pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-3956Research ArticleОБЗОРЫREVIEWМеханизмы утомления респираторной мускулатурыMechanisms of respiratory muscle fatigueБичевА. А.BichevA. A.ЧучалинА. Г.ChuchalinA. G.НИИ пульмонологии М3 РФRussian Federation199204052022048289Copyright © Бичев А.А., Чучалин А.Г., 20222022Бичев А.А., Чучалин А.Г.Bichev A.A., Chuchalin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/3956

При бронхолегочных заболеваниях, сопровождающихся изменением эластических свойств легочной ткани, возникают ситуации, при которых дыхательная мускулатура, межреберные мышцы и диафрагма работают с большими перегрузками. Результатом этого является развитие утомления.

ReferencesAldrich Т. К. Central fatigue of the rabbit diaphragm // Lung.— 1988.— Vol. 166, N 4.— P. 233—243.Aldrich Т. К. Central fatigue of the rabbit diaphragm // Lung.— 1988.— Vol. 166, N 4.— P. 233—243.Aldrich T. K. Transmission fatigue of the rabbit diaphragm // Resp. Physiol.— 1987.— Vol. 69, N 3.— P. 307— 309.Aldrich T. K. Transmission fatigue of the rabbit diaphragm // Resp. Physiol.— 1987.— Vol. 69, N 3.— P. 307— 309.Asano T., Shigenobu K-, Kasuya Y. Effect of hypoxia and reoxigenation of tissue ATP level and eleotrical and mechanical function of isolated guinea pig ventricular muscles // J. Pharmaco — Bio — Dyn.— 1984.— Vol. 7, N 1.— P. 63— 66.Asano T., Shigenobu K-, Kasuya Y. Effect of hypoxia and reoxigenation of tissue ATP level and eleotrical and mechanical function of isolated guinea pig ventricular muscles // J. Pharmaco — Bio — Dyn.— 1984.— Vol. 7, N 1.— P. 63— 66.Aubier M. Effect of the theophylline of diaphragmatic function // Chest.— 1987.— Vol. 92, N 1.— Suppl.— P. 275—315.Aubier M. Effect of the theophylline of diaphragmatic function // Chest.— 1987.— Vol. 92, N 1.— Suppl.— P. 275—315.Aubier M., Roussos C. Effect of theophylline on respiratory muscle function // Ibid.— 1985.— Vol. 88, Suppl.— P. 915—975.Aubier M., Roussos C. Effect of theophylline on respiratory muscle function // Ibid.— 1985.— Vol. 88, Suppl.— P. 915—975.Aubier M., Viires N., Figuet J. Effect of hypocalcemia on diaphragmatic strength generation //J. appl. Physiol.— 1985.— Vol. 58, N 5.— P. 2054—2061.Aubier M., Viires N., Figuet J. Effect of hypocalcemia on diaphragmatic strength generation //J. appl. Physiol.— 1985.— Vol. 58, N 5.— P. 2054—2061.Barclay J. K. A delivery-independent blood flow effect on skeletal muscle fatigue // Ibid.— 1986.— Vol. 61, N 3.— P. 1084—1090.Barclay J. K. A delivery-independent blood flow effect on skeletal muscle fatigue // Ibid.— 1986.— Vol. 61, N 3.— P. 1084—1090.Barcroft H. Circulation in skeletal muskle // Handbook of Physiology. Sect 2. Circulation.— Washington, 1963.— Vol. 11.— P. 1353—1385.Barcroft H. Circulation in skeletal muskle // Handbook of Physiology. Sect 2. Circulation.— Washington, 1963.— Vol. 11.— P. 1353—1385.Bark H., Scharf S. M. Diaphragmatic blood flow in the dog // J. appl. Physiol.— 1986.— Vol. 60, N 1.— P. 554—561.Bark H., Scharf S. M. Diaphragmatic blood flow in the dog // J. appl. Physiol.— 1986.— Vol. 60, N 1.— P. 554—561.Bark H., Supinski G. S., Bundy R. J., Kelsen S. Effect of hypoxia on diaphragm blood flow // Amer. Rev. resp. Dis.— 1988. — Vol. 138, N 6.— P. 1535—1541.Bark H., Supinski G. S., Bundy R. J., Kelsen S. Effect of hypoxia on diaphragm blood flow // Amer. Rev. resp. Dis.— 1988. — Vol. 138, N 6.— P. 1535—1541.Bellemare F., Grassino A. Evaluation of human diaphragm fatigue // J. appl. Physiol.— 1982.— Vol. 53, N 5.— P. 1196—1206.Bellemare F., Grassino A. Evaluation of human diaphragm fatigue // J. appl. Physiol.— 1982.— Vol. 53, N 5.— P. 1196—1206.Bellemare F., Wight D., Lavigne С. M., Grassino A. Effect of tension and timing contraction on blood flow of the diaphragm // Ibid.— 1983.— Vol. 54, N 5.— P. 1597—1606.Bellemare F., Wight D., Lavigne С. M., Grassino A. Effect of tension and timing contraction on blood flow of the diaphragm // Ibid.— 1983.— Vol. 54, N 5.— P. 1597—1606.Bergstrom M., Hultman E. Energy cost and fatigue during intermittent electrical stimulation of human skeletal muscle // Ibid.— 1988.— Vol. 65, N 4.— P. 1500—1505.Bergstrom M., Hultman E. Energy cost and fatigue during intermittent electrical stimulation of human skeletal muscle // Ibid.— 1988.— Vol. 65, N 4.— P. 1500—1505.Bessman S. P. The creatine phosphate energy shuttle: the molecular assymmetry of a “pool” // Analyt. Biochem.— 1987.— Vol. 161, N 2.— P. 519—523.Bessman S. P. The creatine phosphate energy shuttle: the molecular assymmetry of a “pool” // Analyt. Biochem.— 1987.— Vol. 161, N 2.— P. 519—523.Bessman S. P. The creatine-oreatine phosphate energy shuttle // Ann. Rev. Biochem.— 1985.— Vol. 54.— P. 831 — 862.Bessman S. P. The creatine-oreatine phosphate energy shuttle // Ann. Rev. Biochem.— 1985.— Vol. 54.— P. 831 — 862.Blinks J. R., Rudel R., Taylor S. R. Calcium Transients in isolated amphibian skeletal musole fibers: detection whith aequorin // J. Physiol. (Lond.) — 1978.— Vol. 277.— P. 291—323.Blinks J. R., Rudel R., Taylor S. R. Calcium Transients in isolated amphibian skeletal musole fibers: detection whith aequorin // J. Physiol. (Lond.) — 1978.— Vol. 277.— P. 291—323.Braun N. M. T., Arora S. N., Rochester D. F. Force-length relationship of the normal human diaphragm // J. appl. Physiol.— 1982.— Vol. 53, N 1.— P. 405—412.Braun N. M. T., Arora S. N., Rochester D. F. Force-length relationship of the normal human diaphragm // J. appl. Physiol.— 1982.— Vol. 53, N 1.— P. 405—412.Broberg S., Kent S. Adenine nucleotide degradation in human skeletal muscle during prolonged exercise // Ibid.— 1989. — Vol. 67, N 1.— P. 116—122.Broberg S., Kent S. Adenine nucleotide degradation in human skeletal muscle during prolonged exercise // Ibid.— 1989. — Vol. 67, N 1.— P. 116—122.Buehler B., Magder S., Katsardis H. et al. Effect of pleural pressure and abdominal pressure on diaphragmatic blood flow // Ibid.- 1985.- Vol. 58, N 3.— P. 691—697.Buehler B., Magder S., Katsardis H. et al. Effect of pleural pressure and abdominal pressure on diaphragmatic blood flow // Ibid.- 1985.- Vol. 58, N 3.— P. 691—697.Campbell E., Agostoni E., Newson D. J. // The Respiratory Muscles: Mechanics and Neurological Control.— 2-nd Ed.— London: Lloyd-Luke, 1970.— P. 145—160.Campbell E., Agostoni E., Newson D. J. // The Respiratory Muscles: Mechanics and Neurological Control.— 2-nd Ed.— London: Lloyd-Luke, 1970.— P. 145—160.Chance B. S., Eleff S., Leigh J. S. et al. Mitochondrial regulation of phosphocreatine / inorganic phosphate ratios in exercising human muscle: a gated 31P-NMR study // Proc. nat. Acad. Sci. USA.— 1982.— Vol. 79.— P. 6714—6718.Chance B. S., Eleff S., Leigh J. S. et al. Mitochondrial regulation of phosphocreatine / inorganic phosphate ratios in exercising human muscle: a gated 31P-NMR study // Proc. nat. Acad. Sci. USA.— 1982.— Vol. 79.— P. 6714—6718.Clanton T. L., Dixon G. F., Drake J., Gadek J. E. Effect of breathing pattern on inspiratory muscle endurance in humans // J. appl. Physiol.— 1985.— Vol. 59, N 6.— P. 1834—1841.Clanton T. L., Dixon G. F., Drake J., Gadek J. E. Effect of breathing pattern on inspiratory muscle endurance in humans // J. appl. Physiol.— 1985.— Vol. 59, N 6.— P. 1834—1841.Constable S. H., Favier R. J., McLane J. A. Energy metabolism in contraction rat skeletal muscle: adaptation to exercise training // Amer. J. Physiol.— 1987.— Vol. 253.— P. C316—C322.Constable S. H., Favier R. J., McLane J. A. Energy metabolism in contraction rat skeletal muscle: adaptation to exercise training // Amer. J. Physiol.— 1987.— Vol. 253.— P. C316—C322.Dawson M. J., Gadian D. G., Wilkie D. R. Mechanical relaxation rate and metabolism studied in fatiguing muscle by phosphorus magnetic resonance // J. Physiol. (Lond.) — 1980.— Vol. 299.— P. 465—484.Dawson M. J., Gadian D. G., Wilkie D. R. Mechanical relaxation rate and metabolism studied in fatiguing muscle by phosphorus magnetic resonance // J. Physiol. (Lond.) — 1980.— Vol. 299.— P. 465—484.Dawson M. J., Smith S., Wikie D. R. The H2PO4 — may determine cross-bridge cycling rate and force production in living fatiguing muscle // Byophys. J.— 1986.— Vol. 49.— P. 268.Dawson M. J., Smith S., Wikie D. R. The H2PO4 — may determine cross-bridge cycling rate and force production in living fatiguing muscle // Byophys. J.— 1986.— Vol. 49.— P. 268.Diana J. N., Laughlin M. H. Effect of ischemia on capillary pressure and equivalent pore radius in capillaries of the isolated dog hindlimb // Circulat. Res.— 1974.— Vol. 35.— P. 77—101.Diana J. N., Laughlin M. H. Effect of ischemia on capillary pressure and equivalent pore radius in capillaries of the isolated dog hindlimb // Circulat. Res.— 1974.— Vol. 35.— P. 77—101.Edwards R. H. T., Hill D. K., Jones J. A. Metabolic change associated whith the slowing of relaxation of fatigued mouse muscle // J. Physiol. (Lond.) — 1975.— Vol. 252.— P. 281 — 301.Edwards R. H. T., Hill D. K., Jones J. A. Metabolic change associated whith the slowing of relaxation of fatigued mouse muscle // J. Physiol. (Lond.) — 1975.— Vol. 252.— P. 281 — 301.Esan S. A., Bellemare F., Grassino A. Changes in relaxation rate with diaphragmatic fatigue in humans // J. appl. Physiol.— 1983.— Vol. 54, N 5.— P. 1353—1360.Esan S. A., Bellemare F., Grassino A. Changes in relaxation rate with diaphragmatic fatigue in humans // J. appl. Physiol.— 1983.— Vol. 54, N 5.— P. 1353—1360.Farkas G. A., Roussos C. Diaphragmatic alterations in sedentary and exercised emphysematous hamsters // Chest.— 1984.— Vol. 84, N 6.— Suppl.— P. 55S.Farkas G. A., Roussos C. Diaphragmatic alterations in sedentary and exercised emphysematous hamsters // Chest.— 1984.— Vol. 84, N 6.— Suppl.— P. 55S.Ferguson G. T., Irvin C. G., Cherniak R. M. Effect of corticosteroids on diaphragm function and biochemistry in the rabbit // Amer. Rev. resp. Dis.— 1990.— Vol. 141.— N 1.— P. 156—163.Ferguson G. T., Irvin C. G., Cherniak R. M. Effect of corticosteroids on diaphragm function and biochemistry in the rabbit // Amer. Rev. resp. Dis.— 1990.— Vol. 141.— N 1.— P. 156—163.Fitts R. H., Holloszy J. O. Effect of fatigue and recovery on contractile properties of frog muscle // J. appl. Physiol.— 1978.— Vol. 45, N 3.— P. 899—902.Fitts R. H., Holloszy J. O. Effect of fatigue and recovery on contractile properties of frog muscle // J. appl. Physiol.— 1978.— Vol. 45, N 3.— P. 899—902.Friden J., Sfakianos P. N., Hargens A. P., Akeson W. H. Residual muscular swelling after repetitive eccentric contractions // J. orthoped. Res.— 1988.— Vol. 6.— P. 493— 498.Friden J., Sfakianos P. N., Hargens A. P., Akeson W. H. Residual muscular swelling after repetitive eccentric contractions // J. orthoped. Res.— 1988.— Vol. 6.— P. 493— 498.Gardner P. F., Olha A. E. Contractile and EMG characteristics of rat plantaris motor unit types during fatigue in situ // J. Physiol. (Lond.) — 1987.— Vol. 385.— P. 13—34.Gardner P. F., Olha A. E. Contractile and EMG characteristics of rat plantaris motor unit types during fatigue in situ // J. Physiol. (Lond.) — 1987.— Vol. 385.— P. 13—34.Geisbuhler T., Altschuld R. A., Trewyn R. W. et al. Adenine nucleotide metabolism and compartmentalisation in isolated heart cells // Circulat. Res.— 1984.— Vol. 53.— P. 536— 547.Geisbuhler T., Altschuld R. A., Trewyn R. W. et al. Adenine nucleotide metabolism and compartmentalisation in isolated heart cells // Circulat. Res.— 1984.— Vol. 53.— P. 536— 547.Geller S. A. Extreme exertion rhabdomyolysis // Hum. Path.— 1973.—Vol. 4.— P. 241—250.Geller S. A. Extreme exertion rhabdomyolysis // Hum. Path.— 1973.—Vol. 4.— P. 241—250.Gendvilene V., Jurevicius J., Kudzmaitile R., Janushkevicius Z.. The effect of phosphocreatine and glucose on contractile force and development of contracture of gunea pig’s heart in hypoxia // Phosphocreatine / Ed. V. A. Saks, Y. G. Bobkov.— Torino: Minerva medica, 1987.— P. 169— 176.Gendvilene V., Jurevicius J., Kudzmaitile R., Janushkevicius Z.. The effect of phosphocreatine and glucose on contractile force and development of contracture of gunea pig’s heart in hypoxia // Phosphocreatine / Ed. V. A. Saks, Y. G. Bobkov.— Torino: Minerva medica, 1987.— P. 169— 176.Gertz I., Hendensterna G., Hellers G., Wharen J. Musole me-tabolizm in patients with copd and acute respiratory failure // Clin. Sci.— 1977.— Vol. 52.— P. 395—400.Gertz I., Hendensterna G., Hellers G., Wharen J. Musole me-tabolizm in patients with copd and acute respiratory failure // Clin. Sci.— 1977.— Vol. 52.— P. 395—400.Goldberg A., Goldspink D. Influence of food deprivation in various mammalian tissues // Amer. J. Physiol.— 1975.— Vol. 288.— P. 310—317.Goldberg A., Goldspink D. Influence of food deprivation in various mammalian tissues // Amer. J. Physiol.— 1975.— Vol. 288.— P. 310—317.Grassino A., Bellemare F., Laporta D. Diaphragmatic fatigue and the strategy of breathing in COPD // Chest.— 1984.— Vol. 85, N 6.— Suppl. P. 51S—54S.Grassino A., Bellemare F., Laporta D. Diaphragmatic fatigue and the strategy of breathing in COPD // Chest.— 1984.— Vol. 85, N 6.— Suppl. P. 51S—54S.Gray S. D., Carlsson E., Staub N. C. Site of increased vascular resistance during isometric muscular contraction // Amer. J. Physiol.— 1967.— Vol. 213.— P. 683—689.Gray S. D., Carlsson E., Staub N. C. Site of increased vascular resistance during isometric muscular contraction // Amer. J. Physiol.— 1967.— Vol. 213.— P. 683—689.Green H. J., Thomson J. A., Houston M. E. Supramaximal exercise following training induced hypervolemia // J. appl. Physiol.— 1987.— Vol. 62, N 6.— P. 1954—1961.Green H. J., Thomson J. A., Houston M. E. Supramaximal exercise following training induced hypervolemia // J. appl. Physiol.— 1987.— Vol. 62, N 6.— P. 1954—1961.Gudbjarnason S., Mathes P., Ravens K. G. Functional compartmentation of ATP and creatine phosphate in muscle // J. molec. cell. Cardiol.— 1970.— Vol. 1.— P. 325—339.Gudbjarnason S., Mathes P., Ravens K. G. Functional compartmentation of ATP and creatine phosphate in muscle // J. molec. cell. Cardiol.— 1970.— Vol. 1.— P. 325—339.Harris R. C., Edwards R. H. T., Hultman E. The time cource of PCr resynthesis during recovery of the m. quadriceps femoris in man // Phluger’s Arch.— 1976.— Bd 367.— S. 137—142.Harris R. C., Edwards R. H. T., Hultman E. The time cource of PCr resynthesis during recovery of the m. quadriceps femoris in man // Phluger’s Arch.— 1976.— Bd 367.— S. 137—142.Harris R. C, Sahliti K, Hultman E. Phosphagen and lactate contents of m. quadriceps femoris of man after exercise // J. appl. Physiol.— 1977.— Vol. 43, N 2.— P. 852—857.Harris R. C, Sahliti K, Hultman E. Phosphagen and lactate contents of m. quadriceps femoris of man after exercise // J. appl. Physiol.— 1977.— Vol. 43, N 2.— P. 852—857.Herve Ph., Lecarpentier Y., Brenot F. Relaxation of the diaphragm muscles: influence of ryanodin and fatigue // Ibid.— 1988.— Vol. 65, N 5.— P. 1950—1956.Herve Ph., Lecarpentier Y., Brenot F. Relaxation of the diaphragm muscles: influence of ryanodin and fatigue // Ibid.— 1988.— Vol. 65, N 5.— P. 1950—1956.Hoerter J. A., Laner C, Vassort G., Gueron M. Sustained function of normoxic hearts depleted in ATP and PCr: A 31P—NMR study // Amer. J. Physiol.— 1988.— Vol. 255.— P. C192—C201.Hoerter J. A., Laner C, Vassort G., Gueron M. Sustained function of normoxic hearts depleted in ATP and PCr: A 31P—NMR study // Amer. J. Physiol.— 1988.— Vol. 255.— P. C192—C201.Hoppeler H. Exercise-induced ultrastructural changes in skeletal muscles // Int. J. Sports Med..— 1986.— Vol. 7.— P. 187—204.Hoppeler H. Exercise-induced ultrastructural changes in skeletal muscles // Int. J. Sports Med..— 1986.— Vol. 7.— P. 187—204.Hultman E, Del Canale S., Sjohlm H. Effect of induced metabolic acidosis on intracellular pH, buffer capacity, and contraction force of human skeletal muscle // J. clin. Invest.— 1985.— Vol. 69.— P. 505—510.Hultman E, Del Canale S., Sjohlm H. Effect of induced metabolic acidosis on intracellular pH, buffer capacity, and contraction force of human skeletal muscle // J. clin. Invest.— 1985.— Vol. 69.— P. 505—510.Humphrey P. W., Lind A. P. The blood flow through active and inactive muscles of forearm sustained handgrip contractions // J. Physiol. (Lond.) — 1963.— Vol. 166.— P. 120—135.Humphrey P. W., Lind A. P. The blood flow through active and inactive muscles of forearm sustained handgrip contractions // J. Physiol. (Lond.) — 1963.— Vol. 166.— P. 120—135.Huusam S. N. A., Roussos C., Megder S. Autoregulation of diaphragmatic blood flow in dogs // J. appl. Physiol.— 1988.— Vol. 64, N 1.— P. 329—336.Huusam S. N. A., Roussos C., Megder S. Autoregulation of diaphragmatic blood flow in dogs // J. appl. Physiol.— 1988.— Vol. 64, N 1.— P. 329—336.Hussain S. N. A.. Roussos C., Magdee S. Effect of tension, duty cycle and arterial pressure on diaphragmatic blood flow in dogs // Ibid.— 1989.— Vol. 66, N 2.— P. 968—976.Hussain S. N. A.. Roussos C., Magdee S. Effect of tension, duty cycle and arterial pressure on diaphragmatic blood flow in dogs // Ibid.— 1989.— Vol. 66, N 2.— P. 968—976.Jacobus W. E. Respiratory control and the integration of heart high energy phosphate metabolism by mitochondrial CK // Ann. Rev. Physiol.— 1985.— Vol. 47.— P. 707— 725.Jacobus W. E. Respiratory control and the integration of heart high energy phosphate metabolism by mitochondrial CK // Ann. Rev. Physiol.— 1985.— Vol. 47.— P. 707— 725.Juel C. Muscle action potential propagation velocity changes during activity // Muscle Nerve.— 1988.— Vol. 11.— P. 714—719.Juel C. Muscle action potential propagation velocity changes during activity // Muscle Nerve.— 1988.— Vol. 11.— P. 714—719.Netty F. J., Sotldpink D. F. The differing responses of four muscle types to dexamethasone treatment in the rat // Biochem. J.— 1982.— Vol. 208.— P. 147—151.Netty F. J., Sotldpink D. F. The differing responses of four muscle types to dexamethasone treatment in the rat // Biochem. J.— 1982.— Vol. 208.— P. 147—151.Kentera D., Varagic V. The effects of cyclic N-2-0-dibuti-riladenosfss 3’-5’-monophosphate, adrenaline and aminaphyllise on the isometric contractility of the isolated hemidiaphragm // Brit. J. Pharmacol.— 1975.— Vol. 54.— P. 375—381.Kentera D., Varagic V. The effects of cyclic N-2-0-dibuti-riladenosfss 3’-5’-monophosphate, adrenaline and aminaphyllise on the isometric contractility of the isolated hemidiaphragm // Brit. J. Pharmacol.— 1975.— Vol. 54.— P. 375—381.Kim M. J, Druz W. S, Danon J. et al. Mechanics of the canine diaphragm // J. appl. Physiol.— 1976.— Vol. 41, N 1.— P. 369—382.Kim M. J, Druz W. S, Danon J. et al. Mechanics of the canine diaphragm // J. appl. Physiol.— 1976.— Vol. 41, N 1.— P. 369—382.Korthuis R. J., Granger D. N., Townsley M. I., Taylor A. E. The role of oxygen-derived free radicals in muscle micro-vascular permeability // Circulat. Res.— 1985.— Vol. 57.— P. 599—609.Korthuis R. J., Granger D. N., Townsley M. I., Taylor A. E. The role of oxygen-derived free radicals in muscle micro-vascular permeability // Circulat. Res.— 1985.— Vol. 57.— P. 599—609.Kuipers H, Drukker J, Frederic P. M. et al. Muscle degeneration after exercise in rats // Int. J. Sports Med.— 1983.— Vol. 4.— P. 45—51.Kuipers H, Drukker J, Frederic P. M. et al. Muscle degeneration after exercise in rats // Int. J. Sports Med.— 1983.— Vol. 4.— P. 45—51.Le Rumeur E, Le Movec L., Chagneau E. at al. Phosphocreatine and pH recovery without restoration of mechanical function during prolonged activity of rat gastrocnemius muscle: an in vivo 31P—NMR study // Arch. int. Physiol. Biochim.— 1989.— Vol. 97, N 1.— P. 381—388.Le Rumeur E, Le Movec L., Chagneau E. at al. Phosphocreatine and pH recovery without restoration of mechanical function during prolonged activity of rat gastrocnemius muscle: an in vivo 31P—NMR study // Arch. int. Physiol. Biochim.— 1989.— Vol. 97, N 1.— P. 381—388.Le Rumeur E, Le Moyec L., Toulouse P. et al. Muscle fatigue unrelated to phosphocreatine and pH: an “in vivo” 31P-NMR spectroscopy study // Muscle Nerve.— 1990.— Vol. 13.— P. 438—444.Le Rumeur E, Le Moyec L., Toulouse P. et al. Muscle fatigue unrelated to phosphocreatine and pH: an “in vivo” 31P-NMR spectroscopy study // Muscle Nerve.— 1990.— Vol. 13.— P. 438—444.Leith D. E, Bradley M. R. Ventilatory muscle strength and endurance training // J. appl. Physiol.— 1976.— Vol. 41, N 2.— P. 508—516.Leith D. E, Bradley M. R. Ventilatory muscle strength and endurance training // J. appl. Physiol.— 1976.— Vol. 41, N 2.— P. 508—516.Lind A. R, Me Nicol G. W. Cardiovascular responces to holding and carrying weigths by hand and by shoulder harness // Ibid.— 1968.— Vol. 25, N 1.— P. 261—267.Lind A. R, Me Nicol G. W. Cardiovascular responces to holding and carrying weigths by hand and by shoulder harness // Ibid.— 1968.— Vol. 25, N 1.— P. 261—267.Lockhat D, Roussos C, Janurol D. Metabolic changes in the loaded hvpopeeeused and failing diaphragm // Ibid.— 1988.— Vol. 65, N 4.— P. 1563—1671.Lockhat D, Roussos C, Janurol D. Metabolic changes in the loaded hvpopeeeused and failing diaphragm // Ibid.— 1988.— Vol. 65, N 4.— P. 1563—1671.Mackie B. G, Terjung R. L. Blood flow to different skeletal muscle fiber types during contraction // Amer. J. Physiol.— 1983.- Vol. 245.— P. H265—H275.Mackie B. G, Terjung R. L. Blood flow to different skeletal muscle fiber types during contraction // Amer. J. Physiol.— 1983.- Vol. 245.— P. H265—H275.Makitie J., Teravainen H. Ultrastructure of striated muscle of the rat after temporary ischemia // Acta neuropath — 1977.— Vol. 37.— P. 237—245.Makitie J., Teravainen H. Ultrastructure of striated muscle of the rat after temporary ischemia // Acta neuropath — 1977.— Vol. 37.— P. 237—245.Marshall R. Relationships between stimulus and work of breathing at different lung volumes // J. appl. Physiol 1962.— Vol. 17, N 3.— P. 917—921.Marshall R. Relationships between stimulus and work of breathing at different lung volumes // J. appl. Physiol 1962.— Vol. 17, N 3.— P. 917—921.Mekhfi H., Ventura-Clapier R. Dependance upon high energy phosphates of the effects of inorganic phosphate on contractile properties in chemically skinned rat cardial fibers // Phfluger’s Arch.— 1988.— Bd 411.— S. 375—378.Mekhfi H., Ventura-Clapier R. Dependance upon high energy phosphates of the effects of inorganic phosphate on contractile properties in chemically skinned rat cardial fibers // Phfluger’s Arch.— 1988.— Bd 411.— S. 375—378.Metzger J. M., Fitts R. H. Fatigue from low and high-frequency muscle stimulation: contractile and biochemical alteration // J. appl. Physiol.— 1987.— Vol. 62, N 5.— P. 2075— 2085.Metzger J. M., Fitts R. H. Fatigue from low and high-frequency muscle stimulation: contractile and biochemical alteration // J. appl. Physiol.— 1987.— Vol. 62, N 5.— P. 2075— 2085.Metzger J. M., Fitts R. H. Role of intracellular pH in muscle fatigue // Ibid.— N 4.— P. 1392—1397.Metzger J. M., Fitts R. H. Role of intracellular pH in muscle fatigue // Ibid.— N 4.— P. 1392—1397.Miller R. G., Boska M. D., Moussavi R. S. et al. 31P—NMR magnetic resonance studies of high energy phosphates and pH in human muscle fatigue // J. clin. Invest.— 1988.— Vol. 81, N 4.— P. 1190—1196.Miller R. G., Boska M. D., Moussavi R. S. et al. 31P—NMR magnetic resonance studies of high energy phosphates and pH in human muscle fatigue // J. clin. Invest.— 1988.— Vol. 81, N 4.— P. 1190—1196.Minotli J. R., Johnson E. C., Hudson T. L. Training-induced skeletal muscle adaptations are independent of systemic adaptations // J. appl. Physiol.— 1990.— Vol. 68, N 1 — P. 289—294.Minotli J. R., Johnson E. C., Hudson T. L. Training-induced skeletal muscle adaptations are independent of systemic adaptations // J. appl. Physiol.— 1990.— Vol. 68, N 1 — P. 289—294.Moore B. J., Miller M. J., Feldman H. A., Reid H. B. Diaphragm atropy and weakness in cortisone-treated rats // Ibid.— 1989.— Vol. 67, N 6.— P. 2420—2426.Moore B. J., Miller M. J., Feldman H. A., Reid H. B. Diaphragm atropy and weakness in cortisone-treated rats // Ibid.— 1989.— Vol. 67, N 6.— P. 2420—2426.Moxham J. Amynopeylline and respiratory muscles: an alternative view // Clin. Chest. Med.— 1988.— Vol. 9.— P. 325—336.Moxham J. Amynopeylline and respiratory muscles: an alternative view // Clin. Chest. Med.— 1988.— Vol. 9.— P. 325—336.Nayler W. G., Poole-Wilson P. A., Williams A. Hipoxia and calcium // J. molec. cell. Cardiol.— 1979.— Vol. 11.— P. 683—706.Nayler W. G., Poole-Wilson P. A., Williams A. Hipoxia and calcium // J. molec. cell. Cardiol.— 1979.— Vol. 11.— P. 683—706.Neely J. R., Grotyohann L.- W. Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused hearts // Circulat. Res.— 1984.— Vol. 55.— P. 816—824.Neely J. R., Grotyohann L.- W. Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused hearts // Circulat. Res.— 1984.— Vol. 55.— P. 816—824.Peeze Binkhorst F., Kuipers H., Heyman J., Feederik P. M. Exercise-induced focal skeletal muscle fiber degeneration and capillary morphology // J. appl. Physiol.— 1989.— Vol. 66, N 6.— P. 2865—2867.Peeze Binkhorst F., Kuipers H., Heyman J., Feederik P. M. Exercise-induced focal skeletal muscle fiber degeneration and capillary morphology // J. appl. Physiol.— 1989.— Vol. 66, N 6.— P. 2865—2867.Peeze Binkhorst F., Slaaf D. W., Kuipers H., Tangelder G.-J. Exercise-induced swelling of rat soleus muscle: its relationship with intramuscular pressure // Ibid.— 1990.— Vol. 69, N 1.— P. 67—73.Peeze Binkhorst F., Slaaf D. W., Kuipers H., Tangelder G.-J. Exercise-induced swelling of rat soleus muscle: its relationship with intramuscular pressure // Ibid.— 1990.— Vol. 69, N 1.— P. 67—73.Pengelly L. D. Mechanical properties of the diaphragm and their application to a mathematical model // Amer. Rev. resp. Dis.— 1979.— Vol. 119, N 2/2.— P. 33—36.Pengelly L. D. Mechanical properties of the diaphragm and their application to a mathematical model // Amer. Rev. resp. Dis.— 1979.— Vol. 119, N 2/2.— P. 33—36.Picado C., Fiz J. A., Monserrat J. M., Grau J. M. Respiratory and skeletal muscle function in steroid-dependent bronchial asthma // Ibid.— 1990.— Vol. 141, N 1.— P. 13—20.Picado C., Fiz J. A., Monserrat J. M., Grau J. M. Respiratory and skeletal muscle function in steroid-dependent bronchial asthma // Ibid.— 1990.— Vol. 141, N 1.— P. 13—20.Rail T. W. Central nervous system stimulants: The Xantines // The Pharmacological Basis of Therapeutics’ / Ed. A. S. Goodman, A. Gilman.— New York: Macmillan, 1980.— P. 592—607.Rail T. W. Central nervous system stimulants: The Xantines // The Pharmacological Basis of Therapeutics’ / Ed. A. S. Goodman, A. Gilman.— New York: Macmillan, 1980.— P. 592—607.Robertson C. H., Foster G. H., Johnson R. L. The relationship of respiratory failure to the 02 consumption of, lactate production by, and distribution of blood flow among respiratory muscles // J. clin. Invest.— 1977.— Vol. 59, N 1— P. 31—42.Robertson C. H., Foster G. H., Johnson R. L. The relationship of respiratory failure to the 02 consumption of, lactate production by, and distribution of blood flow among respiratory muscles // J. clin. Invest.— 1977.— Vol. 59, N 1— P. 31—42.Rochester D. F., Arora N. S., Goldberg S. K- Effect of oxygen on diaphragmal phosphagen depletion in a canine model of acute respiratory failure // Clin. Res.— 1980.— Vol. 28.— P. 431 A.Rochester D. F., Arora N. S., Goldberg S. K- Effect of oxygen on diaphragmal phosphagen depletion in a canine model of acute respiratory failure // Clin. Res.— 1980.— Vol. 28.— P. 431 A.Rochester D. F., Bettini G. Diaphragmatic blood flow and expenditure in the dog. Effects of inspiratory airflow resistance and hypercapnia // J. clin. Invest.— 1976.— Vol. 57, N 2.— P. 661—672.Rochester D. F., Bettini G. Diaphragmatic blood flow and expenditure in the dog. Effects of inspiratory airflow resistance and hypercapnia // J. clin. Invest.— 1976.— Vol. 57, N 2.— P. 661—672.Rochester D. F., Braun N. M. T., Arora N. S. Respiratory muscle strength in COPO // Amer. Rev. resp. Dis.— 1978.— Vol. 117, N 1.— P. 151 — 154.Rochester D. F., Braun N. M. T., Arora N. S. Respiratory muscle strength in COPO // Amer. Rev. resp. Dis.— 1978.— Vol. 117, N 1.— P. 151 — 154.Roussos C. S., Macklem P. T. Diaphragmatic fatigue in man // J. appl. Physiol.— 1977.— Vol. 43, N 1.— P. 189— 197.Roussos C. S., Macklem P. T. Diaphragmatic fatigue in man // J. appl. Physiol.— 1977.— Vol. 43, N 1.— P. 189— 197.Sahlin K-, Edstrom L., Sjoholm H. Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle // Amer. J. Physiol.— 1983.— Vol. 245.— P. C15— C20.Sahlin K-, Edstrom L., Sjoholm H. Fatigue and phosphocreatine depletion during carbon dioxide-induced acidosis in rat muscle // Amer. J. Physiol.— 1983.— Vol. 245.— P. C15— C20.Sahlin K., Harris R. C., Nylind B., Hultman E. Lactate content and pH in human samples obtained after dynamic exercise // Phliiger’s Arch.— 1976.— Bd 367.— S. 143—149.Sahlin K., Harris R. C., Nylind B., Hultman E. Lactate content and pH in human samples obtained after dynamic exercise // Phliiger’s Arch.— 1976.— Bd 367.— S. 143—149.Saltin B., Nazar K., Costill D. L. The nature of the training response: periferal and central adaptations to onelegged exercise // Acta physiol. scand.— 1976.— Vol. 96.— P. 289— 305.Saltin B., Nazar K., Costill D. L. The nature of the training response: periferal and central adaptations to onelegged exercise // Acta physiol. scand.— 1976.— Vol. 96.— P. 289— 305.Sanderson R. A., Foley R. K., Mclvor G. W. D., Kirkaldy W. H. Histological response on skeletal muscle to ischemia // Clin. Orthop. Relat. Res.— 1975.— Vol. 113.— P. 27— 35.Sanderson R. A., Foley R. K., Mclvor G. W. D., Kirkaldy W. H. Histological response on skeletal muscle to ischemia // Clin. Orthop. Relat. Res.— 1975.— Vol. 113.— P. 27— 35.Sasson L., Tarasiuk A., Heimer A., Bark H. Effect of dexamethasone on diaphragmatic and soleus muscle morphology and fatigability // Resp. Physiol.— 1991.— Vol. 85, N 1.— P. 15—28.Sasson L., Tarasiuk A., Heimer A., Bark H. Effect of dexamethasone on diaphragmatic and soleus muscle morphology and fatigability // Resp. Physiol.— 1991.— Vol. 85, N 1.— P. 15—28.Schnader C., Juan G., Howell S. et al. Artherial CO2 partial pressure affects diaphragmatic function // J. appl. Physiol.— 1985.— Vol. 58, N 2.— P. 823—829.Schnader C., Juan G., Howell S. et al. Artherial CO2 partial pressure affects diaphragmatic function // J. appl. Physiol.— 1985.— Vol. 58, N 2.— P. 823—829.Seow C. Y., Stephens N. L. Fatigue of mouse diaphragm muscle in isometric and isotonic contractions // Ibid.— 1988.— Vol. 64, N 6.— P. 2388—2393.Seow C. Y., Stephens N. L. Fatigue of mouse diaphragm muscle in isometric and isotonic contractions // Ibid.— 1988.— Vol. 64, N 6.— P. 2388—2393.Shepherd J. T. Circulation in skeletal muscle // Handbook of physiology. Sect2. The Cardiovascular System.— Bethesda, 1983.— P. 310—370.Shepherd J. T. Circulation in skeletal muscle // Handbook of physiology. Sect2. The Cardiovascular System.— Bethesda, 1983.— P. 310—370.Shoubridge E. A., Radda G. K. A Gated 31P-NMR study of tetanic contraction in rat muscle depleted of phosphocreatine // Amer. J. Physiol.— 1987.— Vol. 252.— P. C532— C542.Shoubridge E. A., Radda G. K. A Gated 31P-NMR study of tetanic contraction in rat muscle depleted of phosphocreatine // Amer. J. Physiol.— 1987.— Vol. 252.— P. C532— C542.Sjogaard G., Adams R. P., Saltin B. Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension // Ibid.— 1985.— Vol. 248, N 2/2.— P. R190—R196.Sjogaard G., Adams R. P., Saltin B. Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension // Ibid.— 1985.— Vol. 248, N 2/2.— P. R190—R196.Supinsky G. S., Bark H., Guanciale A., Kelsen S. G. Effect of alteration in muscle fiber length on diaphragmatic blood flow // J. appl. Physiol.— 1986.— Vol. 60, N 5.— P. 1789— 1796.Supinsky G. S., Bark H., Guanciale A., Kelsen S. G. Effect of alteration in muscle fiber length on diaphragmatic blood flow // J. appl. Physiol.— 1986.— Vol. 60, N 5.— P. 1789— 1796.Suzuki S., Numata H., Sano F., Yoshike J. Effects and mechanism of fenoterol on fatigued canine diaphragm // Amer. Rev. resp. Dis.— 1988.— Vol. 137, N 5.— P. 1048—1054.Suzuki S., Numata H., Sano F., Yoshike J. Effects and mechanism of fenoterol on fatigued canine diaphragm // Amer. Rev. resp. Dis.— 1988.— Vol. 137, N 5.— P. 1048—1054.Tamacki J. Effect of elastase-induced emphysema on properties of diaphragm // Respiration.— 1988.— Vol. 54, N 1.— P. 16—23.Tamacki J. Effect of elastase-induced emphysema on properties of diaphragm // Respiration.— 1988.— Vol. 54, N 1.— P. 16—23.Taylor D. J., Styles P., Matthews P. M. et al. Energetics of human muscles: exercise induced ATP depletion // Magn. Reson. Med.— 1986.— Vol. 3.— P. 44—54.Taylor D. J., Styles P., Matthews P. M. et al. Energetics of human muscles: exercise induced ATP depletion // Magn. Reson. Med.— 1986.— Vol. 3.— P. 44—54.Tesch P. A., Thorsson A., Fujitsuka N. Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise // J. appl. Physiol.— 1989.— Vol. 66, N 4.— P. 1756—1759.Tesch P. A., Thorsson A., Fujitsuka N. Creatine phosphate in fiber types of skeletal muscle before and after exhaustive exercise // J. appl. Physiol.— 1989.— Vol. 66, N 4.— P. 1756—1759.Trivedi B., Davenport W. H. Effect of pH on the kinetics of frog muscle phosphofructokinase // J. biol. Chem.— 1966.— Vol. 241.— P. 4110—4113.Trivedi B., Davenport W. H. Effect of pH on the kinetics of frog muscle phosphofructokinase // J. biol. Chem.— 1966.— Vol. 241.— P. 4110—4113.Ulf J., Styf J. J., Snurkula M., Herbert P. Intramuscular pressure and muscular blood flow in supraspinatus // Europ. J. appl. Physiol.— 1988.— Vol. 58, N 3.— P. 219—224.Ulf J., Styf J. J., Snurkula M., Herbert P. Intramuscular pressure and muscular blood flow in supraspinatus // Europ. J. appl. Physiol.— 1988.— Vol. 58, N 3.— P. 219—224.Ventura-Clapier R., Vassort G. Electrical and mechanical activities of frog heart during energetic defficiency // J. Muscle Res. Cell. Molec.— 1981.— Vol. 1.— P. 429—444.Ventura-Clapier R., Vassort G. Electrical and mechanical activities of frog heart during energetic defficiency // J. Muscle Res. Cell. Molec.— 1981.— Vol. 1.— P. 429—444.Ventura-Clapier R., Vassort G. Role of myofibrillar creatine-kinase in the relaxation of rigor tension in skinned cardiac muscle // Phliiger’s Arch.— 1985.— Bd 404, N 2.— S. 157— 161.Ventura-Clapier R., Vassort G. Role of myofibrillar creatine-kinase in the relaxation of rigor tension in skinned cardiac muscle // Phliiger’s Arch.— 1985.— Bd 404, N 2.— S. 157— 161.Viires N., Murziano D., Seta J.-Ph. et al. Effect of calcium withdrawal on diaphragmatic fiber tension generation // J. appl. Physiol.— 1988.— Vol. 64, N 1.— P. 26—30.Viires N., Murziano D., Seta J.-Ph. et al. Effect of calcium withdrawal on diaphragmatic fiber tension generation // J. appl. Physiol.— 1988.— Vol. 64, N 1.— P. 26—30.Warhol M. J., Siegel A. J. J., Evans W. J., Silverman L. M. Skeletal Muscle injury and repair in marathon runners after competition // Amer. J. Path.— 1985.— Vol. 118.— P. 331 — 339.Warhol M. J., Siegel A. J. J., Evans W. J., Silverman L. M. Skeletal Muscle injury and repair in marathon runners after competition // Amer. J. Path.— 1985.— Vol. 118.— P. 331 — 339.Wilcox P. G., Hardes J. M., Bockhold K. et al. Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscles // Amer. J. resp. Cell.— 1989.— Vol. 1.— P. 191 — 199.Wilcox P. G., Hardes J. M., Bockhold K. et al. Pathologic changes and contractile properties of the diaphragm in corticosteroid myopathy in hamsters: comparison to peripheral muscles // Amer. J. resp. Cell.— 1989.— Vol. 1.— P. 191 — 199.Zwarts M. J., Arendt-Nielson L. Influence of force and circulation on average muscle fiber conduction velocity during local muscle fatigue // europ. J. appl. Physiol.— 1988.— Vol. 58, N 3.— P. 278—283.Zwarts M. J., Arendt-Nielson L. Influence of force and circulation on average muscle fiber conduction velocity during local muscle fatigue // europ. J. appl. Physiol.— 1988.— Vol. 58, N 3.— P. 278—283.

The authors declare that there are no conflicts of interest present.