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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2011-0-3-101-107</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-338</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Функциональные ответы альвеолярных макрофагов, сурфактантный белок D и заболевания легких</article-title><trans-title-group xml:lang="en"><trans-title>Functions of alveolar macrophages and surfactant protein D in lung disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малышев</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Malyshev</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., проф., зав. лабораторией клеточных биотехнологий, зав. лабораторией стресса и адаптацией</p><p>127473, Москва, ул. Делегатская, 20 / 1</p><p>25315, Москва, ул. Балтийская, 8. Тел.: +7-985-766-24-40.</p></bio><email xlink:type="simple">igor.malyshev@mtu-net.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лямина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyamina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., старший научный сотрудник лаборатории клеточных биотехнологий</p><p>127473, Москва, ул. Делегатская, 20 / 1. Тел.: +7-915-018-50-06.</p></bio><email xlink:type="simple">svlvs@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шимшелашвили</surname><given-names>Ш. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shimshelashvili</surname><given-names>Sh. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ассистент кафедры госпитальной терапевтической стоматологии, пародонтологии и гериатрической стоматологии </p><p>127473, Москва, ул. Делегатская, 20 / 1. Тел.: +7-985-766-24-40.</p></bio><email xlink:type="simple">igor.malyshev@mtu-net.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вассерман</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasserman</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., старший научный сотрудник Школы медицины, отделения легочной и интенсивной терапии </p><p>Vernon and Shirley Hill Pavilion, # H410C 380 S. University Ave. Philadelphia, PA 19104-4539. Тел.: +7-985-766-24-40.</p></bio><email xlink:type="simple">igor.maly-shev@mtu-net.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГОУ ВПО "Московский государственный медико-стоматологический университет Федерального агентства по здравоохранению и социальному развитию"; НИИ общей патологии и патофизиологии РАМН</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>ГОУ ВПО "Московский государственный медико-стоматологический университет Федерального агентства по здравоохранению и социальному развитию"</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Пенсильванский университет</institution><country>United States</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2011</year></pub-date><volume>0</volume><issue>3</issue><fpage>101</fpage><lpage>107</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Малышев И.Ю., Лямина С.В., Шимшелашвили Ш.Л., Вассерман Е.Н., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Малышев И.Ю., Лямина С.В., Шимшелашвили Ш.Л., Вассерман Е.Н.</copyright-holder><copyright-holder xml:lang="en">Malyshev I.Y., Lyamina S.V., Shimshelashvili S.L., Vasserman E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/338">https://journal.pulmonology.ru/pulm/article/view/338</self-uri><abstract><p>Функциональные ответы альвеолярных макрофагов, сурфактантный белок D и заболевания легких.</p></abstract><trans-abstract xml:lang="en"><p>Functions of alveolar macrophages and surfactant protein D in lung disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>макрофаги</kwd><kwd>фенотипы макрофагов</kwd><kwd>репрограммирование</kwd><kwd>сурфактантный белок D</kwd><kwd>заболевания легких</kwd></kwd-group><kwd-group xml:lang="en"><kwd>macrophages</kwd><kwd>macrophage phenotype</kwd><kwd>reprogramming</kwd><kwd>surfactant protein D</kwd><kwd>lung disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Чучалин А.Г. (ред.). Стандарты по диагностике и лечению больных хронической обструктивной болезнью легких (ATS / ERS, пересмотр 2004 г.). Пер. с англ. М.: Атмосфера; 2005.</mixed-citation><mixed-citation xml:lang="en">Чучалин А.Г. (ред.). Стандарты по диагностике и лечению больных хронической обструктивной болезнью легких (ATS / ERS, пересмотр 2004 г.). Пер. с англ. М.: Атмосфера; 2005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Хаитов Р.М. Иммунология: Учебник. М.: ГЭОТАР-Медиа; 2006.</mixed-citation><mixed-citation xml:lang="en">Хаитов Р.М. Иммунология: Учебник. М.: ГЭОТАР-Медиа; 2006.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Janeway C.A., Travers P., Walport M., Shlomchik M. Immunobiology. The immune system in health and disease: New York: Garland Science Publishing, 2005.</mixed-citation><mixed-citation xml:lang="en">Janeway C.A., Travers P., Walport M., Shlomchik M. Immunobiology. The immune system in health and disease: New York: Garland Science Publishing, 2005.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani A., Sica A., Sozzani S. et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004; 25: 677–686.</mixed-citation><mixed-citation xml:lang="en">Mantovani A., Sica A., Sozzani S. et al. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004; 25: 677–686.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani A. Macrophage diversity and polarization: in vivo veritas. Blood 2006; 108 (2): 408–409.</mixed-citation><mixed-citation xml:lang="en">Mantovani A. Macrophage diversity and polarization: in vivo veritas. Blood 2006; 108 (2): 408–409.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani A., Sica A., Locatti A. New vistas on macrophage differentiation and activation. Eur. J. Immunol. 2006; 37 (1): 14–16.</mixed-citation><mixed-citation xml:lang="en">Mantovani A., Sica A., Locatti A. New vistas on macrophage differentiation and activation. Eur. J. Immunol. 2006; 37 (1): 14–16.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Ann. Rev. Immunol. 1997; 15: 749–795.</mixed-citation><mixed-citation xml:lang="en">Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-gamma. Ann. Rev. Immunol. 1997; 15: 749–795.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma M. Chemokines and their receptors: orchestrating a fine balance between health and disease. Crit. Rev. Biotechnol. 2010; 30: 1–22.</mixed-citation><mixed-citation xml:lang="en">Sharma M. Chemokines and their receptors: orchestrating a fine balance between health and disease. Crit. Rev. Biotechnol. 2010; 30: 1–22.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Trost M., English L., Limieux S. et al. The phagosomal proteome in interferon-?-activated macrophages. Immunity 2009; 30 (1): 143–154.</mixed-citation><mixed-citation xml:lang="en">Trost M., English L., Limieux S. et al. The phagosomal proteome in interferon-?-activated macrophages. Immunity 2009; 30 (1): 143–154.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson S. Novel nonantibiotic therapies for pneumonia. Cytokines and host defence. Chest 2001; 119 (2): 419S–425S.</mixed-citation><mixed-citation xml:lang="en">Nelson S. Novel nonantibiotic therapies for pneumonia. Cytokines and host defence. Chest 2001; 119 (2): 419S–425S.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez F.O., Gordon S., Locati A., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. J. Immunol. 2006; 177: 7303–7311.</mixed-citation><mixed-citation xml:lang="en">Martinez F.O., Gordon S., Locati A., Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: New molecules and patterns of gene expression. J. Immunol. 2006; 177: 7303–7311.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Kaplan A.P. Chemokines, chemokine receptors and allergy. Int. Arch. Allergy Immunol. 2001; 124 (4): 423–431.</mixed-citation><mixed-citation xml:lang="en">Kaplan A.P. Chemokines, chemokine receptors and allergy. Int. Arch. Allergy Immunol. 2001; 124 (4): 423–431.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Falcone F.H., Haas H., Gibbs B.F. The human basophil: a new appreciation of its role in immune responses. Blood 2000; 96 (13): 4028–4038.</mixed-citation><mixed-citation xml:lang="en">Falcone F.H., Haas H., Gibbs B.F. The human basophil: a new appreciation of its role in immune responses. Blood 2000; 96 (13): 4028–4038.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">D'Andrea A., Aste5Amezaga M., Valiante N.M. et al. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor / IL-12 synthesis in accessory cells. J. Exp. Med. 1993; 178 (3): 1041–1048.</mixed-citation><mixed-citation xml:lang="en">D'Andrea A., Aste5Amezaga M., Valiante N.M. et al. Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor / IL-12 synthesis in accessory cells. J. Exp. Med. 1993; 178 (3): 1041–1048.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hu S., Sheng W.S., Peterson P.K., Chao C.C. Differential regulation by cytokines of production of nitric oxide by human astrocytes. Glia 1995; 15: 491–494.</mixed-citation><mixed-citation xml:lang="en">Hu S., Sheng W.S., Peterson P.K., Chao C.C. Differential regulation by cytokines of production of nitric oxide by human astrocytes. Glia 1995; 15: 491–494.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon S. The macrophage: Past, present and future. Eur. J. Immunol. 2007; 37: S9.</mixed-citation><mixed-citation xml:lang="en">Gordon S. The macrophage: Past, present and future. Eur. J. Immunol. 2007; 37: S9.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front. Biosci. 2008; 1 (13): 453–461.</mixed-citation><mixed-citation xml:lang="en">Martinez F.O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization. Front. Biosci. 2008; 1 (13): 453–461.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sieling P.A., Abrams J.S., Yamamura M. et al. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J. Immunol. 1993; 150 (12): 5501–5510.</mixed-citation><mixed-citation xml:lang="en">Sieling P.A., Abrams J.S., Yamamura M. et al. Immunosuppressive roles for IL-10 and IL-4 in human infection. In vitro modulation of T cell responses in leprosy. J. Immunol. 1993; 150 (12): 5501–5510.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Oosterhout A.J.M., Motta A.C. Th1 / Th2 paradigm: not seeing the forest for the trees? Eur. Respir. J. 2005; 25: 591–593.</mixed-citation><mixed-citation xml:lang="en">Oosterhout A.J.M., Motta A.C. Th1 / Th2 paradigm: not seeing the forest for the trees? Eur. Respir. J. 2005; 25: 591–593.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani A., Sozzani S., Locati M. et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002; 23 (11): 549–555.</mixed-citation><mixed-citation xml:lang="en">Mantovani A., Sozzani S., Locati M. et al. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002; 23 (11): 549–555.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fritz J., Murphy B.S., Sundareshan V. et al. M1 and M2 Macrophage activation. Azithromycin alters macrophage phenotype. J. Antimicrob. Chemother. 2008; 61 (3): 554–560.</mixed-citation><mixed-citation xml:lang="en">Fritz J., Murphy B.S., Sundareshan V. et al. M1 and M2 Macrophage activation. Azithromycin alters macrophage phenotype. J. Antimicrob. Chemother. 2008; 61 (3): 554–560.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Atochina E.N., Beck J.M., Scanlon S.T. et al. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. J. Lab. Clin. Med. 2001; 137: 429–39.</mixed-citation><mixed-citation xml:lang="en">Atochina E.N., Beck J.M., Scanlon S.T. et al. Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D. J. Lab. Clin. Med. 2001; 137: 429–39.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Atochina E.N., Beers M.F., Hawgood S. et al. Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. Am. J. Respir. Cell Mol. Biol. 2004; 30: 271–279.</mixed-citation><mixed-citation xml:lang="en">Atochina E.N., Beers M.F., Hawgood S. et al. Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. Am. J. Respir. Cell Mol. Biol. 2004; 30: 271–279.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng G., Ueda T., Numao T. et al. Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma. Eur. Respir. J. 2000; 16: 831–835.</mixed-citation><mixed-citation xml:lang="en">Cheng G., Ueda T., Numao T. et al. Increased levels of surfactant protein A and D in bronchoalveolar lavage fluids in patients with bronchial asthma. Eur. Respir. J. 2000; 16: 831–835.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Cheng I.W., Ware L.B., Greene K.E. et al. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003; 31: 20–27.</mixed-citation><mixed-citation xml:lang="en">Cheng I.W., Ware L.B., Greene K.E. et al. Prognostic value of surfactant proteins A and D in patients with acute lung injury. Crit. Care Med. 2003; 31: 20–27.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Eisner M.D., Parsons P., Matthay M.A. et al. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax 2003; 58: 983–988.</mixed-citation><mixed-citation xml:lang="en">Eisner M.D., Parsons P., Matthay M.A. et al. Plasma surfactant protein levels and clinical outcomes in patients with acute lung injury. Thorax 2003; 58: 983–988.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Fujita M., Shannon J.M., Ouchi H. et al. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 2005; 31: 25–33.</mixed-citation><mixed-citation xml:lang="en">Fujita M., Shannon J.M., Ouchi H. et al. Serum surfactant protein D is increased in acute and chronic inflammation in mice. Cytokine 2005; 31: 25–33.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kuan S., Rust K., Crouch E. Interactions of surfactant protein D with bacterial lipopolysaccharides. J. Clin. Invest. 1992; 90: 97–106.</mixed-citation><mixed-citation xml:lang="en">Kuan S., Rust K., Crouch E. Interactions of surfactant protein D with bacterial lipopolysaccharides. J. Clin. Invest. 1992; 90: 97–106.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Wright J.R. Immunomodulatory functions of surfactant. Physiol. Rev. 1997; 77: 931–962.</mixed-citation><mixed-citation xml:lang="en">Wright J.R. Immunomodulatory functions of surfactant. Physiol. Rev. 1997; 77: 931–962.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Crouch E.C. Structure, biologic properties and expression of surfactant protein D. Biochim. Biophys. Acta 1998; 1408: 278–289.</mixed-citation><mixed-citation xml:lang="en">Crouch E.C. Structure, biologic properties and expression of surfactant protein D. Biochim. Biophys. Acta 1998; 1408: 278–289.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sorensen G.L., Husby S., Holmskov U. Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology 2007; 212 (4–5): 381–416.</mixed-citation><mixed-citation xml:lang="en">Sorensen G.L., Husby S., Holmskov U. Surfactant protein A and surfactant protein D variation in pulmonary disease. Immunobiology 2007; 212 (4–5): 381–416.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Sin D.D., Pahlavan P.S., Man P.S.P. Surfactant protein D: A lung specific biomarker in COPD?: Potential biological roles of SP-D in COPD. Ther. Adv. Respir Dis. 2008; 2 (2): 65–74.</mixed-citation><mixed-citation xml:lang="en">Sin D.D., Pahlavan P.S., Man P.S.P. Surfactant protein D: A lung specific biomarker in COPD?: Potential biological roles of SP-D in COPD. Ther. Adv. Respir Dis. 2008; 2 (2): 65–74.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Fisher J.H., Larson J., Cool C., Dow S.W. Lymphocyte activation in the lungs of SP-D null mice. Am. J. Respir. Cell. Mol. Biol. 2002; 27: 24–33.</mixed-citation><mixed-citation xml:lang="en">Fisher J.H., Larson J., Cool C., Dow S.W. Lymphocyte activation in the lungs of SP-D null mice. Am. J. Respir. Cell. Mol. Biol. 2002; 27: 24–33.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Botas C.F., Poulain J., Akiyama J. et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc. Natl. Acad. Sci. USA 1998; 95:11869–11874.</mixed-citation><mixed-citation xml:lang="en">Botas C.F., Poulain J., Akiyama J. et al. Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D. Proc. Natl. Acad. Sci. USA 1998; 95:11869–11874.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Wert S.E., Yoshida M., LeVine A.M. et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc. Natl. Acad. Sci. USA 1997; 97: 5972–5977.</mixed-citation><mixed-citation xml:lang="en">Wert S.E., Yoshida M., LeVine A.M. et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc. Natl. Acad. Sci. USA 1997; 97: 5972–5977.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Korfhagen T.R., Sheftelyevich V., Burhans M.S. et al. Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J. Biol. Chem. 1998; 273: 28438–28443.</mixed-citation><mixed-citation xml:lang="en">Korfhagen T.R., Sheftelyevich V., Burhans M.S. et al. Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo. J. Biol. Chem. 1998; 273: 28438–28443.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Yoshida M., Korfhagen Th.R., Whitsett J.A. Surfactant protein D regulates NF-κB and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J. Immunol. 2001; 166: 7514–7519.</mixed-citation><mixed-citation xml:lang="en">Yoshida M., Korfhagen Th.R., Whitsett J.A. Surfactant protein D regulates NF-κB and matrix metalloproteinase production in alveolar macrophages via oxidant-sensitive pathways. J. Immunol. 2001; 166: 7514–7519.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">LeVine A.M., Whitsett J.A., Gwozdz J.A. et al. Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J. Immunol. 2000; 165: 3934–3940.</mixed-citation><mixed-citation xml:lang="en">LeVine A.M., Whitsett J.A., Gwozdz J.A. et al. Distinct effects of surfactant protein A or D deficiency during bacterial infection on the lung. J. Immunol. 2000; 165: 3934–3940.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Gardai S.J., Xiao Y.5Q., Dickinson M. et al. By binding SIRP-alpha or calreticulin / CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003; 115: 13–23.</mixed-citation><mixed-citation xml:lang="en">Gardai S.J., Xiao Y.5Q., Dickinson M. et al. By binding SIRP-alpha or calreticulin / CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation. Cell 2003; 115: 13–23.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Atochina5Vasserman E.N., Kadire H., Tomer Y. et al. Selective inhibition of iNOS activity in vivo reverses inflammatory abnormalities in SP-D deficient mice. J. Immunol. 2007; 179 (12): 8090–8097.</mixed-citation><mixed-citation xml:lang="en">Atochina5Vasserman E.N., Kadire H., Tomer Y. et al. Selective inhibition of iNOS activity in vivo reverses inflammatory abnormalities in SP-D deficient mice. J. Immunol. 2007; 179 (12): 8090–8097.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Atochina5Vasserman E.N., Abramova E.V., Tomer Y. et al. SP-D-Dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages. Bull. Exp. Biol. Med. 2009; 147 (4): 415–420.</mixed-citation><mixed-citation xml:lang="en">Atochina5Vasserman E.N., Abramova E.V., Tomer Y. et al. SP-D-Dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages. Bull. Exp. Biol. Med. 2009; 147 (4): 415–420.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Sano H., Kuroki Y. The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity. Mol. Immunol. 2005; 42 (3): 279–287.</mixed-citation><mixed-citation xml:lang="en">Sano H., Kuroki Y. The lung collectins, SP-A and SP-D, modulate pulmonary innate immunity. Mol. Immunol. 2005; 42 (3): 279–287.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Guo C.J., Atochina5Vasserman E.N., Abramova H. et al. S-Nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biol. 2008; 6 (11): e266.</mixed-citation><mixed-citation xml:lang="en">Guo C.J., Atochina5Vasserman E.N., Abramova H. et al. S-Nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biol. 2008; 6 (11): e266.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang L., Ikegami M., Crouch E.C. et al. Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure. J. Biol. Chem. 2001; 276 (22): 19214–19219.</mixed-citation><mixed-citation xml:lang="en">Zhang L., Ikegami M., Crouch E.C. et al. Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure. J. Biol. Chem. 2001; 276 (22): 19214–19219.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Guo C.J., Rashman C.S., Wolf B.A., Gow A.J. S-Nitrosylation of surfactant protein-D provides a molecular switch from anti- to pro-inflammatory function. Nitric Oxide 2006; 14 (4): 6.</mixed-citation><mixed-citation xml:lang="en">Guo C.J., Rashman C.S., Wolf B.A., Gow A.J. S-Nitrosylation of surfactant protein-D provides a molecular switch from anti- to pro-inflammatory function. Nitric Oxide 2006; 14 (4): 6.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">McCormack F.X., Whitsett J.A. The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J. Clin. Invest 2002; 109 (6): 707–712.</mixed-citation><mixed-citation xml:lang="en">McCormack F.X., Whitsett J.A. The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung. J. Clin. Invest 2002; 109 (6): 707–712.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Bartlett J.G., Breiman R.F., Mandell L.A. et al. Communityacquired pneumonia in adults-guidelines for management. Clin. Infect. Dis. 1998; 26: 811–838.</mixed-citation><mixed-citation xml:lang="en">Bartlett J.G., Breiman R.F., Mandell L.A. et al. Communityacquired pneumonia in adults-guidelines for management. Clin. Infect. Dis. 1998; 26: 811–838.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bufler P., Schikor D., Schmidt B., Griese M. Cytokine stimulation by Pseudomonas aeruginosa strain variation and modulation by pulmonary surfactant. Exp. Lung Res. 2004; 30 (3): 163–179.</mixed-citation><mixed-citation xml:lang="en">Bufler P., Schikor D., Schmidt B., Griese M. Cytokine stimulation by Pseudomonas aeruginosa strain variation and modulation by pulmonary surfactant. Exp. Lung Res. 2004; 30 (3): 163–179.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Lofdahl M., Wahlstorm J., Skold C.M. Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. Clin. Exp. Immunol. 2006; 145 (3): 428–437.</mixed-citation><mixed-citation xml:lang="en">Lofdahl M., Wahlstorm J., Skold C.M. Different inflammatory cell pattern and macrophage phenotype in chronic obstructive pulmonary disease patients, smokers and non-smokers. Clin. Exp. Immunol. 2006; 145 (3): 428–437.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Pons A.R., Noguera A., Blanquer D. et al. Phenotypic characterization of alveolar macrophages and peripheral blood monocytes in COPD. Eur. Respir. J. 2005; 25 (4): 647–652.</mixed-citation><mixed-citation xml:lang="en">Pons A.R., Noguera A., Blanquer D. et al. Phenotypic characterization of alveolar macrophages and peripheral blood monocytes in COPD. Eur. Respir. J. 2005; 25 (4): 647–652.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Shaykhiev R., Krause A., Salit J. et al. Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J. Immunol. 2009; 183: 2867–2883.</mixed-citation><mixed-citation xml:lang="en">Shaykhiev R., Krause A., Salit J. et al. Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J. Immunol. 2009; 183: 2867–2883.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Лещенко И.В. Глобальная инициатива по хронической обструктивной болезни легких: новые направления в лечении. Урал. мед. Журн. 2006; 8 (36).</mixed-citation><mixed-citation xml:lang="en">Лещенко И.В. Глобальная инициатива по хронической обструктивной болезни легких: новые направления в лечении. Урал. мед. Журн. 2006; 8 (36).</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Sethi S., Maloney J., Grove L. et al. Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Res. Med. COPD Update 2006; 1 (4): 144–145.</mixed-citation><mixed-citation xml:lang="en">Sethi S., Maloney J., Grove L. et al. Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease. Res. Med. COPD Update 2006; 1 (4): 144–145.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Доклад экспертов ВОЗ; 2005.</mixed-citation><mixed-citation xml:lang="en">Доклад экспертов ВОЗ; 2005.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Woodruff P.G., Modrek B., Choy D.F. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009; 180 (5): 388–395.</mixed-citation><mixed-citation xml:lang="en">Woodruff P.G., Modrek B., Choy D.F. et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009; 180 (5): 388–395.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Шмелев Е.И. Дифференциальная диагностика интерстициальных заболеваний легких. Consilium Medicum 2003; 5 (4): 176–181.</mixed-citation><mixed-citation xml:lang="en">Шмелев Е.И. Дифференциальная диагностика интерстициальных заболеваний легких. Consilium Medicum 2003; 5 (4): 176–181.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Kunitake R., Kuwano K., Yoshida K. et al. KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Respiration 2001; 68: 488–495.</mixed-citation><mixed-citation xml:lang="en">Kunitake R., Kuwano K., Yoshida K. et al. KL-6, surfactant protein A and D in bronchoalveolar lavage fluid from patients with pulmonary sarcoidosis. Respiration 2001; 68: 488–495.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Kucejko W., Chyczewska E., Naumnik W., Ossolinska M. Concentration of surfactant protein D, Clara cell protein CC-16 and IL-10 in bronchoalveolar lavage (BAL) in patients with sarcoidosis, hypersensivity pneumonitis and idiopathic pulmonary fibrosis. Folia Histochem. Cytobiol. 2009; 47 (2): 225–230.</mixed-citation><mixed-citation xml:lang="en">Kucejko W., Chyczewska E., Naumnik W., Ossolinska M. Concentration of surfactant protein D, Clara cell protein CC-16 and IL-10 in bronchoalveolar lavage (BAL) in patients with sarcoidosis, hypersensivity pneumonitis and idiopathic pulmonary fibrosis. Folia Histochem. Cytobiol. 2009; 47 (2): 225–230.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Zissel G., Prasse A., Muller5Quernheim J. Sarcoidosisimmunopathogenetic concepts. J. Semin. Respir. Crit. Care Med. 2007; 28 (1): 3–14.</mixed-citation><mixed-citation xml:lang="en">Zissel G., Prasse A., Muller5Quernheim J. Sarcoidosisimmunopathogenetic concepts. J. Semin. Respir. Crit. Care Med. 2007; 28 (1): 3–14.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Prasse A., Georges C.G., Biller H. et al. Тh1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4+ and CD8+ T cells. Clin. Exp. Immunol. 2000; 122 (2): 241–248.</mixed-citation><mixed-citation xml:lang="en">Prasse A., Georges C.G., Biller H. et al. Тh1 cytokine pattern in sarcoidosis is expressed by bronchoalveolar CD4+ and CD8+ T cells. Clin. Exp. Immunol. 2000; 122 (2): 241–248.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
