pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2015-25-4-492-496pulmo-609Research ArticleОБЗОРЫREVIEWПротивовоспалительный фактор слизистых – секретоглобин SCGB1A1Mucosal anti6inflammatory factor secretoglobin SCGB1A1МалаяН. К.MalayaN. K.

аспирант кафедры педиатрии с курсом физиотерапии ФПО ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: (978) 8483121

PhD student at Department of Pediatrics with Course of Physiotherapy, S.I.Georgievskiy Crimea State Medical University; tel.: 9788483121

nm_sn@mail.ruКаладзеН. Н.KaladzeN. N.

д. м. н., профессор, зав. кафедрой педиатрии с курсом физиотерапии ФПО ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: 38 (0652) 276626

MD, Professor, Head of Department of Pediatrics with Course of Physiotherapy, S.I.Georgievskiy Crimea State Medical University; tel.: (380652) 276626

kaladze44@mail.ruМалыйК. Д.MalyyK. D.

к. м. н., ст. преподаватель кафедры биофизики ГУ "Крымский государственный медицинский университет им. С.И.Георгиевского"; тел.: (978) 8483117

PhD, Senior Lecturer at Department of Biophysics, S.I.Georgievskiy Crimea State Medical University; tel.: (978) 8483117

kdmaly@mail.ruГУ "Крымский государственный медицинский университет им. С.И.Георгиевского": 295006, Россия, Республика Крым, Симферополь, бр Ленина, 5 / 7РоссияS.I.Georgievskiy Crimea State Medical University: 5 / 7, Lenina av., Simferopol', 295006, Crimea Republic, RussiaRussian Federation201521102015254492496Copyright © Малая Н.К., Каладзе Н.Н., Малый К.Д., 20152015Малая Н.К., Каладзе Н.Н., Малый К.Д.Malaya N.K., Kaladze N.N., Malyy K.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/609

Секретоглобин SCGB1A1 – белок, синтезируемый секреторными клетками эпителия воздухоносных путей (клубными клетками, или клетками Клара), а также другими эпителиальными клетками дыхательного и урогенитального тракта. Семейство секретоглобинов участвует в обеспечении гомеостаза при окислительном повреждении, воспалении, аутоиммунных процессах и канцерогенезе. Первый член семейства – секретоглобин SCGB1A1 – многофункциональный белок с выраженными противовоспалительными, иммуномодулирующими свойствами. В дополнение к его противовоспалительной функции он также проявляет антихемотактические, противоаллер гические, противоопухолевые свойства, а также оказывает ростостимулирующий эффект на преимплантированный эмбрион. Генетический полиморфизм гена SCGB1A1 связан с частотой развития ряда воспалительных и аутоиммунных заболеваний. Эти свойства предполагают возможность его использования для диагностики и лечения воспалительных, аутоиммунных и аллергических заболеваний.

Secretoglobin SCGB1A1 is a protein produced by airway epithelium secretory cells (club cells or Clara cells) and other epithelial cells of the respiratory and urogenital tracts. Secretoglobin family 1A member 1 (SCGB1A1) refers to as secretoglobin superfamily and participates in maintaining homeostasis under the oxidative stress, inflammation, autoimmune diseases and carcinogenesis. It is a multifunctional protein with antiinflammatory and immunomodulatory properties. It also has antichemotactic, antiallergic, antineoplastic, and grow thstimulatory embryonic activities. SCGB1A1 gene polymorphism appears to be associated with several inflammatory and autoimmune diseases. These properties could be useful for diagnosis and treatment of inflammatory, autoimmune and allergic diseases.

секретоглобин SGB1A1слизистые оболочкирегуляция иммунитетагенетический полиморфизмsecretoglobin SCGB1A1mucous membranesimmunity regulationgene polymorphismReferencesMucherjee A.B., Zhang Z., Chilton B.S. Uteroglobin: a steroid inducible immunomodulatory protein that founded the secreto globin superfamily. Endocrin. Rev. 2007; 28 (7): 707–725.Mucherjee A.B., Zhang Z., Chilton B.S. Uteroglobin: a steroid inducible immunomodulatory protein that founded the secreto globin superfamily. Endocrin. Rev. 2007; 28 (7): 707–725.Wong A.P., Keating A., Waddell T.K. Airway regeneration: The role of the Clara cell secretory protein and the cells that express it. Cytotherapy. 2009; 11: 676–687.Wong A.P., Keating A., Waddell T.K. Airway regeneration: The role of the Clara cell secretory protein and the cells that express it. Cytotherapy. 2009; 11: 676–687.Krishnan R.S., Daniel J.C. Jr. Blastokinin: Inducer and regulator of blastocyst development in the rabbit uterus. Science. 1967; 158: 490–492.Krishnan R.S., Daniel J.C. Jr. Blastokinin: Inducer and regulator of blastocyst development in the rabbit uterus. Science. 1967; 158: 490–492.Beier H.M. Uteroglobin: A hormone sensitive endometrial protein involved in blastocyst development. Biochem. Biophys. Acta. 1968; 160: 289–291.Beier H.M. Uteroglobin: A hormone sensitive endometrial protein involved in blastocyst development. Biochem. Biophys. Acta. 1968; 160: 289–291.Kundu G.C., Zhang Z., Mantile Selvaggi G. et al. Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells. Ann. NY Acad. Sci. 2001; 923: 234–248.Kundu G.C., Zhang Z., Mantile Selvaggi G. et al. Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells. Ann. NY Acad. Sci. 2001; 923: 234–248.Singh G., Katyal S.L., Gottron S.A. Antigenic, molecular and functional heterogeneity of Clara cell secretory proteins in the rat. Biochim. Biophys. Acta. 1985; 829: 156–163.Singh G., Katyal S.L., Gottron S.A. Antigenic, molecular and functional heterogeneity of Clara cell secretory proteins in the rat. Biochim. Biophys. Acta. 1985; 829: 156–163.Bernard A.M., Dumont X., Roels H. et al. The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: a reappraisal. Clin. Chim. Acta. 1993; 223:189–191.Bernard A.M., Dumont X., Roels H. et al. The molecular mass and concentrations of protein 1 or Clara cell protein in biological fluids: a reappraisal. Clin. Chim. Acta. 1993; 223:189–191.Klug J., Beier H.M., Bernard A. et al. Uteroglobin / Clara cell 10 kDa family of proteins: nomenclature committee report. Ann. NY Acad. Sci. 2000; 923: 348–354.Klug J., Beier H.M., Bernard A. et al. Uteroglobin / Clara cell 10 kDa family of proteins: nomenclature committee report. Ann. NY Acad. Sci. 2000; 923: 348–354.Nie W., Xue C., Chen J. et al. Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism is associated with asthma risk: a meta analysis. Gene. 2013; 528 (2): 304–308.Nie W., Xue C., Chen J. et al. Secretoglobin 1A member 1 (SCGB1A1) +38A/G polymorphism is associated with asthma risk: a meta analysis. Gene. 2013; 528 (2): 304–308.http://www.genecards.org/cgibin/carddisp.pl?gene=SCGB1A1http://www.genecards.org/cgibin/carddisp.pl?gene=SCGB1A1Chen C., Schilling K., Hiipakka R.A. et al. Prostate α protein. Isolation and characterization of the polypeptide components and cholesterol binding. J. Biol. Clem. 1982; 256: 116–121.Chen C., Schilling K., Hiipakka R.A. et al. Prostate α protein. Isolation and characterization of the polypeptide components and cholesterol binding. J. Biol. Clem. 1982; 256: 116–121.Fleming T.P., Watson M.A. Mammaglobin, a breast specific gene, and its utility as a marker for breast cancer. Ann. NY Acad. Sci. 2000; 923: 78–89.Fleming T.P., Watson M.A. Mammaglobin, a breast specific gene, and its utility as a marker for breast cancer. Ann. NY Acad. Sci. 2000; 923: 78–89.Ni J., Kalff Sucke M., Gentz R. et. al. All human genes of uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster. Ann. NY Acad. Sci. 2000; 923: 25–42.Ni J., Kalff Sucke M., Gentz R. et. al. All human genes of uteroglobin family are localized on chromosome 11q12.2 and form a dense cluster. Ann. NY Acad. Sci. 2000; 923: 25–42.Callebaut I., Poupon A., Bally R. et al. The uteroglobin fold. Ann. NY Acad. Sci. 2000; 923: 90–112.Callebaut I., Poupon A., Bally R. et al. The uteroglobin fold. Ann. NY Acad. Sci. 2000; 923: 90–112.Pattabiraman N., Matthews J.H., Ward K.B. et al. Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding. Ann. NY Acad. Sci. 2000; 923: 113–127.Pattabiraman N., Matthews J.H., Ward K.B. et al. Crystal structure analysis of recombinant human uteroglobin and molecular modeling of ligand binding. Ann. NY Acad. Sci. 2000; 923: 113–127.Ghafouri B., Stahiborn B., Tagesson C. et.al. Newly identified proteins in human nasal lavage fluid from non smokers and smokers using two dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics. 2002; 2: 112–120.Ghafouri B., Stahiborn B., Tagesson C. et.al. Newly identified proteins in human nasal lavage fluid from non smokers and smokers using two dimensional gel electrophoresis and peptide mass fingerprinting. Proteomics. 2002; 2: 112–120.Nieto A., Ponstingl H., Beato M. Purification and quaternary structure of the hormonally induced protein uteroglobin. Arch. Biochem. Biophys. 1997; 180: 82–92.Nieto A., Ponstingl H., Beato M. Purification and quaternary structure of the hormonally induced protein uteroglobin. Arch. Biochem. Biophys. 1997; 180: 82–92.De la Cruz X., Lee B. The structural homology between utero globin and the pore forming domain of colicin A suggests a possible mechanism of action for uteroglobin. Protein. Sci. 1996; 5: 857–861.De la Cruz X., Lee B. The structural homology between utero globin and the pore forming domain of colicin A suggests a possible mechanism of action for uteroglobin. Protein. Sci. 1996; 5: 857–861.Pilon A.L. Rationale for the development of recombinant human CC10 as a therapeutic for inflammatory and fibrotic disease. Ann. NY Acad. Sci. 2000; 923: 280–299.Pilon A.L. Rationale for the development of recombinant human CC10 as a therapeutic for inflammatory and fibrotic disease. Ann. NY Acad. Sci. 2000; 923: 280–299.Karn R.C., Laukaitis C.M. Characterization of two forms of mouse salivary androgen binding protein (ABP): Implications for evolutionary relationships and ligand binding function. Biochemistry. 2003; 42: 7162–7170.Karn R.C., Laukaitis C.M. Characterization of two forms of mouse salivary androgen binding protein (ABP): Implications for evolutionary relationships and ligand binding function. Biochemistry. 2003; 42: 7162–7170.Hay J.G., Danel C., Chu C.S. et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest lincage to airway disease. Am. J. Physiol. 1995; 268 (4, Pt 1): 565–575.Hay J.G., Danel C., Chu C.S. et al. Human CC10 gene expression in airway epithelium and subchromosomal locus suggest lincage to airway disease. Am. J. Physiol. 1995; 268 (4, Pt 1): 565–575.Wolf M., Klug J., Hackenberg R. et al. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Hum. Mol. Genet. 1992; 1: 371–378.Wolf M., Klug J., Hackenberg R. et al. Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines. Hum. Mol. Genet. 1992; 1: 371–378.Zhang Z., Zimonjic D.B., Popescu N.C. et al. Human uteroglobin gene: structure, subchromosomal localization, and polymorphism. DNA Cell Biol. 1997; 16: 73–83.Zhang Z., Zimonjic D.B., Popescu N.C. et al. Human uteroglobin gene: structure, subchromosomal localization, and polymorphism. DNA Cell Biol. 1997; 16: 73–83.Chilton B.S., Mani S.K., Bullock D.W. Servomechanism of prolactin and progesterone in regulating uterine gene expression. Mol. Endocrinol. 1988; 2: 1169–1175.Chilton B.S., Mani S.K., Bullock D.W. Servomechanism of prolactin and progesterone in regulating uterine gene expression. Mol. Endocrinol. 1988; 2: 1169–1175.Kikukawa T., Cowan B.D., Tejada R.I., Mukherjee A.B. Partial characterization of a uteroglobin like protein in the human uterus and its temporal relationship to prostaglandin levels in this organ. J. Clin. Endocrinol. Metab. 1988; 67: 315–321.Kikukawa T., Cowan B.D., Tejada R.I., Mukherjee A.B. Partial characterization of a uteroglobin like protein in the human uterus and its temporal relationship to prostaglandin levels in this organ. J. Clin. Endocrinol. Metab. 1988; 67: 315–321.Suske G., Wenz M., Cato A.C.B., Beato M. The uteroglobin gene region: hormonal regulation, repetitive elements and complete nucleotide sequence of the gene. Nucleic. Acids Res. 1983; 11: 2257–2271.Suske G., Wenz M., Cato A.C.B., Beato M. The uteroglobin gene region: hormonal regulation, repetitive elements and complete nucleotide sequence of the gene. Nucleic. Acids Res. 1983; 11: 2257–2271.Frerking I., Sengler C., Günther A. et al. Evaluation of the 26G>A CC16 polymorphism in acute respiratory distress syndrome. Crit. Care Med. 2005; 33 (10): 2404–2406.Frerking I., Sengler C., Günther A. et al. Evaluation of the 26G>A CC16 polymorphism in acute respiratory distress syndrome. Crit. Care Med. 2005; 33 (10): 2404–2406.Ray R., Choi M., Zhang Z. Uteroglobin Suppresses SCCA Gene Expression Associated with Allergic Asthma. J. Biol. Chem. 2005; 280: 9761–9764.Ray R., Choi M., Zhang Z. Uteroglobin Suppresses SCCA Gene Expression Associated with Allergic Asthma. J. Biol. Chem. 2005; 280: 9761–9764.Ku M.S., Sun X.L., Lu K.H. The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis. Clin. Exp. Allergy. 2011; 41: 794–800.Ku M.S., Sun X.L., Lu K.H. The CC16 A38G polymorphism is associated with the development of asthma in children with allergic rhinitis. Clin. Exp. Allergy. 2011; 41: 794–800.de Burbure C., Pignatti P., Corradi M., Malerba M. Utero globin related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. Chest. 2007; 131 (1): 172–179.de Burbure C., Pignatti P., Corradi M., Malerba M. Utero globin related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. Chest. 2007; 131 (1): 172–179.Janssen R., Sato H., Grutters J.C. et al. The Clara cell10 Adenine38Guanine polymorphism and sarcoidosis suscepti bility in Dutch and Japanese subjects. Am. J. Respir. Crit. Med. 2004; 170: 1185–1187.Janssen R., Sato H., Grutters J.C. et al. The Clara cell10 Adenine38Guanine polymorphism and sarcoidosis suscepti bility in Dutch and Japanese subjects. Am. J. Respir. Crit. Med. 2004; 170: 1185–1187.Menegatti E., Nardacchione A., Mirella A. et al. Polymorphism of the uteroglobin gene in systemic lupus erythematosus and IgA nephropathy. Lab. Invest. 2002; 82: 543–546.Menegatti E., Nardacchione A., Mirella A. et al. Polymorphism of the uteroglobin gene in systemic lupus erythematosus and IgA nephropathy. Lab. Invest. 2002; 82: 543–546.Chowdhury B., Zhang Z., Mukherjee A.B. Uteroglobin interacts with the heparin binding site of fibronectin and prevents fibronectin IgA complex formation found in IgA nephropathy. FEBS Lett. 2008; 582 (5): 611–615.Chowdhury B., Zhang Z., Mukherjee A.B. Uteroglobin interacts with the heparin binding site of fibronectin and prevents fibronectin IgA complex formation found in IgA nephropathy. FEBS Lett. 2008; 582 (5): 611–615.Yong D., QingQing W., Hua L. et al. Association of uteroglobin G38A polymorphism with IgA nephropathy: a metaanalysis. Am. J. Kidney Dis. 2006; 48 (1): 1–7.Yong D., QingQing W., Hua L. et al. Association of uteroglobin G38A polymorphism with IgA nephropathy: a metaanalysis. Am. J. Kidney Dis. 2006; 48 (1): 1–7.Mansur A.H. Secretoglobin 1A1 gene and asthma predisposition: what is the evidence? Clin. Exp. Allergy. 2009; 39: 8–11.Mansur A.H. Secretoglobin 1A1 gene and asthma predisposition: what is the evidence? Clin. Exp. Allergy. 2009; 39: 8–11.Mandal A.K., Ray R., Zhang Z. et al. Uteroglobin inhibits prostaglandin F2α receptor mediated expression of genes critical for the production of proinflammatory lipid mediators. J. Biol. Chem. 2005; 280: 32897–32904.Mandal A.K., Ray R., Zhang Z. et al. Uteroglobin inhibits prostaglandin F2α receptor mediated expression of genes critical for the production of proinflammatory lipid mediators. J. Biol. Chem. 2005; 280: 32897–32904.Shijubo N., Itoh Y., Abe S. Anti inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases. Rinsho Byori. 2002; 50 (4): 370–373.Shijubo N., Itoh Y., Abe S. Anti inflammatory molecule, Clara cell 10 kilodalton protein and respiratory diseases. Rinsho Byori. 2002; 50 (4): 370–373.Kundu G.C., Zhang Z., Mantile Selvaggi G. et al. Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells. Ann. NY Acad. Sci. 2000; 923: 234–248.Kundu G.C., Zhang Z., Mantile Selvaggi G. et al. Uteroglobin binding proteins: regulation of cellular motility and invasion in normal and cancer cells. Ann. NY Acad. Sci. 2000; 923: 234–248.Schiffmann E., Geetha V., Pencev D. et al. Adherence and regulation of leukotaxis. Agents Actions Suppl. 1983; 12: 106–120.Schiffmann E., Geetha V., Pencev D. et al. Adherence and regulation of leukotaxis. Agents Actions Suppl. 1983; 12: 106–120.Le Y., Murphy P.M., Wang J.M. Formyl peptide receptors revisited. Trends Immunol. 2002; 23: 541–548.Le Y., Murphy P.M., Wang J.M. Formyl peptide receptors revisited. Trends Immunol. 2002; 23: 541–548.Ye B.Q., Geng Z.H., Ma L. et.al. Slit2 Regulates Attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. J. Immunology. 2010; 185: 6294–6305.Ye B.Q., Geng Z.H., Ma L. et.al. Slit2 Regulates Attractive eosinophil and repulsive neutrophil chemotaxis through differential srGAP1 expression during lung inflammation. J. Immunology. 2010; 185: 6294–6305.Riffo M., Gonzalez K.D., Nieto A. Uteroglobin induces the development and cellular proliferation of the mouse early embryo. J. Exp. Zool. Part A Ecol. Genet. Physiol. 2007; 307: 28–34.Riffo M., Gonzalez K.D., Nieto A. Uteroglobin induces the development and cellular proliferation of the mouse early embryo. J. Exp. Zool. Part A Ecol. Genet. Physiol. 2007; 307: 28–34.Robinson D.H., Kirk K.L., Benos D.J. Macromolecular transport in rabbit blastocysts: evidence for a specific utero globin transport system. Mol. Cell. Endocrinol. 1989; 63: 227–237.Robinson D.H., Kirk K.L., Benos D.J. Macromolecular transport in rabbit blastocysts: evidence for a specific utero globin transport system. Mol. Cell. Endocrinol. 1989; 63: 227–237.Linnoila R.I., Szabo E., Demayo F. et al. The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression. Ann. NY Acad. Sci. 2000; 923: 249–267.Linnoila R.I., Szabo E., Demayo F. et al. The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression. Ann. NY Acad. Sci. 2000; 923: 249–267.Zhang Z., Kundu G.C., Panda D. et al. Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene Proc. Natl. Acad. Sci. USA. 1999; 96: 3963–3968.Zhang Z., Kundu G.C., Panda D. et al. Loss of transformed phenotype in cancer cells by overexpression of the uteroglobin gene Proc. Natl. Acad. Sci. USA. 1999; 96: 3963–3968.Zhang Z, Kim SJ, Chowdhury B, et al. Interaction of utero globin with lipocalin 1 receptor suppresses cancer cell motility and invasion. Gene. 2006; 369: 66–71.Zhang Z, Kim SJ, Chowdhury B, et al. Interaction of utero globin with lipocalin 1 receptor suppresses cancer cell motility and invasion. Gene. 2006; 369: 66–71.Moreno J.J. Effects of antiflammins on transglutaminase and phospholipase A2 activation by transglutaminase. Int. Immunopharmacol. 2006; 6: 300–303.Moreno J.J. Effects of antiflammins on transglutaminase and phospholipase A2 activation by transglutaminase. Int. Immunopharmacol. 2006; 6: 300–303.Lesur O., Bernard A., Arsalane K. Clara cell protein (CC16)induces a phospholipase A2 mediated inhibition of fibroblast migration in vitro. Am. J. Respir. Crit. Care Med. 1995; 152:290–297.Lesur O., Bernard A., Arsalane K. Clara cell protein (CC16)induces a phospholipase A2 mediated inhibition of fibroblast migration in vitro. Am. J. Respir. Crit. Care Med. 1995; 152:290–297.Mandal A.K., Zhang Z., Ray R. et al. Uteroglobin represses allergen induced inflammatory response by blocking PGD2 receptor mediated functions. J. Exp. Med. 2004; 199: 1317–1330.Mandal A.K., Zhang Z., Ray R. et al. Uteroglobin represses allergen induced inflammatory response by blocking PGD2 receptor mediated functions. J. Exp. Med. 2004; 199: 1317–1330.Mariniello L., Porta R. Transglutaminases as biotechnological tools. Prog. Exp. Tumor Res. 2005; 38: 174–191.Mariniello L., Porta R. Transglutaminases as biotechnological tools. Prog. Exp. Tumor Res. 2005; 38: 174–191.Lorand L., Graham R.M. Transglutaminases: crosslinking enzymes with pleotropic functions. Nat. Rev. Mol. Cell. Biol. 2003; 4: 140–156.Lorand L., Graham R.M. Transglutaminases: crosslinking enzymes with pleotropic functions. Nat. Rev. Mol. Cell. Biol. 2003; 4: 140–156.Miele L. New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase. J. Clin. Invest. 2003; 111: 19–21.Miele L. New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase. J. Clin. Invest. 2003; 111: 19–21.Zhang Z., Kundu G.C., Zheng F. et al. Insight into the physiological function(s) of uteroglobin by gene knockout and antisense transgenic approaches. Ann. NY Acad. Sci. 2000;923: 210–233.Zhang Z., Kundu G.C., Zheng F. et al. Insight into the physiological function(s) of uteroglobin by gene knockout and antisense transgenic approaches. Ann. NY Acad. Sci. 2000;923: 210–233.Chen L.C., Zhang Z., Myers A.C. et al. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10 kDa protein. Immunology. 2001; 167: 3025–3028.Chen L.C., Zhang Z., Myers A.C. et al. Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10 kDa protein. Immunology. 2001; 167: 3025–3028.Miele L. Antiflammins. Ann. NY Acad. Sci. 2000; 293:128–140.Miele L. Antiflammins. Ann. NY Acad. Sci. 2000; 293:128–140.Moreno J.J. Antiflammin peptides in the regulation of inflammatory response. Ann. NY Acad. Sci. 2000; 923: 147–153.Moreno J.J. Antiflammin peptides in the regulation of inflammatory response. Ann. NY Acad. Sci. 2000; 923: 147–153.Miele L., Cordella Miele E., Facchiano A. et al. Novel antiinflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I. Nature. 1988; 335: 726–730.Miele L., Cordella Miele E., Facchiano A. et al. Novel antiinflammatory peptides from the region of highest similarity between uteroglobin and lipocortin I. Nature. 1988; 335: 726–730.Hope W.C., Patel B.J., Bolin D.R. Antiflammin 2 (HDMNKVLDL) does not inhibit phospholipase A2 activities. Agents Actions. 1991; 34: 77– 80.Hope W.C., Patel B.J., Bolin D.R. Antiflammin 2 (HDMNKVLDL) does not inhibit phospholipase A2 activities. Agents Actions. 1991; 34: 77– 80.Ye J.M., Wolfe J.L. Oxidative degradation of antiflammin 2. Pharm. Res. 1996; 13: 250–255.Ye J.M., Wolfe J.L. Oxidative degradation of antiflammin 2. Pharm. Res. 1996; 13: 250–255.

The authors declare that there are no conflicts of interest present.