pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2015-25-1-113-118pulmo-533Research ArticleКЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯCLINICAL PHARMACOLOGYЭффективность и безопасность агонистов #b2-адренорецепторов ультрадлительного действияEfficacy and safety of long-acting beta-2-agonistsШульженкоЛ. В.Shul'zhenkoL. V.

д. м. н., профессор, зав. кафедрой пульмонологии ФПК и ППС ГБОУ ВПО «Кубанский государственный медицинский университет» Минздрава России; тел.: (988) 244-82-49;

MD, Professor, Head of Chair of Pulmonology, Postgraduate Education Faculty, State Budget High-Level Educational Institution “Kuban State Medical University”, Healthcare Ministry of Russia; tel.: (988) 244-82-49;

larisa_shulzhenk@mail.ruБолотоваЕ. В.BolotovaE. V.

д. м. н., профессор кафедры пульмонологии ФПК и ППС ГБОУ ВПО «Кубанский государственный медицинский университет» Минздрава России; тел.: (862)252-73-93;

MD, Professor, Chair of Pulmonology, Postgraduate Education Faculty, State Budget High-Level Educational Institution “Kuban State Medical University”, Healthcare Ministry of Russia; tel.: (862)252-73-93;

bolotowa_e@mail.ruГБОУ ВПО «Кубанский государственный медицинский университет» Минздрава России: 350063, Краснодар, ул. Седина, 4РоссияState Budget High-Level Educational Institution “Kuban State Medical University”, Healthcare Ministry of Russia: 4, Sedina ul., Krasnodar, 350063, RussiaRussian Federation201530042015251113118Copyright © Шульженко Л.В., Болотова Е.В., 20152015Шульженко Л.В., Болотова Е.В.Shul'zhenko L.V., Bolotova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/533

Агонисты #b2-адренорецепторов (#b2-АР) – одни из ключевых лекарственных средств для лечения хронической обструктивной болезни легких (ХОБЛ) и бронхиальной астмы (БА). Представлены клиническая фармакология агонистов #b2-АР ультрадлительного действия – индакатерола, олодатерола, вилантерола, кармотерола, PF-610355 и AZD-3199, а также данные клинических исследований по эффективности и безопасности агонистов #b2-АР ультрадлительного действия у пациентов с БА и ХОБЛ.

Beta-2-adrenoreceptor agonists (#b2-АA) are one of the key drugs used for treatment of chronic obstructive pulmonary disease (COPD) and asthma. Recently, novel #b2-АA with ultra-long half-life which allows once-day administration have been developed such as indacaterol, olodaterol, vilanterol, carmoterol, PF-610355 and AZD-3199. Pharmacodynamics, pharmacokinetics and clinical effects of these drugs in COPD and asthma are reviewed in the article. Published data suggest that the rational and individualized use of novel ultralong-acting #b2-АA could increase safety and efficacy of treatment in patients with COPD and asthma.

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The authors declare that there are no conflicts of interest present.