pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-3884Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESХарактеристика экспрессии 8 и 17 типов кератина в различных гистологических формах рака легкогоPatterns of expression of type 8 and 17 keratins in different histhological entities of lung cancerФранкГ. А.FrankG. A.

Отделение патоморфологии опухолей

ЛитвиноваЛ. В.LitvinovaL. V.

Отделение патоморфологии опухолей

ВяльцевН. В.VyaltsevaN. V.

Отделение патоморфологии опухолей

Московский научно-исследовательский онкологический институт им. П.А. ГерценаRussian Federation199203052022012731Copyright © Франк Г.А., Литвинова Л.В., Вяльцев Н.В., 20222022Франк Г.А., Литвинова Л.В., Вяльцев Н.В.Frank G.A., Litvinova L.V., Vyaltseva N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/3884

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Expression of type 8 and 17 keratins was assessed immuno-morphologically using commercial kits produced in the Cardiology Centre. The study was done using cryostated slices of the tumors obtained from patients operated on in the Gertzen’s Oncological Institute. Heterogeneicity of the cell contents of squamous cell lung cancer was found. In the morphogenesis of the squamous cell lung carcinoma, despite its differentiation stage, cells with mucinoud and epidermoid differentiation patterns take part. In some adenocarcinomas and small-cell lung carcinomas, besides cell elements, containing mucinoid (8) type of keratin, cells expressing epidermoid (17) type of keratin were also present. The study prompted to conclude that 8 and 17 types of keratins can be used as marker proteins demonstrating mucinoid or epithelial trends of differentiation of the cell elements in different histological entities of lung cancer.

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The authors declare that there are no conflicts of interest present.