pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2022-32-6-876-884pulmo-3419Research ArticleОБЗОРЫREVIEWРоль микробиома верхних дыхательных путей в здоровье человека: барьерная функцияThe upper respiratory tract microbiome and its role in human health: barrier functionhttps://orcid.org/0000-0001-6582-210XСтариковаЕ. В.StarikovaE. V.

Старикова Елизавета Валентиновна - младший научный сотрудник лаборатории геномных исследований и вычислительной биологии.

119435, Москва, ул. Малая Пироговская, 1А

тел.: (499) 245-04-71

SPIN-код: 2230-9387

Elizaveta V. Starikova - Researcher, Laboratory of Genomic Research and Computational Biology, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency.

Malaya Pirogovskaya ul. 1A, Moscow, 119435

tel.: (499) 245-04-71

estarikova@rcpcm.orghttps://orcid.org/0000-0001-6304-4607ГалееваЮ. С.GaleevaYu. S.

Галеева Юлия Сергеевна - лаборант-исследователь лаборатории геномных исследований и вычислительной биологии.

119435, Москва, ул. Малая Пироговская, 1А

тел.: (499) 245-04-71

Yuliya S. Galeeva - Research Assistant at Laboratory of Genomic Research and Computational Biology, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency.

Malaya Pirogovskaya ul. 1A, Moscow, 119435

tel.: (499) 245-04-71

galeeva.yu@rcpcm.orghttps://orcid.org/0000-0003-0130-5079ИльинаЕ. Н.Il’inaE. N.

Ильина Елена Николаевна – доктор биологических наук, профессор, член-корреспондент Российской академии наук, заведующая лабораторией геномных исследований и вычислительной биологии, заместитель директора по науке ФНКЦ ФХМ ФМБА.

119435, Москва, ул. Малая Пироговская, 1А

тел.: (499) 245-04-71

Elena N. Il’ina - Doctor of Biology, Professor, Corresponding Member of Russian Academy of Sciences, Head of Laboratory of Genomic Studies and Computational Biology, Deputy Director for Science, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency.

Malaya Pirogovskaya ul. 1A, Moscow, 119435

tel.: (499) 245-04-71

ilinaen@gmail.comФедеральный научно-клинический центр физико-химической медицины Федерального медико-биологического агентстваРоссияFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological AgencyRussian Federation202211122022326876884Copyright © Старикова Е.В., Галеева Ю.С., Ильина Е.Н., 20222022Старикова Е.В., Галеева Ю.С., Ильина Е.Н.Starikova E.V., Galeeva Y.S., Il’ina E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/3419

Дыхательные пути человека представляют собой сложную систему с собственным микробным профилем. До недавнего времени основной интерес научного сообщества вызывали микробные сообщества легких, ассоциированные с различными заболеваниями. В свете пандемии COVID-19 (COronaVIrus Disease 2019) внимание сфокусировалось на микробиоте верхних дыхательных путей (ВДП), которая, как предполагается, может являться одним из факторов, оказывающих влияние на течение вирусных инфекций. Целью обзора, состоящего из 2 частей, явились сбор и анализ известной к настоящему моменту информации о микробных сообществах каждого из отделов ВДП. Часть 2-я посвящена предположительной барьерной функции респираторной микробиоты. Заключение. Приведенные данные позволяют рассматривать микробные сообщества дыхательных путей в качестве участников патогенеза респираторных вирусных инфекций, в т. ч. SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2).

The human respiratory tract is a complex system characterized by a series of niches colonized with specific microbial communities. Until recently, researchers were mostly interested in lung microbiomes associated with acute and chronic infections. The upper respiratory tract microbiota has gained attention during COVID-19 (COronaVIrus Disease 2019) pandemic because it was suspected to influence the course and the outcome of viral infections. Aim. In this two-part review (see part 1, Pul’monolog;iya. 2022; 32 (5): 745-754), we summarize current knowledge of the microbial communities at each upper respiratory tract location, considering the proposed barrier function of the respiratory microbiome. Conclusion. Based on the evidence presented in this review, we can see how the respiratory microbiome is involved in the pathogenesis of viral respiratory infections, including SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2).

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The authors declare that there are no conflicts of interest present.