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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2022-32-3-295-355</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-4107</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GUIDELINES</subject></subj-group></article-categories><title-group><article-title>Внебольничная пневмония: федеральные клинические рекомендации по диагностике и лечению</article-title><trans-title-group xml:lang="en"><trans-title>Federal guidelines on diagnosis and treatment of community-acquired pneumonia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5999-2150</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеев</surname><given-names>С. Н</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, академик Российской академии наук, заведующий кафедрой пульмонологии Института клинической медицины имени Н.В.Склифосовского, 119991, Москва, ул. Трубецкая, 8, стр. 2;</p><p>ведущий научный сотрудник, 115682, Москва, Ореховый бульвар, 28</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of the Department of Pulmonology, N.V.Sklifosovsky Institute of Clinical Medicine, ul. Trubetskaya 8, build. 2, Moscow, 119991;</p><p>Leading Researcher, Orehovyy bul’var 28, Moscow, 115682</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6897-5486</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дехнич</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dekhnich</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., заместитель директора Научно-исследовательского института антимикробной химиотерапии,</p><p>214019, Смоленск, ул. Крупской, 28</p></bio><bio xml:lang="en"><p>Candidate of Medicine, Deputy Director, Research Institute of Antimicrobial Chemotherapy, </p><p>ul. Krupskoy 28, Smolensk, 214019</p></bio><email xlink:type="simple">Andrey.Dekhnich@antibiotic.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0934-7313</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зайцев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaytsev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, главный пульмонолог,</p><p>105094, Москва, Госпитальная пл., 3</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Chief Pulmonologist,</p><p>Gospital’naya pl. 3, Moscow, 105229</p></bio><email xlink:type="simple">a-zaicev@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8728-1113</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлов</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlov</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, член-корр. Российской академии наук, ректор, 214019, Смоленск, ул. Крупской, 28;</p><p>директор, 214019, Смоленск, ул. Крупской, 28</p><p>главный внештатный специалист Министерства здравоохранения Российской Федерациипо направлению «Клиническая микробиология и антимикробная резистентность»</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Sciences, Rector, ul. Krupskoy 28, Smolensk, 214019;</p><p>Director, ul. Krupskoy 28, Smolensk, 214019;</p><p>Chief Freelance Specialist of the Healthcare Ministry of Russia in the field of “Clinical Microbiology and Antimicrobial Resistance”</p></bio><email xlink:type="simple">Roman.Kozlov@antibiotic.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3329-7846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рачина</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rachina</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., заведующая кафедрой госпитальной терапии № 2,</p><p>119991, Москва, ул. Трубецкая, 8, стр. 2</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Head of Department оf Hospital Therapy No.2, </p><p>ul. Trubetskaya 8, build. 2, Moscow, 119991</p></bio><email xlink:type="simple">svetlana.ratchina@antibiotic.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0830-786X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Руднов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudnov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, заведующий кафедрой анестезиологии и реаниматологии, 620028 Екатеринбург, ул. Репина, 3;</p><p>руководитель службы анестезиологии и реанимации, 620036, Екатеринбург, ул. Соболева, 29</p><p>вице-президент Межрегиональной ассоциации общественных объединений «Межрегиональная ассоциация по клинической микробиологии и антимикробной химиотерапии»</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Head of Department of Anesthesiology and Intensive Care, ul. Repina 3, Ekaterinburg, 620028;</p><p>Head of Anesthesiology and Intensive Care Service, ul. Soboleva, 29, Ekaterinburg, 620036;</p><p>Vice-president, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy</p></bio><email xlink:type="simple">Vrudnov@mail.ru</email><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1990-2042</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Синопальников</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Sinopal’nikov</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, заведующий кафедрой пульмонологии,</p><p>125993, Москва, ул. Баррикадная, 2 / 1, стр. 1</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Head of Department of Pulmonology, </p><p>ul. Barrikadnaya 2/1, build. 1, Moscow, 123995</p></bio><email xlink:type="simple">aisyn@list.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3931-1431</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюрин</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Tyurin</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, заведующий кафедрой рентгенологии и радиологии,</p><p>125993, Москва, ул. Баррикадная, 2 / 1, стр. 1</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Head of Department of Radiology, </p><p>ul. Barrikadnaya 2/1, build. 1, Moscow, 123995</p></bio><email xlink:type="simple">igortyurin@gmail.com</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фесенко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fesenko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор кафедры пульмонологии,</p><p>125993, Москва, ул. Баррикадная, 2 / 1, стр. 1</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Pulmonology Department, </p><p>ul. Barrikadnaya 2/1, build. 1, Moscow, 123995</p></bio><email xlink:type="simple">ofessenko@mail.ru</email><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6808-5528</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чучалин</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chuchalin</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, академик Российской академии наук, заведующий кафедрой госпитальной терапии педиатрического факультета, председатель правления Российского респираторного общества,</p><p>117997, Москва, ул. Островитянова, 1</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Academician of Russian Academy of Sciences, Head of Department of Hospital Internal Medicine, Pediatric Faculty, ul. Ostrovityanova 1, Moscow, 117997;</p><p>Chairman of the Executive Board of Russian Respiratory Society</p></bio><email xlink:type="simple">pulmomoskva@mail.ru</email><xref ref-type="aff" rid="aff-8"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет);&#13;
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт пульмонологии» Федерального медико-биологического агентства</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University);&#13;
Federal Pulmonology Research Institute, Federal Medical and Biological Agency of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Смоленский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University, Healthcare Ministry of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Главный военный клинический госпиталь имени академика Н.Н.Бурденко» Министерства обороны Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Main Military Clinical Hospital named after academician N.N.Burdenko, Ministry of Defense of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Смоленский государственный медицинский университет» Министерства здравоохранения Российской Федерации;&#13;
Межрегиональная ассоциация общественных объединений «Межрегиональная ассоциация по клинической микробиологии и антимикробной химиотерапии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University, Healthcare Ministry of Russia;&#13;
Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Первый Московский государственный медицинский университет имени И.М.Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Autonomous Educational Institution of Higher Education I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Уральский государственный медицинский университет» Министерства здравоохранения Российской Федерации;&#13;
Государственное автономное учреждение здравоохранения Свердловской области «Свердловский областной онкологический диспансер»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budget Educational Institution of Higher Education “Ural State Medical University” of the Ministry of Health of the Russian Federation;&#13;
State Autonomous Healthcare Institution of the Sverdlovsk Region “Sverdlovsk Regional Oncological Dispensary”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education, Healthcare Ministry of Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Российский национальный исследовательский медицинский университет имени Н.И.Пирогова» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University (Pirogov Medical University), Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>14</day><month>07</month><year>2022</year></pub-date><volume>32</volume><issue>3</issue><issue-title>Спецвыпуск</issue-title><fpage>295</fpage><lpage>355</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Авдеев С.Н., Дехнич А.В., Зайцев А.А., Козлов Р.С., Рачина С.А., Руднов В.А., Синопальников А.И., Тюрин И.Е., Фесенко О.В., Чучалин А.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Авдеев С.Н., Дехнич А.В., Зайцев А.А., Козлов Р.С., Рачина С.А., Руднов В.А., Синопальников А.И., Тюрин И.Е., Фесенко О.В., Чучалин А.Г.</copyright-holder><copyright-holder xml:lang="en">Avdeev S.N., Dekhnich A.V., Zaytsev A.A., Kozlov R.S., Rachina S.A., Rudnov V.A., Sinopal’nikov A.I., Tyurin I.E., Fesenko O.V., Chuchalin A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/4107">https://journal.pulmonology.ru/pulm/article/view/4107</self-uri><abstract><p>Внебольничная пневмония (ВП) является одним из наиболее распространенных острых инфекционных заболеваний и занимает существенную долю в структуре смертности от заболеваний органов дыхания. Крайне актуальным является подбор рациональной антибактериальной терапии, предполагающий оптимальную клиническую эффективность, улучшение прогноза, снижение скорости селекции антибиотикорезистентности и минимизацию побочных эффектов.</p><sec><title>Методология</title><p>Методология. Целевой аудиторией данных клинических рекомендаций являются врачи-терапевты, врачи общей практики, врачи-пульмонологи, врачи-анестезиологи-реаниматологи, клинические фармакологи. Каждый тезис-рекомендация по проведению диагностических и лечебных мероприятий оценивается по шкалам уровней достоверности доказательств от 1 до 5 и шкале оценки уровней убедительности рекомендаций по категориям А, В, С. Клинические рекомендации содержат также комментарии и разъяснения к указанным тезисам-рекомендациям, алгоритмы по диагностике, тактике терапии, справочные материалы по использованию антибактериальных препаратов и проведению микробиологических (культуральных) исследований.</p></sec><sec><title>Заключение</title><p>Заключение. По данным представленных клинических рекомендаций освещаются современные сведения об этиологии, клинических проявлениях, диагностике и тактике терапии ВП. Одобрены решением Научно-практического совета Министерства здравоохранения Российской Федерации (2021). </p></sec></abstract><trans-abstract xml:lang="en"><p>Community-acquired pneumonia is one of the most common acute infectious diseases that has a significant share in the structure of mortality from respiratory diseases. It is extremely important to select rational antibiotic therapy which ensures optimal clinical efficacy, improved outcome, reduced rate of antibiotic resistance selection, and minimization of side effects.</p><sec><title>Methods</title><p>Methods. The target audience of these clinical recommendations are therapists, general practitioners, pulmonologists, anesthesiologist-resuscitators, and clinical pharmacologists. Each thesis-recommendation about diagnostic and therapeutic procedures has been scored according to the scale of classes of recommendations from 1 to 5 and A, B, C scale of the levels of evidence. The clinical recommendations also contain comments and explanations to these theses, algorithms for the diagnosis and treatment, and reference materials on the use of antibacterial drugs and microbiological (culture) tests.</p></sec><sec><title>Conclusion</title><p>Conclusion. The presented clinical guidelines cover current information about the etiology, clinical manifestations, diagnosis and treatment tactics for community-acquired pneumonia. The presented clinical guidelines have been approved by the Scientific and Practical Council of the Ministry of Health of the Russian Federation in 2021. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>внебольничная пневмония</kwd><kwd>тяжелая пневмония</kwd><kwd>диагностика</kwd><kwd>рекомендации</kwd><kwd>антибактериальная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>community-acquired pneumonia</kwd><kwd>severe pneumonia</kwd><kwd>diagnostics</kwd><kwd>recommendations</kwd><kwd>antibiotic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г., Синопальников А.И., Козлов Р.С. и др. 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