pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2016-26-6-748-752pulmo-799Research ArticleОБЗОРЫREVIEWДефицит маннозосвязывающего лектина при заболеваниях респираторного трактаMannose-binding lectin deficiency in respiratory diseasesТерещенкоС. Ю.TereshchenkoS. Yu.

660022, Красноярск, ул. Партизана Железняка, 3Г

д. м. н., профессор, заведующий отделением соматического и психического здоровья детей Федерального государственного бюджетного научного учреждения «Научно-исследовательский институт медицинских проблем Севера»; тел.: (391)2280683

ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022, Russia

Doctor of Medicine, Professor, Head of Division of Children's Somatic and Psychiatric Health, Federal Research Institute of Medical Problems of the North; tel.: (391) 2280683

child@impn.ruКаспаровЭ. В.KasparovE. V.

660022, Красноярск, ул. Партизана Железняка, 3Г

д. м. н., профессор, исполняющий обязанности директора Федерального государственного бюджетного научного учреждения «Научноисследовательский институт медицинских проблем Севера»; тел.: (391) 2280683

ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022, Russia

Doctor of Medicine, Professor, Alternative Director of Federal Research Institute of Medical Problems of the North; tel.: (391)2280683

impn@impn.ruСмольниковаМ. В.Smol'nikovaM. V.

660022, Красноярск, ул. Партизана Железняка, 3Г

к. б. н., ведущий научный сотрудник лаборатории клеточномолекулярной физиологии и патологии Федерального государственного бюджетного научного учреждения «Научноисследовательский институт медицинских проблем Севера»; тел.: (391) 2280683

ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022, Russia

Candidate of Medicine, Leading Researcher at Laboratory of Molecular Physiology and Pathology, Federal Research Institute of Medical Problems of the North; tel.: (391) 2280683

smarinv@ya.ruКувшиноваЕ. В.KuvshinovaE. V.

660022, Красноярск, ул. Партизана Железняка, 3Г

врач отделения детской пульмонологии клиники Федерального государственного бюджетного научного учреждения «Научноисследовательский институт медицинских проблем Севера»; тел.: (391) 2280683 

ul. Partizana Zheleznyaka 3G, Krasnoyarsk, 660022, Russia

Physician at Department of Pediatric Pulmonology, Federal Research Institute of Medical Problems of the North; tel.: (391) 2280683

child@impn.ruФедеральное государственное бюджетное научное учреждение «Научно-исследовательский институт медицинских проблем Севера»РоссияFederal Research Institute of Medical Problems of the North, Siberian Department of Russian Academy of Medical ScienceRussian Federation201628022017266748752Copyright © Терещенко С.Ю., Каспаров Э.В., Смольникова М.В., Кувшинова Е.В., 20172017Терещенко С.Ю., Каспаров Э.В., Смольникова М.В., Кувшинова Е.В.Tereshchenko S.Y., Kasparov E.V., Smol'nikova M.V., Kuvshinova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/799

Маннозосвязывающий лектин (Mannosebinding lectin – MBL) относится к системе врожденного иммунитета – самому первому рубежу противоинфекционной защиты, реализующему свое действие уже в первые минуты и часы после внедрения патогенного микроорганизма. В обзоре представлены общие данные о механизмах действия MBL и частные случаи патогенетической роли его дефицита при широком круге респираторных заболеваний: бактериальной пневмонии, вирусных инфекциях респираторного тракта, туберкулезе, муковисцидозе, хронической обструктивной болезни легких и бронхиальной астме у взрослых и детей.

Mannosebinding lectin is a part of the innate immunity that, being the first barrier of the antiinfectious defense, acts in first minutes or hours after pathogen challenge. The review provides data about mechanisms of action of mannosebinding lectin and its particular pathogenic role in a wide range of respiratory diseases: bacterial pneumonia, viral respiratory tract infections, tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, and asthma in adults and children.

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The authors declare that there are no conflicts of interest present.