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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2021-31-6-710-717</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-3289</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности медицинской реабилитации пациентов, перенесших COVID-19, на основе изучения функциональных возможностей сердечно-сосудистой и дыхательной систем</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of the effectiveness of medical rehabilitation after COVID-19 based on the functional capacity of the cardiovascular and respiratory systems</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8488-0858</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каменская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamenskaya</surname><given-names>Oksana V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каменская Оксана Васильевна — доктор медицинских наук, заведующая лабораторией клинической физиологии научно-исследовательского отдела анестезиологии и реаниматологии.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Oksana V. Kamenskaya - Doctor of Medicine, Head of Laboratory of clinical physiology, Department of Anesthesiology and Intensive Care.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">o_kamenskaya@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3219-0107</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>Irina Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Логинова Ирина Юрьевна — кандидат биологических наук, старший научный сотрудник лаборатории клинической физиологии научно-исследовательского отдела анестезиологии и реаниматологии.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Irina Yu. Loginova - Candidate of Biology, Senior Researcher, Laboratory of clinical physiology, Department ofAnesthesiology and Intensive Care.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">i_loginova@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2845-930X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клинкова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Klinkova</surname><given-names>Asya S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клинкова Ася Станиславовна — кандидат медицинских наук, научный сотрудник лаборатории клинической физиологии научно-исследовательского отдела анестезиологии и реаниматологии.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Candidate of Medicine, Researcher, Laboratory of clinical physiology, Department of Anesthesiology and Intensive Care.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">a_klinkova@meshalkin.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9818-8678</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернявский</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernyavsky</surname><given-names>Alexander M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чернявский Александр Михайлович — доктор медицинских наук, профессор, заслуженный деятель науки.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-40</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Director.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-40</p></bio><email xlink:type="simple">a_cherniavsky@meshalkin.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1530-1327</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Берген</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bergen</surname><given-names>Tatiana A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Берген Татьяна Андреевна — кандидат медицинских наук, заведующая отделом лучевой и инструментальной диагностики.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Candidate of Medicine, Head of the Department of radiation and instrumental diagnostics.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">bergen_t@meshalkin.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4291-6047</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таркова</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Tarkova</surname><given-names>Alexandra R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таркова Александра Романовна — кандидат медицинских наук, научный сотрудник отдела лучевой и инструментальной диагностики.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Candidate of Medicine, Researcher of the Department of radiation and instrumental diagnostics.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">a_tarkova@meshalkin.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5348-6927</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришин</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishin</surname><given-names>Oleg V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гришин Олег Витальевич — доктор медицинских наук, главный научный сотрудник.</p><p>630117, Новосибирск, ул. Тимакова, 2; тел.: (913) 018-78-84</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Leading Researcher.</p><p>Ul. Timakova 2, Novosibirsk, 630117; tel.: (913) 018-78-84</p></bio><email xlink:type="simple">ovgrishin@frcftm.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9425-413X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Воевода</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Voevoda</surname><given-names>Michail I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воевода Михаил Иванович — доктор медицинских наук, профессор, академик Российской академии наук, директор.</p><p>630117, Новосибирск, ул. Тимакова, 2; тел.: (383) 335-97-74</p></bio><bio xml:lang="en"><p>Professor, Academician of Russian Academy of Sciences, Director.</p><p>Ul. Timakova 2, Novosibirsk, 630117; tel.: (383) 335-97-74</p></bio><email xlink:type="simple">director@frcftm.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8591-6461</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ломиворотов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lomivorotov</surname><given-names>Vladimir V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ломиворотов Владимир Владимирович — доктор медицинских наук, профессор, член-корр. Российской академии наук, руководитель научно-исследовательского отдела анестезиологии и реаниматологии.</p><p>630055, Новосибирск, ул. Речкуновская, 15; тел.: (383) 347-60-66</p></bio><bio xml:lang="en"><p>Doctor of Medicine, Professor, Corresponding Member of Russian Academy of Sciences, Head of the Department of Anesthesiology and Intensive Care.</p><p>Ul. Rechkunovskaya 15, Novosibirsk, 630055; tel.: (383) 347-60-66</p></bio><email xlink:type="simple">vv_lomivorotov@meshalkin.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution National Medical Research Center named after Academician E.N.Meshalkin, Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение Национальный медицинский исследовательский центр имени академика Е.Н. Мешалкина Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution National Medical Research Center named after Academician E.N. Meshalkin, Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение Федеральный исследовательский центр фундаментальной и трансляционной медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Scientific Institution Federal Research Center for Fundamental and Translational Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2021</year></pub-date><volume>31</volume><issue>6</issue><fpage>710</fpage><lpage>717</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каменская О.В., Логинова И.Ю., Клинкова А.С., Чернявский А.М., Берген Т.А., Таркова А.Р., Гришин О.В., Воевода М.И., Ломиворотов В.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Каменская О.В., Логинова И.Ю., Клинкова А.С., Чернявский А.М., Берген Т.А., Таркова А.Р., Гришин О.В., Воевода М.И., Ломиворотов В.В.</copyright-holder><copyright-holder xml:lang="en">Kamenskaya O.V., Loginova I.Y., Klinkova A.S., Chernyavsky A.M., Bergen T.A., Tarkova A.R., Grishin O.V., Voevoda M.I., Lomivorotov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/3289">https://journal.pulmonology.ru/pulm/article/view/3289</self-uri><abstract><p>Целью исследования явилась оценка эффективности медицинской реабилитации (МР) пациентов, перенесших пневмонию, ассоциированную с новой коронавирусной инфекцией (COVID-19), на основе изучения функциональных возможностей (ФВ) сердечно-сосудистой системы (ССС) и системы внешнего дыхания (СВД).</p><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование были включены пациенты (n = 70), перенесшие пневмонию, обусловленную COVID-19, и выполнившие программу МР с сентября по декабрь 2020 г. До включения в программу МР у всех пациентов проводились легочные функциональные тесты (ЛФТ), включая оценку диффузионной способности легких (ДСЛ), кардиопульмональное нагрузочное тестирование, мультиспиральную компьютерную томографию (МСКТ) органов грудной клетки, эхокардиографию, оценку качества жизни (КЖ) по данным вопросника SF-36 и выраженности одышки в соответствии со шкалой выраженности одышки (Modified Medical Research Council — mMRC). Оценка эффективности МР проводилась по динамике показателей ЛФТ, толерантности к физической нагрузке (ТФН) и уровню КЖ.</p></sec><sec><title>Результаты</title><p>Результаты. При включении в исследование у 46 % пациентов сохранялись участки поражения легочной ткани по данным МСКТ, что сопровождалось снижением ДСЛ (67 (55—79) %долж), одышкой 1,6 (1,0—3,0) балла по шкале mMRC; показатели ТФН и КЖ при этом составляли средние значения. При комплексной сердечно-легочной (КСЛ) МР в течение 12—14 дней в условиях специализированного стационара значимо улучшились параметры легочной вентиляции и газообмена, пикового потребления кислорода и резервные возможности кардиореспираторной системы. Факторами, лимитирующими улучшение легочного газообмена, явились старший возраст пациентов и повышенное давление в системе легочной артерии. Отмечено положительное влияние реабилитации как на физический, так и на психоэмоциональный компоненты КЖ.</p></sec><sec><title>Заключение</title><p>Заключение. Показаны безопасность и высокая эффективность КСЛ МР с оценкой динамики параметров кислородного метаболизма и ФВ ССС и дыхательной системы у пациентов, перенесших пневмонию, обусловленную COVID-19.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the effectiveness of medical rehabilitation after pneumonia associated with the novel coronavirus infection (COVID-19), based on the study of functional capacity of the cardiovascular system and the external respiratory system.</p></sec><sec><title>Methods</title><p>Methods. The study included 70 patients who had COVID-19 pneumonia and underwent a medical rehabilitation program from September to December 2020. Before being included in the rehabilitation program, all patients underwent pulmonary function tests (PFT), including an assessment of the lungs diffusion capacity, cardiopulmonary exercise testing, multispiral computed tomography (MSCT) of the chest, echocardiography, an evaluation of the quality of life according to the SF-36 questionnaire and the severity of shortness of breath on the mMRC scale. The effectiveness of rehabilitation was evaluated against the changes in PFT parameters, exercise tolerance, and quality of life.</p></sec><sec><title>Results</title><p>Results. At the enrollment, 46% of patients retained lung tissue lesions shown by MSCT and accompanied by a decrease in the lung diffusion capacity (67 (55 - 79%) of predicted value), dyspnea of 1.6 (1.0 - 3.0) points according to mMRC scale, moderate level of exercise tolerance and quality of life. Complex cardiopulmonary rehabilitation for 12 - 14 days in a specialized hospital led to a significant improvement in the parameters of pulmonary gas exchange and ventilation, peak oxygen consumption, and an increase in the reserve capacity of the cardiorespiratory system. The factors limiting the improvement of pulmonary gas exchange were the older age of the patients and the increased pressure in the pulmonary artery system. The positive influence of rehabilitation on both the physical and psycho-emotional components of the quality of life was noted.</p></sec><sec><title>Conclusion</title><p>Conclusion. Complex cardiopulmonary rehabilitation with the assessment of changes in the oxygen metabolism parameters and functional capacity of the cardiovascular and respiratory systems has shown to be safe and highly effective in the studied group of patients who have had COVID-19 pneumonia.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>новая коронавирусная инфекция</kwd><kwd>медицинская реабилитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>new coronavirus infection</kwd><kwd>medical rehabilitation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках внутреннего клинического исследования Федерального государственного бюджетного учреждения «Национальный медицинский исследовательский центр имени академика Е.Н.Мешалкина» Министерства здравоохранения Российской Федерации</funding-statement><funding-statement xml:lang="en">The work was carried out as part of an internal clinical study of the Federal State Budgetary Institution National Medical Research Center named after Academician E.N.Meshalkin under the Ministry of Health of the Russian Federation</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Авдеев С.Н., Царева Н.А., Мержоева З.М. и др. 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