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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2011-0-5-79-86</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-401</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Влияние недостаточности α1-антитрипсина на поражение легких</article-title><trans-title-group xml:lang="en"><trans-title>Effects of alfa-1-antitripsin deficiency on lung disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Овчаренко</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ovcharenko</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф. кафедры факультетской терапии № 1 лечебного факультета </p><p>119991, Москва, ул. Большая Пироговская, 6. Тел.: (499) 248-56-67.</p></bio><email xlink:type="simple">svetftk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сон</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Son</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ассистент кафедры факультетской терапии № 1 лечебного факультета</p><p>119991, Москва, ул. Большая Пироговская, 6. Тел.: (499) 248-55-24.</p></bio><email xlink:type="simple">sonalex1110@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО "Первый Московский государственный медицинский университет им. И.М.Сеченова"</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>10</month><year>2011</year></pub-date><volume>0</volume><issue>5</issue><fpage>79</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Овчаренко С.И., Сон Е.А., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Овчаренко С.И., Сон Е.А.</copyright-holder><copyright-holder xml:lang="en">Ovcharenko S.I., Son E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/401">https://journal.pulmonology.ru/pulm/article/view/401</self-uri><abstract><p>Влияние недостаточности α1-антитрипсина на поражение легких.</p></abstract><trans-abstract xml:lang="en"><p>Effects of alfa-1-antitripsin deficiency on lung disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>α1-антитрипсин</kwd><kwd>недостаточность α1-антитрипсина</kwd><kwd>нейтрофильная эластаза</kwd><kwd>синдром Лаурелла–Эрикссона</kwd><kwd>эмфизема легких</kwd><kwd>хроническая обструктивная болезнь легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>alfa-1-antitripsin</kwd><kwd>alfa-1-antitripsin deficiency</kwd><kwd>neurophil elastase</kwd><kwd>Laurell-Eriksson syndrome</kwd><kwd>pulmonary emphysema</kwd><kwd>chronic obstructive pulmonary disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Travis J., Salvesen G.S. 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