pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-3736Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESПрофилактическое действие аэрозолей дитека на бронхоспазм, вызываемый физическим напряжениемThe profilactic action of Ditec airsoles on bronchial constriction caused by physical exertionЦойА. Н.TsoyA. N.

Кафедра клинической фармакологии

ГавриленкоЛ. Н.GaurilenkoL. H.

Кафедра клинической фармакологии

ТитоваЕ. В.TitovaE. V.

Кафедра клинической фармакологии

Московской медицинской академии им. И.М. СеченоваRussian Federation199324042022016265Copyright © Цой А.Н., Гавриленко Л.Н., Титова Е.В., 20222022Цой А.Н., Гавриленко Л.Н., Титова Е.В.Tsoy A.N., Gaurilenko L.H., Titova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/3736

У 7 больных бронхиальной астмой смешанного генеза, у которых наблюдалось снижение ОФВ| на 20 % и более после окончания теста с физической нагрузкой на ВЭМ, изучался профилактический эффект однократной ингаляции и курсового лечения препаратами Беротек, Дитек, Бихромат.

Через 30 минут и 2 часа после однократной ингаляции Беротека, Дитека, Бихромата выявлено увеличение ОФВ] на 23 и 21,6; 26 и 23,5; 5,8 и 6,3 % соответственно. Проведение велоэргометрии (ВЭМ) через 2 часа после 2 вдохов Дитека вызвало снижение ОФВ| в среднем на 7,4 % через 10 минут после окончания ВЭМ, бронхоспазм не развивался у всех 7 больных. После 2 вдохов Беротека — в среднем на 8,9 % на 8—10-й минуте отдыха. Хорошее протективное действие Беротека отмечалось у 4 больных. На фоне ингаляции 2 вдохов Бихромата протективное действие на бронхоспазм выявлено у 6 из 7 больных. Через 4 недели курсового лечения Дитеком ВЭМ, проведенная через 12 часов после вечерней дозы препарата, выявила максимальное снижение ОФВ1 на 7,8 % на 8—10-й минуте после оконания ВЭМ, на фоне курсового лечения Бихроматом — на 6,6 %, Беротеком — на 10,8 %.

In 7 patients with mixed genesis bronchial asthma which demontrated the FEV1 decrease more than 20 percents after finishing the test with the exercise on the bicycle, the profilactic effect of single inhalation and course treatment of Berotec. Ditec, and Bichromate was studied.

In 30 minutes and 2 hours after single inhalation of Berotec, Ditec, and Bichromate, the FEV1 increase was revealed in 23 and 21.6 %, in 26 and 23.5 %, and in 5.8 and 6.3 % respectively. The ergometry in 2 hours after two inhalations of Ditec caused the FEV1 decrease in 7.4 % on average in 10 minutes after cancelling the exercise. Bronchial constriction was not determined in all the 7 patients. After two inhalations of Berotec the FEV1 decrease in 8.9 % on average in 8—10 minutes of recovery was observed. 4 patients indicated subjectively favorable protective action of Berotec. The protective action at the background of two Bichromate inhalations on bronchial constriction was revealed in 6 patients. The ergometry being executed in 12 hours after the preparation dose evening administration revealed the FEV1 maximal decrease in 7.8 % in 8—10 minutes after finishing the exercise after the 4-weeks course treatment of Ditec, at the background of the Bichromate treatment — in 6.6 %; at the Berotec one — in 10.8 %.

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The authors declare that there are no conflicts of interest present.