pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2025-35-1-95-101pulmo-4532Research ArticleОБЗОРЫREVIEWРоль рецептора к конечным продуктами гликирования (RAGE) в патогенезе бронхиальной астмыThe role of the receptor for advanced glycation endproducts (RAGE) in the pathogenesis of asthmahttps://orcid.org/0000-0001-6193-2774СорокинаЛ. Н.SorokinaL. N.

Сорокина Лада Николаевна – д. м. н., профессор, профессор кафедры терапии госпитальной с курсом аллергологии и иммунологии имени академика М.В.Черноруцкого с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, тел.: (812) 338-68-98 

Lada N.Sorokina, Doctor of Medicine, Professor, Professor, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic

ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-68-98 

lada_sorokina@mail.ruhttps://orcid.org/0000-0003-0352-8137МинеевВ. Н.MineevV. N.

Минеев Валерий Николаевич – д. м. н., профессор, профессор кафедры терапии госпитальной с курсом аллергологии и иммунологии имени академика М.В.Черноруцкого с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, тел.: (812) 338-67-46 

Valery N. Mineev, Doctor of Medicine, Professor, Professor, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic

ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-67-46  

vnmineev@mail.ruhttps://orcid.org/0000-0001-7934-0718ПавловаА. С.PavlovaA. S.

Павлова Анастасия Сергеевна – ассистент кафедры терапии госпитальной с курсом аллергологии и иммунологии имени академика М.В.Черноруцкого с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, тел.: (812) 338-68-98 

Anastasiia S. Pavlova, Assistant, Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic

ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-68-98 

pavast02@gmail.comhttps://orcid.org/0000-0002-6430-6960ТрофимовВ. И.TrofimovV. I.

Трофимов Василий Иванович – д. м. н., профессор, заведующий кафедрой терапии госпитальной с курсом аллергологии и иммунологии имени академика М.В.Черноруцкого с клиникой

197022, Санкт-Петербург, ул. Льва Толстого, 6–8, тел.: (812) 338-67-46 

Vasiliy I. Trofimov, Doctor of Medicine, Professor, Head of Department of Hospital Therapy with a course of Allergology and Immunology named after Academician M.V.Chernorutsky with a clinic

ul. L’va Tolstogo 6–8, Saint-Petersburg, 197022, tel.: (812) 338-67-46 

trofvi@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П.Павлова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Budgetary Educational Institution of Higher Education “Pavlov First Saint Petersburg State Medical University”, Ministry of Healthcare of Russian FederationRussian Federation20250802202535195101Copyright © Сорокина Л.Н., Минеев В.Н., Павлова А.С., Трофимов В.И., 20252025Сорокина Л.Н., Минеев В.Н., Павлова А.С., Трофимов В.И.Sorokina L.N., Mineev V.N., Pavlova A.S., Trofimov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/4532

В настоящее время обсуждается роль рецептора к конечным продуктам гликирования (Receptor for Advanced Glycation Endproducts – RAGE), а также его изоформ, в патогенезе бронхиальной астмы. Целью исследования являлся обзор отечественной и зарубежной литературы, посвященной роли RAGE в патогенезе БА. Поиск литературных данных осуществлялся в реферативных базах данных PubMed и РИНЦ. Результаты. Согласно литературным данным, RAGE рассматривается как возможный биомаркер заболевания или позволяет использовать лиганд-RAGE в качестве мишени для терапевтического вмешательства. Заключение. Для изучения данной темы и возможной разработки новых подходов к тактике ведения пациентов с БА требуются дальнейшие экспериментальные и клинические исследования.

Now the role of the receptor for advanced glycation endproducts (RAGE) and its isoforms in the pathogenesis of asthma is discussed. The aim was to review national and foreign literature on the role of RAGE in the pathogenesis of asthma. The search was performed in the PubMed and RISC databases. Results. The available literature data allow considering RAGE as a possible biomarker of the disease or to use the ligand-RAGE axis as a target for therapeutic intervention. Conclusion. This subject requires further experimental and clinical studies for the possible development of new approaches to the management of patients with asthma.

бронхиальная астмаRAGEгликированиеasthmaRAGEglycationReferencesФедосеев Г.Б., Трофимов В.И., Шапорова Н.Л. и др. В поисках истины: что такое бронхиальная астма? Пульмонология. 2015; 25 (1): 5–18. DOI: 10.18093/0869-0189-2015-25-1-5-18.Fedoseev G.B., Trofimov V.I., Shaporova N.L. et al. [Searching the truth: what is bronchial asthma?]. Pulmonologiya. 2015; 25 (1): 5–18. DOI: 10.18093/0869-0189-2015-25-1-5-18 (in Russian).Brandt E., Lewkowich I. RAGE-induced asthma: A role for the receptor for advanced glycation end-products in promoting allergic airway disease. J. Allergy Clin. Immunol. 2019; 144 (3): 651–653. DOI: 10.1016/j.jaci.2019.06.012.Brandt E., Lewkowich I. RAGE-induced asthma: A role for the receptor for advanced glycation end-products in promoting allergic airway disease. J. Allergy Clin. Immunol. 2019; 144 (3): 651–653. DOI: 10.1016/j.jaci.2019.06.012.Колычев А.П., Минеев В.Н., Булатова Н.Ю., Федосеев Г.Б. Особенности инсулин-рецепторных взаимодействий при бронхиальной астме. Пульмонология. 1994; (2): 48–51. Доступно на: https://journal.pulmonology.ru/pulm/article/view/3585/2953?locale=ru_RUKolychev A.P., Mineev V.N., Bulatova N.Yu., Fedoseev G.B. [Insulin-receptor interactions in bronchial asthma]. Pul'monologiya. 1994; (2): 48–51. Available at: https://journal.pulmonology.ru/pulm/article/view/3585/2953?locale=ru_RU (in Russian).Иванов В.А., Сорокина Л.Н., Минеев В.Н. и др. Сочетание бронхиальной астмы и сахарного диабета: синергизм или антагонизм? Пульмонология. 2014; (6): 103–107. DOI: 10.18093/0869-0189-2014-0-6-103-107.Ivanov V.A., Sorokina L.N., Mineev V.N. et al. [Comorbidity of asthma and diabetes: synergism or antagonism?]. Pul'monologiya. 2014; (6): 103–107. DOI: 10.18093/0869-0189-2014-0-6-103-107 (in Russian).Иванов В.А., Рубеко Е., Сорокина Л.Н. и др. Бронхиальная астма в сочетании с сахарным диабетом типа 2: клинико-патогенетические особенности. Врач. 2016; (7): 36–38. Доступно на: https://vrachjournal.ru/ru/25877305-2016-07-11Ivanov V.A., Rubeko E., Sorokina L.N. et al. [Asthma in combination with type 2 diabetes mellitus: clinical and pathogenetic features]. Vrach. 2016; (7): 36–38. Available at: https://vrachjournal.ru/ru/25877305-2016-07-11 (in Russian).Минеев В.Н., Сорокина Л.Н. Феномен гликирования белков при бронхиальной астме. Университетский терапевтический вестник. 2023; 5 (4): 73–81. DOI: 10.56871/UTJ.2023.73.75.006.Mineev V.N., Sorokina L.N. [Protein glycation phenomenon in bronchial asthma]. Universitetskiy terapevticheskiy vestnik. 2023; 5 (4): 73–81. DOI: 10.56871/UTJ.2023.73.75.006 (in Russian).Ullah M.A., Loh Z., Gan W.J. et al. Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation. J. Allergy Clin. Immunol. 2014; 134 (2): 440–450. DOI: 10.1016/j.jaci.2013.12.1035.Ullah M.A., Loh Z., Gan W.J. et al. Receptor for advanced glycation end products and its ligand high-mobility group box-1 mediate allergic airway sensitization and airway inflammation. J. Allergy Clin. Immunol. 2014; 134 (2): 440–450. DOI: 10.1016/j.jaci.2013.12.1035.Гусев Е.Ю., Зотова Н.В., Журавлева Ю.А., Черешнев В.А. Физиологическая и патогенетическая роль рецепторов-мусорщиков у человека. Медицинская иммунология. 2020; 22 (1): 7–48. DOI: 10.15789/1563-0625-PAP-1893.Gusev E.Yu., Zotova N.V., Zhuravleva Yu.A., Chereshnev V.A. [Physiological and pathogenic role of scavenger receptors in humans]. Meditsinskaya immunologiya. 2020; 22 (1): 7–48. DOI: 10.15789/1563-0625-PAP-1893 (in Russian).Smith P.K., Venter C., O'Mahony L. et al. Do advanced glycation end products contribute to food allergy? Front. Allergy. 2023; 4: 1148181. DOI: 10.3389/falgy.2023.1148181.Smith P.K., Venter C., O'Mahony L. et al. Do advanced glycation end products contribute to food allergy? Front. Allergy. 2023; 4: 1148181. DOI: 10.3389/falgy.2023.1148181.Asadipooya K., Uy E. M. Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature. J. Endocr. Soc. 2019; 3 (10): 1799–1818. DOI: 10.1210/js.2019-00160.Asadipooya K., Uy E. M. Advanced glycation end products (AGEs), receptor for AGEs, diabetes, and bone: review of the literature. J. Endocr. Soc. 2019; 3 (10): 1799–1818. DOI: 10.1210/js.2019-00160.Oczypok E.A., Perkins T.N., Oury T.D. All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr. Respir. Rev. 2017; 23: 40–49. DOI: 10.1016/j.prrv.2017.03.012.Oczypok E.A., Perkins T.N., Oury T.D. All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses. Paediatr. Respir. Rev. 2017; 23: 40–49. DOI: 10.1016/j.prrv.2017.03.012.Perkins T.N., Donnell M.L., Oury T.D. The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease. Allergy. 2021; 76 (5): 1350–1366. DOI: 10.1111/all.14600.Perkins T.N., Donnell M.L., Oury T.D. The axis of the receptor for advanced glycation endproducts in asthma and allergic airway disease. Allergy. 2021; 76 (5): 1350–1366. DOI: 10.1111/all.14600.Sukkar M.B., Ullah M.A., Gan W.J. et al. RAGE: a new frontier in chronic airways disease. Br. J. Pharmacol. 2012; 167 (6): 1161–1176. DOI: 10.1111/j.1476-5381.2012.01984.x.Sukkar M.B., Ullah M.A., Gan W.J. et al. RAGE: a new frontier in chronic airways disease. Br. J. Pharmacol. 2012; 167 (6): 1161–1176. DOI: 10.1111/j.1476-5381.2012.01984.x.Lyu Y., Zhao H., Ye Y. et al. Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants. Mol. Med. Rep. 2018; 17 (3): 4131–4137. DOI: 10.3892/mmr.2017.8302.Lyu Y., Zhao H., Ye Y. et al. Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants. Mol. Med. Rep. 2018; 17 (3): 4131–4137. DOI: 10.3892/mmr.2017.8302.Sukkar M.B., Wood L.G., Tooze M. et al. Soluble RAGE is deficient in neutrophilic asthma and COPD. Eur. Respir. J. 2012; 39 (3): 721–729. DOI: 10.1183/09031936.00022011.Sukkar M.B., Wood L.G., Tooze M. et al. Soluble RAGE is deficient in neutrophilic asthma and COPD. Eur. Respir. J. 2012; 39 (3): 721–729. DOI: 10.1183/09031936.00022011.Sparvero L.J., Asafu-Adjei D., Kang R. et al. RAGE (receptor for advanced glycation endproducts), RAGE ligands, and their role in cancer and inflammation. J. Transl. Med. 2009; 7: 17. DOI: 10.1186/1479-5876-7-17.Sparvero L.J., Asafu-Adjei D., Kang R. et al. RAGE (receptor for advanced glycation endproducts), RAGE ligands, and their role in cancer and inflammation. J. Transl. Med. 2009; 7: 17. DOI: 10.1186/1479-5876-7-17.Patregnani J.T., Brooks B.A., Chorvinsky E., Pillai D. K. High BAL sRAGE is associated with low serum eosinophils and IgE in children with asthma. Children (Basel). 2020; 7 (9): 110. DOI: 10.3390/children7090110.Patregnani J.T., Brooks B.A., Chorvinsky E., Pillai D. K. High BAL sRAGE is associated with low serum eosinophils and IgE in children with asthma. Children (Basel). 2020; 7 (9): 110. DOI: 10.3390/children7090110.Serban A.I., Stanca L., Geicu O.I. et al. RAGE and TGF-β1 cross-talk regulate extracellular matrix turnover and cytokine synthesis in AGEs exposed fibroblast cells. PLoS One. 2016; 11 (3): e0152376. DOI: 10.1371/journal.pone.0152376.Serban A.I., Stanca L., Geicu O.I. et al. RAGE and TGF-β1 cross-talk regulate extracellular matrix turnover and cytokine synthesis in AGEs exposed fibroblast cells. PLoS One. 2016; 11 (3): e0152376. DOI: 10.1371/journal.pone.0152376.Гаврилова А.О., Северина А.С., Шамхалова М.Ш., Шестакова М.В. Роль конечных продуктов гликирования в патогенезе диабетической нефропатии. Сахарный диабет. 2021; 24 (5): 461–469. DOI: 10.14341/DM12784.Gavrilova A.O., Severina A.S., Shamhalova M.Sh., Shestakova M.V. [The role of advanced glycation end products in patogenesis of diabetic nephropathy]. Sakharnyy diabet. 2021; 24 (5): 461–469. DOI: 10.14341/DM12784 (in Russian).Hilmenyuk T., Bellinghausen I., Heydenreich B. et al. Effects of glycation of the model food allergen ovalbumin on antigen uptake and presentation by human dendritic cells. Immunology. 2010; 129 (3): 437–445. DOI: 10.1111/j.1365-2567.2009.03199.x.Hilmenyuk T., Bellinghausen I., Heydenreich B. et al. Effects of glycation of the model food allergen ovalbumin on antigen uptake and presentation by human dendritic cells. Immunology. 2010; 129 (3): 437–445. DOI: 10.1111/j.1365-2567.2009.03199.x.Smith P.K., Venter C., O'Mahony L. et al. Do advanced glycation end products contribute to food allergy? Front. Allergy. 2023; 4: 1148181. DOI: 10.3389/falgy.2023.1148181.Smith P.K., Venter C., O'Mahony L. et al. Do advanced glycation end products contribute to food allergy? Front. Allergy. 2023; 4: 1148181. DOI: 10.3389/falgy.2023.1148181.Chuah Y.K., Basir R., Talib H. et al. Receptor for advanced glycation end products and its involvement in inflammatory diseases. Int. J. Inflam. 2013; 2013: 403460. DOI: 10.1155/2013/403460.Chuah Y.K., Basir R., Talib H. et al. Receptor for advanced glycation end products and its involvement in inflammatory diseases. Int. J. Inflam. 2013; 2013: 403460. DOI: 10.1155/2013/403460.Bediwy A.S., Hassan S.M., El-Najjar M.R. Receptor of advanced glycation end products in childhood asthma exacerbation. Egypt. J. Chest Dis. Tuberc. 2016; 65 (1): 15–8. DOI: 10.1016/j. ejcdt.2015.10.008.Bediwy A.S., Hassan S.M., El-Najjar M.R. Receptor of advanced glycation end products in childhood asthma exacerbation. Egypt. J. Chest Dis. Tuberc. 2016; 65 (1): 15–8. DOI: 10.1016/j. ejcdt.2015.10.008.Medeiros M.L., Oliveira A.L., Mello G.C., Antunes E. Metformin counteracts the deleterious effects of methylglyoxal on ovalbumin-induced airway eosinophilic inflammation and remodeling. Int. J. Mol. Sci. 2023; 24 (11): 9549. DOI: 10.3390/ijms24119549.Medeiros M.L., Oliveira A.L., Mello G.C., Antunes E. Metformin counteracts the deleterious effects of methylglyoxal on ovalbumin-induced airway eosinophilic inflammation and remodeling. Int. J. Mol. Sci. 2023; 24 (11): 9549. DOI: 10.3390/ijms24119549.Milutinovic P.S., Alcorn J.F., Englert J.M. et al. The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. Am. J. Pathol. 2012; 181 (4): 1215–1225. DOI: 10.1016/j.ajpath.2012.06.031.Milutinovic P.S., Alcorn J.F., Englert J.M. et al. The receptor for advanced glycation end products is a central mediator of asthma pathogenesis. Am. J. Pathol. 2012; 181 (4): 1215–1225. DOI: 10.1016/j.ajpath.2012.06.031.Killian K.N., Kosanovich J.L., Lipp M.A. et al. RAGE contributes to allergen driven severe neutrophilic airway inflammation via NLRP3 inflammasome activation in mice. Front. Immunol. 2023; 14: 1039997. DOI: 10.3389/fimmu.2023.1039997.Killian K.N., Kosanovich J.L., Lipp M.A. et al. RAGE contributes to allergen driven severe neutrophilic airway inflammation via NLRP3 inflammasome activation in mice. Front. Immunol. 2023; 14: 1039997. DOI: 10.3389/fimmu.2023.1039997.Yao L., Zhao H., Tang H. et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br. J. Pharmacol. 2016; 173: 2600–2613. DOI: 10.1111/bph.13539.Yao L., Zhao H., Tang H. et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br. J. Pharmacol. 2016; 173: 2600–2613. DOI: 10.1111/bph.13539.Zhang F., Su X., Huang G. et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells. Sci Rep. 2017; 7 (1): 14268. DOI: 10.1038/s41598-017-14667-4.Zhang F., Su X., Huang G. et al. sRAGE alleviates neutrophilic asthma by blocking HMGB1/RAGE signalling in airway dendritic cells. Sci Rep. 2017; 7 (1): 14268. DOI: 10.1038/s41598-017-14667-4.Fan Y., Chen J., Zhu X. Effect of vitamin D on the HMGB1/RAGE pathway and adipokines levels in obese asthmatic mice. Iran. J. Allergy Asthma Immunol. 2023; 22 (3): 254–264. DOI: 10.18502/ijaai.v22i3.13053.Fan Y., Chen J., Zhu X. Effect of vitamin D on the HMGB1/RAGE pathway and adipokines levels in obese asthmatic mice. Iran. J. Allergy Asthma Immunol. 2023; 22 (3): 254–264. DOI: 10.18502/ijaai.v22i3.13053.Chen Y., Akirav E.M., Chen W. et al. RAGE ligation affects T cell activation and controls T cell differentiation. J. Immunol. 2008; 181 (6): 4272–4278. DOI: 10.4049/jimmunol.181.6.4272.Chen Y., Akirav E.M., Chen W. et al. RAGE ligation affects T cell activation and controls T cell differentiation. J. Immunol. 2008; 181 (6): 4272–4278. DOI: 10.4049/jimmunol.181.6.4272.Van Crombruggen K., Holtappels G., De Ruyck N. et al. RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP. J. Allergy Clin. Immunol. 2012; 129 (6): 1515–1521.e8. DOI: 10.1016/j.jaci.2012.02.021.Van Crombruggen K., Holtappels G., De Ruyck N. et al. RAGE processing in chronic airway conditions: involvement of Staphylococcus aureus and ECP. J. Allergy Clin. Immunol. 2012; 129 (6): 1515–1521.e8. DOI: 10.1016/j.jaci.2012.02.021.El-Seify M.Y., Fouda E.M., Nabih E.S. Serum level of soluble receptor for advanced glycation end products in asthmatic children and its correlation to severity and pulmonary functions. Clin. Lab. 2014; 60 (6): 957–962. DOI: 10.7754/clin.lab.2013.130418.El-Seify M.Y., Fouda E.M., Nabih E.S. Serum level of soluble receptor for advanced glycation end products in asthmatic children and its correlation to severity and pulmonary functions. Clin. Lab. 2014; 60 (6): 957–962. DOI: 10.7754/clin.lab.2013.130418.Alzayadneh E.M., Al Bdour S.A., Elayeh E.R. et al. Assessment of fraction of exhaled nitric oxide and soluble receptor for advanced glycation end products biomarkers for Jordanian asthmatic children. J. Asthma Allergy. 2023; 16: 793–811. DOI: 10.2147/JAA.S415481.Alzayadneh E.M., Al Bdour S.A., Elayeh E.R. et al. Assessment of fraction of exhaled nitric oxide and soluble receptor for advanced glycation end products biomarkers for Jordanian asthmatic children. J. Asthma Allergy. 2023; 16: 793–811. DOI: 10.2147/JAA.S415481.Терещенко С.Ю., Смольникова М.В., Горбачева Н.Н. Растворимый рецептор конечных продуктов гликозилирования как новый биомаркер бронхиальной астмы у детей: краткий обзор литературы и собственные данные. Российский иммунологический журнал. 2024; 27 (2): 237–242. DOI: 10.46235/1028-7221-16663-SRF.Tereshchenko S.Y., Smolnikova M.V., Gorbacheva N.N. [Soluble receptor for advanced glycation endproducts (sRAGE) as a new biomarker of asthma in children: a brief review of the literature and our own findings]. Rossiyskiy immunologicheskiy zhurnal. 2024; 27 (2): 237–242. DOI: 10.46235/1028-7221-16663-SRF (in Russian).Zhou Y., Jiang Y.Q., Wang W.X. et al. HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage. Hum. Immunol. 2012; 73 (11): 1171–1174. DOI: 10.1016/j.humimm.2012.08.016.Zhou Y., Jiang Y.Q., Wang W.X. et al. HMGB1 and RAGE levels in induced sputum correlate with asthma severity and neutrophil percentage. Hum. Immunol. 2012; 73 (11): 1171–1174. DOI: 10.1016/j.humimm.2012.08.016.Magnier J., Julian V., Sapin V. et al. Soluble receptor of advanced glycation end products (sRAGE) in pediatric asthma: a prospective study in 68 children aged 7 years. Appl. Sci. 2022; 12 (12): 5926. DOI: 10.3390/app12125926.Magnier J., Julian V., Sapin V. et al. Soluble receptor of advanced glycation end products (sRAGE) in pediatric asthma: a prospective study in 68 children aged 7 years. Appl. Sci. 2022; 12 (12): 5926. DOI: 10.3390/app12125926.Watanabe T., Asai K., Fujimoto H. et al. Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients. Respir. Med. 2011; 105 (4): 519–525. DOI: 10.1016/j.rmed.2010.10.016.Watanabe T., Asai K., Fujimoto H. et al. Increased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patients. Respir. Med. 2011; 105 (4): 519–525. DOI: 10.1016/j.rmed.2010.10.016.Li Y., Wu R., Tian Y. et al. Fraction of exhaled nitric oxide and soluble receptors for advanced glycation end products are negatively correlated in children with recurrent wheezing. Asian. Pac. J. Allergy Immunol. 2017; 35 (1): 33–37. DOI: 10.12932/AP0746.Li Y., Wu R., Tian Y. et al. Fraction of exhaled nitric oxide and soluble receptors for advanced glycation end products are negatively correlated in children with recurrent wheezing. Asian. Pac. J. Allergy Immunol. 2017; 35 (1): 33–37. DOI: 10.12932/AP0746.Birben E., Şahiner Ü.M., Kalaycı C.Ö. Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turk. J. Med. Sci. 2023; 53 (1): 160–170. DOI: 10.55730/1300-0144.5569.Birben E., Şahiner Ü.M., Kalaycı C.Ö. Determination of the effects of advanced glycation end products receptor polymorphisms and its activation on structural cell responses and inflammation in asthma. Turk. J. Med. Sci. 2023; 53 (1): 160–170. DOI: 10.55730/1300-0144.5569.Zhang H., Lu X., Liu Z., Du K. Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats. Int. J. Mol. Med. 2018; 42 (6): 3415–3423. DOI: 10.3892/ijmm.2018.3928.Zhang H., Lu X., Liu Z., Du K. Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats. Int. J. Mol. Med. 2018; 42 (6): 3415–3423. DOI: 10.3892/ijmm.2018.3928.O'Carroll M.R., Huetsch J.C., Hamilton J. et al. A first-in-human study of ARO-RAGE, a novel inhaled RNA-interference therapy for asthma. Thematic poster session. 2024; 209: A1376. DOI: 10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A1376.O'Carroll M.R., Huetsch J.C., Hamilton J. et al. A first-in-human study of ARO-RAGE, a novel inhaled RNA-interference therapy for asthma. Thematic poster session. 2024; 209: A1376. DOI: 10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A1376.

The authors declare that there are no conflicts of interest present.