pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2024-34-5-719-726pulmo-4378Research ArticleОБЗОРЫREVIEWЛегочная гиалинизирующаяся гранулема: обзор литературы и презентация случаяPulmonary hyalinizing granuloma: literature review and case presentationhttps://orcid.org/0000-0002-0519-0523БаженовА. В.BazhenovA. V.

Баженов Александр Викторович – к. м. н., старший научный сотрудник лаборатории инвазивных технологий в составе научно-клинического отдела.

620039, Екатеринбург, 22-го Партсъезда, 50; тел.: (343) 333-44-38

Alexander V. Bazhenov - Candidate of Medicine, Senior Researcher, Laboratory of Invasive Technologies, part of the Scientific and Clinical Department.

Ul. 22-go Parts’ezda 50, Ekaterinburg, 620039; tel.: (343) 333-4438

ai0803@mail.ruКочуроваА. В.KochurovaA. V.

Кочурова Александра Вячеславовна – врач-пульмонолог отделения дифференциальной диагностики.

620039, Екатеринбург, 22-го Партсъезда, 50; тел.: (343) 333-44-31

Alexandra V. Kochurova - Pulmonologist, Department of Differential Diagnostics.

Ul. 22-go Parts’ezda 50, Ekaterinburg, 620039; tel.: (343) 333-44-31

www.sashok1510@mail.ruПетрунинаЕ. М.PetruninaE. M.

Петрунина Екатерина Михайловна – врач-патологоанатом патологоанатомического отделения.

620039, Екатеринбург, 22-го Партсъезда, 50; тел.: (343) 333-44-46

Ekaterina M. Petrunina - Pathologist, Pathological Anatomy Department.

Ul. 22-go Parts’ezda 50, Ekaterinburg, 620039; tel.: (343) 333-44-46

Ekaterina_b89@list.ruhttps://orcid.org/0000-0002-0537-025XБердниковР. Б.BerdnikovR. B.

Бердников Роман Борисович – к. м. н., врач-патологоанатом патологоанатомического отделения.

620039, Екатеринбург, 22-го Партсъезда, 50; тел.: (343) 333-44-46

Roman B. Berdnikov - Candidate of Medicine, Pathologist, Pathological Anatomy Department.

Ul. 22-go Parts’ezda 50, Ekaterinburg, 620039; tel.: (343) 333-44-46

rberdnikov@yandex.ruОвчинниковаЕ. А.OvchinnikovaE. A.

Овчинникова Екатерина Альфредовна – к. м. н., врач-рентгенолог отделения лучевой диагностики.

620039, Екатеринбург, 22-го Партсъезда, 50; тел.: (343) 333-40-64

Ekaterina A. Ovchinnikova - Candidate of Medicine, Radiologist, Department of Radiation Diagnostics.

Ul. 22-go Parts’ezda 50, Ekaterinburg, 620039; tel.: (343) 333-40-64

aurorochka@yandex.ruУральский научно-исследовательский институт фтизиопульмонологии – филиал Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» Министерства здравоохранения Российской ФедерацииРоссияUral Research Institute of Phthisiopulmonology – A Branch of National Medical Research Center for Phthisiology, Pulmonology and Infectious Diseases, Healthcare Ministry of RussiaRussian Federation202411102024345719726Copyright © Баженов А.В., Кочурова А.В., Петрунина Е.М., Бердников Р.Б., Овчинникова Е.А., 20242024Баженов А.В., Кочурова А.В., Петрунина Е.М., Бердников Р.Б., Овчинникова Е.А.Bazhenov A.V., Kochurova A.V., Petrunina E.M., Berdnikov R.B., Ovchinnikova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/4378

Легочная гиалинизирующаяся гранулема (ЛГГ) – патология чрезвычайно редкая. В настоящее время по всему миру описано около 170–200 случаев. Все случаи описаны в иностранной литературе, в отечественной – сообщений о данной патологии не встречалось. Этиология заболевания неизвестна. Рентгенологическая картина очень неспецифична, в дифференциально-диагностический ряд входят опухоли легкого и плевры, а также инфекционные процессы в легких. У заболевших пациентов отмечается длительное стабильное течение данной патологии, а к длительной стойкой ремиссии может приводить лечение глюкокортикостероидами.

Целью работы явилось информирование врачей-пульмонологов, терапевтов, торакальных хирургов, онкологов, инфекционистов о существовании ЛГГ, особенностях диагностики, клинического течения и вариантах лечения данной патологии.

Заключение. В силу своей редкости ЛГГ в клинической деятельности врача-специалиста может и не встретиться за всю профессиональную карьеру. Однако следует знать о ее существовании и включать в дифференциально-диагностический ряд при рентгенологическом выявлении очаговых и фокусных теней при исследовании органов грудной клетки. Возможно, это заболевание обусловлено различными иммуномедиаторными процессами, хотя его патогенез до сих пор остается неясным. Для морфологического подтверждения диагноза необходимо выполнять резекцию легкого с целью последующего гистологического исследования. Прогноз течения благоприятный, а при своевременно начатом лечении возможно существенно продлить период ремиссии.

Pulmonary hyalinizing granuloma (PHG) is an extremely rare condition. Only 170-200 cases have been described until now all over the world. There have been no reports in the Russian medical literature. Etiology of the disease is unknown. The X-ray picture is very unspecific. Tumors of lungs and pleura and infectious diseases are included in the differential line. Patients with pulmonary hyalinizing granuloma have long stabile progression of the disease, and the treatment with glucocorticoids can lead to the long lasting remission.

The aim of the review was to inform pulmonologists, general practitioners, infectious disease specialists, thoracic surgeons, and oncologists about the existence of pulmonary hyalinizing granuloma, its diagnosis, clinical course, and treatment. Also we present one clinical case of patient with pulmonary hyalinizing granuloma.

Conclusion. Because of very low incidence of PHG, an internist or a pulmonologist can never encounter it in their professional life. However it is worth keeping this condition in mind and including it into the diagnostic process when focal and focused shadows are identified in the lungs during chest X-ray. Probably, the disease is caused by different immune-mediatory processes, but the exact pathogenesis is still unknown. Biopsy of the lung tissue by means of lung resection is crucial for the morphological verification of the diagnosis. The prognosis of the disease is favorable. The timely initiation of treatment can sufficiently prolong the remission.

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The authors declare that there are no conflicts of interest present.