pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2011-0-1-107-110pulmo-326Research ArticleОБЗОРЫREVIEWДОСТАВКА ПРЕПАРАТОВ В ЛЕГКИЕ: ПРОБЛЕМНЫЕ АСПЕКТЫDRUG DELIVERY TO THE LUNGS: ISSUES OF CONCERNАрхиповВ. В.ArkhipovV. V.

д. м. н., проф. кафедры клинической фармакологии и пропедевтики внутренних болезней

119991, Москва, ул. Трубецкая, 8, стр. 2

тел.: (495) 966-54-14

д. м. н., проф. кафедры клинической фармакологии и пропедевтики внутренних болезней

119991, Москва, ул. Трубецкая, 8, стр. 2

тел.: (495) 966-54-14

9665414@gmail.comБердниковаН. Г.BerdnikovaN. G.

к. м. н., доцент кафедры клинической фармакологии и пропедевтики внутренних болезней 

119991, Москва, ул. Трубецкая, 8, стр. 2

тел.: 8-985-190-17-00

к. м. н., доцент кафедры клинической фармакологии и пропедевтики внутренних болезней

119991, Москва, ул. Трубецкая, 8, стр. 2

тел.: 8-985-190-17-00

file@gmx.usПоляковаИ. П.PolyakovaI. P.

врач 

109240, Москва, ул. Яузская, 11

врач

109240, Москва, ул. Яузская, 11

Первый МГМУ им. И.М.СеченоваРоссияПервый МГМУ им. И.М.СеченоваRussian FederationГКБ № 23 им. "Медсантруд"РоссияГКБ № 23 им. "Медсантруд"Russian Federation20112802201101107110Copyright © Архипов В.В., Бердникова Н.Г., Полякова И.П., 20112011Архипов В.В., Бердникова Н.Г., Полякова И.П.Arkhipov V.V., Berdnikova N.G., Polyakova I.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/326

Доставка препаратов в легкие: проблемные аспекты

Drug delivery to the lungs: issues of concern

ингаляционнные глюкокортикостероидыбронхиальная астмаингаляционные средства доставкиinhaled corticosteroidsbronchial asthmainhalational delivery systemsReferencesCates C.J., Crilly J.A., Rowe B.H. Holding chambers (spacers) versus nebulisers for beta agonist treatment of acute asthma. Cochrane Database Syst. Rev. 2006, Issue 2. Art.No.: CD000052. DOI: 10.1002/14651858.CD000052.pub2Cates C.J., Crilly J.A., Rowe B.H. Holding chambers (spacers) versus nebulisers for beta agonist treatment of acute asthma. Cochrane Database Syst. Rev. 2006, Issue 2. Art.No.: CD000052. DOI: 10.1002/14651858.CD000052.pub2Parkin P.C., Saunders N.R., Diamond S.A. et al. Randomised trial spacer v nebuliser for acute asthma. Arch. Dis. Child.1995; 72 (3): 239–240.Parkin P.C., Saunders N.R., Diamond S.A. et al. Randomised trial spacer v nebuliser for acute asthma. Arch. Dis. Child.1995; 72 (3): 239–240.Amirav I., Newhouse M.T. Aerosol therapy in infants and toddlers: past, present and future. Exp. Rev. Respir. Med.2008; 2 (5): 597–605.Amirav I., Newhouse M.T. Aerosol therapy in infants and toddlers: past, present and future. Exp. Rev. Respir. Med.2008; 2 (5): 597–605.Bisca N., Cernatescu I., Dragomir D. et al. Comparison of the efficacy and safety of beclometasone dipropionate suspension for nebulization and beclometasone dipropionatevia a metered-dose inhaler in paediatric patients with moderate to severe exacerbation of asthma. Respir. Med. 2003;97 (Suppl. B): S15–S20.Bisca N., Cernatescu I., Dragomir D. et al. Comparison of the efficacy and safety of beclometasone dipropionate suspension for nebulization and beclometasone dipropionatevia a metered-dose inhaler in paediatric patients with moderate to severe exacerbation of asthma. Respir. Med. 2003;97 (Suppl. B): S15–S20.Devadason S.G., Huang Т., Walker S. et al. Distribution of technetium 99m labelled QVAR delivered using an Autohaler device in children. Eur. Respir. J. 2003; 21:1007–1010.Devadason S.G., Huang Т., Walker S. et al. Distribution of technetium 99m labelled QVAR delivered using an Autohaler device in children. Eur. Respir. J. 2003; 21:1007–1010.Tal A., Golan H., Grauer N.et al. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J. Pediatr. 1996; 128: 479–484.Tal A., Golan H., Grauer N.et al. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J. Pediatr. 1996; 128: 479–484.Jackson V. Pulmicort. International product monograph.AstraZeneca Global; 2008. 95.Jackson V. Pulmicort. International product monograph.AstraZeneca Global; 2008. 95.Marguet C., Couderc L., Le Roux P. et al. Inhalation treatment: errors in application and difficulties in acceptance of the devices are frequent in wheezy infants and young children. Pediatr. Allergy Immunol. 2001; 12 (4): 224–230.Marguet C., Couderc L., Le Roux P. et al. Inhalation treatment: errors in application and difficulties in acceptance of the devices are frequent in wheezy infants and young children. Pediatr. Allergy Immunol. 2001; 12 (4): 224–230.Janssens H.M., van der Wiel E.C., Verbraak A.F. et al.Aerosol therapy and the fighting toddler: is administration during sleep an alternative? J. Aerosol Med. 2003; 16 (4):395–400.Janssens H.M., van der Wiel E.C., Verbraak A.F. et al.Aerosol therapy and the fighting toddler: is administration during sleep an alternative? J. Aerosol Med. 2003; 16 (4):395–400.Schuepp K.G., Devadason S.G., Roller C. et al. Aerosol delivery of nebulised budesonide in young children with asthma.Respir. Med. 2009; 103: 1738–1745.Schuepp K.G., Devadason S.G., Roller C. et al. Aerosol delivery of nebulised budesonide in young children with asthma.Respir. Med. 2009; 103: 1738–1745.Salmon B., Wilson N.M., Silverman M. How much aerosol reaches the lungs of wheezy infants and toddlers? Arch. Dis.Child. 1990; 65: 401–403.Salmon B., Wilson N.M., Silverman M. How much aerosol reaches the lungs of wheezy infants and toddlers? Arch. Dis.Child. 1990; 65: 401–403.Chua H.L., Collis G.G., Newbury A.M. et al. The influence of age on aerosol deposition in children with cystic fibrosis.Eur. Respir. J. 1994; 7: 2185–2191.Chua H.L., Collis G.G., Newbury A.M. et al. The influence of age on aerosol deposition in children with cystic fibrosis.Eur. Respir. J. 1994; 7: 2185–2191.Meyer Т., Brand Р., Ehlich Н. et al. Deposition of Foradil Pin human lungs: comparison of in vitro and in vivo data.J. Aerosol Med. March 2004: 43–49.Meyer Т., Brand Р., Ehlich Н. et al. Deposition of Foradil Pin human lungs: comparison of in vitro and in vivo data.J. Aerosol Med. March 2004: 43–49.Thorsson L., Edsbacker S. Less variability in lung deposition of budesonide via Turbuhaler® than of fluticasone via Diskus® / Accuhaler® and pMDI in adults. Am. J. Respir.Crit. Care Med. 2003; 167 (Suppl. 7): A896.Thorsson L., Edsbacker S. Less variability in lung deposition of budesonide via Turbuhaler® than of fluticasone via Diskus® / Accuhaler® and pMDI in adults. Am. J. Respir.Crit. Care Med. 2003; 167 (Suppl. 7): A896.Mallol J., Rattray S., Walker G. et al. Aerosol deposition in infants with cystic fibrosis. Pediatr. Pulmonol. 1996; 21:276–281.Mallol J., Rattray S., Walker G. et al. Aerosol deposition in infants with cystic fibrosis. Pediatr. Pulmonol. 1996; 21:276–281.Wildhaber J.H., Dore N.D., Wilson J.M. et al. Inhalation therapy in asthma; Nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children. J. Pediatr. 1999; 135: 28–33Wildhaber J.H., Dore N.D., Wilson J.M. et al. Inhalation therapy in asthma; Nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children. J. Pediatr. 1999; 135: 28–33Camargo C.A., Ramachandran S., Ryskina K.L. et al. Association between common asthma therapies and recurrent asthma exacerbations in children enrolled in a state Medicaid plan. Am. J. Hlth Syst. Pharm. 2007; 64:1054–1060.Camargo C.A., Ramachandran S., Ryskina K.L. et al. Association between common asthma therapies and recurrent asthma exacerbations in children enrolled in a state Medicaid plan. Am. J. Hlth Syst. Pharm. 2007; 64:1054–1060.McLaughlin T., Leibman C., Patel P., Camargo С.А. Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications. Curr. Med. Res. Opin. 2007; 23 (6):1319–1328.McLaughlin T., Leibman C., Patel P., Camargo С.А. Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications. Curr. Med. Res. Opin. 2007; 23 (6):1319–1328.Engel T., Heinig J.M., Medsen F., Nikander K. Peak inspiratory flowrate and inspiratory vital capacity of patients with asthma measured with and without a new dry powder inhaler device (Turbuhaler). Eur. Respir. J. 1990; 3:1037–1041.Engel T., Heinig J.M., Medsen F., Nikander K. Peak inspiratory flowrate and inspiratory vital capacity of patients with asthma measured with and without a new dry powder inhaler device (Turbuhaler). Eur. Respir. J. 1990; 3:1037–1041.Dewar M.H., Jamieson A., McLean A., Crompton GK. Peak inspiratory flow through Turbuhaler in chronic obstructive airways disease. Respir. Med. 1999; 93: 342–344.Dewar M.H., Jamieson A., McLean A., Crompton GK. Peak inspiratory flow through Turbuhaler in chronic obstructive airways disease. Respir. Med. 1999; 93: 342–344.Pedersen S., Hansen O.R., Fuglsang G. Influence of inspiratory flow rate upon the effect of a Turbuhaler. Arch. Dis.Child. 1990; 65: 308–310.Pedersen S., Hansen O.R., Fuglsang G. Influence of inspiratory flow rate upon the effect of a Turbuhaler. Arch. Dis.Child. 1990; 65: 308–310.Weuthen T., Roeder S., Brand P. et al. In vitro testing of two formoterol dry powder inhalers at different flow rates.J. Aerosol Med. 2002; 15: 297–303.Weuthen T., Roeder S., Brand P. et al. In vitro testing of two formoterol dry powder inhalers at different flow rates.J. Aerosol Med. 2002; 15: 297–303.Nielsen K.G., Auk I.L., Bojsen K. et al. Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children. Eur. Respir. J. 1998; 11:350–354.Nielsen K.G., Auk I.L., Bojsen K. et al. Clinical effect of Diskus dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children. Eur. Respir. J. 1998; 11:350–354.Olsson B. Aerosol particle generation from dry powder inhalers: can they equal pressurized metered dose inhalers?J. Aerosol. Med. 1995; 8 (Suppl. 3): S13–S19.Olsson B. Aerosol particle generation from dry powder inhalers: can they equal pressurized metered dose inhalers?J. Aerosol. Med. 1995; 8 (Suppl. 3): S13–S19.Usmani O.S., Biddiscombe M.F., Barnes P.J. Regional lung deposition and bronchodilator response as a function of β2 agonist particle size. Am. J. Respir. Crit. Care Med.2005; 172: 1497–1504.Usmani O.S., Biddiscombe M.F., Barnes P.J. Regional lung deposition and bronchodilator response as a function of β2 agonist particle size. Am. J. Respir. Crit. Care Med.2005; 172: 1497–1504.Giraud V., Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur.Respir. J. 2002; 19: 246–251.Giraud V., Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Eur.Respir. J. 2002; 19: 246–251.

The authors declare that there are no conflicts of interest present.