pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2014-0-4-112-117pulmo-447Research ArticleОБЗОРЫREVIEWЭффективность тиотропия бромида в лечении пациентов с бронхиальной астмойEfficacy of tiotropium bromide in patients with bronchial asthmaИвановА. Ф.IvanovA. F.

к. м. н., ассистент кафедры клинической аллергологии и пульмонологии ГБОУ ДПО "Иркутская медицинская академия последипломного образования"; тел.: (902) 5163972

afivanov@rambler.ruЧернякБ. А.ChernjakB. A.

д. м. н., проф., зав. кафедрой клинической аллергологии и пульмонологии ГБОУ ДПО "Иркутская медицинская академия последипломного образования"; тел.: (902) 5687870

ba.chernyak@gmail.comГБОУ ДПО "Иркутская медицинская академия последипломного образования"РоссияState Institution of Аdditional Еducation Irkutsk Medical Academy of Postgraduate TrainingRussian Federation20142808201404112117Copyright © Иванов А.Ф., Черняк Б.А., 20142014Иванов А.Ф., Черняк Б.А.Ivanov A.F., Chernjak B.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/447

Рассматривается применение антихолинергического препарата тиотропия бромида (ТБ) у больных бронхиальной астмой (БА). Согласно результатам плацебоконтролируемых рандомизированных клинических исследований, применение ТБ у больных БА эффективно и безопасно. Так, при недостаточном контроле над БА добавление ТБ более эффективно, чем удвоение дозы ингаляционных глюкокортикостероидов (иГКС). У больных с плохо контролируемой БА на фоне комбинированной терапии иГКС и длительно действующими β2агонистами при дополнительном лечении ТБ, доставляемым с помощью ингаляционного устройства Респимат®, улучшаются функциональные параметры, снижается количество тяжелых обострений и увеличивается период до 1го обострения.

A review on use of an anticholinergic drug tiotropium bromide (TB) in patients with bronchial asthma (BA) is presented in this article. An analysis of published data including placebocontrolled, randomized clinical trials showed that administration of TB is effective and safe in patients with BA. In patients with uncontrolled BA, addition of TB to the standard therapy was more effective than doubling a dose of inhaled corticosteroids (ICS). In patients with BA that was poorly controlled with combination of ICS plus longacting β2agonists, addition of TB via Respimat® improved lung function, reduced number of severe exacerbations and increased time to first exacerbation.

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The authors declare that there are no conflicts of interest present.