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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pulmo-3345</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Молекулярные и клеточные механизмы иммунопатологии при бронхиальной астме</article-title><trans-title-group xml:lang="en"><trans-title>Immunopathology molecular and cellular mechanisms for bronchial asthma patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Потапнев</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Potapnev</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Печковский</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pechkovsky</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>НИИ гематологии и переливания крови М3 РБ;&#13;
НИИ пульмонологии и фтизиатрии М3 РБ</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>1997</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>1997</year></pub-date><volume>0</volume><issue>3</issue><fpage>74</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Потапнев М.П., Печковский Д.В., 1997</copyright-statement><copyright-year>1997</copyright-year><copyright-holder xml:lang="ru">Потапнев М.П., Печковский Д.В.</copyright-holder><copyright-holder xml:lang="en">Potapnev M.P., Pechkovsky D.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/3345">https://journal.pulmonology.ru/pulm/article/view/3345</self-uri><abstract><p>.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Беклемишев Н.Д. Т-хелпер 2 — ключевая клетка противометазойного иммунитета и реакций аллергии немедленного типа / / Иммунология.— 1995.— № 5.— С.4 — 9.</mixed-citation><mixed-citation xml:lang="en">Беклемишев Н.Д. Т-хелпер 2 — ключевая клетка противометазойного иммунитета и реакций аллергии немедленного типа / / Иммунология.— 1995.— № 5.— С.4 — 9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Бронхиальная астма. Глобальная стратегия. Совместный доклад Н И З (СШ А) и В О З (1993) / / Пульмонология .— 1996.— Приложение.— С.2—8.</mixed-citation><mixed-citation xml:lang="en">Бронхиальная астма. Глобальная стратегия. Совместный доклад Н И З (СШ А) и В О З (1993) / / Пульмонология .— 1996.— Приложение.— С.2—8.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Воспаление / Под ред. В.В. Серова, B.C. Паукова.— М.: Медицина, 1995.— 640 с.</mixed-citation><mixed-citation xml:lang="en">Воспаление / Под ред. В.В. Серова, B.C. Паукова.— М.: Медицина, 1995.— 640 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Медуницын Н.В. Цитокины и аллергия, опосредованная IgE / / Иммунология.— 1993.— № 5.— С . 11 — 13.</mixed-citation><mixed-citation xml:lang="en">Медуницын Н.В. Цитокины и аллергия, опосредованная IgE / / Иммунология.— 1993.— № 5.— С . 11 — 13.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Потапнев М.П. Цитокиновая сеть нейтрофилов при воспалении / / Там ж е .— 1995.— № 4.— С.34 — 40.</mixed-citation><mixed-citation xml:lang="en">Потапнев М.П. Цитокиновая сеть нейтрофилов при воспалении / / Там ж е .— 1995.— № 4.— С.34 — 40.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ackerman V., Marini М., Vittori Е. et al. Detection of cytokines and their sources in bronchial biopsy specim ents from asthmatic patients. Relationship to atopic status, symptoms, and level of airway hyperresponsiveness / / Chest.— 1994.— Vol.105, № 3 . — P.687—696.</mixed-citation><mixed-citation xml:lang="en">Ackerman V., Marini М., Vittori Е. et al. Detection of cytokines and their sources in bronchial biopsy specim ents from asthmatic patients. Relationship to atopic status, symptoms, and level of airway hyperresponsiveness / / Chest.— 1994.— Vol.105, № 3 . — P.687—696.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Agostini C., Sancetta R., Cerutti A. et al. Alveoiar macrophages as a cell source of cytokine hyperproduction in HIV-related lung disease / / J. Leukoc. Biol.— 1995.— Vol.58, № 5.— P.495—500.</mixed-citation><mixed-citation xml:lang="en">Agostini C., Sancetta R., Cerutti A. et al. Alveoiar macrophages as a cell source of cytokine hyperproduction in HIV-related lung disease / / J. Leukoc. Biol.— 1995.— Vol.58, № 5.— P.495—500.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Alatn R., York J., Boyars M. et al. Increased MCP-1, RANTES and M I P - la in bronchoalveoiar fluid of allergic asthmatic patients / / Am. J. Respir. Crit. Care M ed .— 1996.— Vol. 153, № 4.— P.1398—1404.</mixed-citation><mixed-citation xml:lang="en">Alatn R., York J., Boyars M. et al. Increased MCP-1, RANTES and M I P - la in bronchoalveoiar fluid of allergic asthmatic patients / / Am. J. Respir. Crit. Care M ed .— 1996.— Vol. 153, № 4.— P.1398—1404.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bissonnette E.Y. Histamine inhibits tumor necrosis factor # a release by mast cells through H2 and H3 receptors / / Am. J. Respir. Cell. Mol. Biol.— 1996.— Vol. 14, № 6.— P.620—626.</mixed-citation><mixed-citation xml:lang="en">Bissonnette E.Y. Histamine inhibits tumor necrosis factor # a release by mast cells through H2 and H3 receptors / / Am. J. Respir. Cell. Mol. Biol.— 1996.— Vol. 14, № 6.— P.620—626.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bradding P., Roberts J.A., Britten К.M. et al. Interleukin-4, -5 and -6 and tu m o r necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines / / Ibid.— 1994.— V ol.10, № 5.— P.471—480.</mixed-citation><mixed-citation xml:lang="en">Bradding P., Roberts J.A., Britten К.M. et al. Interleukin-4, -5 and -6 and tu m o r necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines / / Ibid.— 1994.— V ol.10, № 5.— P.471—480.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Corticosteroid action and resistancein asthm a / / Am. J. Respir. Crit. Care Med.— 1996.— Vol.154, № 2.— Pt 2, Suppl.— P.s79.</mixed-citation><mixed-citation xml:lang="en">Corticosteroid action and resistancein asthm a / / Am. J. Respir. Crit. Care Med.— 1996.— Vol.154, № 2.— Pt 2, Suppl.— P.s79.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cox G., Gauldie J., Jordana M. Bronchial epithelial cell-derived cytokines (G-CSF and GM-CSF) promote the survival of peripheral blood neutrophils in vitro / / Am. J. Respir. Cell. Mol. Bioi.— 1992.— Vol.7, № 5.— P.507—513.</mixed-citation><mixed-citation xml:lang="en">Cox G., Gauldie J., Jordana M. Bronchial epithelial cell-derived cytokines (G-CSF and GM-CSF) promote the survival of peripheral blood neutrophils in vitro / / Am. J. Respir. Cell. Mol. Bioi.— 1992.— Vol.7, № 5.— P.507—513.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Czarny D. Asthma and allergy. What is the connection? / / Aust. Fam. Physician.— 1993.— Vol.22, № 11.— P. 1967—1970.</mixed-citation><mixed-citation xml:lang="en">Czarny D. Asthma and allergy. What is the connection? / / Aust. Fam. Physician.— 1993.— Vol.22, № 11.— P. 1967—1970.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Djukanovic R., Wilson J.W., Britten K.M. et al. Quantitation of mast cell and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochem istry / / Am. Rev. Respir. Dis.— 1990.— Vol. 142, № 4.— P.863—871.</mixed-citation><mixed-citation xml:lang="en">Djukanovic R., Wilson J.W., Britten K.M. et al. Quantitation of mast cell and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochem istry / / Am. Rev. Respir. Dis.— 1990.— Vol. 142, № 4.— P.863—871.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Erb K.J., Le Gros G. The role of Th2 type C D 4+ T cells and TH2 type CDS’1' cells in asthma / / Immunol. Cell. Biol.— 1996.— Vol.74. № 2.— P.206—208.</mixed-citation><mixed-citation xml:lang="en">Erb K.J., Le Gros G. The role of Th2 type C D 4+ T cells and TH2 type CDS’1' cells in asthma / / Immunol. Cell. Biol.— 1996.— Vol.74. № 2.— P.206—208.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuda T., Asakawa J., Motojima S., Makino S. Cyclosporine A reduces T lymphocyte activity and improves airway hyperresponsiveness in corticosteroid-dependent chronic severe asthma / / Ann. Allergy A sthm a Immunol.— 1995.— Vol.75, № 1.— P.65—72.</mixed-citation><mixed-citation xml:lang="en">Fukuda T., Asakawa J., Motojima S., Makino S. Cyclosporine A reduces T lymphocyte activity and improves airway hyperresponsiveness in corticosteroid-dependent chronic severe asthma / / Ann. Allergy A sthm a Immunol.— 1995.— Vol.75, № 1.— P.65—72.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuda T., Fukushima Y., Numao T. et al. Role of IL-4 and Vascullar Cell Adhesion Molecuie-1 in selective eosinophil migration into the airways in allergic asthma / / Am. j. Respir. Cell Mol. Biol.— 1996.— Vol.14, № 1.— P.84—94.</mixed-citation><mixed-citation xml:lang="en">Fukuda T., Fukushima Y., Numao T. et al. Role of IL-4 and Vascullar Cell Adhesion Molecuie-1 in selective eosinophil migration into the airways in allergic asthma / / Am. j. Respir. Cell Mol. Biol.— 1996.— Vol.14, № 1.— P.84—94.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Gagro A., Ratatic S. Allergen-induced CD23 on CD4^ T lymphocytes and CD21 in B lymphocytes in patients with allergic asthma: evidence and regulation / / Eur. J. Immunol.— 1994.— Vol.24, № 5.— P.l109—1114.</mixed-citation><mixed-citation xml:lang="en">Gagro A., Ratatic S. Allergen-induced CD23 on CD4^ T lymphocytes and CD21 in B lymphocytes in patients with allergic asthma: evidence and regulation / / Eur. J. Immunol.— 1994.— Vol.24, № 5.— P.l109—1114.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Garlisi C.G., Falcone A., Billah M.M., Egan R.W., Uinland S.P. Ncell are the predominant source of interleukin-5 but not interieukin-4 mRNA expression in the lungs of antigen-challenged allergic mice / / Am. J. Respir. Cell Mol. Biol.— 1996.— Vol. 15, № 3.— P.420—428.</mixed-citation><mixed-citation xml:lang="en">Garlisi C.G., Falcone A., Billah M.M., Egan R.W., Uinland S.P. Ncell are the predominant source of interleukin-5 but not interieukin-4 mRNA expression in the lungs of antigen-challenged allergic mice / / Am. J. Respir. Cell Mol. Biol.— 1996.— Vol. 15, № 3.— P.420—428.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Guidot D.M., Stevens E.E., Repine M.J. et al. Intratracheal but not intravascuiar interleukin-1 causes acute edemato us injury in isolated neutrophil — perfused lung through an oxygen radical — mediated mechanism / / J. Lab. Clin. Med.— 1994.— Vol. 123, No 4.— P.605—609.</mixed-citation><mixed-citation xml:lang="en">Guidot D.M., Stevens E.E., Repine M.J. et al. Intratracheal but not intravascuiar interleukin-1 causes acute edemato us injury in isolated neutrophil — perfused lung through an oxygen radical — mediated mechanism / / J. Lab. Clin. Med.— 1994.— Vol. 123, No 4.— P.605—609.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hallsworth M.P., Son C.P., Lane J.P. et al. Selective production of G M -C SF , TNF-alpha, IL-1 beta and IL-8 production by monocytes and macro phages of asthmatic subjects / / Eur. Respir. J.— 1994.— Vol.7, № 6 .— P. 1096—1102.</mixed-citation><mixed-citation xml:lang="en">Hallsworth M.P., Son C.P., Lane J.P. et al. Selective production of G M -C SF , TNF-alpha, IL-1 beta and IL-8 production by monocytes and macro phages of asthmatic subjects / / Eur. Respir. J.— 1994.— Vol.7, № 6 .— P. 1096—1102.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Holt P. Developmental immunology and host defense. Kinetics of postnatal maturation of immune competence as a potential etiologic factor in early chidhood asthma / / Am. J. Respir. Crit. Care Med .— 1995.— Vol.151, № 2.— P t 2, Suppl.— P. sll—sl3.</mixed-citation><mixed-citation xml:lang="en">Holt P. Developmental immunology and host defense. Kinetics of postnatal maturation of immune competence as a potential etiologic factor in early chidhood asthma / / Am. J. Respir. Crit. Care Med .— 1995.— Vol.151, № 2.— P t 2, Suppl.— P. sll—sl3.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Hope J.C., Dearman R.J., Kimber I., Hopkins S.J. Differential kinetics of IL-4 production by draining lymph node cells following topical exposure of mice to contact and respiratory allergens / / Cytokine.— 1995.— Vol.7, № 6.— P.629.</mixed-citation><mixed-citation xml:lang="en">Hope J.C., Dearman R.J., Kimber I., Hopkins S.J. Differential kinetics of IL-4 production by draining lymph node cells following topical exposure of mice to contact and respiratory allergens / / Cytokine.— 1995.— Vol.7, № 6.— P.629.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Hoshi H., Ohno I., Honma M. et a l. IL-5, IL-8 and GM -CSF im munostaining of sputum cells in bronchial asthma and chronic bronchitis / / Clin. exp. Allergy.— 1995.— Vol.25. № 8.— P.720—728.</mixed-citation><mixed-citation xml:lang="en">Hoshi H., Ohno I., Honma M. et a l. IL-5, IL-8 and GM -CSF im munostaining of sputum cells in bronchial asthma and chronic bronchitis / / Clin. exp. Allergy.— 1995.— Vol.25. № 8.— P.720—728.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Huang S.-K., Xiao H.-Q., Kleine-Tebbe J. et al. IL-13 expression at the sites of allergen challenge in patients with asthma / / J. Immunol.— 1995.— Vol. 155, № 5.— P.2688—2694.</mixed-citation><mixed-citation xml:lang="en">Huang S.-K., Xiao H.-Q., Kleine-Tebbe J. et al. IL-13 expression at the sites of allergen challenge in patients with asthma / / J. Immunol.— 1995.— Vol. 155, № 5.— P.2688—2694.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kaneko M., Swanson M.C., Gleich G.J., Kita H. Allergen-specific igG l and lgG3 through Fc gamma Rii induce eosinophil degranulation / / J. Clin. Invest.— 1995.— Vol.95, № 6.— P.2813—2821.</mixed-citation><mixed-citation xml:lang="en">Kaneko M., Swanson M.C., Gleich G.J., Kita H. Allergen-specific igG l and lgG3 through Fc gamma Rii induce eosinophil degranulation / / J. Clin. Invest.— 1995.— Vol.95, № 6.— P.2813—2821.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kline J.N., Hunninghake G.W. T-lympiiocyte dysregulation in asthma / / Proc. Soc. Exp. Biol. M e d .— 1994.— Vol.207, № 3.— P.243—253.</mixed-citation><mixed-citation xml:lang="en">Kline J.N., Hunninghake G.W. T-lympiiocyte dysregulation in asthma / / Proc. Soc. Exp. Biol. M e d .— 1994.— Vol.207, № 3.— P.243—253.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Knochel B., Luttman W., Forsster M., Matthys H., Virchow J.C., Kroegel C. Survivalenhancing activity of interleukin-13 in human eosinophils. Comparison to interleukin-4 and granuo cyte/m acrophage colony-stimulating factor / / Eur. Respir. J.— 1996.— Vol.9. Suppl.23.— P.450s (2792).</mixed-citation><mixed-citation xml:lang="en">Knochel B., Luttman W., Forsster M., Matthys H., Virchow J.C., Kroegel C. Survivalenhancing activity of interleukin-13 in human eosinophils. Comparison to interleukin-4 and granuo cyte/m acrophage colony-stimulating factor / / Eur. Respir. J.— 1996.— Vol.9. Suppl.23.— P.450s (2792).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kroegel C., Liu M.C., Hubbard W.C. et al. Blood and bronc'noalveoiar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production / / J. Aliergy Clin. Immunoi.— 1994.— Vol.93, № 4,— P.725—734.</mixed-citation><mixed-citation xml:lang="en">Kroegel C., Liu M.C., Hubbard W.C. et al. Blood and bronc'noalveoiar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production / / J. Aliergy Clin. Immunoi.— 1994.— Vol.93, № 4,— P.725—734.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kuna P. Chemokines in allergic inflammation. Progress in asthma and allergy / / Centra"! and Eastern European Conference on Asthma, Allergy and Clinical Immunology / Ed. M. Kowalski. Proceedings.— Lodz, 1996.— P.l12—120.</mixed-citation><mixed-citation xml:lang="en">Kuna P. Chemokines in allergic inflammation. Progress in asthma and allergy / / Centra"! and Eastern European Conference on Asthma, Allergy and Clinical Immunology / Ed. M. Kowalski. Proceedings.— Lodz, 1996.— P.l12—120.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Linden A. (3-Adrenoreceptor agonists increase interleukin-8 production in human bronchial epithelial cells / / Eur. Respir. J.— 1996.— Vol.9, Suppl.23.— P. 124s (P0831).</mixed-citation><mixed-citation xml:lang="en">Linden A. (3-Adrenoreceptor agonists increase interleukin-8 production in human bronchial epithelial cells / / Eur. Respir. J.— 1996.— Vol.9, Suppl.23.— P. 124s (P0831).</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Levine S.J. Bronchial epithelial cell-cytokine interactions in airway inflammation / / J.Invest. Med.— 1995.— Vol.43.— P.241—249.</mixed-citation><mixed-citation xml:lang="en">Levine S.J. Bronchial epithelial cell-cytokine interactions in airway inflammation / / J.Invest. Med.— 1995.— Vol.43.— P.241—249.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Lock S.H., Kay A.B., Barnes N.C. Double-blind, placedo-controlIed study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma / / Am. J. Respir. Crit. Care Med.— 1996,— Vol.153, № 2.— P.509—514.</mixed-citation><mixed-citation xml:lang="en">Lock S.H., Kay A.B., Barnes N.C. Double-blind, placedo-controlIed study of cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma / / Am. J. Respir. Crit. Care Med.— 1996,— Vol.153, № 2.— P.509—514.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Mengelers H.J., Maikoe T., Brinkman L. et al. Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics / / Ibid.— 1994.— Vol. 149, № 2.— Pt 1.— P.345—351.</mixed-citation><mixed-citation xml:lang="en">Mengelers H.J., Maikoe T., Brinkman L. et al. Immunophenotyping of eosinophils recovered from blood and BAL of allergic asthmatics / / Ibid.— 1994.— Vol. 149, № 2.— Pt 1.— P.345—351.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Montefort S., Gratziou C., Goulding D. et a l. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyteendothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways / / J. Clin. Invest.— 1994.— Vol.93, № 4.— P.1411—1421.</mixed-citation><mixed-citation xml:lang="en">Montefort S., Gratziou C., Goulding D. et a l. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyteendothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways / / J. Clin. Invest.— 1994.— Vol.93, № 4.— P.1411—1421.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mudde G.C., Reischl I.G., Corvaia N., Hren A., Poellabauer E.-M. A ntigen presentation in allergic sensitization / / Immunol Cell Biol.— 1996.— Vol.74, № 2.— P.167—173.</mixed-citation><mixed-citation xml:lang="en">Mudde G.C., Reischl I.G., Corvaia N., Hren A., Poellabauer E.-M. A ntigen presentation in allergic sensitization / / Immunol Cell Biol.— 1996.— Vol.74, № 2.— P.167—173.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Nakajitna H., Iwamoto I., Yoshida S. Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment f in mouse trachea / / Am . Rev. Respir. Dis.— 1993.— Vol. 148 № 4.— P.l102—1104.</mixed-citation><mixed-citation xml:lang="en">Nakajitna H., Iwamoto I., Yoshida S. Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment f in mouse trachea / / Am . Rev. Respir. Dis.— 1993.— Vol. 148 № 4.— P.l102—1104.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nonaka M., Nonaka R., Jordana M., Dolavich J. GM-CSF, IL-8, IL-1 R. T N F a R and HLA-DR in nasal epithelial cell in allergic rhinitis / / Am. J. Respir. Crit. Care M ed .— 1996.— Vol. 153, № 5.— P.1675—1681.</mixed-citation><mixed-citation xml:lang="en">Nonaka M., Nonaka R., Jordana M., Dolavich J. GM-CSF, IL-8, IL-1 R. T N F a R and HLA-DR in nasal epithelial cell in allergic rhinitis / / Am. J. Respir. Crit. Care M ed .— 1996.— Vol. 153, № 5.— P.1675—1681.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ohkawara Y., Yamauchi K., Maruyama N. et a l. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1 / VLA-4 interaction in selective eosinophil infiltration / / Am. J. Respir. Cell Mol. Biol.— 1995.— V ol.12, № 1.— P.4—12.</mixed-citation><mixed-citation xml:lang="en">Ohkawara Y., Yamauchi K., Maruyama N. et a l. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1 / VLA-4 interaction in selective eosinophil infiltration / / Am. J. Respir. Cell Mol. Biol.— 1995.— V ol.12, № 1.— P.4—12.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ohno I., Nitta Y., Yamauchi K. et al. Transfonm ing growth factor ß (T G F ßl) gene expression by eosinophils in asthmatic airway inflamation / / Ibid.— 1996.— Vol. 15, № 3 .— P.404—409.</mixed-citation><mixed-citation xml:lang="en">Ohno I., Nitta Y., Yamauchi K. et al. Transfonm ing growth factor ß (T G F ßl) gene expression by eosinophils in asthmatic airway inflamation / / Ibid.— 1996.— Vol. 15, № 3 .— P.404—409.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Rak S. The m echanism of specific immunotherapy in allergic disease caused by inhaled allergen / / Central and Eastern European Conference on Asthma. Allergy and Clinicfl Immunology / Ed. M. Kowalski: Proceedings.— Lodz, 1996.— P. 179—184.</mixed-citation><mixed-citation xml:lang="en">Rak S. The m echanism of specific immunotherapy in allergic disease caused by inhaled allergen / / Central and Eastern European Conference on Asthma. Allergy and Clinicfl Immunology / Ed. M. Kowalski: Proceedings.— Lodz, 1996.— P. 179—184.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Reed C.E. The im portance of eosinophils in the immunology of &amp; asthma and allergic disease / / Ann. Allergy.— 1994.— Vol.74, № 4.— P.376—380.</mixed-citation><mixed-citation xml:lang="en">Reed C.E. The im portance of eosinophils in the immunology of &amp; asthma and allergic disease / / Ann. Allergy.— 1994.— Vol.74, № 4.— P.376—380.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Renzi P.M., Yang J.P., Diamantstein T., Martin J.G. Effects of depletion of cells bearing the interleukin-2 recepto r in immunoglobulin production and allergic airway responses in the rat / / Am . J. Respir. Crit. Care M e d .— 1996.— Vol. 153, № 4.— P.1214—1221.</mixed-citation><mixed-citation xml:lang="en">Renzi P.M., Yang J.P., Diamantstein T., Martin J.G. Effects of depletion of cells bearing the interleukin-2 recepto r in immunoglobulin production and allergic airway responses in the rat / / Am . J. Respir. Crit. Care M e d .— 1996.— Vol. 153, № 4.— P.1214—1221.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Romagnani S. Human TH1 and Th2 subsets: doubt no more / / Immunol. Today.— 1991.— Vol.12, № 8.— P.256—257.</mixed-citation><mixed-citation xml:lang="en">Romagnani S. Human TH1 and Th2 subsets: doubt no more / / Immunol. Today.— 1991.— Vol.12, № 8.— P.256—257.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Shakib F., Smith S.J. In vitro basophil histam ine-releasing activity of circulating IgGi and IgG4 autoanti-IgE antibodies from asthma patients and the demonstration that anti-IgE modula tes allergeninduced basophil activation / / Clin. Exp. Allergy.— 1994.— Vol.24, № 3.— P.270—275.</mixed-citation><mixed-citation xml:lang="en">Shakib F., Smith S.J. In vitro basophil histam ine-releasing activity of circulating IgGi and IgG4 autoanti-IgE antibodies from asthma patients and the demonstration that anti-IgE modula tes allergeninduced basophil activation / / Clin. Exp. Allergy.— 1994.— Vol.24, № 3.— P.270—275.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Shuaib Nasser S.M., Pfister R., Christie P.E. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects / / Am. J. Respir. Crit. Care Med.— 1996.— Vol. 153, № 1.— P.90—96.</mixed-citation><mixed-citation xml:lang="en">Shuaib Nasser S.M., Pfister R., Christie P.E. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects / / Am. J. Respir. Crit. Care Med.— 1996.— Vol. 153, № 1.— P.90—96.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sim T.C., Grant A., Hilsmeier K.A., Fukuda Y., Alam R. Proinflammatory cytokines in nasal secretions of allergic subjects after . antigen challenge / / Ibid.— 1994.— Vol. 149, № 2.— P.339—344.</mixed-citation><mixed-citation xml:lang="en">Sim T.C., Grant A., Hilsmeier K.A., Fukuda Y., Alam R. Proinflammatory cytokines in nasal secretions of allergic subjects after . antigen challenge / / Ibid.— 1994.— Vol. 149, № 2.— P.339—344.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Smith R.E., Strieter R.M., Zhang K. et a l. A role for C-C chemokines in fibrotic lung disease / / J. Leukoc. Biol.— 1995.— Vol.57, No 5,— P.782—787.</mixed-citation><mixed-citation xml:lang="en">Smith R.E., Strieter R.M., Zhang K. et a l. A role for C-C chemokines in fibrotic lung disease / / J. Leukoc. Biol.— 1995.— Vol.57, No 5,— P.782—787.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Spiegelberg H.L., Beck L., Stevenson D.D., Ishioka G.Y. Recognition of T-cell epitopes and lymphokine secretion by rye grass allergen Lolium perenne I — specific human T cell clones / / J. Immunol.— 1994.— Vol.152, № 9.— P.4706—4711.</mixed-citation><mixed-citation xml:lang="en">Spiegelberg H.L., Beck L., Stevenson D.D., Ishioka G.Y. Recognition of T-cell epitopes and lymphokine secretion by rye grass allergen Lolium perenne I — specific human T cell clones / / J. Immunol.— 1994.— Vol.152, № 9.— P.4706—4711.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Spiteri M.A., Knight R.A., Jeremy J.Y. et al. Alveolar macrophage-induced suppression of peripheral blood mononuclear responsiveness is reversed by in v itro allergen exposure in bronchial asthma / / Eur. Respir. J .— 1994.— Vol.7, № 8.— P. 1431 — 1438.</mixed-citation><mixed-citation xml:lang="en">Spiteri M.A., Knight R.A., Jeremy J.Y. et al. Alveolar macrophage-induced suppression of peripheral blood mononuclear responsiveness is reversed by in v itro allergen exposure in bronchial asthma / / Eur. Respir. J .— 1994.— Vol.7, № 8.— P. 1431 — 1438.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Swain S.L. CD4 T cell development and cytokine polarization: an overview / / J. Leukoc. Biol.— 1995.— Vol.57, № 5.— P.795—798.</mixed-citation><mixed-citation xml:lang="en">Swain S.L. CD4 T cell development and cytokine polarization: an overview / / J. Leukoc. Biol.— 1995.— Vol.57, № 5.— P.795—798.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Till S., Li B., Durham S. et al. Secretion of the eosinophol-active cytokines interleukin-5, granulocute/m acrophage colony-stimulating factor and interleukin-3 by bronchoaiveoiar lavage CD4'*' and C D 8 + T cell line in atopic asthm acics, and atopic and nonatopic controls / / Eur. J. Immunol.— 1995.— Vol.25. № 10.— P.2727—2731.</mixed-citation><mixed-citation xml:lang="en">Till S., Li B., Durham S. et al. Secretion of the eosinophol-active cytokines interleukin-5, granulocute/m acrophage colony-stimulating factor and interleukin-3 by bronchoaiveoiar lavage CD4'*' and C D 8 + T cell line in atopic asthm acics, and atopic and nonatopic controls / / Eur. J. Immunol.— 1995.— Vol.25. № 10.— P.2727—2731.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Vignola A.M., Chanez P., Paul-Lacoste P. et al. Phenotypic and functional modulation of norman alveolar macrophage s by hista- (mine / / Am. J. Respir. Cell. Mol. Biol.— 1994.— Vol. 11, № 4.— P.456—463.</mixed-citation><mixed-citation xml:lang="en">Vignola A.M., Chanez P., Paul-Lacoste P. et al. Phenotypic and functional modulation of norman alveolar macrophage s by hista- (mine / / Am. J. Respir. Cell. Mol. Biol.— 1994.— Vol. 11, № 4.— P.456—463.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Virchow J.C., Walker C., Hafner D. et al. T cells and cytokines in bronchoalveolar lavage fluid after segm ental allergen provocation in atopic asthma / / Am. J. Respir. Crit. Care M e d .— 1995.— Voi. 151, № 4 .— P.960 — 968.</mixed-citation><mixed-citation xml:lang="en">Virchow J.C., Walker C., Hafner D. et al. T cells and cytokines in bronchoalveolar lavage fluid after segm ental allergen provocation in atopic asthma / / Am. J. Respir. Crit. Care M e d .— 1995.— Voi. 151, № 4 .— P.960 — 968.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Walker C., Bauer W., Braun R.K. et al. Activated T cell and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia / / ibid.— 1994.— Vol. 150, № 4 .— P.1038 — 1048.</mixed-citation><mixed-citation xml:lang="en">Walker C., Bauer W., Braun R.K. et al. Activated T cell and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia / / ibid.— 1994.— Vol. 150, № 4 .— P.1038 — 1048.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Wang J.H., Devalia J.L., Xia L., Sapsford R.J., Daves R.J. Expression of RANTES by human bronchial eputhelial cells in vitro and in vivo and the effect of corticosteroids / / Am. J. Respir. Cell. Mol. Biol.— 1996.— Vol.14. № 1.— P.27—35.</mixed-citation><mixed-citation xml:lang="en">Wang J.H., Devalia J.L., Xia L., Sapsford R.J., Daves R.J. Expression of RANTES by human bronchial eputhelial cells in vitro and in vivo and the effect of corticosteroids / / Am. J. Respir. Cell. Mol. Biol.— 1996.— Vol.14. № 1.— P.27—35.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Wardlaw A.J. Eosinophils in the 1990-s: new perspectives in their role in the health and disease / / Postgrad. Med. J .— 1994.— Vol.70, № 826.— P.536—552.</mixed-citation><mixed-citation xml:lang="en">Wardlaw A.J. Eosinophils in the 1990-s: new perspectives in their role in the health and disease / / Postgrad. Med. J .— 1994.— Vol.70, № 826.— P.536—552.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Werfel S.J., Yednock T.A., Matsumoto K. et al. Functional regulation of ßi integrins on human eosinophils by divalent cations and cytokines / / Am. J. Rrspir. Cell. Mol. Biol.— 1996.— Voi. 14, № 1.— P.44—52.</mixed-citation><mixed-citation xml:lang="en">Werfel S.J., Yednock T.A., Matsumoto K. et al. Functional regulation of ßi integrins on human eosinophils by divalent cations and cytokines / / Am. J. Rrspir. Cell. Mol. Biol.— 1996.— Voi. 14, № 1.— P.44—52.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Xiu Q., Fujimura M., Nomura M. et al. Bronchial hyperresponsiveness and airway neutrophil accumulation induced by unterleukin-8 and the effect of the thromboxane A2 antagonist S-1452 in guinea pigs / / Clin. Exp. Allergy.— 1995.— Vol.25, № 1.— P.51—59.</mixed-citation><mixed-citation xml:lang="en">Xiu Q., Fujimura M., Nomura M. et al. Bronchial hyperresponsiveness and airway neutrophil accumulation induced by unterleukin-8 and the effect of the thromboxane A2 antagonist S-1452 in guinea pigs / / Clin. Exp. Allergy.— 1995.— Vol.25, № 1.— P.51—59.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
