pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2011-0-5-5-11pulmo-375Research ArticleПЕРЕДОВАЯ СТАТЬЯEDITORIALГенетический анализ вируса гриппа А / Н1N1 "пандемический" в условиях эпидемииGenetic analysis of pandemic influenza A / H1N1 virus during epidemiaКострюковаЕ. С.KostryukovaE. S.

к. б. н., старший научный сотрудник лаборатории постгеномных исследований в биологии

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

el-es@yandex.ruЗахаржевскаяН. Б.ZakharzhevskayaN. B.

младший научный сотрудник лаборатории молекулярной генетики человека

119435, Москва, ул. Малая Пироговская, 1а. Тел. (499) 246-04-71.

natazaha@gmail.comКостинП. А.KostinP. A.

научный сотрудник лаборатории молекулярной генетики человека 

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-04-71.

kostin.ru@gmail.comИльинаЕ. Н.IlyinaE. N.

д. б. н., зав. лабораторией молекулярной генетики микроорганизмов 

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-04-71.

ilinaen@gmail.comЛаринА. К.LarinA. K.

младший научный сотрудник лаборатории постгеномных исследований в биологии

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

zelaz@yandex.ruГрибановО. Г.GribanovO. G.

к. б. н., старший научный сотрудник лаборатории постгеномных исследований в биологии

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

gribanov@hotmail.comСелезневаО. В.SeleznevaO. V.

лаборант-исследователь лаборатории постгеномных исследований в биологии 

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

oks-selezneva@yandex.ruПриходькоЕ. А.PrikhodkoE. A.

младший научный сотрудник лаборатории постгеномных исследований в биологии

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

less_lena@rambler.ruАкопианТ. А.AkopianT. A.

к. х. н., старший научный сотрудник лаборатории постгеномных исследований в биологии

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-44-38.

ta-akopian@yandex.ruГенерозовЭ. В.GenerozovE. V.

к. б. н., зав. лабораторией молекулярной генетики человека 

119435, Москва, ул. Малая Пироговская, 1а. Тел.: (499) 246-04-71.

generozov@gmail.comЛазаревВ. Н.LazarevV. N.

к. б. н., зав. лабораторией генной инженерии 

119435, Москва, ул. Малая Пироговская, 1а

117997, Москва, ГСП-7, ул. Миклухо-Маклая, 16 / 10. Тел.: (499) 245-42-36.

lazarev0@gmail.comЛевицкийС. А.LevitskyS. A.

119435, Москва, ул. Малая Пироговская, 1а

117997, Москва, ГСП-7, ул. Миклухо-Маклая, 16 / 10

КондратовИ. Г.KondratovI. G.

119435, Москва, ул. Малая Пироговская, 1а

АлексеевД. Г.AlexeevD. G.

119435, Москва, ул. Малая Пироговская, 1а

БазалеевН. А.BazaleevN. A.

119435, Москва, ул. Малая Пироговская, 1а

КлимоваЕ. А.KlimovaE. A.

103473, Москва, ул. Делегатская, 20 / 1

ЕсауловаМ. Р.EsaulovaM. R.

125367, Москва, Волоколамское ш., 63;

ЮщукН. Д.YushchukN. D.ГоворунВ. М.GovorunV. M.

119435, Москва, ул. Малая Пироговская, 1а

117997, Москва, ГСП-7, ул. Миклухо-Маклая, 16 / 10

123182, Москва, пл. Академика Курчатова, 1

СергиенкоВ. И.SergienkoV. I.ФГУ "НИИ физико-химической медицины" ФМБА РоссииRussian FederationФГУ "НИИ физико-химической медицины" ФМБА России; УРАН "Институт биоорганической химии РАН"Russian FederationГОУ ВПО "Московский государственный медико-стоматологический университет" РосздраваRussian FederationГУЗ г. Москвы "Инфекционная клиническая больница № 1 ДЗ г. Москвы"Russian FederationФГУ "НИИ физико-химической медицины" ФМБА России; УРАН "Институт биоорганической химии РАН"; ФГУ "РНЦ "Курчатовский институт"Russian Federation20112810201105511Copyright © Кострюкова Е.С., Захаржевская Н.Б., Костин П.А., Ильина Е.Н., Ларин А.К., Грибанов О.Г., Селезнева О.В., Приходько Е.А., Акопиан Т.А., Генерозов Э.В., Лазарев В.Н., Левицкий С.А., Кондратов И.Г., Алексеев Д.Г., Базалеев Н.А., Климова Е.А., Есаулова М.Р., Ющук Н.Д., Говорун В.М., Сергиенко В.И., 20112011Кострюкова Е.С., Захаржевская Н.Б., Костин П.А., Ильина Е.Н., Ларин А.К., Грибанов О.Г., Селезнева О.В., Приходько Е.А., Акопиан Т.А., Генерозов Э.В., Лазарев В.Н., Левицкий С.А., Кондратов И.Г., Алексеев Д.Г., Базалеев Н.А., Климова Е.А., Есаулова М.Р., Ющук Н.Д., Говорун В.М., Сергиенко В.И.Kostryukova E.S., Zakharzhevskaya N.B., Kostin P.A., Ilyina E.N., Larin A.K., Gribanov O.G., Selezneva O.V., Prikhodko E.A., Akopian T.A., Generozov E.V., Lazarev V.N., Levitsky S.A., Kondratov I.G., Alexeev D.G., Bazaleev N.A., Klimova E.A., Esaulova M.R., Yushchuk N.D., Govorun V.M., Sergienko V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/375

Генетический анализ вируса гриппа А / Н1N1 "пандемический" в условиях эпидемии.

Genetic analysis of pandemic influenza A / H1N1 virus during epidemia.

вирус гриппа А / Н1N1 "пандемический"устойчивость к осельтамивиругенетические полиморфизмы человекаполногеномное секвенирование вирусных геномовReferences"Transcript of virtual press conference with Dr Keiji Fukuda, Assistant Director-General ad Interim for Health Security and Environment, World Health Organization". World Health Organization. 2009-07-07. http://www.who.int/mediacentre/Pandemic_h1n1_presstranscript_2009_07_07.pdf."Transcript of virtual press conference with Dr Keiji Fukuda, Assistant Director-General ad Interim for Health Security and Environment, World Health Organization". World Health Organization. 2009-07-07. http://www.who.int/mediacentre/Pandemic_h1n1_presstranscript_2009_07_07.pdf."Interim Novel Influenza A (H1N1) Guidance for Cruise Ships". Centers for Disease Control and Prevention. 2009-08-05. http://www.cdc.gov/h1n1flu/guidance/cruiseships. html."Interim Novel Influenza A (H1N1) Guidance for Cruise Ships". Centers for Disease Control and Prevention. 2009-08-05. http://www.cdc.gov/h1n1flu/guidance/cruiseships. html.Chan M. World now at the start of 2009 influenza pandemic. World Health Organization. 2009-06-11. http://www.who.int/mediacentre/news/statements/2009/h1n1_pandemic_phase6_ 20090611/en/index.html.Chan M. World now at the start of 2009 influenza pandemic. World Health Organization. 2009-06-11. http://www.who.int/mediacentre/news/statements/2009/h1n1_pandemic_phase6_ 20090611/en/index.html."CDC Briefing on Investigation of Human Cases of H1N1 Flu". Centers for Disease Control and Prevention. 2009-07-24. http://www.webcitation.org/5jeG7e0IC"CDC Briefing on Investigation of Human Cases of H1N1 Flu". Centers for Disease Control and Prevention. 2009-07-24. http://www.webcitation.org/5jeG7e0ICInterim Guidance for 2009 H1N1 Flu (Swine Flu): Taking Care of a Sick Person in Your Home. Centers for Disease Control and Prevention. 2009-08-05. http://www.cdc.gov/h1n1flu/guidance_homecare.html.Interim Guidance for 2009 H1N1 Flu (Swine Flu): Taking Care of a Sick Person in Your Home. Centers for Disease Control and Prevention. 2009-08-05. http://www.cdc.gov/h1n1flu/guidance_homecare.html.Mauad T., Hajjar L.A., Callegari G.D. et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am. J. Respir. Crit. Care Med. 2010; 181 (1): 72–79.Mauad T., Hajjar L.A., Callegari G.D. et al. Lung pathology in fatal novel human influenza A (H1N1) infection. Am. J. Respir. Crit. Care Med. 2010; 181 (1): 72–79.Clinical features of severe cases of pandemic influenza. World Health Organization. 2009-10-16 http://www.who. int/csr/disease/swineflu/notes/h1n1_clinical_features_20091016/enClinical features of severe cases of pandemic influenza. World Health Organization. 2009-10-16 http://www.who. int/csr/disease/swineflu/notes/h1n1_clinical_features_20091016/enCDC protocol of realtime RTPCR for influenza A (H1N1). World Health Organization. http://www.who.int/csr/resources/publications/swineflu/CDCRealtimeRTPCR_SwineH1Assay)2009_20090430.pdf.CDC protocol of realtime RTPCR for influenza A (H1N1). World Health Organization. http://www.who.int/csr/resources/publications/swineflu/CDCRealtimeRTPCR_SwineH1Assay)2009_20090430.pdf.Ilina E.N., Malakhova M.V., Generozov E.V. et al. Matrixassisted laser desorption ionization-time of flight (mass spectrometry) for hepatitis C virus genotyping. J. Clin. Microbiol. 2005; 43 (6): 2810–2815.Ilina E.N., Malakhova M.V., Generozov E.V. et al. Matrixassisted laser desorption ionization-time of flight (mass spectrometry) for hepatitis C virus genotyping. J. Clin. Microbiol. 2005; 43 (6): 2810–2815.Sequencing primers and protocol. World Health Organization. http://www.who.int/csr/resources/publications/swineflu/GenomePrimers_20090512.pdf.Sequencing primers and protocol. World Health Organization. http://www.who.int/csr/resources/publications/swineflu/GenomePrimers_20090512.pdf.Le Q.M., Wertheim H.F., Tran N.D. et al. A community cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. N. Engl. J. Med. 2010; 362 (1): 86–87.Le Q.M., Wertheim H.F., Tran N.D. et al. A community cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. N. Engl. J. Med. 2010; 362 (1): 86–87.Gulland A. First cases of spread of oseltamivir resistant swine flu between patients are reported in Wales. Br. Med. J. 2009; 339: b4975.Gulland A. First cases of spread of oseltamivir resistant swine flu between patients are reported in Wales. Br. Med. J. 2009; 339: b4975.Eshaghi A., Bolotin S., Burton L. et al. Genetic microheterogeneity of emerging H275Y influenza virus A (H1N1) in Toronto, Ontario, Canada from the 2007–2008 respiratory seasons. J. Clin. Virol. 2009; 45: 142–145.Eshaghi A., Bolotin S., Burton L. et al. Genetic microheterogeneity of emerging H275Y influenza virus A (H1N1) in Toronto, Ontario, Canada from the 2007–2008 respiratory seasons. J. Clin. Virol. 2009; 45: 142–145.Holsinger L.J., Nichani D., Pinto L.H. et al. Influenza A virus M2 ion channel protein: a structure-function analysis. J. Virol. 1994; 68 (3): 1551–1563.Holsinger L.J., Nichani D., Pinto L.H. et al. Influenza A virus M2 ion channel protein: a structure-function analysis. J. Virol. 1994; 68 (3): 1551–1563.Pinto L.H., Holsinger L.J., Lamb R.A. Influenza virus M2 protein has ion channel activity. Cell 1992; 69 (3): 517-528.Pinto L.H., Holsinger L.J., Lamb R.A. Influenza virus M2 protein has ion channel activity. Cell 1992; 69 (3): 517-528.Pinto L.H., Lamb R.A. Controlling influenza virus replication by inhibiting its proton channel. Mol. Biosyst. 2007; 3 (1): 18–23.Pinto L.H., Lamb R.A. Controlling influenza virus replication by inhibiting its proton channel. Mol. Biosyst. 2007; 3 (1): 18–23.Wang W.Y.S., Glenn C.L., Zhang W. et al. Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian Anglo-Caucasians. Am. J. Med. Genet. 1999; 87: 53–60.Wang W.Y.S., Glenn C.L., Zhang W. et al. Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian Anglo-Caucasians. Am. J. Med. Genet. 1999; 87: 53–60.Kobashi G., Yamada H., Ohta K. et al. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am. J. Med. Genet. 2001; 103: 241–244.Kobashi G., Yamada H., Ohta K. et al. Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy. Am. J. Med. Genet. 2001; 103: 241–244.Contopoulos-Ioannidis D.G., Manoli E.N., Ioannidis J.P.A. Meta-analysis of the association of beta-2-adrenergic receptor polymorphisms with asthma phenotypes. J. Allergy Clin. Immunol. 2005; 115: 963–972.Contopoulos-Ioannidis D.G., Manoli E.N., Ioannidis J.P.A. Meta-analysis of the association of beta-2-adrenergic receptor polymorphisms with asthma phenotypes. J. Allergy Clin. Immunol. 2005; 115: 963–972.Lahti M., Marttila R., Hallman M. Surfactant protein C gene variation in the Finnish population-association with perinatal respiratory disease. Eur. J. Hum. Genet. 2004; 12: 312–320.Lahti M., Marttila R., Hallman M. Surfactant protein C gene variation in the Finnish population-association with perinatal respiratory disease. Eur. J. Hum. Genet. 2004; 12: 312–320.Nogee L.M., Dunbar A.E., Wert S. et al. Mutations in the surfactant protein C gene associated with interstitial lung disease. N. Engl. J. Med. 2001; 344: 573–579.Nogee L.M., Dunbar A.E., Wert S. et al. Mutations in the surfactant protein C gene associated with interstitial lung disease. N. Engl. J. Med. 2001; 344: 573–579.Joos L., He J.-Q., Shepherdson M.B. et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Mol. Genet. 2002; 11: 569–576.Joos L., He J.-Q., Shepherdson M.B. et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum. Mol. Genet. 2002; 11: 569–576.Franco R.F., Trip M.D., ten Cate H. et al. The 20210G-A mutation in the 3-prime-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. Br. J. Haematol. 1999; 104: 50–54.Franco R.F., Trip M.D., ten Cate H. et al. The 20210G-A mutation in the 3-prime-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. Br. J. Haematol. 1999; 104: 50–54.Tybjaerg-Hansen A., Agerholm-Larsen B., Humphries S.E. et al. A common mutation (G(-455)-to-A) in the beta-fib-rinogen promoter is an independent predictor of plasma fib-rinogen, but not of ischemic heart disease: a study of 9,127 individuals based on the Copenhagen City Heart Study. J. Clin. Invest. 1997; 99: 3034–3039.Tybjaerg-Hansen A., Agerholm-Larsen B., Humphries S.E. et al. A common mutation (G(-455)-to-A) in the beta-fib-rinogen promoter is an independent predictor of plasma fib-rinogen, but not of ischemic heart disease: a study of 9,127 individuals based on the Copenhagen City Heart Study. J. Clin. Invest. 1997; 99: 3034–3039.Gómez-Gómez A., Magan~a-Aquino M., García-Sepúlveda C.A. Severe pneumonia associated with Pandemic (H1N1) 2009 outbreak, San Luis Potosí, Mexico. Emerg. Infect. Dis. 2010; 16: 27–34.Gómez-Gómez A., Magan~a-Aquino M., García-Sepúlveda C.A. Severe pneumonia associated with Pandemic (H1N1) 2009 outbreak, San Luis Potosí, Mexico. Emerg. Infect. Dis. 2010; 16: 27–34.

The authors declare that there are no conflicts of interest present.