pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2016-26-5-584-590pulmo-767Research ArticleОБЗОРЫREVIEWМЕСТО ГИПЕРТОНИЧЕСКОГО РАСТВОРА ХЛОРИДА НАТРИЯ В ТЕРАПИИ МУКОВИСЦИДОЗАA ROLE OF HYPERTONIC SALINE SOLUTION IN TREATMENT OF CYSTIC FIBROSISКаширскаяН. Ю.KashirskayaN. Yu.

д. м. н., профессор, главный научный сотрудник лаборатории генетической эпидемиологии

MD, Professor, Principal Researcher at Laboratory of Genetic Epidemiology

kashirskayanj@mail.ruШерманВ. Д.ShermanV. D.

к. м. н., старший научный сотрудник научно-клинического отдела муковисцидоза

PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis

tovika@yandex.ruКапрановН. И.KapranovN. I.

д. м. н., профессор, главный научный сотрудник научно-клинического отдела муковисцидоза

MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis

nikolay.i.kapranov@gmail.comКондратьеваЕ. И.Kondrat'evaE. I.

д. м. н., профессор, главный научный сотрудник научно-клинического отдела муковисцидоза

MD, Professor, Principal Researcher at Research and Clinical Division of Cystic Fibrosis

elenafpk@mail.ruКрасовскийС. А.KrasovskiyS. A.

к. м. н., старший научный сотрудник научно-клинического отдела муковисцидоза ФГБУ «Медико- генетический научный центр» РАН, старший научный сотрудник лаборатории муковисцидоза ФГБУ «НИИ пульмонологии» ФМБА России, врач-пульмонолог 2-го пульмонологического отделения ГБУЗ города Москвы «Городская клиническая больница имени Д.Д.Плетнева» ДЗМ города Москвы

PhD, Senior Researcher at Research and Clinical Division of Cystic Fibrosis, Federal Medical Genetic Academic Center, Russian Academy of Science; Senior Researcher at Laboratory of Cystic Fibrosis, Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia; pneumologist at the 2#nd Pulmonology Department of D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department

sa_krasovsky@mail.ruАмелинаЕ. Л.AmelinaE. L.

к. м. н., заведующая лабораторией муковисцидоза ФГБУ «НИИ пульмонологии» ФМБА России

PhD, Head of Laboratory of Cystic Fibrosis

eamelina@mail.ruФГБУ «Медико"генетический научный центр» РАН: 115478, Москва, ул. Москворечье, 1РоссияFederal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, RussiaRussian FederationФГБУ «Медико"генетический научный центр» РАН: 115478, Москва, ул. Москворечье, 1 ФГБУ «НИИ пульмонологии» ФМБА России: 105077, Москва, ул. 11"я Парковая, 32, корп. 4; ГБУЗ Москвы «Городская клиническая больница имени Д.Д.Плетнева» ДЗ г. Москвы: 105077, Москва, ул. 11"я Парковая, 32РоссияFederal Medical Genetic Academic Center, Russian Academy of Science: 1, Moskvorech'e str., Moscow, 1115478, Russia Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, Russia; 3D.D.Pletnev City Clinical Hospital, Moscow Healthcare Department: 32, 11th Parkovaya str., Moscow, 105077, RussiaRussian FederationФГБУ «НИИ пульмонологии» ФМБА России: 105077, Москва, ул. 11"я Парковая, 32, корп. 4РоссияFederal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia: 32, build. 4, 11th Parkovaya str., Moscow, 105077, RussiaRussian Federation201620122016265584590Copyright © Каширская Н.Ю., Шерман В.Д., Капранов Н.И., Кондратьева Е.И., Красовский С.А., Амелина Е.Л., 20162016Каширская Н.Ю., Шерман В.Д., Капранов Н.И., Кондратьева Е.И., Красовский С.А., Амелина Е.Л.Kashirskaya N.Y., Sherman V.D., Kapranov N.I., Kondrat'eva E.I., Krasovskiy S.A., Amelina E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/767

Прогноз заболевания при муковисцидозе (МВ) в подавляющем большинстве случаев определяется выраженностью поражения бронхо-легочной системы. Именно поэтому изучению новых методов терапии бронхолегочной системы уделяется самое пристальное внимание. Помимо антибактериальных средств и кинезитерапии, важную роль играют муколитические препараты, среди которых все боль шее значение придается применению гипертонического раствора хлорида натрия (ГРХН), который было бы более корректно отнести к регидратантам мокроты. В статье представлен систематический обзор литературы, посвященный безопасности и клинической эффективности применения ингаляций ГРХН (в комбинации с гиалуроновой кислотой или без таковой), а также возможности его длительного приема в качестве базисной терапии в сочетании с муколитическим препаратом дорназа альфа больными МВ разных возрастных групп.

Outcomes and prognosis in cystic fibrosis (CF) are generally related to severity of respiratory system injury. That is why new therapeutic methods are in focus. Mucolytic agents play an important role along with antibacterial therapy and kinesiotherapy. Hypertonic saline solution (HSS) is one of the most important mucolytic agents though it should be referred to as sputum rehydratant. A systematic review of safety and clinical efficacy of inhaled HSS (alone or in combination with hyaluronic acid) has been done in this article. A long-term treatment with inhaled HSS in combination with dornase alfa as a basic therapy of CF in various age groups of patients has been also discussed.

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The authors declare that there are no conflicts of interest present.