pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-3442Research ArticleЛЕКЦИИLECTIONSКлиническая фармакология ингаляционных глюкокортикостероидовClinical pharmacology of inhaled glucocorticosteroidsЦойА. Н.TsoyA. N.Московская медицинская академия им. И.М .СеченоваRussian Federation199630061996028590Copyright © Цой А.Н., 19961996Цой А.Н.Tsoy A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/3442
.
.
ReferencesJohansson S.A., Andersson К.А., Brattsand R. et al. Topical and systemic glucocorticoid potences of budesonide, beclomethasone dipropionate and prednisolone in man // Eur. Respir. J. — 1982. — Vol. 63, Suppl. 122. — P. 74—82.Johansson S.A., Andersson К.А., Brattsand R. et al. Topical and systemic glucocorticoid potences of budesonide, beclomethasone dipropionate and prednisolone in man // Eur. Respir. J. — 1982. — Vol. 63, Suppl. 122. — P. 74—82.Barnes P.J., Pedersen S. Efficacy and Safety of inhaled corticosteroids in asthma // Am. Rev. Respir. Dis. — 1993. — Vol. 148. — P. S1—S26.Barnes P.J., Pedersen S. Efficacy and Safety of inhaled corticosteroids in asthma // Am. Rev. Respir. Dis. — 1993. — Vol. 148. — P. S1—S26.Wikstrom A.C., Bakke O., Bronnegard М., Gustafsson J.A. Intracellular localisation of the glucocorticoid receptor; evidence for cytoplasmic and nuclear localization // Endocrinology. — 1987. — Vol. 120. — P. 1232—1242.Wikstrom A.C., Bakke O., Bronnegard М., Gustafsson J.A. Intracellular localisation of the glucocorticoid receptor; evidence for cytoplasmic and nuclear localization // Endocrinology. — 1987. — Vol. 120. — P. 1232—1242.Londgren J.D., Hirata F. et al. Dexamethasone inhibits respiratory glucoconjugate secretion from airways in vitro by the induction of lipocortin (lipomodulin) synthesis // Am. Rev. Respir. Dis. — 1988. — Vol. 137. — P. 353—357.Londgren J.D., Hirata F. et al. Dexamethasone inhibits respiratory glucoconjugate secretion from airways in vitro by the induction of lipocortin (lipomodulin) synthesis // Am. Rev. Respir. Dis. — 1988. — Vol. 137. — P. 353—357.Davidson F.F., D ennis E.A. Biological relevance of lipocortins and related proteins as inhibitors of phospholipase A2 // Biochem. Pharmacol. — 1989. — Vol. 38. — P. 3645—3651.Davidson F.F., D ennis E.A. Biological relevance of lipocortins and related proteins as inhibitors of phospholipase A2 // Biochem. Pharmacol. — 1989. — Vol. 38. — P. 3645—3651.Flower R.J. Lipocortin and the mechanism of action of the glucocorticoids // Br. J. Pharmacol. — 1988. — Vol. 94. — P. 987—1015.Flower R.J. Lipocortin and the mechanism of action of the glucocorticoids // Br. J. Pharmacol. — 1988. — Vol. 94. — P. 987—1015.Goudling N.J., Godolphin J.L. et al. Anti-inflammatory lipocortin-1 production by perpheral leucocytes in response to hydrocortisone // Lancet. — 1990. — Vol. 335. — P. 1416—1418.Goudling N.J., Godolphin J.L. et al. Anti-inflammatory lipocortin-1 production by perpheral leucocytes in response to hydrocortisone // Lancet. — 1990. — Vol. 335. — P. 1416—1418.Mac J.C.W., Adcock I., Barnes P.J. Dexamethasone increases beta-2-adrenoceptor gene expression in human lung (abstract) // Am. Rev. Respir. Dis. — 1992. — Vol. 145. — P. A834.Mac J.C.W., Adcock I., Barnes P.J. Dexamethasone increases beta-2-adrenoceptor gene expression in human lung (abstract) // Am. Rev. Respir. Dis. — 1992. — Vol. 145. — P. A834.Laitinen L.A., Laitinen A., Haahtela T.A. A comparative study of effects of an inhaled corticosteroid budesonide and of a ß2-agonists terbutaline on airway inflammation in newly diagnosed asthma // J. Allergy Clin. Immunol. — 1992. — Vol. 90. — P. 32—42.Laitinen L.A., Laitinen A., Haahtela T.A. A comparative study of effects of an inhaled corticosteroid budesonide and of a ß2-agonists terbutaline on airway inflammation in newly diagnosed asthma // J. Allergy Clin. Immunol. — 1992. — Vol. 90. — P. 32—42.Boschetto P., Rogers D.F., Fabbri L.M., Barnes P.J. Corticosteroid inhibition of airway microvascular leakage // Am. Rev. Respir. Dis. — 1991. — Vol. 145. — P. 605—609.Boschetto P., Rogers D.F., Fabbri L.M., Barnes P.J. Corticosteroid inhibition of airway microvascular leakage // Am. Rev. Respir. Dis. — 1991. — Vol. 145. — P. 605—609.Dahlberg E., Thalen A., Brattsand R. et al. Correlation between chemical structure, receptor binding and biological of some novel highly active 16a, 17a-acetate-substituted glucocorticoids // Mol. Pharmacol. — 1984. — Vol. 25. — P. 70—78.Dahlberg E., Thalen A., Brattsand R. et al. Correlation between chemical structure, receptor binding and biological of some novel highly active 16a, 17a-acetate-substituted glucocorticoids // Mol. Pharmacol. — 1984. — Vol. 25. — P. 70—78.Phillips G.H. Structure-activity relationship of topically active steroids: the selection of fluticasone propionate // Respir. Med. — 1990. — Vol. 84, Suppl. A. — P. 19—23.Phillips G.H. Structure-activity relationship of topically active steroids: the selection of fluticasone propionate // Respir. Med. — 1990. — Vol. 84, Suppl. A. — P. 19—23.Me Kenzie A.W., Stroughton R.B. Method for comparing percutaneus absorbtion of steroids // Arch. Dermatol. — 1962. — Vol. 86. — P. 608—610.Me Kenzie A.W., Stroughton R.B. Method for comparing percutaneus absorbtion of steroids // Arch. Dermatol. — 1962. — Vol. 86. — P. 608—610.Baigelman W., Chodosh S., Pzzuto D., Cupples L.A. Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma // Am. J. Med. — 1983. — Vol. 75. — P. 929—936.Baigelman W., Chodosh S., Pzzuto D., Cupples L.A. Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma // Am. J. Med. — 1983. — Vol. 75. — P. 929—936.Evans P.M., OConnor B.J. Fuller R. W., Barnes P.J., Chung K.F. Effect of inhaled corticosteroids of peripherial eosinophil counts and density profiles in asthma // J. Allergy Clin. Immunol. — 1992. — Vol. 91. — P. 643—649.Evans P.M., OConnor B.J. Fuller R. W., Barnes P.J., Chung K.F. Effect of inhaled corticosteroids of peripherial eosinophil counts and density profiles in asthma // J. Allergy Clin. Immunol. — 1992. — Vol. 91. — P. 643—649.Martinel N., Vaillant P., Charles I. el al. Dexamethasone modulation of tumor necrosis factor activated normal human alveolar macrophages // Eur. Respir. J. — 1992. — Vol. 5. — P. 67—72.Martinel N., Vaillant P., Charles I. el al. Dexamethasone modulation of tumor necrosis factor activated normal human alveolar macrophages // Eur. Respir. J. — 1992. — Vol. 5. — P. 67—72.Van de Graaf E.A., Out T.A., Loos S.M., Jansen H.M. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma // Am. Rev. Respir. Dis. — 1991. — Vol. 143. — P. 362—368.Van de Graaf E.A., Out T.A., Loos S.M., Jansen H.M. Respiratory membrane permeability and bronchial hyperreactivity in patients with stable asthma // Am. Rev. Respir. Dis. — 1991. — Vol. 143. — P. 362—368.Bel E.N., Timers M.C., Zwinderman A.H. et al. The effect of inhaled corticosterids on the maximal degree of airway narrowing to methacholine // Ibid. — 1991. — Vol. 143. — P. 109—113.Bel E.N., Timers M.C., Zwinderman A.H. et al. The effect of inhaled corticosterids on the maximal degree of airway narrowing to methacholine // Ibid. — 1991. — Vol. 143. — P. 109—113.Barnes P.J. Effect of corticosteroids on airway hyperresponsiveness // Ibid. — 1990. — Vol. 141, Suppl. — P. S70—S76.Barnes P.J. Effect of corticosteroids on airway hyperresponsiveness // Ibid. — 1990. — Vol. 141, Suppl. — P. S70—S76.Molema J., van Herwaarden C.L.A., Folgering H.T.M. Effect of long-term treatment witn inhaled cromoglycate and budesonide on bronchial hyperresponsiveness in patients with allergic asthma // Eur. Respir. J. — 1989. — Vol. 2. — P. 308—316.Molema J., van Herwaarden C.L.A., Folgering H.T.M. Effect of long-term treatment witn inhaled cromoglycate and budesonide on bronchial hyperresponsiveness in patients with allergic asthma // Eur. Respir. J. — 1989. — Vol. 2. — P. 308—316.Groot C.A.A.R., Lamers J.W.J., Molema J. et al. Effect of inhaled beclomethasone and nedocromil sodium on bronchial hyperresponsivenes to histamine and distilled water // Ibid. — 1992. — Vol. 5. — P. 1075—1082.Groot C.A.A.R., Lamers J.W.J., Molema J. et al. Effect of inhaled beclomethasone and nedocromil sodium on bronchial hyperresponsivenes to histamine and distilled water // Ibid. — 1992. — Vol. 5. — P. 1075—1082.Barnes P.J. Antiinflammatory therapy of asthma // Annu Rev. Med. — 1993. — Vol. 44. — P. 229—249.Barnes P.J. Antiinflammatory therapy of asthma // Annu Rev. Med. — 1993. — Vol. 44. — P. 229—249.B ettery P.K., Goldfrey R.W., Adelroth E. et al. Effect of treatment on airway inflammation and thickening of basament membrane reticular collagen in asthma // Am. Rev. Respir. Dis. — 1992. — Vol. 145. — P. 890—899.B ettery P.K., Goldfrey R.W., Adelroth E. et al. Effect of treatment on airway inflammation and thickening of basament membrane reticular collagen in asthma // Am. Rev. Respir. Dis. — 1992. — Vol. 145. — P. 890—899.Brithish Thoracic society and others. Guidelines for management of asthma in adults: I-Chronic persistent asthma // Br. Med. J. — 1990. — Vol. 301. — P. 651—653.Brithish Thoracic society and others. Guidelines for management of asthma in adults: I-Chronic persistent asthma // Br. Med. J. — 1990. — Vol. 301. — P. 651—653.International Consensus Report on diagnosis and management of asthma. National Institute of health publication No. 92—3091 // Eur. Respir. J. — 1992. — Vol. 5. — P. 601—641.International Consensus Report on diagnosis and management of asthma. National Institute of health publication No. 92—3091 // Eur. Respir. J. — 1992. — Vol. 5. — P. 601—641.Smith M.J., Hodson M.E. High dose beclomethasone inhaler in the treatment of asthma // Lancet. — 1983. — Vol. l. — P. 265—269.Smith M.J., Hodson M.E. High dose beclomethasone inhaler in the treatment of asthma // Lancet. — 1983. — Vol. l. — P. 265—269.Toogood J.H. High dose inhaled steroid therapy for asthma // J. Allergy Clin. Immunol. — 1989. — Vol. 83. — P. 528—536.Toogood J.H. High dose inhaled steroid therapy for asthma // J. Allergy Clin. Immunol. — 1989. — Vol. 83. — P. 528—536.Svendsen U.G., Frolund L., Heinig J.H. et al. High dose inhaled steroids in the management of asthma: a comparison of the effects of budesonide and beclomethasone dipropionate on pulmonary function, symptoms, bronchial responsivenes and adrenal function // Allergy. — 1992. — Vol. 47. — P. 174—180.Svendsen U.G., Frolund L., Heinig J.H. et al. High dose inhaled steroids in the management of asthma: a comparison of the effects of budesonide and beclomethasone dipropionate on pulmonary function, symptoms, bronchial responsivenes and adrenal function // Allergy. — 1992. — Vol. 47. — P. 174—180.Salmeron S., Guerin J.C., Godard P. et al. High doses of inhaled corticosterids in instable chronic asthma // Am. Rev. Respir. Dis. — 1989. — Vol. 140. — P. 167—171.Salmeron S., Guerin J.C., Godard P. et al. High doses of inhaled corticosterids in instable chronic asthma // Am. Rev. Respir. Dis. — 1989. — Vol. 140. — P. 167—171.Rafferty P., Tucker L.G., Frame M.H. et al. Comparison of budesonide and beclomethasone dipropionate in patients with severe chronic asthma: assesment of relative prednisolone-sparing effects // Br. J. Dis. Chest. — 1985. — Vol. 79. — P. 244—250.Rafferty P., Tucker L.G., Frame M.H. et al. Comparison of budesonide and beclomethasone dipropionate in patients with severe chronic asthma: assesment of relative prednisolone-sparing effects // Br. J. Dis. Chest. — 1985. — Vol. 79. — P. 244—250.Laursen L.C., Taudort E., Weeke B. High dose inhaled budesonide in treatment of severe steroid-dependent asthma // Eur. J. Respir. Dis. — 1986. — Vol. 68. — P. 19—28.Laursen L.C., Taudort E., Weeke B. High dose inhaled budesonide in treatment of severe steroid-dependent asthma // Eur. J. Respir. Dis. — 1986. — Vol. 68. — P. 19—28.Hummel S, Lehtonen L. Comparison of oral steroid-sparing bv high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma. Lancet 1992;340:1483—7.Hummel S, Lehtonen L. Comparison of oral steroid-sparing bv high-dose and low-dose inhaled steroid in maintenance treatment of severe asthma. Lancet 1992;340:1483—7.Ebden P, Jenkins A, Houston G, Davies B.N. Comparison of two high-dose corticosteroid aerosol treatments: beclomethasone dipropionate (1500 mq/day) and budesonide (1600 mq/day)for chronic asthma. Thorax 1986;41:869—74.Ebden P, Jenkins A, Houston G, Davies B.N. Comparison of two high-dose corticosteroid aerosol treatments: beclomethasone dipropionate (1500 mq/day) and budesonide (1600 mq/day)for chronic asthma. Thorax 1986;41:869—74.Barnes N.C, Marone G, Di Maria G.U. et all. A comparison o[fluticasone pripionate, 1 mg daly with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. Eur Respir I 1993;6:877-84.Barnes N.C, Marone G, Di Maria G.U. et all. A comparison o[fluticasone pripionate, 1 mg daly with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. Eur Respir I 1993;6:877-84.Fabbri L, Burge P.S., Croonenborg L. et all. Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. Thorax 1993;48:817-23.Fabbri L, Burge P.S., Croonenborg L. et all. Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. Thorax 1993;48:817-23.Smith M.J., Hodson M.E. Effects of long-term inhaled high dose beclomethasone dipropionate on adrenal function // Thorax. - 1983. — Vol. 38. — P. 76—81.Smith M.J., Hodson M.E. Effects of long-term inhaled high dose beclomethasone dipropionate on adrenal function // Thorax. - 1983. — Vol. 38. — P. 76—81.Stiksa G., Nemcek K., Glennow C. Adrenal function in asthmatics treated with high-dose budesonide // Respiration. — 1985. - Vol. 48. — P. 91—93.Stiksa G., Nemcek K., Glennow C. Adrenal function in asthmatics treated with high-dose budesonide // Respiration. — 1985. - Vol. 48. — P. 91—93.Teelucksingh S., Padfield P.I., Dicker I. et al. A double-blind placebo controlled crossover study of effects upon the hypothalamic- pituitary-adrenal axis of beclomethasone dipropionate metered dose inhaler at 100, 350 and 500 mq four times daily in healthy adults (abstract) // Am. Rev. Respir. Dis. — 1991. - Vol. 143. — P. A626.Teelucksingh S., Padfield P.I., Dicker I. et al. A double-blind placebo controlled crossover study of effects upon the hypothalamic- pituitary-adrenal axis of beclomethasone dipropionate metered dose inhaler at 100, 350 and 500 mq four times daily in healthy adults (abstract) // Am. Rev. Respir. Dis. — 1991. - Vol. 143. — P. A626.Andersson P., Ryrfeld A. Biotransformation of the topical glucocorticoids budesonide and beclomethasone 17a, 21 dipropionate in human liver and lung homogenate // J. Pharm. Pharmacol. — 1984. — Vol. 36. — P. 763—765.Andersson P., Ryrfeld A. Biotransformation of the topical glucocorticoids budesonide and beclomethasone 17a, 21 dipropionate in human liver and lung homogenate // J. Pharm. Pharmacol. — 1984. — Vol. 36. — P. 763—765.Harding S.M. The human pharmacology of fluticasone dipropionate // Respir. Med. — 1990. — Vol. 84, Suppl. A. — P. 25—29.Harding S.M. The human pharmacology of fluticasone dipropionate // Respir. Med. — 1990. — Vol. 84, Suppl. A. — P. 25—29.Mollman H., Rohdewald P., Schmidt E.W. et al. Pharmacokinetics of trimcinolone acetonide and its phosphate ester // Eur. J. Clin Pharmacol. — 1985. — Vol. 29. — P. 85—89.Mollman H., Rohdewald P., Schmidt E.W. et al. Pharmacokinetics of trimcinolone acetonide and its phosphate ester // Eur. J. Clin Pharmacol. — 1985. — Vol. 29. — P. 85—89.Ryrfeldt A., Andersson P., Edsbacker S. et al. Pharmacokinetics ans metabolism of budesonide - a selective glucocorticoid // Eur J. Respir. Dis. — 1982. — Vol. 63, Suppl. 122. — P. 86—95.Ryrfeldt A., Andersson P., Edsbacker S. et al. Pharmacokinetics ans metabolism of budesonide - a selective glucocorticoid // Eur J. Respir. Dis. — 1982. — Vol. 63, Suppl. 122. — P. 86—95.Pesersson S., Steffensson G., Ekman I. et al. Pharmacokinetics of budesonide in children with asthma // Eur. J. CIin. Pharmacol. - 1987. — Vol. 31. — P. 579—582.Pesersson S., Steffensson G., Ekman I. et al. Pharmacokinetics of budesonide in children with asthma // Eur. J. CIin. Pharmacol. - 1987. — Vol. 31. — P. 579—582.Chaplin M.D., Rooks W., Svenson E.W. et al. Flunisolide meta bolism and dinamiks of a metabolite // Clin. Pharmacol. Ther. - 1980. — Vol. 27.— P. 402—413.Chaplin M.D., Rooks W., Svenson E.W. et al. Flunisolide meta bolism and dinamiks of a metabolite // Clin. Pharmacol. Ther. - 1980. — Vol. 27.— P. 402—413.Allen M.B., Ray S.G., Dhillon B. et al. Steroid aerosoles anc cataract formatio // Br. Med. J. — 1989. — Vol. 299. — P. 432—433.Allen M.B., Ray S.G., Dhillon B. et al. Steroid aerosoles anc cataract formatio // Br. Med. J. — 1989. — Vol. 299. — P. 432—433.Toogood J.H., Crilly R.G., Jones G. et al. Effect of high dose inhaled budesonide on calcium and phosphate metabolism and thf risk of osteoporosis // Am. Rev. Respir. Dis. — 1988. — Vol. 138. - P. 57—61.Toogood J.H., Crilly R.G., Jones G. et al. Effect of high dose inhaled budesonide on calcium and phosphate metabolism and thf risk of osteoporosis // Am. Rev. Respir. Dis. — 1988. — Vol. 138. - P. 57—61.Toogood J.H., Jennings B., Greenway R.W., Chung L. Candidi asis and dysphonia complicating beclomethasone treatment o asthma // J. Allergy Clin. Immunol. — 1980. — Vol. 65. - P. 145—153.Toogood J.H., Jennings B., Greenway R.W., Chung L. Candidi asis and dysphonia complicating beclomethasone treatment o asthma // J. Allergy Clin. Immunol. — 1980. — Vol. 65. - P. 145—153.Salsman G.A., Mszczynski D.R. Oropharyngeal candidiasis ir patients treated with beclomethasone delivered by metered — dost inhaler alone and with aerochamber // J. Allergy Clin. Immunol. — 1988. — Vol. 81. — P. 424—428.Salsman G.A., Mszczynski D.R. Oropharyngeal candidiasis ir patients treated with beclomethasone delivered by metered — dost inhaler alone and with aerochamber // J. Allergy Clin. Immunol. — 1988. — Vol. 81. — P. 424—428.Siewert W., Holmes P., King R.W.F. Oesophageal candidosis it patients on high-dose inhaler steroids // Lancet. — 1992. - Vol. 339. — P. 1551—1552.Siewert W., Holmes P., King R.W.F. Oesophageal candidosis it patients on high-dose inhaler steroids // Lancet. — 1992. - Vol. 339. — P. 1551—1552.
The authors declare that there are no conflicts of interest present.