pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2015-25-4-483-491pulmo-608Research ArticleОБЗОРЫREVIEWВзгляд на пневмонию с позиции коммуникационных системPneumonia from the point of view of organ interactionЗибировР. Ф.ZibirovR. F.

ассистент кафедры патологической анатомии ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России, врачпатологоанатом отделения клинической патологии № 2 ОГБУЗ "Смоленский областной институт патологии"; тел.: (4812) 383102

Assistant Lecturer at Department of Pathological Anatomy, Smolensk State Medical University, Healthcare Ministry of Russia; pathologist at the Division of Clinical Pathology N2, State Regional Smolensk Institute of Pathology; tel.: (4812) 383102

patologr@mail.ruКозловД. В.KozlovD. V.

д. м. н., профессор кафедры патологической анатомии ГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России, зав. отделением клинической патологии № 2 областного государственного бюджетного учреждения здравоохранения "Смоленский областной институт патологии"; тел.: (4812) 383102

MD, Professor at Department of Pathological Anatomy, Smolensk State Medical University, Healthcare Ministry of Russia; Head of the Division of Clinical Pathology N2, State Regional Smolensk Institute of Pathology; tel.: (4812) 383102

kdv.47@mail.ruГБОУ ВПО "Смоленский государственный медицинский университет" Минздрава России; 214019, Смоленск, ул. Крупской, 28 ОГБУЗ "Смоленский областной институт патологии": 214018, Смоленск, проспект Гагарина, 27РоссияSmolensk State Medical University, Healthcare Ministry of Russia: 28, Krupskoy str., Smolensk, 214019, Russia State Regional Smolensk Institute of Pathology: 27, Gagarina av., Smolensk, 214018, RussiaRussian Federation201521102015254483491Copyright © Зибиров Р.Ф., Козлов Д.В., 20152015Зибиров Р.Ф., Козлов Д.В.Zibirov R.F., Kozlov D.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/608

Данный обзор литературы посвящен функциональным особенностям взаимодействия между компонентами паренхимы, стромы, гематогенными клеточными популяциями в легочной альвеоле при развитии острого воспаления. Показано взаимное влияние клеток через цитокины, факторы роста и роль этого влияния на патогенез пневмонии. Обсуждается необходимость комплексного изучения патогенеза пневмонии с акцентом на всех структурных компонентах очага воспаления, в связи с чем используется понятие о коммуникационных системах. В работе описаны элементы паренхимы (пневмоциты 1го и 2го порядка, щеточные клетки) и стромы (основное межуточное вещество, волокна и клеточные популяции, альвеолярные капилляры легких, вегетативные нервные терминали). Обращается внимание на недостаточно изученные аспекты патогенеза пневмоний – механизмы миграции нейтрофильных лейкоцитов в легочную альвеолу и роль компонентов коммуникационных систем в этом процессе. Предлагается использовать понятие о коммуникационных системах применительно к легочной ткани при исследовании пневмонии.

Functional interaction between parenchyma components, stroma, and hematopoietic cell populations of the alveoli under acute inflammation have been described in this review. Cells interact via cytokines and growth factors; a role of this interaction for the pathogenesis of pneumonia is also discussed. We suppose a need of omprehensive research of pneumonia pathogenesis in terms of all structural components of inflammation focus. Thereafter we introduced a concept of interaction systems. Parenchymal elements, such as type I and type II pneumocytes, brush cells, and stromal elements, such as interstitial tissue, fibers, cell populations, alveolar capillaries, and autonomic nerve terminals, are describes in the article. Certain aspects of pneumonia pathogenesis are poorly understood including mechanisms of neutrophil migration to the alveoli and a role of interaction systems in this process. We offer to apply the term of interaction systems relating to the lung tissue when investigating pneumonia.

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The authors declare that there are no conflicts of interest present.