<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2011-0-4-126-132</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Остеопороз у больных муковисцидозом: новая проблема и нерешенные вопросы</article-title><trans-title-group xml:lang="en"><trans-title>Osteoporosis in cystic fibrosis patients: a new problem and unresolved issues</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Baranova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф. кафедры госпитальной терапии педиатрического факультета</p><p>117997, Москва, ул. Островитянова, 1. Тел.: (495) 965-45-20.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Красовский</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krasovsky</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник </p><p>105077, Москва, ул. 11-я Парковая, 32, корп. 4. Тел.: 8-926-273-76-34.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амелина</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Amelina</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., зав. лабораторией муковисцидоза </p><p>105077, Москва, ул. 11-я Парковая, 32, корп. 4. Тел.: 8-926-205-03-91.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО "РНИМУ им. Н.И.Пирогова" Росздрава; РГМУ</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ФГУ "НИИ пульмонологии" ФМБА России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2011</year></pub-date><volume>0</volume><issue>4</issue><fpage>126</fpage><lpage>132</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баранова И.А., Красовский С.А., Амелина Е.Л., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Баранова И.А., Красовский С.А., Амелина Е.Л.</copyright-holder><copyright-holder xml:lang="en">Baranova I.A., Krasovsky S.A., Amelina E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/369">https://journal.pulmonology.ru/pulm/article/view/369</self-uri><abstract><p>Остеопороз у больных муковисцидозом: новая проблема и нерешенные вопросы.</p></abstract><trans-abstract xml:lang="en"><p>Osteoporosis in cystic fibrosis patients: a new problem and unresolved issues.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>муковисцидоз</kwd><kwd>остеопороз</kwd><kwd>минеральная плотность кости</kwd><kwd>переломы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cystic fibrosis</kwd><kwd>osteoporosis</kwd><kwd>bone mineral density</kwd><kwd>fractures</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Капранов Н.И., Каширская Н.Ю. (ред.). Муковисцидоз. Современные достижения и актуальные проблемы: Метод. рекомендации. 3-е изд. М.: ООО "4ТЕ Арт"; 2008.</mixed-citation><mixed-citation xml:lang="en">Капранов Н.И., Каширская Н.Ю. (ред.). Муковисцидоз. Современные достижения и актуальные проблемы: Метод. рекомендации. 3-е изд. М.: ООО "4ТЕ Арт"; 2008.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кусова З.А., Каширская Н.Ю., Капранов Н.И. Особенности массового скрининга новорожденных на муковисцидоз. Рус. мед. журн. 2010; 5: 265–270.</mixed-citation><mixed-citation xml:lang="en">Кусова З.А., Каширская Н.Ю., Капранов Н.И. Особенности массового скрининга новорожденных на муковисцидоз. Рус. мед. журн. 2010; 5: 265–270.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cystic Fibrosis Foundation, patient registry 2008. Annual report Cystic Fibrosis Foundation. Bethesda, Md, USA, 2009.</mixed-citation><mixed-citation xml:lang="en">Cystic Fibrosis Foundation, patient registry 2008. Annual report Cystic Fibrosis Foundation. Bethesda, Md, USA, 2009.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">King S.J., Topliss D.J., Kotsimbos T. et al. Reduced bone density in cystic fibrosis: DeltaF508 mutation is an independent risk factor. Eur. Respir. J. 2005; 25: 54–61.</mixed-citation><mixed-citation xml:lang="en">King S.J., Topliss D.J., Kotsimbos T. et al. Reduced bone density in cystic fibrosis: DeltaF508 mutation is an independent risk factor. Eur. Respir. J. 2005; 25: 54–61.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Grey A.B., Ames R.W., Matthews R.D. et al. Bone mineral density and body composition in adult patients with cystic fibrosis. Thorax 1993; 48: 589–593.</mixed-citation><mixed-citation xml:lang="en">Grey A.B., Ames R.W., Matthews R.D. et al. Bone mineral density and body composition in adult patients with cystic fibrosis. Thorax 1993; 48: 589–593.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Elkin S.L., Fairney A., Burnett S. et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int 2001; 12: 366–372.</mixed-citation><mixed-citation xml:lang="en">Elkin S.L., Fairney A., Burnett S. et al. Vertebral deformities and low bone mineral density in adults with cystic fibrosis: a cross-sectional study. Osteoporos Int 2001; 12: 366–372.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Stephenson A., Jamal S., Dowdell T. et al. Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density. Chest 2006; 130: 539–544.</mixed-citation><mixed-citation xml:lang="en">Stephenson A., Jamal S., Dowdell T. et al. Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density. Chest 2006; 130: 539–544.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R.M., Renner J.B., Winders A.D. et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann. Intern. Med. 1998; 128 (3): 186–193.</mixed-citation><mixed-citation xml:lang="en">Aris R.M., Renner J.B., Winders A.D. et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann. Intern. Med. 1998; 128 (3): 186–193.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Paccou J., Zeboulon N., Combescure C. et al. The prevalence of osteoporosis, osteopenia, and fractures: a systematic literature review with meta-analysis. Calcif. Tissue Int. 2010; 86: 1–7.</mixed-citation><mixed-citation xml:lang="en">Paccou J., Zeboulon N., Combescure C. et al. The prevalence of osteoporosis, osteopenia, and fractures: a systematic literature review with meta-analysis. Calcif. Tissue Int. 2010; 86: 1–7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Aringer M., Kiener H.P., Koeller M.D. et al. High turnover bone disease following lung transplantation. Bone 1998; 23 (5): 485–488.</mixed-citation><mixed-citation xml:lang="en">Aringer M., Kiener H.P., Koeller M.D. et al. High turnover bone disease following lung transplantation. Bone 1998; 23 (5): 485–488.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Shane E., Papadopoulos A., Staron R.B. et al. Bone loss and fracture after lung transplantation. Transplantation 1999; 68 (2): 220–227.</mixed-citation><mixed-citation xml:lang="en">Shane E., Papadopoulos A., Staron R.B. et al. Bone loss and fracture after lung transplantation. Transplantation 1999; 68 (2): 220–227.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Official position of the International Society for Clinical Densitometry. c Copyright ISCD, October 2007, Supersedes all prior "Official Position" publications.</mixed-citation><mixed-citation xml:lang="en">Official position of the International Society for Clinical Densitometry. c Copyright ISCD, October 2007, Supersedes all prior "Official Position" publications.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Report of the UK Cystic Fibrosis Trust Bone Mineralisation Working Group. Bone mineralisation in cystic fibrosis. February 2007. Cystic Fibrosis Trust.</mixed-citation><mixed-citation xml:lang="en">Report of the UK Cystic Fibrosis Trust Bone Mineralisation Working Group. Bone mineralisation in cystic fibrosis. February 2007. Cystic Fibrosis Trust.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R.M., Merkel P.A., Bachrach L.K. et al. Consensus statement: Guide to bone health and disease in cystic fibrosis. J. Clin. Endocrinol. 2005; 90 (3):1888–1896.</mixed-citation><mixed-citation xml:lang="en">Aris R.M., Merkel P.A., Bachrach L.K. et al. Consensus statement: Guide to bone health and disease in cystic fibrosis. J. Clin. Endocrinol. 2005; 90 (3):1888–1896.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Haworth C.S., Webb A.K., Egan J.J. et al. Bone histomorphometry in adult patients with cystic fibrosis. Chest 2000; 118: 434–439.</mixed-citation><mixed-citation xml:lang="en">Haworth C.S., Webb A.K., Egan J.J. et al. Bone histomorphometry in adult patients with cystic fibrosis. Chest 2000; 118: 434–439.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Elkin S.L., Vedi S., Bord S. et al. Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2002; 166: 1470–1474.</mixed-citation><mixed-citation xml:lang="en">Elkin S.L., Vedi S., Bord S. et al. Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2002; 166: 1470–1474.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Mischler E.H., Chesney P.J., Chesney R.W. et al. Demineralization in cystic fibrosis detected by direct photon absorptiometry. Am. J. Dis. Child. 1979; 133: 632–635.</mixed-citation><mixed-citation xml:lang="en">Mischler E.H., Chesney P.J., Chesney R.W. et al. Demineralization in cystic fibrosis detected by direct photon absorptiometry. Am. J. Dis. Child. 1979; 133: 632–635.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hahn T.J., Squires A.E., Halstead L.R. et al. Reduced serum 25-hydroxyvitamin D concentration and disordered mineral metabolism in patients with cystic fibrosis. J. Pediatr. 1979; 94: 38–42.</mixed-citation><mixed-citation xml:lang="en">Hahn T.J., Squires A.E., Halstead L.R. et al. Reduced serum 25-hydroxyvitamin D concentration and disordered mineral metabolism in patients with cystic fibrosis. J. Pediatr. 1979; 94: 38–42.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Paccou J., Zeboulon N., Combescure C. et al. The prevalence of osteoporosis, osteopenia, and fractures: a systematic literature review with meta-analysis. Calcif. Tissue Int. 2010; 86: 1–7.</mixed-citation><mixed-citation xml:lang="en">Paccou J., Zeboulon N., Combescure C. et al. The prevalence of osteoporosis, osteopenia, and fractures: a systematic literature review with meta-analysis. Calcif. Tissue Int. 2010; 86: 1–7.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Haworth C.S., Selby P.L., Webb A.K. et al. Low bone mineral density in adults with cystic fibrosis. Thorax 1999; 54: 961–967.</mixed-citation><mixed-citation xml:lang="en">Haworth C.S., Selby P.L., Webb A.K. et al. Low bone mineral density in adults with cystic fibrosis. Thorax 1999; 54: 961–967.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Buntain H.M., Schluter P.J., Bell S.C. et al. Controlled longitudinal study of bone mass accrual in children and adolescents with cystic fibrosis. Thorax 2006; 61: 146–154.</mixed-citation><mixed-citation xml:lang="en">Buntain H.M., Schluter P.J., Bell S.C. et al. Controlled longitudinal study of bone mass accrual in children and adolescents with cystic fibrosis. Thorax 2006; 61: 146–154.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Haworth C.S., Selby P.L., Horrrocks A.W. et al. A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 2002; 57: 719–723.</mixed-citation><mixed-citation xml:lang="en">Haworth C.S., Selby P.L., Horrrocks A.W. et al. A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 2002; 57: 719–723.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Bhudhikanok G.S., Wang M.)C., Marcus R. et al. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J. Pediatr. 1998; 133: 18–27.</mixed-citation><mixed-citation xml:lang="en">Bhudhikanok G.S., Wang M.)C., Marcus R. et al. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J. Pediatr. 1998; 133: 18–27.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dif F., Marty C., Baudoin C. et al. Severe osteopenia in CFTR-null mice. Bone 2004; 35: 595–603.</mixed-citation><mixed-citation xml:lang="en">Dif F., Marty C., Baudoin C. et al. Severe osteopenia in CFTR-null mice. Bone 2004; 35: 595–603.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Haston C.K., Li W., Li A. et al. Persistent osteopenia in adult cystic fibrosis transmembrane conductance regulator-deficient mice. Am. J. Respir. Crit. Care Med. 2008; 177: 309–315.</mixed-citation><mixed-citation xml:lang="en">Haston C.K., Li W., Li A. et al. Persistent osteopenia in adult cystic fibrosis transmembrane conductance regulator-deficient mice. Am. J. Respir. Crit. Care Med. 2008; 177: 309–315.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">King S.L., Topliss D.J., Kotsimbos T. et al. Reduced bone density in cystic fibrosis: ΔF508 mutation is an independent risk factor. Eur. Respir. J. 2005; 25: 54–61.</mixed-citation><mixed-citation xml:lang="en">King S.L., Topliss D.J., Kotsimbos T. et al. Reduced bone density in cystic fibrosis: ΔF508 mutation is an independent risk factor. Eur. Respir. J. 2005; 25: 54–61.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Buntain H.M., Greer R.M., Schluter P.J. et al. Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 2004; 59: 149–155.</mixed-citation><mixed-citation xml:lang="en">Buntain H.M., Greer R.M., Schluter P.J. et al. Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 2004; 59: 149–155.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R.M., Guise T.A. Cystic fibrosis and bone disease: are we missing a genetic link? Eur. Respir. J. 2005; 25 (1): 9–11.</mixed-citation><mixed-citation xml:lang="en">Aris R.M., Guise T.A. Cystic fibrosis and bone disease: are we missing a genetic link? Eur. Respir. J. 2005; 25 (1): 9–11.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Shead E.F., Haworth C.S., Condliffe A.M. et al. Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone. Thorax 2007; 62: 650–651.</mixed-citation><mixed-citation xml:lang="en">Shead E.F., Haworth C.S., Condliffe A.M. et al. Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human bone. Thorax 2007; 62: 650–651.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Le Heron L., Guillaume C., Velard F. et al. Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone. J. Cyst. Fibros. 2010; 9: 69–72.</mixed-citation><mixed-citation xml:lang="en">Le Heron L., Guillaume C., Velard F. et al. Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone. J. Cyst. Fibros. 2010; 9: 69–72.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Lacativa P.G.S., de Farias V.L.F. Osteoporosis and inflammation. Arq. Bras. Endocrinol. 2010: 54 (2): 123–132.</mixed-citation><mixed-citation xml:lang="en">Lacativa P.G.S., de Farias V.L.F. Osteoporosis and inflammation. Arq. Bras. Endocrinol. 2010: 54 (2): 123–132.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Shead E.F., Haworth C.S., Gunn E. et al. Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174: 306–311.</mixed-citation><mixed-citation xml:lang="en">Shead E.F., Haworth C.S., Gunn E. et al. Osteoclastogenesis during infective exacerbations in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2006; 174: 306–311.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Shead E.F., Haworth C.S., Barker H. et al. Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis. J. Cyst. Fibros. 2010; 9: 93–98.</mixed-citation><mixed-citation xml:lang="en">Shead E.F., Haworth C.S., Barker H. et al. Osteoclast function, bone turnover and inflammatory cytokines during infective exacerbations of cystic fibrosis. J. Cyst. Fibros. 2010; 9: 93–98.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Ionescu A., Nixon L., Evans W. et al. Bone density, body composition, and inflammatory status in cystic fibrosis. Am. J. Respir. Crit. Care Med. 2000; 162 (3): 789–794.</mixed-citation><mixed-citation xml:lang="en">Ionescu A., Nixon L., Evans W. et al. Bone density, body composition, and inflammatory status in cystic fibrosis. Am. J. Respir. Crit. Care Med. 2000; 162 (3): 789–794.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R., Stephens A., Ontjes D. et al. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2000; 162 (5): 1674–1678.</mixed-citation><mixed-citation xml:lang="en">Aris R., Stephens A., Ontjes D. et al. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2000; 162 (5): 1674–1678.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Haworth C., Selby P., Webb A. et al. Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax 2004; 59 (7): 613–617.</mixed-citation><mixed-citation xml:lang="en">Haworth C., Selby P., Webb A. et al. Inflammatory related changes in bone mineral content in adults with cystic fibrosis. Thorax 2004; 59 (7): 613–617.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Boyle M.P., Noschese M.L., Watts S.L. et al. Failure of highdose ergocalciferol to correct vitamin D deficiency in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2005; 172 (2): 212–217.</mixed-citation><mixed-citation xml:lang="en">Boyle M.P., Noschese M.L., Watts S.L. et al. Failure of highdose ergocalciferol to correct vitamin D deficiency in adults with cystic fibrosis. Am. J. Respir. Crit. Care Med. 2005; 172 (2): 212–217.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rovner A.J., Stallings V.A., Schall J.A. et al. Vitamin D insufficiency in children, adolescents, and young adults with cystic fibrosis despite routine oral supplementation. Am. J. Clin. Nutr. 2007; 86 (6): 1694-1699.</mixed-citation><mixed-citation xml:lang="en">Rovner A.J., Stallings V.A., Schall J.A. et al. Vitamin D insufficiency in children, adolescents, and young adults with cystic fibrosis despite routine oral supplementation. Am. J. Clin. Nutr. 2007; 86 (6): 1694-1699.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hall W.B., Sparks A.A., Aris R.M. Vitamin D deficiency in cystic fibrosis. Int. J. Endocrinol. 2010: Article ID 218691.</mixed-citation><mixed-citation xml:lang="en">Hall W.B., Sparks A.A., Aris R.M. Vitamin D deficiency in cystic fibrosis. Int. J. Endocrinol. 2010: Article ID 218691.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Cranney A., Horsley T., O'Donnell S. et al. Effectiveness and safety of vitamin D in relation to bone health. Evidence Report / Technology Assessment 2007; 158: 1–235.</mixed-citation><mixed-citation xml:lang="en">Cranney A., Horsley T., O'Donnell S. et al. Effectiveness and safety of vitamin D in relation to bone health. Evidence Report / Technology Assessment 2007; 158: 1–235.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Wolfenden L.L., Judd S.E., Shah R. et al. Vitamin D and bone health in adults with cystic fibrosis. Clin. Endocrinol. 2008; 69: 374–381.</mixed-citation><mixed-citation xml:lang="en">Wolfenden L.L., Judd S.E., Shah R. et al. Vitamin D and bone health in adults with cystic fibrosis. Clin. Endocrinol. 2008; 69: 374–381.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Gronowitz E., Larkö O., Gilljam M. et al. Ultraviolet B radiation improves serum levels of vitamin D in patients with cystic fibrosis. Acta Paediatr. 2005; 94 (5): 547–552. Баранова И.А. и др. Остеопороз у больных муковисцидозом: новая проблема и нерешенные вопросы 132 Пульмонология 4’2011</mixed-citation><mixed-citation xml:lang="en">Gronowitz E., Larkö O., Gilljam M. et al. Ultraviolet B radiation improves serum levels of vitamin D in patients with cystic fibrosis. Acta Paediatr. 2005; 94 (5): 547–552. Баранова И.А. и др. Остеопороз у больных муковисцидозом: новая проблема и нерешенные вопросы 132 Пульмонология 4’2011</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Khazai N.B., Judd S.E., Jeng L. et al. Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light. J. Clin. Endocrinol. 2009; 94: 2037–2043.</mixed-citation><mixed-citation xml:lang="en">Khazai N.B., Judd S.E., Jeng L. et al. Treatment and prevention of vitamin D insufficiency in cystic fibrosis patients: comparative efficacy of ergocalciferol, cholecalciferol, and UV light. J. Clin. Endocrinol. 2009; 94: 2037–2043.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Conway S.P., Wolfe S.P., Brownlee K.G. et al. Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Pediatrics 2005; 115: 1325–1331.</mixed-citation><mixed-citation xml:lang="en">Conway S.P., Wolfe S.P., Brownlee K.G. et al. Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Pediatrics 2005; 115: 1325–1331.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Fewtrell M.S., Benden C., Williams J.E. et al. Undercarboxylated osteocalcin and bone mass in 8–12 year old children with cystic fibrosis. J. Cyst. Fibros. 2008; 7: 307–312.</mixed-citation><mixed-citation xml:lang="en">Fewtrell M.S., Benden C., Williams J.E. et al. Undercarboxylated osteocalcin and bone mass in 8–12 year old children with cystic fibrosis. J. Cyst. Fibros. 2008; 7: 307–312.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Grey V., Atkinson S., Drury D. et al. Prevalence of low bone mass and deficiencies of vitamins D and K in pediatric patients with cystic fibrosis from 3 Canadian centers. Pediatrics 2008; 122: 1014–1020.</mixed-citation><mixed-citation xml:lang="en">Grey V., Atkinson S., Drury D. et al. Prevalence of low bone mass and deficiencies of vitamins D and K in pediatric patients with cystic fibrosis from 3 Canadian centers. Pediatrics 2008; 122: 1014–1020.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Nicolaidou P., Stavrinadis I., Loukou I. et al. The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis. Eur. J. Pediatr. 2006; 165: 540–545.</mixed-citation><mixed-citation xml:lang="en">Nicolaidou P., Stavrinadis I., Loukou I. et al. The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis. Eur. J. Pediatr. 2006; 165: 540–545.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Drury D., Grey V.L., Ferland G. et al. Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis. J. Cyst. Fibros. 2008; 7: 457–459.</mixed-citation><mixed-citation xml:lang="en">Drury D., Grey V.L., Ferland G. et al. Efficacy of high dose phylloquinone in correcting vitamin K deficiency in cystic fibrosis. J. Cyst. Fibros. 2008; 7: 457–459.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R.M., Lester G.E., Renner J.B. et al. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am. J. Respir. Crit. Care Med. 2000; 162 (3, Pt 1): 941–946.</mixed-citation><mixed-citation xml:lang="en">Aris R.M., Lester G.E., Renner J.B. et al. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am. J. Respir. Crit. Care Med. 2000; 162 (3, Pt 1): 941–946.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Aris R.M., Lester G.E., Caminiti M. et al. Efficacy of alendronate in adults with cystic fibrosis with low bone density. Am. J. Res. Crit. Care Med. 2004; 169 (1): 77–82.</mixed-citation><mixed-citation xml:lang="en">Aris R.M., Lester G.E., Caminiti M. et al. Efficacy of alendronate in adults with cystic fibrosis with low bone density. Am. J. Res. Crit. Care Med. 2004; 169 (1): 77–82.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Boyle M.P., Lechtzin N., Watts S. Zoledronate therapy for decreased bone density in adults with cystic fibrosis [abstract]. Pediatr. Pulmonol. 2005; 40 (S28): 353.</mixed-citation><mixed-citation xml:lang="en">Boyle M.P., Lechtzin N., Watts S. Zoledronate therapy for decreased bone density in adults with cystic fibrosis [abstract]. Pediatr. Pulmonol. 2005; 40 (S28): 353.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Chapman I., Greville H., Ebeling P.R. et al. Intravenous zoledronate improves bone density in adults with cystic fibrosis (CF). Clin. Endocrinol. 2009; 70: 838–846.</mixed-citation><mixed-citation xml:lang="en">Chapman I., Greville H., Ebeling P.R. et al. Intravenous zoledronate improves bone density in adults with cystic fibrosis (CF). Clin. Endocrinol. 2009; 70: 838–846.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Haworth C.S., Selby P.L., Adams J.E. et al. Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax 2001; 56 (4): 314–316.</mixed-citation><mixed-citation xml:lang="en">Haworth C.S., Selby P.L., Adams J.E. et al. Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax 2001; 56 (4): 314–316.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Papaioannou A., Kennedy C.C., Freitag A. et al. Alendronate once weekly for the prevention and treatment of bone loss in Canadian adult cystic fibrosis patients (CFOS Trial). Chest 2008; 134: 794–800.</mixed-citation><mixed-citation xml:lang="en">Papaioannou A., Kennedy C.C., Freitag A. et al. Alendronate once weekly for the prevention and treatment of bone loss in Canadian adult cystic fibrosis patients (CFOS Trial). Chest 2008; 134: 794–800.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
