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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2012-0-2-46-51</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-37</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title></article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черняк</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyak</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., зав. кафедрой клинической аллергологии и пульмонологии</p><p>664049, Иркутск, м / р Юбилейный, 100. Тел.: 8-902-568-78-70.</p></bio><email xlink:type="simple">bores@angara.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофименко</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimenko</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ассистент кафедры клинической аллергологии и пульмонологии </p><p>664049, Иркутск, м / р Юбилейный, 100. Тел.: 8-914-877-80-96.</p></bio><email xlink:type="simple">tin11@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Иркутская государственная медицинская академия последипломного образования</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>04</month><year>2012</year></pub-date><volume>0</volume><issue>2</issue><fpage>46</fpage><lpage>51</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черняк Б.А., Трофименко И.Н., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Черняк Б.А., Трофименко И.Н.</copyright-holder><copyright-holder xml:lang="en">Chernyak B.A., Trofimenko I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/37">https://journal.pulmonology.ru/pulm/article/view/37</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma. UPDATED 2011. www.ginasthma.org</mixed-citation><mixed-citation xml:lang="en">Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma. UPDATED 2011. www.ginasthma.org</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Mechanisms in COPD. Differences from asthma. Chest 2000; 117: 10–14.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Mechanisms in COPD. Differences from asthma. Chest 2000; 117: 10–14.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kanner R.E., Connett J.E., Altose M.D. et al. Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study. Am. J. Respir. Crit. Care Med. 1994; 150 (4): 956–961.</mixed-citation><mixed-citation xml:lang="en">Kanner R.E., Connett J.E., Altose M.D. et al. Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study. Am. J. Respir. Crit. Care Med. 1994; 150 (4): 956–961.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Yang S.C., Lin B.Y. Comparison of airway hyperreactivity in chronic obstructive pulmonary disease and asthma. Chang Gung Med. J. 2010; 33: 515–523.</mixed-citation><mixed-citation xml:lang="en">Yang S.C., Lin B.Y. Comparison of airway hyperreactivity in chronic obstructive pulmonary disease and asthma. Chang Gung Med. J. 2010; 33: 515–523.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Трофименко И.Н., Черняк Б.А. Бронхиальная гиперреактивность как фенотипическая характеристика хронической обструктивной болезни легких. Пульмонология 2011; 4: 49–53.</mixed-citation><mixed-citation xml:lang="en">Трофименко И.Н., Черняк Б.А. Бронхиальная гиперреактивность как фенотипическая характеристика хронической обструктивной болезни легких. Пульмонология 2011; 4: 49–53.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Brutsche M.H., Downs S.H., Schindler C. et al. Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA Cohort Study. Thorax 2006; 61: 671–677.</mixed-citation><mixed-citation xml:lang="en">Brutsche M.H., Downs S.H., Schindler C. et al. Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA Cohort Study. Thorax 2006; 61: 671–677.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Xu X., Rijcken B., Schouten J.P. et al. Airways responsiveness and development and remission of chronic respiratory symptoms in adults. Lancet 1997; 350: 1431–1434.</mixed-citation><mixed-citation xml:lang="en">Xu X., Rijcken B., Schouten J.P. et al. Airways responsiveness and development and remission of chronic respiratory symptoms in adults. Lancet 1997; 350: 1431–1434.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">De Marco R., Accordini S., Marcon A. et al. Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults. Am. J. Respir. Crit. Care Med. 2011; 183 (7): 891–897.</mixed-citation><mixed-citation xml:lang="en">De Marco R., Accordini S., Marcon A. et al. Risk factors for chronic obstructive pulmonary disease in a European cohort of young adults. Am. J. Respir. Crit. Care Med. 2011; 183 (7): 891–897.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Tashkin D.P., Altose M.D., Connett J.E. et al. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am. J. Respir. Crit. Care Med. 1996; 153: 1802–1811.</mixed-citation><mixed-citation xml:lang="en">Tashkin D.P., Altose M.D., Connett J.E. et al. Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am. J. Respir. Crit. Care Med. 1996; 153: 1802–1811.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hospers J.J., Postma D.S., Rijcken B. et al. Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet 2000; 356: 1313–1317.</mixed-citation><mixed-citation xml:lang="en">Hospers J.J., Postma D.S., Rijcken B. et al. Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet 2000; 356: 1313–1317.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Grootendorst D.C., Rabe K.F. Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2004; 1: 77–87.</mixed-citation><mixed-citation xml:lang="en">Grootendorst D.C., Rabe K.F. Mechanisms of bronchial hyperreactivity in asthma and chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2004; 1: 77–87.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wise R.A., Kanner R.E., Lindgren P. et al. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study. Chest 2003; 124: 449–458.</mixed-citation><mixed-citation xml:lang="en">Wise R.A., Kanner R.E., Lindgren P. et al. The effect of smoking intervention and an inhaled bronchodilator on airways reactivity in COPD: the Lung Health Study. Chest 2003; 124: 449–458.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Postma D.S., Kerstjens H.A.M. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 158: 187–192.</mixed-citation><mixed-citation xml:lang="en">Postma D.S., Kerstjens H.A.M. Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 158: 187–192.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lancas T., Kasahara D.I., Gross J.L. et al. Cholinergic hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease. Respiration 2011; 82: 177–184.</mixed-citation><mixed-citation xml:lang="en">Lancas T., Kasahara D.I., Gross J.L. et al. Cholinergic hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease. Respiration 2011; 82: 177–184.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher J.T., Vincent S.G., Gomeza J. et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J. 2004; 18 (6): 711–713.</mixed-citation><mixed-citation xml:lang="en">Fisher J.T., Vincent S.G., Gomeza J. et al. Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors. FASEB J. 2004; 18 (6): 711–713.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Belmonte K.E. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005; 2: 297–304.</mixed-citation><mixed-citation xml:lang="en">Belmonte K.E. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2005; 2: 297–304.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">O'Connor B.J., Towse L.J., Barnes P.J. Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma. Am. J. Respir. Crit. Care Med. 1996; 154: 876–880.</mixed-citation><mixed-citation xml:lang="en">O'Connor B.J., Towse L.J., Barnes P.J. Prolonged effect of tiotropium bromide on methacholine-induced bronchoconstriction in asthma. Am. J. Respir. Crit. Care Med. 1996; 154: 876–880.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gosens R., Zaagsma J., Meurs H. et al. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir. Res. 2006; 7 (1): 73.</mixed-citation><mixed-citation xml:lang="en">Gosens R., Zaagsma J., Meurs H. et al. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir. Res. 2006; 7 (1): 73.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Cao R., Dong X.W., Jiang J.X. et al. M (3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur. J. Pharmacol. 2011; 655: 83–90.</mixed-citation><mixed-citation xml:lang="en">Cao R., Dong X.W., Jiang J.X. et al. M (3) muscarinic receptor antagonist bencycloquidium bromide attenuates allergic airway inflammation, hyperresponsiveness and remodeling in mice. Eur. J. Pharmacol. 2011; 655: 83–90.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011. www.goldcopd.org</mixed-citation><mixed-citation xml:lang="en">Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011. www.goldcopd.org</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gulsvik A., Refvem O.K. Ascoring system on respiratory symptoms. Eur. Respir. J. 1988; 1: 428–432.</mixed-citation><mixed-citation xml:lang="en">Gulsvik A., Refvem O.K. Ascoring system on respiratory symptoms. Eur. Respir. J. 1988; 1: 428–432.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г. (ред.). Пульмонология. Клинические рекомендации. М.: ГЭОТАР-Медиа; 2005. 212–213.</mixed-citation><mixed-citation xml:lang="en">Чучалин А.Г. (ред.). Пульмонология. Клинические рекомендации. М.: ГЭОТАР-Медиа; 2005. 212–213.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Klein G., Köhler D., Bauer C.P. et al. Standartization of inhalation chal-lenges for measuring the unspecific bronchial inhalation challenge by re-servuar-method. Pneumologie 1991; 45: 60–64.</mixed-citation><mixed-citation xml:lang="en">Klein G., Köhler D., Bauer C.P. et al. Standartization of inhalation chal-lenges for measuring the unspecific bronchial inhalation challenge by re-servuar-method. Pneumologie 1991; 45: 60–64.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Стандартизация легочных функциональных тестов: Пер. с англ. под ред. А.Г.Чучалина. М.; 1993. 68–69.</mixed-citation><mixed-citation xml:lang="en">Стандартизация легочных функциональных тестов: Пер. с англ. под ред. А.Г.Чучалина. М.; 1993. 68–69.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Troosters T., Celli B., Lystig T. et al. Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT® trial. Eur. Respir. J. 2010; 36 (1): 65–73.</mixed-citation><mixed-citation xml:lang="en">Troosters T., Celli B., Lystig T. et al. Tiotropium as a first maintenance drug in COPD: secondary analysis of the UPLIFT® trial. Eur. Respir. J. 2010; 36 (1): 65–73.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Selivanova P.A., Kulikov E.S., Kozina O.V. et al. Differential expression of the β2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann. Allergy Asthma Immunol. 2012; 108: 39–43.</mixed-citation><mixed-citation xml:lang="en">Selivanova P.A., Kulikov E.S., Kozina O.V. et al. Differential expression of the β2-adrenoreceptor and M3-cholinoreceptor genes in bronchial mucosa of patients with asthma and chronic obstructive pulmonary disease. Ann. Allergy Asthma Immunol. 2012; 108: 39–43.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
