pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2024-34-5-643-654pulmo-4525Research ArticleМАТЕРИАЛЫ КОНГРЕССА: ПРИМЕНЕНИЕ ВОДОРОДА В МЕДИЦИНЕCONGRESS: APPLICATION OF HYDROGEN IN MEDICINEВопросы митохондриальной дисфункции у больных респираторными заболеваниямиMitochondrial dysfunction in patients with respiratory diseaseshttps://orcid.org/0000-0002-8428-6020МишлановВ. Ю.MishlanovV. Ju.

Мишланов Виталий Юрьевич – д. м. н., профессор, член-корреспондент Российской академии наук, заведующий кафедрой пропедевтики внутренних болезней № 1, Author ID: 14042209800, Web of Science Researcher ID: AAI-1576-2021.

614990, Пермь, ул. Петропавловская, 26; тел.: (950) 467-76-96

Vitaliy Ju. Mishlanov - Doctor of Medicine, Professor, Corresponding member of Russian Academy of Sciences, Head of the Department of Propaedeutics of Internal Diseases No.1, Author ID: 14042209800; Web of Science Researcher ID: AAI-1576-2021.

Ul. Petropavlovskaya 26, Perm, 614990; tel.: (950) 467-76-96

permmed@hotmail.comhttps://orcid.org/0000-0002-1797-7585ЧучалинА. Г.ChuchalinA. G.

Чучалин Александр Григорьевич – д. м. н., профессор, академик Российской академии наук, заведующий кафедрой госпитальной терапии педиатрического факультета, председатель правления Российского респираторного общества.

117997, Москва, ул. Островитянова, 1; тел.: (499) 780-08-50

Alexander G. Chuchalin - Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of Department of Hospital Internal Medicine, Pediatric Faculty, N.I. Pirogov Russian National Research Medical University; Chairman of the Executive Board of Russian Respiratory Society.

Ul. Ostrovityanova 1, Moscow, 117997; tel.: (499) 780-08-50

chuchalin@inbox.ruhttps://orcid.org/0000-0003-4329-147XЧерешневВ. А.ChereshnevV. A.

Черешнев Валерий Александрович – д. м. н., профессор, академик Российской академии наук, заведующий кафедрой микробиологии и иммунологии биологического факультета Пермский государственный медицинский университет имени академика Е.А.Вагнера; директор Институт иммунологии и физиологии» Уральского отделения Российской академии наук; член президиума регионального отделения Уральского отделения РАН. Scopus ID: 6602886513.

614990, Пермь, ул. Петропавловская, 26; 620049, Екатеринбург, ул. Первомайская, 106

Valeriy A. Chereshnev - Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of the Department of Microbiology and Immunology, Faculty of Biology, Perm State Medical University named after Academician E.A.Wagner; Director, Institute of Immunology and Physiology” of the Ural Branch of the Russian Academy of Sciences. Scopus ID: 6602886513.

Ul. Petropavlovskaya 26, Perm, 614990; ul. Pervomayskaya 106, Ekaterinburg, 620049

v.chereshnev@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е.А. Вагнера» Министерства здравоохранения Российской ФедерацииРоссияState Budgetary Educational Institution of Higher Professional Training “Perm State Medical University named after Academician E.A.Wagner” of the Ministry of Healthcare of the Russian FederationRussian FederationФедеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Autonomous Educational Institution of Higher Education “N.I. Pirogov Russian National Research Medical University” of the Ministry of Health of the Russian FederationRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Пермский государственный медицинский университет имени академика Е.А. Вагнера» Министерства здравоохранения Российской Федерации; Федеральное государственное бюджетное учреждение науки «Институт иммунологии и физиологии» Уральского отделения Российской академии наукРоссияState Budgetary Educational Institution of Higher Professional Training “Perm State Medical University named after Academician E.A. Wagner” of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Institution of Science “Institute of Immunology and Physiology” of the Ural Branch of the Russian Academy of SciencesRussian Federation202411102024345643654Copyright © Мишланов В.Ю., Чучалин А.Г., Черешнев В.А., 20242024Мишланов В.Ю., Чучалин А.Г., Черешнев В.А.Mishlanov V.J., Chuchalin A.G., Chereshnev V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/4525

Целью обзора научной литературы явился поиск новых решений актуальных задач лечения, снижения сроков временной утраты трудоспособности и инвалидности у больных респираторными заболеваниями. Приведены результаты анализа 62 научных работ, опубликованных за 23 года (2001–2023), по проблемам изучения митохондриальной дисфункции (МД), новых методов ее диагностики и путей коррекции при заболеваниях органов дыхания. В качестве актуальной научной проблемы респираторной медицины определено нарушение энергетической функции митохондрий. Отмечено, что для решения указанной проблемы разрабатываются новые методы патогенетической терапии при распространенных и труднокурабельных в настоящее время заболеваниях. Ключевой раздел обзора посвящен результатам исследований нарушений функций митохондрий у больных бронхиальной астмой, хронической обструктивной болезнью легких, идиопатическим легочным фиброзом и легочной гипертензией.

Заключение. Представлена оценка методов диагностики МД, потенциально применимых в условиях реальной клинической практики. Проведено сопоставление результатов изучения электрического потенциала внутренней мембраны митохондрии, накопления активных форм кислорода, продукции аденозинтрифосфата в клетках крови, альвеоцитах и эпителии дыхательных путей, а также гладкомышечных клетках (ГМК) бронхов, эндотелии и ГМК сосудов системы легочной артерии, определения митохондриальной ДНК в биологических cредах. Кратко освещаются отдельные предложения для коррекции синдрома МД в клинической картине респираторных заболеваний.

The aim of this scientific literature review was to find new solutions to urgent problems of treating respiratory diseases and reducing the associated temporary loss of ability to work and disability. The article presents the results of the analysis of 62 scientific papers published over 23 years (2001 – 2023) on mitochondrial dysfunction (MD), new methods of its diagnosis, and ways of its correction in respiratory diseases. Disorder of the energy function of mitochondria has been identified as an urgent scientific problem of respiratory medicine. It is noted that new methods of pathogenetic therapy for common and currently difficult-to-treat diseases are being developed to solve this problem. The key section of the review is devoted to the results of studies of mitochondrial dysfunction in patients with asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and pulmonary hypertension.

Conclusion. The article assesses MD diagnostic methods that are potentially applicable in real clinical practice. The results of studying the electric potential of the inner mitochondrial membrane, accumulation of active forms of oxygen, production of adenosine triphosphate in blood cells, alveocytes and epithelium of the respiratory tract, as well as bronchial smooth muscle cells, endothelium and vascular smooth muscle cells in the pulmonary artery system, determination of mitochondrial DNA in biological environments are compared. Proposed methods for the correction of MD syndrome in the clinical picture of respiratory diseases are briefly covered.

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The authors declare that there are no conflicts of interest present.