References

pulmo

Пульмонология

PULMONOLOGIYA

0869-01892541-9617

Scientific and Practical Journal “PULMONOLOGIYA” LLC

10.18093/0869-0189-2024-34-6-887-895

pulmo-4326

Research Article

ОБЗОРЫ

REVIEW

Новые подходы в лечении легочной артериальной гипертензии

New approaches to the treatment of pulmonary arterial hypertension

https://orcid.org/0000-0001-7606-6565

Хачатуров

М. В.

Kchachaturov

M. V.

Хачатуров Михаил Викторович – студент VI курса Института клинической медицины имени Н.В. Склифосовского.

119991, Москва, ул. Трубецкая, 8, стр. 2; тел.: (495) 609-14-00

Michael V. Kchachaturov - 6th year student, N.V.Sklifosovsky Institute of Clinical Medicine.

Ul. Trubetskaya 8, build. 2, Moscow, 119991; tel.: (495) 609-14-00

khachaturov.michael@gmail.com

https://orcid.org/0000-0001-9357-4924

Царева

Н. А.

Tsareva

N. A.

Царева Наталья Анатольевна – к. м. н., доцент кафедры пульмонологии Института клинической медицины имени Н.В. Склифосовского Первый МГМУ имени И.М. Сеченова; заведующая лабораторией интенсивной терапии и дыхательной недостаточности НИИП Федерального медико-биологического агентства.

119991, Москва, ул. Трубецкая, 8, стр. 2; тел.: (495) 609-14-00

Natalya A. Tsareva - Candidate of Medicine, Associate Professor, Department of Pulmonology, N.V. Sklifosovsky Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov FMSMU; Head of the Laboratory of Intensive Care and Respiratory Failure, Pulmonology Scientific Research Institute.

Ul. Trubetskaya 8, build. 2, Moscow, 119991; (495) 609-14-00

n_tsareva@mail.ru

https://orcid.org/0000-0002-5999-2150

Авдеев

С. Н.

Avdeev

S. N.

Авдеев Сергей Николаевич – д. м. н., профессор, академик Российской академии наук, проректор по научной и инновационной работе, заведующий кафедрой пульмонологии Института клинической медицины имени Н.В. Склифосовского Первый МГМУ имени И.М. Сеченова; директор Национального медицинского исследовательского центра по профилю «Пульмонология»; главный внештатный специалист-пульмонолог Министерства здравоохранения Российской Федерации.

119991, Москва, ул. Трубецкая, 8, стр. 2; тел.: (499) 246-75-18

Sergey N. Avdeev - Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Vice-Rector for Research and Innovation, Head of the Department of Pulmonology, N.V. Sklifosovsky Institute of Clinical Medicine, Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov FMSMU; Chief Freelance Pulmonologist of the Ministry of Health of the Russian Federation; Director of the NMRCP; Chief Freelance Pulmonologist of the MH RF.

Ul. Trubetskaya 8, build. 2, Moscow, 119991; tel.: (499) 246-75-18

serg_avdeev@list.ru

Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)РоссияFederal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Russian Federation

2024

11122024

346887895

2024

Хачатуров М.В., Царева Н.А., Авдеев С.Н.

Kchachaturov M.V., Tsareva N.A., Avdeev S.N.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.pulmonology.ru/pulm/article/view/4326

Легочная гипертензия является полиэтиологическим заболеванием и характеризуется повышением среднего давления в легочной артерии > 20 мм рт. ст. в покое. Наиболее изученной с точки зрения подбора оптимальной терапии является идиопатическая легочная артериальная гипертензия (ЛАГ), относящаяся к 1-й группе по классификации легочной гипертензии (2022). Это редкое и прогностически крайне неблагоприятное заболевание, которое возникает в результате ремоделирования сосудов дистальных отделов легочной артерии. В настоящее время лечение ЛАГ нацелено на 3 основных метаболических каскада: простациклиновый, эндотелиновый и путь оксида азота. Благодаря имеющимся методам терапии симптомы и качество жизни пациентов с ЛАГ улучшаются, но, к сожалению, ни один из них не влияет непосредственно на патогенез и не позволяет добиться полного контроля над заболеванием.

Целью обзора явился анализ литературных источников и демонстрация наиболее перспективных методов и потенциальных мишеней для лечения ЛАГ.

Заключение. В настоящий момент терапия ЛАГ является актуальной проблемой, при этом продолжаются активные исследования, направленные на поиск новых терапевтических мишеней и разработку потенциальных препаратов для них.

Pulmonary hypertension (PH) is a polyetiological disease characterized by an increase in mean pulmonary artery pressure (MPP) by more than 20 mm Hg at rest. Idiopathic pulmonary arterial hypertension (PAH), which is assigned to the first group according to the 2018 PH classification, is the most studied in terms of optimal therapy selection. This is a rare but fatal disease that occurs as a result of vascular remodeling of the distal pulmonary arteries. Currently, PAH treatments target three major metabolic cascades: prostacyclin, endothelin, and nitric oxide. The available therapies improve the symptoms and quality of life of patients with PAH, but, unfortunately, none of them directly affect the pathogenesis or allow to achieve complete control of the disease.

The aim of the review was to analyze the literature and demonstrate of the most promising methods and potential targets for the treatment of PAH.

Conclusion. At the moment, PAH therapy is a serious clinical problem, and therefore, it is essential to study new therapeutic targets and develop the corresponding drugs.

легочная артериальная гипертензиякостный морфогенетический белоктромбоцитарный фактор ростамитохондриальная дисфункциясеротонинэстрогенмоноклональные антителатромбоксан

pulmonary arterial hypertensionbone morphogenetic proteinplatelet growth factormitochondrial dysfunctionserotoninestrogenmonoclonal antibodiesthromboxane

Спонсорская поддержка отсутствовала

The study was not sponsored

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