pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2014-0-4-100-104pulmo-445Research ArticleОБЗОРЫREVIEWДиагностическое значение биомаркеров при обострении хронической обструктивной болезни легкихDiagnostic values of biomarkers in acute exacerbation of chronic obstructive pulmonary diseaseБудневскийА. В.BudnevskiyA. V.

д. м. н., профессор, зав. кафедрой факультетской терапии ГБОУ ВПО "ВГМА им. Н.Н.Бурденко"; тел.: (473) 2638130

budnev@list.ruОвсянниковЕ. С.OvsyannikovE. S.

к. м. н., доцент кафедры факультетской терапии ГБОУ ВПО "ВГМА им. Н.Н.Бурденко"; тел.: (473) 2638130

ovses@yandex.ruЧерновА. В.ChernovA. V.

к. м. н., доцент кафедры общественного здоровья, экономики и управления в здравоохранении ФПРКЗ ГБОУ ВПО "ВГМА им. Н.Н.Бурденко"; тел.: (473) 2638130

k.f.ter@yandex.ruДробышеваЕ. С.DrobyshevaE. S.

к. м. н., доцент, доцент кафедры факультетской терапии ГБОУ ВПО "ВГМА им. Н.Н.Бурденко"; тел.: (473) 2638130

k.f.ter@yandex.ruГБОУ ВПО "Воронежская государственная медицинская академия им. Н.Н.Бурденко" Минздрава РоссииРоссияState Institution N.N.Burdenko Voronezh Medical Academy, Healthcare MinistryRussian Federation20142808201404100104Copyright © Будневский А.В., Овсянников Е.С., Чернов А.В., Дробышева Е.С., 20142014Будневский А.В., Овсянников Е.С., Чернов А.В., Дробышева Е.С.Budnevskiy A.V., Ovsyannikov E.S., Chernov A.V., Drobysheva E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/445

Обострения хронической обструктивной болезни легких (ХОБЛ) играют важную роль в прогрессировании заболевания, значительно снижают качество жизни больных. Целью настоящего обзора явилось обобщение результатов исследований о возможной роли биомаркеров в диагностике, выборе тактики ведения больных, а также прогнозировании исходов обострений заболевания. Наиболее изученными биомаркерами являются Среактивный белок и сывороточный амилоид А. Оценка уровня копептина и проадреномедуллина может быть полезной в прогнозировании краткосрочных исходов. Биомаркернаправленное ведение пациентов с обострениями ХОБЛ имеет большое значение при выборе лекарственных препаратов.

An acute exacerbation of chronic obstructive pulmonary disease (COPD) plays an important role in the disease progression and significantly reduces the patients' quality of life. The aim of this review was to summarize published findings about a possible role of biomarkers in diagnosis, management and predicting outcomes in COPD patients. Creactive protein and serum amyloid A are the most investigated biomarkers in this field. Measurement of copeptin and proadrenomedullin may be useful in predicting shortterm outcomes. Biomarkeroriented management of patients with acute exacerbation of COPD could be important for choosing medications.

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The authors declare that there are no conflicts of interest present.