pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2014-0-4-5-12pulmo-436Research ArticleПЕРЕДОВАЯ СТАТЬЯEDITORIALПерсонализированная терапия, основанная на генотипированииPersonalized genotyping!based therapyЧучалинА. Г.ChuchalinA. G.

д. м. н., академик РАН, директор ФГБУ "НИИ пульмонологии" ФМБА России тел.\факс: (495) 4655264

chuchalin@inbox.ruФГБУ "НИИ пульмонологии" ФМБА РоссииРоссияPulmonology Research Institute, Federal Medical and Biological Agency of RussiaRussian Federation20142808201404512Copyright © Чучалин А.Г., 20142014Чучалин А.Г.Chuchalin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/436

Клиническая медицина постгеномного периода характеризуется развитием персонализированной терапии, в основу которой положен принцип генотипирования. Данный аналитический обзор посвящен клиническим исследованиям 2013 года, которые были одобрены FDA (Food and Drug Administration – Управление по контролю за продуктами и лекарствами, США), и включает 8 клинических исследований в области гематологии / онкологии, 3 – в области эндокринологии, по 2 клинических исследования в области гастроэнтерологии, инфекционных заболеваний, болезней органов дыхания, кардиологии, акушерства / гинекологии, неврологии и новых диагностических процедур и 1 клиническое исследование в области психиатрии. Проведенный анализ свидетельствует о дальнейшем развитии доказательной медицины, касающейся персонализированной терапии, основанной на генотипировании.

In the postgenome era, clinical medicine is characterized by development of personalized genotypingbased approach to treatment. Clinical stud ies published in 2013–2014 and approved by FDA (Food and Drug Administration, USA) have been analyzed in this review. These include 8 clini cal studies on hematology / oncology, 3 clinical studies on endocrinology, 2 clinical studies on gastroenterology, infection diseases, respiratory dis eases, cardiology, gynecology / obstetrics, neurology and novel diagnostic procedures each and one clinical study on psychiatrics. The analysis demonstrated further development of evidencebased medicine that provided personalized genotypingbased therapy.

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The authors declare that there are no conflicts of interest present.