pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/086901892016266719724pulmo-796Research ArticleДИСКУССИИDiscussionsБронхиальная астма, свистящие хрипы, флаттер. Возможные взаимоотношенияBronchial asthma, wheezing, flatter: probable relationshipsАбросимовВ. Н.AbrosimovV. N.

390026, Рязань, ул. Высоковольтная, 9

д. м. н., профессор, заведующий кафедрой терапии факультета дополнительного профессионального образования с курсом семейной медицины Федерального государственного бюджетного образовательного учреждения высшего образования «Рязанский государственный медицинский университет имени академика И.П.Павлова» Министерства здравоохранения Российской Федерации; тел. / факс: (4912) 962793

ul. Vysokovol'tnaya 9, Ryazan, 390026, Russia

Doctor of Medicine, Professor, Head of Department of Therapy, Faculty of Postsecondary Education and Family Medicine, I.P.Pavlov Ryazan State Medical University, Healthcare Ministry of Russia; tel. / fax: (4912) 962793

abrosimov_r@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Рязанский государственный медицинский университет имени академика И.П.Павлова» Министерства здравоохранения Российской ФедерацииРоссияI.P.Pavlov Ryazan State Medical University, Healthcare Ministry of RussiaRussian Federation201628022017266719724Copyright © Абросимов В.Н., 20172017Абросимов В.Н.Abrosimov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/796

В статье рассматриваются взаимоотношения свистящих хрипов (wheezing) и вибрации (флаттера) у больных бронхиальной астмой (БА). Приводятся сведения о влиянии вибрации на патофизиологические изменениях верхних дыхательных путей в эксперименте. Высказано предположение, что вибрация (флаттер) как один из ключевых механизмов свистящих хрипов может способствовать развитию воспалительных изменений, эндотелиальной дисфункции микроциркуляторного русла в нижних отделах дыхательных путей у больных БА.

Wheezing is the most common clinical sign and one of the key diagnostic criteria of asthma. Pathophysiology of wheezing is not fully recognized. A theory of hemodynamic flatter is widely adopted. Effects of vibration are actively investigated in patients with snore and obstructive sleep apnea. Vibration can contribute to the upper airway inflammation and endothelial dysfunction in snoring patients. Therefore, the flatter (vibration) effect could be the key mechanism of wheezing in asthma patients and could promote similar changes in the lower airway microvasculature. Recently, CPAP therapy has been shown to reduce asthma symptoms and bronchial hyperresponsiveness and acts as a mechanical bronchodilator is patients with asthma without sleepassociated breathing disorders.

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The authors declare that there are no conflicts of interest present.