pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC617.234.015pulmo-4034Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESФармакокинетика теофиллина в ночное время при однократном приеме: сравнение трех препаратов в одинаковых условияхNight pharmacokinetics of single dosage theophylline: comparison of three drugs in similar conditionsКарттуненП.KarttunenP.

отделы фармакологии и заболеваний легких

ТукиаиненХ.TukiainenH.

отделы фармакологии и заболеваний легких

НикяненС.NykanenS.

отделы фармакологии и заболеваний легких

СааноВ.SaanoV.

отделы фармакологии и заболеваний легких

А/О «Орион Фармацевтика»; Университет КуопиоFinland199114052022032832Copyright © Карттунен П., Тукиаинен Х., Никянен С., Саано В., 20222022Карттунен П., Тукиаинен Х., Никянен С., Саано В.Karttunen P., Tukiainen H., Nykanen S., Saano V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/4034

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We have carried out a stead y state pharmacokynetic comparison of three different theophylline preparations in nine healthy volunteers using a once a day dosage schedule of 600 mg theophylline given before bedtime for four days. The preparations tested were Retafyllin 200 mg depot tablet (R), Theo-Dur 200 mg depot tablet (T) and Uniphyllin 200 mg tablet (U). All preparations in steady state reached the serum level of 8.9— 10.2 microg/ml after a single evening dose of theophylline 600 mg. The pharmacokinetic profile of these slow release theophylline preparations was such that there is no risk of exceeding the therapeutic range even after a rather high evening dose. Individual variation was also observed in the present study but nobody exceeded the therapeutic range. The pharmacokinetic profiles of R and U were quite similar and they seemed to have suitable pharmacokinetic properties for once a day dosage, and they showed a more sustained action than T. Only minimal gastrointestinal side effects were reported during this study.

ReferencesBarnes Р. J., Greening А. P., Neville L. et al. / / Lancet 1982.—Vol. 1.—P. 299.Barnes Р. J., Greening А. P., Neville L. et al. / / Lancet 1982.—Vol. 1.—P. 299.Elenbaas R. М., Massoud N. / / Pharmacokinetic basis for drug treatment.—New York, 1984.—P. 82—84.Elenbaas R. М., Massoud N. / / Pharmacokinetic basis for drug treatment.—New York, 1984.—P. 82—84.Hendeles L., Iafrate R. P., Weinberger M. / / Clin. Pharm aco kinet.—1984 , - Vol. 9.—P. 95.Hendeles L., Iafrate R. P., Weinberger M. / / Clin. Pharm aco kinet.—1984 , - Vol. 9.—P. 95.Jatlow P. / / Clin. Chem .—1975.—Vol. 21.—P. 1518.Jatlow P. / / Clin. Chem .—1975.—Vol. 21.—P. 1518.Jonkman J. H. G., Berg W. C., de Zeeuw R. A. Sustained release theophylline, a biopharm aceutical challenge to a clinical need.—E xcerpta Medica, Amsterdam , Oxford, Princeton.—1983.—P. 156—158.Jonkman J. H. G., Berg W. C., de Zeeuw R. A. Sustained release theophylline, a biopharm aceutical challenge to a clinical need.—E xcerpta Medica, Amsterdam , Oxford, Princeton.—1983.—P. 156—158.Jonkman J. H. G., van der Boon W. J. V., Balant L. B. et al. / / Eur. J. Clin. Pharmacol.—1984.—Vol. 26.—P. 215.Jonkman J. H. G., van der Boon W. J. V., Balant L. B. et al. / / Eur. J. Clin. Pharmacol.—1984.—Vol. 26.—P. 215.Kyle G. M., Smolensky M. H., Thorne L. G. et al. / / Recent advantages in the chronobiology of allergy and immunology. — Oxford, 1980,—P. 186.Kyle G. M., Smolensky M. H., Thorne L. G. et al. / / Recent advantages in the chronobiology of allergy and immunology. — Oxford, 1980,—P. 186.Kyle G. M., Smolensky M. H., Thorne L. G., McGovern J. P. /, Recent advantages in the chronobiology of allergy and Immunology.—Oxford, 1980.—P. 558.Kyle G. M., Smolensky M. H., Thorne L. G., McGovern J. P. /, Recent advantages in the chronobiology of allergy and Immunology.—Oxford, 1980.—P. 558.Lesko L. J., Brousseau D., Canada A. T., Eastwood G. / / J. Pharm . Sci.—1980.—Vol. 69.—P. 358.Lesko L. J., Brousseau D., Canada A. T., Eastwood G. / / J. Pharm . Sci.—1980.—Vol. 69.—P. 358.MacLeod S., Isles A., Levinson H., Thiessen J. / / Sustained release theophylline, a biopharm aceutical challenge to a clinical need.—Excerpta Medica, Amsterdam , Oxford, Princeton .—1983.—P. 454—457.MacLeod S., Isles A., Levinson H., Thiessen J. / / Sustained release theophylline, a biopharm aceutical challenge to a clinical need.—Excerpta Medica, Amsterdam , Oxford, Princeton .—1983.—P. 454—457.Milledge J. S., Morris J. / / J. Int. Med. Res.—1979.—Vol. 7, Supp l.—P. 106.Milledge J. S., Morris J. / / J. Int. Med. Res.—1979.—Vol. 7, Supp l.—P. 106.Osman M. A ., Patel R. B., Welling P. G. Sustained release theophylline, a biopharm aceutical challenge to a clinical Need.—Excerpta Medica, Amsterdam , Oxford, Princeton .—1983.—P. 99—102.Osman M. A ., Patel R. B., Welling P. G. Sustained release theophylline, a biopharm aceutical challenge to a clinical Need.—Excerpta Medica, Amsterdam , Oxford, Princeton .—1983.—P. 99—102.Scheffe H. The analyses of varian ce.—New York, 1959.Scheffe H. The analyses of varian ce.—New York, 1959.Scott P. H., Tabachnik E., McLeod S. et al. / / J. Pediatr.1981.—Vol. 99.—P. 476.Scott P. H., Tabachnik E., McLeod S. et al. / / J. Pediatr.1981.—Vol. 99.—P. 476.Taylor D. R., Kinney C. D., McDevitt D. / / Br. J. Clin. Pharmacol.—1983.—Vol. 16.—P. 511.Taylor D. R., Kinney C. D., McDevitt D. / / Br. J. Clin. Pharmacol.—1983.—Vol. 16.—P. 511.Taylor D. R., Kinney C. D., McDevitt D. / / Br. J. Clin. Pharmacol.—1984.—Vol. 17.—P. 15.Taylor D. R., Kinney C. D., McDevitt D. / / Br. J. Clin. Pharmacol.—1984.—Vol. 17.—P. 15.

The authors declare that there are no conflicts of interest present.