et al. Efficacy and safety of umeclidinium added to fluticasone propionate/salmeterol in patients with COPD: results of two randomized, double-blind studies. COPD. 2016; 13 (1): 1–10. DOI: 10.3109/15412555.2015.1034256.</mixed-citation><mixed-citation xml:lang="en">Siler T.M., Kerwin E., Singletary K. et al. Efficacy and safety of umeclidinium added to fluticasone propionate/salmeterol in patients with COPD: results of two randomized, double-blind studies. COPD. 2016; 13 (1): 1–10. DOI: 10.3109/15412555.2015.1034256.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Singh D., Papi A., Corradi M. et al. Single inhaler triple therapy versus inhaled corticosteroid plus ling-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomized controlled trial. Lancet. 2016; 388 (10048): 963–973. DOI: 10.1016/S0140-6736(16)31354-X.</mixed-citation><mixed-citation xml:lang="en">Singh D., Papi A., Corradi M. et al. Single inhaler triple therapy versus inhaled corticosteroid plus ling-acting β2-agonist therapy for chronic obstructive pulmonary disease (TRILOGY): a double-blind, parallel group, randomized controlled trial. Lancet. 2016; 388 (10048): 963–973. DOI: 10.1016/S0140-6736(16)31354-X.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">McCarthy B., Casey D., Devane D. et al. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst. Rev. 2015; (2): CD003793. DOI: 10.1002/14651858.CD003793.pub3.</mixed-citation><mixed-citation xml:lang="en">McCarthy B., Casey D., Devane D. et al. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst. Rev. 2015; (2): CD003793. DOI: 10.1002/14651858.CD003793.pub3.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Galli J.A., Krahnke J.S., James Mamary A. et al. Home non-invasive ventilation use following acute hypercapnic respiratory failure in COPD. Respir. Med. 2014; 108 (5): 722–728. DOI: 10.1016/j.rmed.2014.03.006.</mixed-citation><mixed-citation xml:lang="en">Galli J.A., Krahnke J.S., James Mamary A. et al. Home non-invasive ventilation use following acute hypercapnic respiratory failure in COPD. Respir. Med. 2014; 108 (5): 722–728. DOI: 10.1016/j.rmed.2014.03.006.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Coughlin S., Liang W.E., Parthasarathy S. Retrospective assessment of home ventilation to reduce rehospitalization in chronic obstructive pulmonary disease. J. Clin. Sleep Med. 2015; 11 (6): 663–670. DOI: 10.5664/jcsm.4780.</mixed-citation><mixed-citation xml:lang="en">Coughlin S., Liang W.E., Parthasarathy S. Retrospective assessment of home ventilation to reduce rehospitalization in chronic obstructive pulmonary disease. J. Clin. Sleep Med. 2015; 11 (6): 663–670. DOI: 10.5664/jcsm.4780.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Marin J.M., Soriano J.B., Carrizo S.J. et al. Outcomes in patients with in chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am. J. Respir. Crit. Care Med. 2010; 182 (3): 325–331. DOI: 10.1164/rccm.200912-1869OC.</mixed-citation><mixed-citation xml:lang="en">Marin J.M., Soriano J.B., Carrizo S.J. et al. Outcomes in patients with in chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am. J. Respir. Crit. Care Med. 2010; 182 (3): 325–331. DOI: 10.1164/rccm.200912-1869OC.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gavish R., Levy A., Dekel O.K. et al. The association between hospital readmission and pulmonologist follow-up visits in patients with COPD. Chest. 2015; 148 (2): 375–381. DOI: 10.1378/chest.14-1453.</mixed-citation><mixed-citation xml:lang="en">Gavish R., Levy A., Dekel O.K. et al. The association between hospital readmission and pulmonologist follow-up visits in patients with COPD. Chest. 2015; 148 (2): 375–381. DOI: 10.1378/chest.14-1453.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Masa J.F., Utrabo I., Gomez de Terreros J. et al. Noninvasive ventilation for severely acidotic patients in respiratory intermediate care units: precision medicine in intermediate care units. BMC Pulm. Med. 2016; 16 (1): 97. DOI: 10.1186/s12890-016-0262-9.</mixed-citation><mixed-citation xml:lang="en">Masa J.F., Utrabo I., Gomez de Terreros J. et al. Noninvasive ventilation for severely acidotic patients in respiratory intermediate care units: precision medicine in intermediate care units. BMC Pulm. Med. 2016; 16 (1): 97. DOI: 10.1186/s12890-016-0262-9.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Houben-Wilke S., Jorres R.A., Bals R. et al. Peripheral artery disease and its clinical relevance in patients with COPD in the COSYCONET study. Am. J. Respir. Crit. Care Med. 2017; 195 (2): 189–197. DOI: 10.1164/rccm.2016020354OC.</mixed-citation><mixed-citation xml:lang="en">Houben-Wilke S., Jorres R.A., Bals R. et al. Peripheral artery disease and its clinical relevance in patients with COPD in the COSYCONET study. Am. J. Respir. Crit. Care Med. 2017; 195 (2): 189–197. DOI: 10.1164/rccm.2016020354OC.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt S.P., Dransfield M.T. Chronic obstructive pulmonary disease and cardiovascular disease. Transl. Res. 2013; 162 (4): 237–251. DOI: 10.1016/j.trsl.2013.05.001.</mixed-citation><mixed-citation xml:lang="en">Bhatt S.P., Dransfield M.T. Chronic obstructive pulmonary disease and cardiovascular disease. Transl. Res. 2013; 162 (4): 237–251. DOI: 10.1016/j.trsl.2013.05.001.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Jaramillo J.D., Wilson C., Stinson D.S. et al. Reduced bone density and vertebral fractures in smokers. Men and COPD patients at increased risk. Ann. Am. Thorac. Soc. 2015; 12 (5): 648–656. DOI: 10.1513/AnnalsATS.201412-591OC.</mixed-citation><mixed-citation xml:lang="en">Jaramillo J.D., Wilson C., Stinson D.S. et al. Reduced bone density and vertebral fractures in smokers. Men and COPD patients at increased risk. Ann. Am. Thorac. Soc. 2015; 12 (5): 648–656. DOI: 10.1513/AnnalsATS.201412-591OC.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">de Torres J.P., Wilson D.O., Sanchez-Salcedo P. et al. Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am. J. Respir. Crit. Care Med. 2015; 191 (3): 285–291. DOI: 10.1164/rccm.2014071210OC.</mixed-citation><mixed-citation xml:lang="en">de Torres J.P., Wilson D.O., Sanchez-Salcedo P. et al. Lung cancer in patients with chronic obstructive pulmonary disease. Development and validation of the COPD Lung Cancer Screening Score. Am. J. Respir. Crit. Care Med. 2015; 191 (3): 285–291. DOI: 10.1164/rccm.2014071210OC.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sasaki T., Nakayama K., Yasuda H. et al. A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patient. J. Am. Geriatr. Soc. 2009; 57 (8): 1453–1457.</mixed-citation><mixed-citation xml:lang="en">Sasaki T., Nakayama K., Yasuda H. et al. A randomized, single-blind study of lansoprazole for the prevention of exacerbations of chronic obstructive pulmonary disease in older patient. J. Am. Geriatr. Soc. 2009; 57 (8): 1453–1457.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
