References

pulmo

Пульмонология

PULMONOLOGIYA

0869-01892541-9617

Scientific and Practical Journal “PULMONOLOGIYA” LLC

10.18093/0869-0189-2014-0-3-104-112

pulmo-404

Research Article

ОБЗОРЫ

REVIEW

ДЕФЕНЗИНЫ И ДРУГИЕ ПРОТИВОМИКРОБНЫЕ ПЕПТИДЫ: РОЛЬ НАРУШЕНИЙ БЕЛОКСИНТЕЗИРУЮЩЕЙ СПОСОБНОСТИ НЕЙТРОФИЛОВ В ПАТОГЕНЕЗЕ ЗАБОЛЕВАНИЙ ОРГАНОВ ДЫХАНИЯ

DEFENSINS AND OTHER ANTIMICROBIAL PEPTIDES AND A ROLE OF NEUTROPHIL PROTEIN-SYNTHESING FUNCTION DISORDERS FOR PATHOGENESIS OF RESPIRATORY DISEASES

Мишланов

В. Ю.

Mishlanov

V. Yu.

д. м. н., профессор, зав. кафедрой пропедевтики внутренних болезней № 1 ГБОУ ВПО ПГФА им. акад. Е.А.Вагнера Минздрава России; тел.: (342) 12-90-98

permmed@hotmail.com

ГБОУ ВПО "Пермская государственная фармацевтическая академия им. акад. Е.А.Вагнера" Минздрава России: 614990, Пермь, ул. Петропавловская, 26РоссияState Institution E.A.Vagner State Pharmaceutical Academy, the Healthcare Ministry of Russia; Perm¢, RussiaRussian Federation

2014

28062014

03104112

2014

Мишланов В.Ю.

Mishlanov V.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.pulmonology.ru/pulm/article/view/404

Обзор научных публикаций предназначен для ознакомления научной и врачебной общественности с новыми механизмами противомикробной защиты при заболеваниях органов дыхания. Обсуждаются вопросы применения методов их диагностики в клинической практике и определения перспективных путей научных исследований в данном направлении.

The aim. A review of published articles has been made to highlight new data on antimicrobial defensive mechanisms in the respiratory system, to discuss clinical diagnostic methods and future research directions on this field.Methods. This is a review of published data on antimicrobial peptides and their role in respiratory disease.Results. Novel antimicrobial factors such as defensins and other cationic peptides are synthesized by neutrophils and epithelial cell in human.Antimicrobial peptides are thought to play an important role in daily defense of the skin and the mucus membranes against gram negative flora. Thisfact could explain quite rare occurrence of infections caused by these pathogens in human. In patients with disorders of liver protein-synthesizing activity, the defensins' production could decrease that could be a risk factor of pneumonia, tuberculosis and other lower respiratory infections.

противомикробные пептидыдефензинынейтрофилыэпителиальные клеткилипидвысвобождающая способность лейкоцитовзаболевания органов дыханияпневмония

antimicrobial peptidesdefensinsneutrophilsepithelial cellsleukocyte lipid releasing propertiesrespiratory diseasespneumonia

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Пат. РФ № 2194995 от 20.12.02. Туев А.В. Мишланов В.Ю. Способ диагностики прогрессирующей стенокардии у больных ишемической болезнью сердца. / Pat. RF N 2194995 issued on December, 20th, 2012. Tuev A.B., Mishlanov V.Yu. A Method for Diagnosis of Unstable Angina Pectoris in Patients with Ischaemic Heart Disease (in Russian).

The authors declare that there are no conflicts of interest present.