pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2014-0-6-94-102pulmo-498Research ArticleОБЗОРЫREVIEWБронхиальная астма и ожирение: поиск терапевтических моделейBronchial asthma and obesity: search for therapeutic modelsФоминаД. С.FominaD. S.

к. м. н., доцент кафедры клинической аллергологии ГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава России, зав. аллергологическим отделением ГБУЗ "Городская клиническая больница No 52" ДЗ Москвы; тел.: (499) 196-19-54

PhD, Associate Professor, Chair of Clinical Allergology, State Budget Educational Institution of Аdditional Еducation "Russian Medical Postgraduate Academy", Healthcare Ministry of Russia; Head of Department of Allergology, State Budget Healthcare Institution "City Clinical Hospital N 52", Moscow Healthcare Department; tel.: (499) 196-19-54

daria.s.fomina@gmail.comГорячкинаЛ. А.GoryachkinaL. A.

д. м. н., профессор, зав. кафедрой клинической аллергологии ГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава России; тел.: (499) 196-19-54

MD, Professor, Head of Chair of Clinical Allergology, State Budget Educational Institution of Аdditional Еducation "Russian Medical Postgraduate Academy", Healthcare Ministry of Russia; tel.: (499) 196-19-54

gorkash@yandex.ruАлексееваЮ. Г.AlekseevaYu. G.

врач аллерголог-иммунолог ГБУЗ "Городская клиническая больница No 52" ДЗ Москвы; тел.: (499) 196-29-88

allergist, immunologist, State Budget Healthcare Institution "City Clinical Hospital N 52", Moscow Healthcare Department; tel.: (499) 196-29-88

solnjshko@hotmail.comБобриковаЕ. Н.BobrikovaE. N.

врач аллерголог-иммунолог ГБУЗ "Филиал No 2 Городская поликлиника No 62" ДЗ Москвы, главный внештатный аллерголог САО Москвы; тел.: (962) 962-00-96

allergist, immunologist, State Budget Healthcare Institution "City Outpatient Hospital N 62, Branch N 2", Moscow Healthcare Department; Chief Allergist of the Northern Administrative District of Moscow; tel.: (962) 962-00-96

bobrikova.e@icloud.comГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава России: 125993, Москва, ул. Баррикадная, 2 / 1 ГБУЗ "Городская клиническая больница No52" Департамента здравоохранения Москвы: 123182, Москва, ул. Пехотная, 3РоссияState Institution of Аdditional Еducation "Russian Medical Postgraduate Academy", Healthcare Ministry of Russia: 2 / 1, Barrikadnaya ul., Moscow, 123995, Russia State Institution "City Clinical Hospital N 52", Moscow Healthcare Department: 3, Pekhotnaya ul., Moscow, 123182, RussiaRussian FederationГБОУ ДПО "Российская медицинская академия последипломного образования" Минздрава России: 125993, Москва, ул. Баррикадная, 2 / 1РоссияState Institution of Аdditional Еducation "Russian Medical Postgraduate Academy", Healthcare Ministry of Russia: 2 / 1, Barrikadnaya ul., Moscow, 123995, RussiaRussian FederationГБУЗ "Городская клиническая больница No52" Департамента здравоохранения Москвы: 123182, Москва, ул. Пехотная, 3РоссияState Institution "City Clinical Hospital N 52", Moscow Healthcare Department: 3, Pekhotnaya ul., Moscow, 123182, RussiaRussian FederationГБУЗ "Филиал No2 Городская поликлиника No62" Департамента здравоохранения Москвы: 125083, Москва, ул. Юннатов, 12РоссияState Institution "City Outpatient Hospital N 62, Branch N 2", Moscow Healthcare Department: 12, Yunnatov ul., Moscow, 125083, RussiaRussian Federation2014281220140694102Copyright © Фомина Д.С., Горячкина Л.А., Алексеева Ю.Г., Бобрикова Е.Н., 20142014Фомина Д.С., Горячкина Л.А., Алексеева Ю.Г., Бобрикова Е.Н.Fomina D.S., Goryachkina L.A., Alekseeva Y.G., Bobrikova E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/498

Все большее внимание экспертов уделяется фенотип-обоснованному подходу к лечению пациентов с бронхиальной астмой (БА). Одним из основных клинических фенотипов является сочетание БА и избыточной массы тела, а в некоторых случаях – ожирения. Ряд клинических особенностей этого тандема объясняется результатами молекулярно-генетических исследований. Активный поиск взаимосвязей между фенотипом, генотипом и механизмом развития заболевания позволит разработать эффективный терапевтический алгоритм, наиболее прогностически оправданный у данной подгруппы пациентов. 

A phenotype-based approach to treatment of bronchial asthma draws the growing attention of experts worldwide. One of asthma phеnotypes is comorbidity of asthma and overweight (including obesity). Some features of this phenotype have recently been described in molecular studies. An intensive search of relationships between phenotype, genotype and pathogenic mechanisms of the disease is suggested to be useful for development of effective therapeutic algorithm with the highest predictive value in this cohort of patiens. 

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The authors declare that there are no conflicts of interest present.