pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2024-34-1-74-79pulmo-4186Research ArticleОБЗОРЫREVIEWВлияние адипоцитокинов на бронхолегочную систему при абдоминальном ожиренииInfluence of adipocytokines on the bronchopulmonary system in abdominal obesityhttps://orcid.org/0000-0001-7875-1566ХудяковаА. Д.KhudiakovaA. D.

Худякова Алена Дмитриевна – к. м. н., заведующая лабораторией генетических и средовых детерминант жизненного цикла человека

630089, Новосибирск, ул. Б.Богаткова, 175 / 1

Alena D. Khudiakova, Candidate of Medicine, Head of the Laboratory ofgenetic and environmental determinants of the human life cycle

ul. B.Bogatkova 175/1, Novosibirsk, 630089

alene.elene@gmail.comhttps://orcid.org/0000-0002-4936-8362РагиноЮ. И.RaginoYu. I.

Рагино Юлия Игоревна – д. м. н., профессор, член-корр. Российскойакадемии наук, руководитель

630089, Новосибирск, ул. Б.Богаткова, 175 / 1

Yulia I. Ragino, Doctor of Medicine, Professor, Corresponding Member ofRussian Academy of Sciences, Head

ul. B.Bogatkova 175/1, Novosibirsk, 630089

ragino@mail.ruНаучно-исследовательский институт терапии и профилактической медицины – филиал Федерального государственного бюджетного научного учреждения «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesRussian Federation2024111220233417479Copyright © Худякова А.Д., Рагино Ю.И., 20242024Худякова А.Д., Рагино Ю.И.Khudiakova A.D., Ragino Y.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/4186

В патогенезе развития хронических заболеваний легких предполагается участие факторов системного воспаления, а также гормоноподобных веществ, вырабатываемых жировой тканью (ЖТ), которая является самостоятельным эндокринным органом, продуцирующим адипокины. Адипокины вызывают системное воспаление под воздействием гипоксемии вследствие ожирения и сопутствующих дыхательных расстройств, таких как синдром обструктивного апноэ сна, хроническая обструктивная болезнь легких, синдром гиповентиляции и т. д. Однако остается неясным влияние конкретных адипоцитов на развитие и течение бронхолегочных заболеваний.

Целью данного обзора явилась оценка вклада некоторых адипоцитокинов в развитие бронхолегочной патологии на фоне абдоминального ожирения (АО). Собраны данные, посвященные исследованиям адипонектина, адипсина, липокалина-2, интерлейкина-6, инсулина, глюкагона, лептина, моноцитарно-хемоаттрактантного протеина 1-го типа, фактора некроза опухоли-α, амилина, глюкозозависимого инсулинотропного полипептида, грелина и панкреатического полипептида у пациентов с нарушением со стороны бронхолегочной системы при АО.

Заключение. Подтверждено, что участие гормоноподобных веществ, вырабатываемых ЖТ, вносит весомый вклад в тяжесть течения заболеваний с нарушением со стороны органов дыхания.

Pathogenesis of chronic lung diseases is assumed to involve systemic inflammation factors, as well as hormone-like substances adipokines produced by adipose tissue, which is an independent endocrine organ. Adipokines cause systemic inflammation under the influence of hypoxemia due to obesity and associated respiratory disorders such as obstructive sleep apnea syndrome, chronic obstructive pulmonary disease, hypoventilation syndrome, etc. However, the influence of specific adipocytes on the development and course of bronchopulmonary diseases remains unclear.

Purpose of this review was to evaluate the contribution of some adipocytokines to the development of bronchopulmonary conditions against abdominal obesity. We collected data on adiponectin, adipsin, lipocalin-2, interleukin 6, insulin, glucagon, leptin, monocyte-chemoattractant protein type 1, tumor necrosis factor-α, amylin, glucose-dependent insulinotropic polypeptide, ghrelin, and pancreatic polypeptide in patients with abdominal obesity and bronchopulmonary disorders.

Conclusion. The presented data confirm that hormone-like substances produced by adipose tissue make a significant contribution to the severity of respiratory disorders.

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The authors declare that there are no conflicts of interest present.