pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2015-25-4-477-482pulmo-607Research ArticleОБЗОРЫREVIEWСовременные устройства доставки лекарственных веществ в дыхательные пути при лечении хронической обструктивной болезни легкихModern inhalation drug delivery devices for treatment of chronic obstructive pulmonary diseaseВатутинН. Т.VatutinN. T.

д. м. н., профессор, зав. кафедрой госпитальной терапии ГО "Донецкий национальный медицинский университет им. М.Горького", и. о. зав. отделом неотложной и восстановительной кардиохирургии ГУ "Институт неотложной и восстановительной хирургии им. В.К.Гусака НАМН Украины"; тел.: (38062) 3850517

MD, Professor, Head of Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.: (38062) 3850517

kafedra_vatutin@mail.ruСмирноваА. С.SmirnovaA. S.

к. м. н., ассистент кафедры госпитальной терапии ГО "Донецкий национальный медицинский университет им. М.Горького"; тел.: (38062) 3850517

PhD, Assistant Lecturer at Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.: (38062) 3850517

a.smyrnova@mail.ruТарадинГ. Г.TaradinG. G.

к. м. н., доцент кафедры госпитальной терапии ГО "Донецкий национальный медицинский университет им. М.Горького"; тел.: (38062) 3850517

PhD, Associate Professor at Department of Internal Diseases N1, M.Gor'kiy Donetsk National State Medical University; tel.: (38062) 3850517

taradin@inbox.ruГО "Донецкий национальный медицинский университет им. М.Горького": 83003, Украина, Донецк, пр. Ильича, 16 ГУ "Институт неотложной и восстановительной хирургии им. В.К.Гусака НАМН Украины": 83000, Украина, Донецк, Ленинский проспект, 47РоссияM.Gor'kiy Donetsk National State Medical University: 16, Il'icha av., Donetsk, 83003, Ukraine V.K.Gusak State Institute of Urgent and Reconstructive Surgery, National Medical Science Academy of Ukraine: 47, Leninskiy av., Donetsk, 83000, UkraineRussian FederationГО "Донецкий национальный медицинский университет им. М.Горького": 83003, Украина, Донецк, пр. Ильича, 16РоссияM.Gor'kiy Donetsk National State Medical University: 16, Il'icha av., Donetsk, 83003, UkraineRussian Federation201521102015254477482Copyright © Ватутин Н.Т., Смирнова А.С., Тарадин Г.Г., 20152015Ватутин Н.Т., Смирнова А.С., Тарадин Г.Г.Vatutin N.T., Smirnova A.S., Taradin G.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/607

представленном обзоре литературных данных отражены вопросы истории создания устройств доставки лекарственных веществ в дыхательные пути. Описан широкий ассортимент различных устройств доставки для ингаляционной терапии хронической обструктивной болезни легких (ХОБЛ). В настоящее время различаются дозированные аэрозольные ингаляторы под давлением (активируемые и неактивируемые вдохом), сухопорошковые устройства доставки (одно и многодозовые), небулайзеры (струйные, ультразвуковые), а также ингаляторы "мягкого тумана". Сформулированы выводы о том, что при помощи существующего в настоящее время широкого ассортимента различных устройств доставки для ингаляционной терапии пациентов с различной бронхолегочной патологией, прежде всего ХОБЛ, обеспечивается возможность оптимизации терапии путем индивидуального подбора типа ингалятора с учетом возраста, сопутствующей патологии и тяжести состояния.

This review includes history of development of devices for drug delivery to the airways. Currently, there is a large diversity of different drug delivery devices for inhalation therapy of chronic obstructive pulmonary disease (COPD): pressurized metered dosing aerosol inhalers (activated or not activated by breath), dry powder nhalers (single dose or multiple dose), jet nebulizers, ultrasound nebulizers and soft mist inhalers. This wide spectrum of different inhalation drug delivery devices provides an improvement in treatment of various respiratory diseases, primarily COPD, due to individual choice of an inhaler considering the patient's age, comorbidity and severity of the disease.

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The authors declare that there are no conflicts of interest present.