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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2011-0-2-101-108</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-432</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ВОЗМОЖНОСТИ КОНТРОЛЯ НАД БРОНХИАЛЬНОЙ АСТМОЙ: РОЛЬ МАЛЫХ ДЫХАТЕЛЬНЫХ ПУТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>OPPORTUNITY TO CONTROL ASTHMA: A ROLE OF SMALL AIRWAYS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будневский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budnevsky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф. кафедры общей врачебной практики (семейной медицины),глав.внештат. пульмонолог УЗ г. Воронежа</p><p>394036, Воронеж, ул. Студенческая, 10</p><p>тел.: +7 (4732) 52-03-80</p></bio><bio xml:lang="en"><p>д. м. н., проф. кафедры общей врачебной практики (семейной медицины),глав.внештат. пульмонолог УЗ г. Воронежа</p><p>394036, Воронеж, ул. Студенческая, 10</p><p>тел.: +7 (4732) 52-03-80</p></bio><email xlink:type="simple">budnev@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бурлачук</surname><given-names>В. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Burlachuk</surname><given-names>V. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., зав. кафедрой общей врачебной практики (семейной медицины),глав. внештат. пульмонолог ДЗ Воронежской области</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><bio xml:lang="en"><p>д. м. н., проф., зав. кафедрой общей врачебной практики (семейной медицины),глав. внештат. пульмонолог ДЗ Воронежской области</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олышева</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Olysheva</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры общей врачебной практики (семейной медицины) </p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><bio xml:lang="en"><p>аспирант кафедры общей врачебной практики (семейной медицины)</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Токмачев</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tokmachev</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры общей врачебной практики (семейной медицины)</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><bio xml:lang="en"><p>ассистент кафедры общей врачебной практики (семейной медицины)</p><p>394036, Воронеж, ул. Студенческая, 10</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ИПМО ГОУ ВПО "Воронежская государственная медицинская академия им. Н.Н.Бурденко МЗ и СР"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>ИПМО ГОУ ВПО "Воронежская государственная медицинская академия им. Н.Н.Бурденко МЗ и СР"</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2011</year></pub-date><volume>0</volume><issue>2</issue><fpage>101</fpage><lpage>108</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Будневский А.В., Бурлачук В.Т., Олышева И.А., Токмачев Е.В., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Будневский А.В., Бурлачук В.Т., Олышева И.А., Токмачев Е.В.</copyright-holder><copyright-holder xml:lang="en">Budnevsky A.V., Burlachuk V.T., Olysheva I.A., Tokmachev E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/432">https://journal.pulmonology.ru/pulm/article/view/432</self-uri><abstract><p>Возможности контроля над бронхиальной астмой: роль малых дыхательных путей</p></abstract><trans-abstract xml:lang="en"><p>Opportunity to control asthma: a role of small airways</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>лечение</kwd><kwd>мелкие бронхи</kwd><kwd>беклометазона дипропионат / формотеро</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>treatment</kwd><kwd>small airways</kwd><kwd>beclomethasone dipropionate / formotero</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Beasley R. The Global Burden of Asthma Report, Global Initiative for Asthma (GINA). Available from http:// www.ginasthma.org; 2004.</mixed-citation><mixed-citation xml:lang="en">Beasley R. The Global Burden of Asthma Report, Global Initiative for Asthma (GINA). Available from http:// www.ginasthma.org; 2004.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Masoli M., Fabian D., Holt S., Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59 (5): 469–478.</mixed-citation><mixed-citation xml:lang="en">Masoli M., Fabian D., Holt S., Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59 (5): 469–478.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J., Jeffery P.K., Busse W.W. et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am. J. Respir. Crit. Care Med. 2000; 161 (5): 1720–1745.</mixed-citation><mixed-citation xml:lang="en">Bousquet J., Jeffery P.K., Busse W.W. et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am. J. Respir. Crit. Care Med. 2000; 161 (5): 1720–1745.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cohn L., Elias J.A., Chupp G.L. Asthma: mechanisms of disease persistence and progression. Ann. Rev. Immunol. 2004; 22:789–815.</mixed-citation><mixed-citation xml:lang="en">Cohn L., Elias J.A., Chupp G.L. Asthma: mechanisms of disease persistence and progression. Ann. Rev. Immunol. 2004; 22:789–815.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">GINA Report, Global Strategy for Asthma Management and Prevention. Updated December 2009.</mixed-citation><mixed-citation xml:lang="en">GINA Report, Global Strategy for Asthma Management and Prevention. Updated December 2009.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Vignola A.M., Mirabella F., Costanzo G. et al. Airway remodeling in asthma. Chest 2003; 123: 417–422.</mixed-citation><mixed-citation xml:lang="en">Vignola A.M., Mirabella F., Costanzo G. et al. Airway remodeling in asthma. Chest 2003; 123: 417–422.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Royce S.G., Tang M.L. The effects of current therapies on airway remodeling in asthma and new possibilities for treatment and prevention. Curr. Mol. Pharmacol.; 2009; 2 (2): 169–181.</mixed-citation><mixed-citation xml:lang="en">Royce S.G., Tang M.L. The effects of current therapies on airway remodeling in asthma and new possibilities for treatment and prevention. Curr. Mol. Pharmacol.; 2009; 2 (2): 169–181.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Saetta M., Di Stefano A., Rosina C. et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am. Rev. Respir. Dis.; 1991; 143: 138–143.</mixed-citation><mixed-citation xml:lang="en">Saetta M., Di Stefano A., Rosina C. et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am. Rev. Respir. Dis.; 1991; 143: 138–143.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Corren J. Small airways disease in asthma. Curr. Allergy Asthma Rep. 2008; 8: 533–539.</mixed-citation><mixed-citation xml:lang="en">Corren J. Small airways disease in asthma. Curr. Allergy Asthma Rep. 2008; 8: 533–539.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tulic M.K., Christodoulopoulos P., Hamid Q. Small airway inflammation in asthma. Respir. Res. 2001; (2): 333–339.</mixed-citation><mixed-citation xml:lang="en">Tulic M.K., Christodoulopoulos P., Hamid Q. Small airway inflammation in asthma. Respir. Res. 2001; (2): 333–339.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Яшина Л.А. Особенности бронхиальной астмы с тяжелым течением. Здоровье Украины 2010; 1: 6–8.</mixed-citation><mixed-citation xml:lang="en">Яшина Л.А. Особенности бронхиальной астмы с тяжелым течением. Здоровье Украины 2010; 1: 6–8.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Contoli M., Bousquet J., Fabbri L.M. et al. The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 2010; 65 (2): 141–151.</mixed-citation><mixed-citation xml:lang="en">Contoli M., Bousquet J., Fabbri L.M. et al. The small airways and distal lung compartment in asthma and COPD: a time for reappraisal. Allergy 2010; 65 (2): 141–151.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Гриппи М.А. Патофизиология легких. М.: Восточная книжная компания; 1997.</mixed-citation><mixed-citation xml:lang="en">Гриппи М.А. Патофизиология легких. М.: Восточная книжная компания; 1997.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Турина О.И., Лаптева И.М., Калечиц О.М. и др. Организация работы по исследованию функционального состояния легких методами спирографии и пневмотахографии и применение этих методов в клинической практике: Методические указания. Минск; 2002.</mixed-citation><mixed-citation xml:lang="en">Турина О.И., Лаптева И.М., Калечиц О.М. и др. Организация работы по исследованию функционального состояния легких методами спирографии и пневмотахографии и применение этих методов в клинической практике: Методические указания. Минск; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Booker R. Interpretation and evaluation of pulmonary function tests. Nurs. Stand. 2009; 23: 46–56.</mixed-citation><mixed-citation xml:lang="en">Booker R. Interpretation and evaluation of pulmonary function tests. Nurs. Stand. 2009; 23: 46–56.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider A., Gindner L., Tilemann L. et al. Diagnostic accuracy of spirometry in primary care. BMC Pulm. Med. 2009; 10:9–31.</mixed-citation><mixed-citation xml:lang="en">Schneider A., Gindner L., Tilemann L. et al. Diagnostic accuracy of spirometry in primary care. BMC Pulm. Med. 2009; 10:9–31.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Miller M.R., Hankinson J., Brusasco V. et al. Standardisation of spirometry. Series "ATS / ERS task force: standardisation of lung function testing". Eur. Respir. J. 2005; 26: 319–338.</mixed-citation><mixed-citation xml:lang="en">Miller M.R., Hankinson J., Brusasco V. et al. Standardisation of spirometry. Series "ATS / ERS task force: standardisation of lung function testing". Eur. Respir. J. 2005; 26: 319–338.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kraft M., Cairns C.B., Ellison M.C. et al. Improvements in distal lung function correlate with asthma symptoms after treatment with oral Montelukast. Chest 2006; 130: 1726–1732.</mixed-citation><mixed-citation xml:lang="en">Kraft M., Cairns C.B., Ellison M.C. et al. Improvements in distal lung function correlate with asthma symptoms after treatment with oral Montelukast. Chest 2006; 130: 1726–1732.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Полянская М.А. Бодиплетизмография и исследование DLCO – методика проведения и интерпретация результатов. Здоровье Украины 2008; 9 (1): 52–53.</mixed-citation><mixed-citation xml:lang="en">Полянская М.А. Бодиплетизмография и исследование DLCO – методика проведения и интерпретация результатов. Здоровье Украины 2008; 9 (1): 52–53.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ярцев С.С. Структурный анализ диагностической эффективности показателей бодиплетизмографии у больных бронхиальной астмой. Медицинская техника 2005; 3:21–23.</mixed-citation><mixed-citation xml:lang="en">Ярцев С.С. Структурный анализ диагностической эффективности показателей бодиплетизмографии у больных бронхиальной астмой. Медицинская техника 2005; 3:21–23.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Levitzky M.G. Pulmonary physiology. 7th ed. New York: McGraw-Hill Medical; 2007.</mixed-citation><mixed-citation xml:lang="en">Levitzky M.G. Pulmonary physiology. 7th ed. New York: McGraw-Hill Medical; 2007.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Яшина Л.А., Полянская М.А., Загребельный М.Р. Импульсная осциллометрия – новые возможности в диагностике и мониторинге обструктивных заболеваний легких. Здоровье Украины 2009; 23 (1): 26–27.</mixed-citation><mixed-citation xml:lang="en">Яшина Л.А., Полянская М.А., Загребельный М.Р. Импульсная осциллометрия – новые возможности в диагностике и мониторинге обструктивных заболеваний легких. Здоровье Украины 2009; 23 (1): 26–27.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kaminsky D.A., Irvin C.G., Lundblad L. et al. Oscillation mechanics of the human lung periphery in asthma. J. Appl.Physiol. 2004; 97: 1849–1858.</mixed-citation><mixed-citation xml:lang="en">Kaminsky D.A., Irvin C.G., Lundblad L. et al. Oscillation mechanics of the human lung periphery in asthma. J. Appl.Physiol. 2004; 97: 1849–1858.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Winkler J., Hagert-Winkler A., Wirtz H. et al. Impulse oscillometry in the diagnosis of the severity of obstructive pulmonary disease. Pneumologie 2009; 63 (5): 266–275.</mixed-citation><mixed-citation xml:lang="en">Winkler J., Hagert-Winkler A., Wirtz H. et al. Impulse oscillometry in the diagnosis of the severity of obstructive pulmonary disease. Pneumologie 2009; 63 (5): 266–275.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Goldman M.D. Clinical application of forced oscillation. Pulm.Pharmacol. Ther. 2001; 14: 341–350.</mixed-citation><mixed-citation xml:lang="en">Goldman M.D. Clinical application of forced oscillation. Pulm.Pharmacol. Ther. 2001; 14: 341–350.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Bourdin A., Paganin F., Prefaut C. et al. Nitrogen washout slope in poorly controlled asthma. Allergy 2006; 61: 85–89.</mixed-citation><mixed-citation xml:lang="en">Bourdin A., Paganin F., Prefaut C. et al. Nitrogen washout slope in poorly controlled asthma. Allergy 2006; 61: 85–89.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">in't Veen J.C., Beekman A.J., Bel E.H., Sterk P.J. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes Am. J. Respir. Crit. Care Med. 2000; 161: 1902–1906.</mixed-citation><mixed-citation xml:lang="en">in't Veen J.C., Beekman A.J., Bel E.H., Sterk P.J. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes Am. J. Respir. Crit. Care Med. 2000; 161: 1902–1906.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Magnussen H., Holz O. Monitoring airway inflammation in asthma by induced sputum. Eur. Respir. J. 1999; 13: 5–7.</mixed-citation><mixed-citation xml:lang="en">Magnussen H., Holz O. Monitoring airway inflammation in asthma by induced sputum. Eur. Respir. J. 1999; 13: 5–7.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Tsoumakidou M., Tzanakis N., Siafakas N.M. Induced sputum in the investigation of airway inflammation of COPD. Respir.Med. 2003; 97: 863–871.</mixed-citation><mixed-citation xml:lang="en">Tsoumakidou M., Tzanakis N., Siafakas N.M. Induced sputum in the investigation of airway inflammation of COPD. Respir.Med. 2003; 97: 863–871.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen J., Douma W.R., ten Hacken N.H. et al. Ciclesonide improves measures of small airway involvement in asthma. Eur.Respir. J. 2008; 31 (6): 1213–1220.</mixed-citation><mixed-citation xml:lang="en">Cohen J., Douma W.R., ten Hacken N.H. et al. Ciclesonide improves measures of small airway involvement in asthma. Eur.Respir. J. 2008; 31 (6): 1213–1220.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">van Veen I.H., Sterk P.J., Schot R. et al. Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma. Eur. Respir. J. 2006; 27: 951–956.</mixed-citation><mixed-citation xml:lang="en">van Veen I.H., Sterk P.J., Schot R. et al. Alveolar nitric oxide versus measures of peripheral airway dysfunction in severe asthma. Eur. Respir. J. 2006; 27: 951–956.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kosciuch J., Krenke R., Gorska K. et al. Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease. J. Physiol. Pharmacol.2009; 60 (Suppl. 5): 71–76.</mixed-citation><mixed-citation xml:lang="en">Kosciuch J., Krenke R., Gorska K. et al. Relationship between airway wall thickness assessed by high-resolution computed tomography and lung function in patients with asthma and chronic obstructive pulmonary disease. J. Physiol. Pharmacol.2009; 60 (Suppl. 5): 71–76.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mikos M., Grzanka P., Sladek K. et al. Highresolution computed tomography evaluation of peripheral airways in asthma patients: comparison of focal and diffuse air trapping.Respiration 2009; 77: 381–388.</mixed-citation><mixed-citation xml:lang="en">Mikos M., Grzanka P., Sladek K. et al. Highresolution computed tomography evaluation of peripheral airways in asthma patients: comparison of focal and diffuse air trapping.Respiration 2009; 77: 381–388.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">de Jong P.A., Muller N.L., Pare P.D., Coxson H.O. Computed tomographic imaging of the airways: relationship to structure and function. Eur. Respir. J. 2005; 26: 140–152.</mixed-citation><mixed-citation xml:lang="en">de Jong P.A., Muller N.L., Pare P.D., Coxson H.O. Computed tomographic imaging of the airways: relationship to structure and function. Eur. Respir. J. 2005; 26: 140–152.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Awadh N., Muller N.L., Park C.S. et al. Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning. Thorax 1998; 53: 248–253.</mixed-citation><mixed-citation xml:lang="en">Awadh N., Muller N.L., Park C.S. et al. Airway wall thickness in patients with near fatal asthma and control groups: assessment with high resolution computed tomographic scanning. Thorax 1998; 53: 248–253.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Goldin J.G., Tashkin D.P., Kleerup E.C. et al. Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways:assessment with functional helical thinsection computed tomography. J. Allergy Clin. Immunol. 1999; 104: 258–267.</mixed-citation><mixed-citation xml:lang="en">Goldin J.G., Tashkin D.P., Kleerup E.C. et al. Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways:assessment with functional helical thinsection computed tomography. J. Allergy Clin. Immunol. 1999; 104: 258–267.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kauczor H.U., Chen X.J., van Beek E.J., Schreiber W.G.Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application. Eur. Respir. J. 2001; 17:1008–1023.</mixed-citation><mixed-citation xml:lang="en">Kauczor H.U., Chen X.J., van Beek E.J., Schreiber W.G.Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application. Eur. Respir. J. 2001; 17:1008–1023.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Samee S., Altes T., Powers P. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance:assessment of response to methacholine and exercise challenge.J. Allergy Clin. Immunol. 2003; 111: 1205–1211.</mixed-citation><mixed-citation xml:lang="en">Samee S., Altes T., Powers P. Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance:assessment of response to methacholine and exercise challenge.J. Allergy Clin. Immunol. 2003; 111: 1205–1211.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Fain S.B., Korosec F.R., Holmes J.H. et al. Functional lung imaging using hyperpolarized gas MRI. J. Magn. Reson.Imaging. 2007; 25: 910–923.</mixed-citation><mixed-citation xml:lang="en">Fain S.B., Korosec F.R., Holmes J.H. et al. Functional lung imaging using hyperpolarized gas MRI. J. Magn. Reson.Imaging. 2007; 25: 910–923.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Bai T.R., Knight D.A. Structural changes in the airways in asthma: observations and consequences. Clin. Sci. (Lond.) 2005;108: 463–477.</mixed-citation><mixed-citation xml:lang="en">Bai T.R., Knight D.A. Structural changes in the airways in asthma: observations and consequences. Clin. Sci. (Lond.) 2005;108: 463–477.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Boxall C., Holgate S.T., Davies D.E. The contribution of transforming growth factorβ and epidermal growth factor signaling to airway remodelling in chronic asthma. Eur. Respir. J. 2006;27: 208–229.</mixed-citation><mixed-citation xml:lang="en">Boxall C., Holgate S.T., Davies D.E. The contribution of transforming growth factorβ and epidermal growth factor signaling to airway remodelling in chronic asthma. Eur. Respir. J. 2006;27: 208–229.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Sutherland E.R., Martin R.J. Distal lung inflammation in asthma. Ann. Allergy Asthma Immunol. 2002; 89: 119–124.</mixed-citation><mixed-citation xml:lang="en">Sutherland E.R., Martin R.J. Distal lung inflammation in asthma. Ann. Allergy Asthma Immunol. 2002; 89: 119–124.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Leach C.L., Davidson P.J., Boudreau R.J. Improved airway targeting with the CFCfree HFA-beclomethasone metered dose inhaler compared with CFC-beclomethasone. Eur. Respir. J.1998; 12: 1346–1353.</mixed-citation><mixed-citation xml:lang="en">Leach C.L., Davidson P.J., Boudreau R.J. Improved airway targeting with the CFCfree HFA-beclomethasone metered dose inhaler compared with CFC-beclomethasone. Eur. Respir. J.1998; 12: 1346–1353.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Powell H., Gibson P.G. Inhaled corticosteroid doses in asthma: an evidence-based approach. Med. J. Aust. 2003; 178 (5): 223–225.</mixed-citation><mixed-citation xml:lang="en">Powell H., Gibson P.G. Inhaled corticosteroid doses in asthma: an evidence-based approach. Med. J. Aust. 2003; 178 (5): 223–225.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Szefler S.J., Martin R.J., King T.S. et al. Significant variability in response to inhaled corticosteroids for persistent asthma.J. Allergy Clin. Immunol. 2002; 109 (3): 410–418.</mixed-citation><mixed-citation xml:lang="en">Szefler S.J., Martin R.J., King T.S. et al. Significant variability in response to inhaled corticosteroids for persistent asthma.J. Allergy Clin. Immunol. 2002; 109 (3): 410–418.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Van Schayck C.P., Donnell D. The efficacy and safety of QVAR (hydrofluoroalkane-beclometasone diproprionate extrafine aerosol) in asthma (pt 1): an update of clinical experience in adults. Int. J. Clin. Pract. 2004; 58: 678–688.</mixed-citation><mixed-citation xml:lang="en">Van Schayck C.P., Donnell D. The efficacy and safety of QVAR (hydrofluoroalkane-beclometasone diproprionate extrafine aerosol) in asthma (pt 1): an update of clinical experience in adults. Int. J. Clin. Pract. 2004; 58: 678–688.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Hauber H.P., Taha R., Bergeron C. et al. Effects of hydrofluo-roalkane and dry powder-formulated corticosteroids on sputum inflammatory markers in asthmatic patients. Can. Respir. J.2006; 13: 73–78.</mixed-citation><mixed-citation xml:lang="en">Hauber H.P., Taha R., Bergeron C. et al. Effects of hydrofluo-roalkane and dry powder-formulated corticosteroids on sputum inflammatory markers in asthmatic patients. Can. Respir. J.2006; 13: 73–78.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bousquet J. Introduction. Modulite: simplifying the changeover.Respir. Med. 2002; 96 (Suppl. D): S1–S2.</mixed-citation><mixed-citation xml:lang="en">Bousquet J. Introduction. Modulite: simplifying the changeover.Respir. Med. 2002; 96 (Suppl. D): S1–S2.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Huchon G., Magnussen H., Chuchalin A. et al. Lung function and asthma control with beclomethasone and formoterol in a single inhaler. Respir. Med. 2009; 103 (1): 41–49.</mixed-citation><mixed-citation xml:lang="en">Huchon G., Magnussen H., Chuchalin A. et al. Lung function and asthma control with beclomethasone and formoterol in a single inhaler. Respir. Med. 2009; 103 (1): 41–49.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Papi A., Paggiaro P.L., Nicolini G. et al. Bеclomethasone / formoterol versus budesonide / formoterol combination therapy in asthma. Eur. Respir. J. 2007; 29: 682–689.</mixed-citation><mixed-citation xml:lang="en">Papi A., Paggiaro P.L., Nicolini G. et al. Bеclomethasone / formoterol versus budesonide / formoterol combination therapy in asthma. Eur. Respir. J. 2007; 29: 682–689.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Papi A., Paggiaro P., Nicolini G. et al. Beclomethasone / formoterol vs fluticasone / salmeterol inhaled combination in moderate to severe asthma. Allergy 2007; 62: 1182–1188.</mixed-citation><mixed-citation xml:lang="en">Papi A., Paggiaro P., Nicolini G. et al. Beclomethasone / formoterol vs fluticasone / salmeterol inhaled combination in moderate to severe asthma. Allergy 2007; 62: 1182–1188.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Ильина Н.И., Павлова К.С. Эффективность и безопасность препарата Фостер у больных бронхиальной астмой в реальной клинической практике. Росс. аллерголог. Журнал 2010; 5: 82–90.</mixed-citation><mixed-citation xml:lang="en">Ильина Н.И., Павлова К.С. Эффективность и безопасность препарата Фостер у больных бронхиальной астмой в реальной клинической практике. Росс. аллерголог. Журнал 2010; 5: 82–90.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
