<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pulmo-3221</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Антагонисты и ингибиторы лейкотриенов в терапии бронхиальной астмы</article-title><trans-title-group xml:lang="en"><trans-title>Leucotriene antagonists and inhibitors in bronchial asthma treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалева</surname><given-names>В. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovaleva</surname><given-names>V. L.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чучалин</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chuchalin</surname><given-names>A. G.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колганова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolganova</surname><given-names>N. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ВНЦ БАВ;&#13;
НИИ пульмонологии М3 РФ</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>1998</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>1998</year></pub-date><volume>0</volume><issue>1</issue><fpage>79</fpage><lpage>87</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковалева В.Л., Чучалин А.Г., Колганова Н.А., 1998</copyright-statement><copyright-year>1998</copyright-year><copyright-holder xml:lang="ru">Ковалева В.Л., Чучалин А.Г., Колганова Н.А.</copyright-holder><copyright-holder xml:lang="en">Kovaleva V.L., Chuchalin A.G., Kolganova N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/3221">https://journal.pulmonology.ru/pulm/article/view/3221</self-uri><abstract><p>.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abraham W.M., Stevenson J.S. A new leukotriene D4 antagonist L-660711 blocks allergen-induced late responses in allergic sheep / / FASEB J .— 1988.— Vol.2.— P.4425.</mixed-citation><mixed-citation xml:lang="en">Abraham W.M., Stevenson J.S. A new leukotriene D4 antagonist L-660711 blocks allergen-induced late responses in allergic sheep / / FASEB J .— 1988.— Vol.2.— P.4425.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Adelroth E., Morris M.M., Hargreave F.E., O’Byrne P.M. Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patient with asthma and normal controls / / N. Engl. J. Med.— 1986.— Vol.315.— P.480—484.</mixed-citation><mixed-citation xml:lang="en">Adelroth E., Morris M.M., Hargreave F.E., O’Byrne P.M. Airway responsiveness to leukotrienes C4 and D4 and to methacholine in patient with asthma and normal controls / / N. Engl. J. Med.— 1986.— Vol.315.— P.480—484.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ann J.P., Lee T.H. Sulphidopeptide leukotriene in asthma / / # Clin. Sci.— 1993.— Vol.84.— P.501—510.</mixed-citation><mixed-citation xml:lang="en">Ann J.P., Lee T.H. Sulphidopeptide leukotriene in asthma / / # Clin. Sci.— 1993.— Vol.84.— P.501—510.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes N.C., Kuitert L. Influence of leukotriene antagonists on baseline pulmonary function and asthm atic responses / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.217—226.</mixed-citation><mixed-citation xml:lang="en">Barnes N.C., Kuitert L. Influence of leukotriene antagonists on baseline pulmonary function and asthm atic responses / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.217—226.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J., Lee Т.Н. Recent advances in asthma / / Postgrad. Med. J.— 1992.— Vol.68.— P.942—953.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J., Lee Т.Н. Recent advances in asthma / / Postgrad. Med. J.— 1992.— Vol.68.— P.942—953.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bateman E.D., Holgate S.Т., Binks S.М., Tams I.P. A multicentre study to assess the steroid — sparing potential of Accolate (zafirlucast; 20m g b d ) / / Allergy.— 1995.— Vol.50, Suppl.26.— P.320.</mixed-citation><mixed-citation xml:lang="en">Bateman E.D., Holgate S.Т., Binks S.М., Tams I.P. A multicentre study to assess the steroid — sparing potential of Accolate (zafirlucast; 20m g b d ) / / Allergy.— 1995.— Vol.50, Suppl.26.— P.320.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Becker A.B., Black C., Lilley M.K. et al. Antiasthmatic effects of leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs / / J. Appl. Physiol.— 1995.— Vol.78.— P.615—622.</mixed-citation><mixed-citation xml:lang="en">Becker A.B., Black C., Lilley M.K. et al. Antiasthmatic effects of leukotriene biosynthesis inhibitor (MK-0591) in allergic dogs / / J. Appl. Physiol.— 1995.— Vol.78.— P.615—622.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bel E.H., Tanaka W., Spector R. et al. MK-886, an effective oral leukotriene biosynthesis inhibitor on antigen-induced early and late asthm atic reactions in man / / Am. Rev. Respir. Dis.— 1990.— Vol.141.— P.A31.</mixed-citation><mixed-citation xml:lang="en">Bel E.H., Tanaka W., Spector R. et al. MK-886, an effective oral leukotriene biosynthesis inhibitor on antigen-induced early and late asthm atic reactions in man / / Am. Rev. Respir. Dis.— 1990.— Vol.141.— P.A31.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bel E.H ., van der Veen H., Kramps I.A. et al. Maximal airway narrow ingto inhaled leukotriene D4 in normal subjects / / Ibid.— 1987.— Vol.136.— P.979—984.</mixed-citation><mixed-citation xml:lang="en">Bel E.H ., van der Veen H., Kramps I.A. et al. Maximal airway narrow ingto inhaled leukotriene D4 in normal subjects / / Ibid.— 1987.— Vol.136.— P.979—984.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bisgaard H., Groth S., Madsen F. Bronchial hyperreactivity to leukotriene D4 and histamine to exogenous asthma / / Br. Med. j . _ 1985.— Vol.290.— P.1468—1471.</mixed-citation><mixed-citation xml:lang="en">Bisgaard H., Groth S., Madsen F. Bronchial hyperreactivity to leukotriene D4 and histamine to exogenous asthma / / Br. Med. j . _ 1985.— Vol.290.— P.1468—1471.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bochnowicz J., Underwood D.C. Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea-pig / / Prostagland. Leukotr. Essent Fatty Acids.— 1995.— Vol.52.— P.403—411.</mixed-citation><mixed-citation xml:lang="en">Bochnowicz J., Underwood D.C. Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea-pig / / Prostagland. Leukotr. Essent Fatty Acids.— 1995.— Vol.52.— P.403—411.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bone R.C. Asthma: new treatments will improve disease management / / Clin. Pulmon. M ed.— 1995.— Vol.2, № 5.— P.249—257.</mixed-citation><mixed-citation xml:lang="en">Bone R.C. Asthma: new treatments will improve disease management / / Clin. Pulmon. M ed.— 1995.— Vol.2, № 5.— P.249—257.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Boot J.R., Bond A., Thomas K.H. et al. The pharmacology of LY 290324 in the guinea-pig: an orally active, potent and selective cysteinyl leikotriene receptor antogonist / / Eur. J. Pharmacol.— 1993.— Vol.231.— P.83—89.</mixed-citation><mixed-citation xml:lang="en">Boot J.R., Bond A., Thomas K.H. et al. The pharmacology of LY 290324 in the guinea-pig: an orally active, potent and selective cysteinyl leikotriene receptor antogonist / / Eur. J. Pharmacol.— 1993.— Vol.231.— P.83—89.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Borgeat P., Samuelsson B. Leukotrienes: M ediators of immediate hypersensitivity reactions and infflammation / / Proc. Natl. Acad. Sci. USA.— 1979.— Vol.76.— P.3213—3217.</mixed-citation><mixed-citation xml:lang="en">Borgeat P., Samuelsson B. Leukotrienes: M ediators of immediate hypersensitivity reactions and infflammation / / Proc. Natl. Acad. Sci. USA.— 1979.— Vol.76.— P.3213—3217.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Brooks D.W., Summers J.B., Stewart A.O. et al. Novel inhibitors of leukotriene biosynthesis / / Perspectives in Medicinal Chemistry.— Weinheim, 1993.— P .119—134.</mixed-citation><mixed-citation xml:lang="en">Brooks D.W., Summers J.B., Stewart A.O. et al. Novel inhibitors of leukotriene biosynthesis / / Perspectives in Medicinal Chemistry.— Weinheim, 1993.— P .119—134.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Busse W.W., Gaddy J.N. The role of leukotriene antagonists and inhibitors in the treatm ent airway disease / / Am. Rev. Respir. Dis.— 1991,— V ol.143.— P.103—107.</mixed-citation><mixed-citation xml:lang="en">Busse W.W., Gaddy J.N. The role of leukotriene antagonists and inhibitors in the treatm ent airway disease / / Am. Rev. Respir. Dis.— 1991,— V ol.143.— P.103—107.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Brideau C., Chan C., Charleson S. et al. Pharmacology of MK-0591, a potent orally active leukotriene biosynthesis inhibitor / / Can. J. Physiol. Pharmacol.— 1992.— Vol.70.— P.799—807.</mixed-citation><mixed-citation xml:lang="en">Brideau C., Chan C., Charleson S. et al. Pharmacology of MK-0591, a potent orally active leukotriene biosynthesis inhibitor / / Can. J. Physiol. Pharmacol.— 1992.— Vol.70.— P.799—807.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Busse W.W., Gaddy J.N. The role of leukotriene antagonists and inhibitors in the treatm ent of airway disease / / Am. Rev. Respir. Dis.— 1991,— V ol.143, Pt 2.— P.S103—S107.</mixed-citation><mixed-citation xml:lang="en">Busse W.W., Gaddy J.N. The role of leukotriene antagonists and inhibitors in the treatm ent of airway disease / / Am. Rev. Respir. Dis.— 1991,— V ol.143, Pt 2.— P.S103—S107.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Calhoun W.J., Lavins B.J., Glass M. Effect of ‘Accolate’ (zafirlucast) on bronchoalveolar lavage fluid (BAL) after segmental antigen bronchoprovocation (SBP) in patients with mild to moderate asthm a / / Am. J. Respir. Crit. Care M ed.— 1995.— Vol.151, Pt 2.— P.A42.</mixed-citation><mixed-citation xml:lang="en">Calhoun W.J., Lavins B.J., Glass M. Effect of ‘Accolate’ (zafirlucast) on bronchoalveolar lavage fluid (BAL) after segmental antigen bronchoprovocation (SBP) in patients with mild to moderate asthm a / / Am. J. Respir. Crit. Care M ed.— 1995.— Vol.151, Pt 2.— P.A42.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M.A. Asthma / / Postgrad. Med. J.— 1996.— Vol.72,— P.12—18.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M.A. Asthma / / Postgrad. Med. J.— 1996.— Vol.72,— P.12—18.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Carruthers N.I., Kaminski J.J. Recent developments with investigational drugs potentially useful in the treatm ent of allergic and inflammatory disorders / / Exp. Opin. Invest. Drugs.— 1995.— Vol.4.— P.1021 — 1025.</mixed-citation><mixed-citation xml:lang="en">Carruthers N.I., Kaminski J.J. Recent developments with investigational drugs potentially useful in the treatm ent of allergic and inflammatory disorders / / Exp. Opin. Invest. Drugs.— 1995.— Vol.4.— P.1021 — 1025.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Carter G.W., Voung P.R., Albert D.R. et al. 5-Lipoxygenase inhibitory activity of Zeleuton / / J. Pharmacol. Exp. Ther.— * 1991.— Vol.256.— P.929—937.</mixed-citation><mixed-citation xml:lang="en">Carter G.W., Voung P.R., Albert D.R. et al. 5-Lipoxygenase inhibitory activity of Zeleuton / / J. Pharmacol. Exp. Ther.— * 1991.— Vol.256.— P.929—937.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Chanarin N., Johnston S.L. Leukotrienes as a target in asthma therapy / / Drugs.— 1994.— Vol.47.— P.12—24.</mixed-citation><mixed-citation xml:lang="en">Chanarin N., Johnston S.L. Leukotrienes as a target in asthma therapy / / Drugs.— 1994.— Vol.47.— P.12—24.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Christie P.E., Tagari P., Ford-Hutchinson A.W. et al. Urinary leukotriene E4 concentracions increase after aspirin challenge in aspirin-sensitive asthm atic subjects / / Am. Rev. Respir. Dis.— 1991.— Vol.143.— P.1025—1029.</mixed-citation><mixed-citation xml:lang="en">Christie P.E., Tagari P., Ford-Hutchinson A.W. et al. Urinary leukotriene E4 concentracions increase after aspirin challenge in aspirin-sensitive asthm atic subjects / / Am. Rev. Respir. Dis.— 1991.— Vol.143.— P.1025—1029.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Chung K.F. Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy / / Eur. Respir. J.— 1995,— Vol.8.— P.1203—1213.</mixed-citation><mixed-citation xml:lang="en">Chung K.F. Leukotriene receptor antagonists and biosynthesis inhibitors: potential breakthrough in asthma therapy / / Eur. Respir. J.— 1995,— Vol.8.— P.1203—1213.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen B. Leukotrienes as mediators of asthma induced by aspirin and allergen 1993, 1-68 / / ISBN: 91-628-0961-X.</mixed-citation><mixed-citation xml:lang="en">Dahlen B. Leukotrienes as mediators of asthma induced by aspirin and allergen 1993, 1-68 / / ISBN: 91-628-0961-X.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen B., Dahlen S.E. Leukotrienes as mediators of airway obstruction and inflammation in asthma / / Clin. Exp. Allergy.— 1995.— Vol.25, Suppl. 2.— P.50—54.</mixed-citation><mixed-citation xml:lang="en">Dahlen B., Dahlen S.E. Leukotrienes as mediators of airway obstruction and inflammation in asthma / / Clin. Exp. Allergy.— 1995.— Vol.25, Suppl. 2.— P.50—54.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen B., Zetterstrom O., Bjorck T. et al. The leukoctriene antagonist ICI-204219 inhibits the aerly airway reaction to cum ulative bronchial challenge with allergen in atopic asthm atics / / Eur. Respir. J.— 1994.— Vol.7.— P.324—331.</mixed-citation><mixed-citation xml:lang="en">Dahlen B., Zetterstrom O., Bjorck T. et al. The leukoctriene antagonist ICI-204219 inhibits the aerly airway reaction to cum ulative bronchial challenge with allergen in atopic asthm atics / / Eur. Respir. J.— 1994.— Vol.7.— P.324—331.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen S.E., Bjork J., Hedqvist P. et al. Leukotrienes promotes plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response / / Proc. Natl. Acad. Sci. USA.— 1981.— Vol.78.— P.3887—3891.</mixed-citation><mixed-citation xml:lang="en">Dahlen S.E., Bjork J., Hedqvist P. et al. Leukotrienes promotes plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response / / Proc. Natl. Acad. Sci. USA.— 1981.— Vol.78.— P.3887—3891.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen S.E., Dahlen B., Kumlin M., Bjoerck T., Ihre E. Clinical and experimental studies of leukotrienes as mediators of airway obstruction in humans / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.155—166.</mixed-citation><mixed-citation xml:lang="en">Dahlen S.E., Dahlen B., Kumlin M., Bjoerck T., Ihre E. Clinical and experimental studies of leukotrienes as mediators of airway obstruction in humans / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.155—166.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlen S.E., Hedqvist P., Hammarstrom S., Samuelsson B. Leukotrienes are potent constrictors of human bronchi / / Nature.— 1980.— Vol.288.— P.484—486.</mixed-citation><mixed-citation xml:lang="en">Dahlen S.E., Hedqvist P., Hammarstrom S., Samuelsson B. Leukotrienes are potent constrictors of human bronchi / / Nature.— 1980.— Vol.288.— P.484—486.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Daines R.A., Chambers P.A., Pendrak I. et al. Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships / / J. Med. Chem.— 1993.— Vol.36.— P.3321—3332.</mixed-citation><mixed-citation xml:lang="en">Daines R.A., Chambers P.A., Pendrak I. et al. Trisubstituted pyridine leukotriene B4 receptor antagonists: synthesis and structure-activity relationships / / J. Med. Chem.— 1993.— Vol.36.— P.3321—3332.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dixon R.A.F., Diehl R.E., Opas E. et al. Requirement of a 5-lipoxygenase protein for leukotriene synthesis / / Nature.— 1990.— Vol.343.— P.282—284.</mixed-citation><mixed-citation xml:lang="en">Dixon R.A.F., Diehl R.E., Opas E. et al. Requirement of a 5-lipoxygenase protein for leukotriene synthesis / / Nature.— 1990.— Vol.343.— P.282—284.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Drazen J. The role of leukotrienes in asthm a. M ediating the inflammation in asthma / / European Academy of Allergology and Clinical Immunology. Satellite Symposium.— Rotterdam, 1993.— P.4.</mixed-citation><mixed-citation xml:lang="en">Drazen J. The role of leukotrienes in asthm a. M ediating the inflammation in asthma / / European Academy of Allergology and Clinical Immunology. Satellite Symposium.— Rotterdam, 1993.— P.4.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Drazen J.M., Austen K.F. Leukotrienes and airway responses / / Am. Rev. Respir. Dis.— 1987.— Vol.136.— P.985—988.</mixed-citation><mixed-citation xml:lang="en">Drazen J.M., Austen K.F. Leukotrienes and airway responses / / Am. Rev. Respir. Dis.— 1987.— Vol.136.— P.985—988.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Drazen J.M., Lilly C.M., Sperling R., Rubin P., Israel E. Role of cysteinil leucotrienes in spontaneus asthmatic responses / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.251—262.</mixed-citation><mixed-citation xml:lang="en">Drazen J.M., Lilly C.M., Sperling R., Rubin P., Israel E. Role of cysteinil leucotrienes in spontaneus asthmatic responses / / Adv. Prostagland. Thrombox. Leukotr. Res.— 1994.— Vol.22.— P.251—262.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Evans T.W., Rogers D.F., Aursudkij B. et al. Regional and time-dependent effects of inflammatory on airway microvascular permeability in the guinea-pig / / Clin. Sci.— 1989.— Vol.76.— P.479—485.</mixed-citation><mixed-citation xml:lang="en">Evans T.W., Rogers D.F., Aursudkij B. et al. Regional and time-dependent effects of inflammatory on airway microvascular permeability in the guinea-pig / / Clin. Sci.— 1989.— Vol.76.— P.479—485.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Findlay S.R., Barden J.M., Easley C.B. et al. Effect of the oral leukotriene antagonist JCJ 204. 219 on antigen-induced bronchoconstriction in subjects with asthma / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P. 1040— 1045.</mixed-citation><mixed-citation xml:lang="en">Findlay S.R., Barden J.M., Easley C.B. et al. Effect of the oral leukotriene antagonist JCJ 204. 219 on antigen-induced bronchoconstriction in subjects with asthma / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P. 1040— 1045.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Floreani A., Robbins R., Melson J., Rennard S. Inhibitory effect of LTD4 receptor antagonist ‘Accolate on agonistinduced bronchoconstriction in asthmatic subjects / / Ann. Allergy. Asthma Immunol.— 1996.— Vol.76.— P.98.</mixed-citation><mixed-citation xml:lang="en">Floreani A., Robbins R., Melson J., Rennard S. Inhibitory effect of LTD4 receptor antagonist ‘Accolate on agonistinduced bronchoconstriction in asthmatic subjects / / Ann. Allergy. Asthma Immunol.— 1996.— Vol.76.— P.98.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Ford-Hutchinson A.W., Bray M.A., Doig M.E. et al. Leukotriene B: a potent chemokinetic and aggregating sustance released from polymorphonuclear leukocytes / / Nature.— 1980.— Vol.286.— P.264.</mixed-citation><mixed-citation xml:lang="en">Ford-Hutchinson A.W., Bray M.A., Doig M.E. et al. Leukotriene B: a potent chemokinetic and aggregating sustance released from polymorphonuclear leukocytes / / Nature.— 1980.— Vol.286.— P.264.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Foster A., Chan C.C. Peptide leukotriene involment in pulmonary eosinophil migration upon antigen challenge in the actively sensitized guinea pig / / Arch. Allergy Appl. Immunol.— 1991.— Vol.96.— P.279—284.</mixed-citation><mixed-citation xml:lang="en">Foster A., Chan C.C. Peptide leukotriene involment in pulmonary eosinophil migration upon antigen challenge in the actively sensitized guinea pig / / Arch. Allergy Appl. Immunol.— 1991.— Vol.96.— P.279—284.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Friedman B.S., Bel E.H., Buntinx A. et al. Oral leukotriene inhibitor (MK-886) blocks allergen- induced airway responses / / Am. Rev. Respir. Dis.— 1993.— Vol.147.— P.839—844.</mixed-citation><mixed-citation xml:lang="en">Friedman B.S., Bel E.H., Buntinx A. et al. Oral leukotriene inhibitor (MK-886) blocks allergen- induced airway responses / / Am. Rev. Respir. Dis.— 1993.— Vol.147.— P.839—844.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fujimura M., Sakamoto S., Kamio Y. et al. Effect of a leukotriene antagonist ONO-1078 on bronchial hyperresponsiveness in patients with asthma / / Respir. Med.— 1993.— Vol.87.— P. 133— 138.</mixed-citation><mixed-citation xml:lang="en">Fujimura M., Sakamoto S., Kamio Y. et al. Effect of a leukotriene antagonist ONO-1078 on bronchial hyperresponsiveness in patients with asthma / / Respir. Med.— 1993.— Vol.87.— P. 133— 138.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Fuller R.W., Black P.N., Dolley C.T. Effect of the oral leukotriene D4 antagonist LY 171883 on inhaled and inradermal challenge with antigen and leukotriene D4 in atopic subjects / / J. Allergy Clin. Immunol.— 1989.— Vol.83.— P.939— 944.</mixed-citation><mixed-citation xml:lang="en">Fuller R.W., Black P.N., Dolley C.T. Effect of the oral leukotriene D4 antagonist LY 171883 on inhaled and inradermal challenge with antigen and leukotriene D4 in atopic subjects / / J. Allergy Clin. Immunol.— 1989.— Vol.83.— P.939— 944.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Gaddy J.N., Buch R.K., Margoleskee D. et al. The effects of leukotriene D4 antagonist (MK 571) in mild to moderate asthma / / J. Allergy Clin. Immunol.— 1990.— Vol.85.— P .195.</mixed-citation><mixed-citation xml:lang="en">Gaddy J.N., Buch R.K., Margoleskee D. et al. The effects of leukotriene D4 antagonist (MK 571) in mild to moderate asthma / / J. Allergy Clin. Immunol.— 1990.— Vol.85.— P .195.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Gaddy J.N., Margoleskee D.J., Buch R.K. et al. The effects of a potent and selective leucotriene D4 antagonist (MK 571) in moderate asthm a / / Am. Rev. Respir. Dis.— 1992.— Vol. 146.— P.358—363.</mixed-citation><mixed-citation xml:lang="en">Gaddy J.N., Margoleskee D.J., Buch R.K. et al. The effects of a potent and selective leucotriene D4 antagonist (MK 571) in moderate asthm a / / Am. Rev. Respir. Dis.— 1992.— Vol. 146.— P.358—363.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Gillard J., Ford-Hutchinson A.W., Chan C. et al. MK-886, njvel orally active leukotriene biosynthesis inhibitor / / Can. J. Physiol. Pharm acol.— 1989.— Vol.67.— P.456—464.</mixed-citation><mixed-citation xml:lang="en">Gillard J., Ford-Hutchinson A.W., Chan C. et al. MK-886, njvel orally active leukotriene biosynthesis inhibitor / / Can. J. Physiol. Pharm acol.— 1989.— Vol.67.— P.456—464.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Glass M. Initial results with oral administration of ICI 204219 / / Ann. N. Y. Acad. Sei.— 1991.— Vol.629.— P.143—147.</mixed-citation><mixed-citation xml:lang="en">Glass M. Initial results with oral administration of ICI 204219 / / Ann. N. Y. Acad. Sei.— 1991.— Vol.629.— P.143—147.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Haahtela T. The importance of inflammation in early asthma / / Respir. M ed.— 1995.— Vol.89, № 7.— P.461—462.</mixed-citation><mixed-citation xml:lang="en">Haahtela T. The importance of inflammation in early asthma / / Respir. M ed.— 1995.— Vol.89, № 7.— P.461—462.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Harris R.R., Carter G.W., Bell R. et al. Clinical activity of leukotriene inhibitors / / Int. J. Immunopharmacol.— 1995.— Vol.17,— P.147—156.</mixed-citation><mixed-citation xml:lang="en">Harris R.R., Carter G.W., Bell R. et al. Clinical activity of leukotriene inhibitors / / Int. J. Immunopharmacol.— 1995.— Vol.17,— P.147—156.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Hay D.W.P., Muccietelli R.M., Tucker S.S. et al. Pharmacologic profile of SK&amp;F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways / / J. Pharmacol. Exp. Ther.— 1987.— Vol.243.— P.474—481.</mixed-citation><mixed-citation xml:lang="en">Hay D.W.P., Muccietelli R.M., Tucker S.S. et al. Pharmacologic profile of SK&amp;F 104353: a novel, potent and selective peptidoleukotriene receptor antagonist in guinea pig and human airways / / J. Pharmacol. Exp. Ther.— 1987.— Vol.243.— P.474—481.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hay D.W.P., Torphy T.J., Undem B.J. Cysteinyl leukotrienes in asthm a: old mediators up to new tricks / / Trends Pharmacol. Sei.— 1995.— Vol. 16.— P.304—309.</mixed-citation><mixed-citation xml:lang="en">Hay D.W.P., Torphy T.J., Undem B.J. Cysteinyl leukotrienes in asthm a: old mediators up to new tricks / / Trends Pharmacol. Sei.— 1995.— Vol. 16.— P.304—309.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Hoover R.L., Karnovsky M.J., Austen K.F. et al. Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion / / Proc. Natl. Acad. Sei. USA.— 1984.— Vol.81.— P.2191— 2193.</mixed-citation><mixed-citation xml:lang="en">Hoover R.L., Karnovsky M.J., Austen K.F. et al. Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion / / Proc. Natl. Acad. Sei. USA.— 1984.— Vol.81.— P.2191— 2193.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Hui K.P., Barnes N.C. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist / / Lancet.— 1991.— Vol.337.— P. 1062.</mixed-citation><mixed-citation xml:lang="en">Hui K.P., Barnes N.C. Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist / / Lancet.— 1991.— Vol.337.— P. 1062.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Hui K.P., Taylor J.K., Taylor G.W. et al. Effect of 5-Lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthm atic patients / / Thorax.— 1991.— Vol.46.— P.184— 189.</mixed-citation><mixed-citation xml:lang="en">Hui K.P., Taylor J.K., Taylor G.W. et al. Effect of 5-Lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthm atic patients / / Thorax.— 1991.— Vol.46.— P.184— 189.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Hutchinson J.H., Reindeau D., Brideau C. et al. Thiopyrano [ 2, 3, 4 — cd] indoles as 5-Lipoxygenase inhibitors: synthesis, biological profile / / J. Med. Chem.— 1994.— Vol.37.— P.l153—1164.</mixed-citation><mixed-citation xml:lang="en">Hutchinson J.H., Reindeau D., Brideau C. et al. Thiopyrano [ 2, 3, 4 — cd] indoles as 5-Lipoxygenase inhibitors: synthesis, biological profile / / J. Med. Chem.— 1994.— Vol.37.— P.l153—1164.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Ishichara Y., Uchida Y., Kitamura S. Measurement of leukotrienes in peripheral venous blood from patients with bronchial asthm a / / Clin. Res.— 1985.— Vol.33.— P.466A.</mixed-citation><mixed-citation xml:lang="en">Ishichara Y., Uchida Y., Kitamura S. Measurement of leukotrienes in peripheral venous blood from patients with bronchial asthm a / / Clin. Res.— 1985.— Vol.33.— P.466A.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Israel E., Dermarkarian R., Rosenberg M. et al. The effects of 5-lipoxygenase inhibitor on asthm a induced by cold dry air / / N. Engl. J. M ed.— 1990.— Vol.323.— P.1740—1744.</mixed-citation><mixed-citation xml:lang="en">Israel E., Dermarkarian R., Rosenberg M. et al. The effects of 5-lipoxygenase inhibitor on asthm a induced by cold dry air / / N. Engl. J. M ed.— 1990.— Vol.323.— P.1740—1744.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Israel E., Drazen J., Cohn J., Rubin P. A double blind m ulticenter study of Zileuton, a potent 5-Lipoxygenase inhibitor versus placebo in the treatm ent of spontaneous asthm a in adults / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P.236—238.</mixed-citation><mixed-citation xml:lang="en">Israel E., Drazen J., Cohn J., Rubin P. A double blind m ulticenter study of Zileuton, a potent 5-Lipoxygenase inhibitor versus placebo in the treatm ent of spontaneous asthm a in adults / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P.236—238.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Israel E., Rubin P., Kemo I.P. et al. The effect of inhibition of 5-lipoxigenase by zileuton in mild-to-moderate asthm a / / Ann. Intern. M ed.— 1993.— Vol.119.— P.1059—1066.</mixed-citation><mixed-citation xml:lang="en">Israel E., Rubin P., Kemo I.P. et al. The effect of inhibition of 5-lipoxigenase by zileuton in mild-to-moderate asthm a / / Ann. Intern. M ed.— 1993.— Vol.119.— P.1059—1066.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Jacobs R.T., Veale C.A., Wolanin D.J. Pulmonary and antiallergy agents / / Annu. Rep. Med. Chem.— 1992.— Vol.27.— P. 109—118.</mixed-citation><mixed-citation xml:lang="en">Jacobs R.T., Veale C.A., Wolanin D.J. Pulmonary and antiallergy agents / / Annu. Rep. Med. Chem.— 1992.— Vol.27.— P. 109—118.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Jones T.R., Zamboni R., Belley M. et al. Pharmacology of L-660711 (MK 571): a novel potent and selective leukotriene D4 receptor antagonist / / Can. J. Physiol. Pharmacol.— 1989.— Vol.67.— P. 17—28.</mixed-citation><mixed-citation xml:lang="en">Jones T.R., Zamboni R., Belley M. et al. Pharmacology of L-660711 (MK 571): a novel potent and selective leukotriene D4 receptor antagonist / / Can. J. Physiol. Pharmacol.— 1989.— Vol.67.— P. 17—28.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Joris J., Majno G., Corey E.J., Lewis R.A. The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction / / Am. J. Pathol.— 1987.— Vol. 126.— P. 19—24.</mixed-citation><mixed-citation xml:lang="en">Joris J., Majno G., Corey E.J., Lewis R.A. The mechanism of vascular leakage induced by leukotriene E4. Endothelial contraction / / Am. J. Pathol.— 1987.— Vol. 126.— P. 19—24.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Kaliner M.A. Allergic inflammation and asthm a / / Prog. Allergy Clin. Immunol.— 1994.— Vol.3.— P.301—304.</mixed-citation><mixed-citation xml:lang="en">Kaliner M.A. Allergic inflammation and asthm a / / Prog. Allergy Clin. Immunol.— 1994.— Vol.3.— P.301—304.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Kikawa V., Hosoi S., Inoue V. et al. Exercise-induced urinary excretion of leukotriene E4 in children with atopic asthma / / Pediatr. Res.— 1991.— Vol.29.— P.455.</mixed-citation><mixed-citation xml:lang="en">Kikawa V., Hosoi S., Inoue V. et al. Exercise-induced urinary excretion of leukotriene E4 in children with atopic asthma / / Pediatr. Res.— 1991.— Vol.29.— P.455.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Knapp H.R. Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor / / N. Engl. J. M ed.— 1990.— Vol.323.— P. 1745—1748.</mixed-citation><mixed-citation xml:lang="en">Knapp H.R. Reduced allergen-induced nasal congestion and leukotriene synthesis with an orally active 5-lipoxygenase inhibitor / / N. Engl. J. M ed.— 1990.— Vol.323.— P. 1745—1748.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">König W., Schonjeld W., Raaulf M. et al. The neutrophil and leukotrienes — basic in health and disease / / Eucosanoids.— 1990.— Vol.3.— P .l— 22.</mixed-citation><mixed-citation xml:lang="en">König W., Schonjeld W., Raaulf M. et al. The neutrophil and leukotrienes — basic in health and disease / / Eucosanoids.— 1990.— Vol.3.— P .l— 22.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Krell R.D., Aharony D., Bucker C.K. et al. The preclinical of ICI 204219, a peptide leukotriene antagonist / / Am. Rev. Respir. Dis.— 1990,— V ol.141.— P.978—987.</mixed-citation><mixed-citation xml:lang="en">Krell R.D., Aharony D., Bucker C.K. et al. The preclinical of ICI 204219, a peptide leukotriene antagonist / / Am. Rev. Respir. Dis.— 1990,— V ol.141.— P.978—987.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Kumlin M., Dahlen B., Bjouck T. et al. Urinary exretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4 and histamine in asthm atics / / Am. Rev. Respir. Dis.— 1992.— Vol.146.— P.96—103.</mixed-citation><mixed-citation xml:lang="en">Kumlin M., Dahlen B., Bjouck T. et al. Urinary exretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4 and histamine in asthm atics / / Am. Rev. Respir. Dis.— 1992.— Vol.146.— P.96—103.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Labat C., Ortiz J.L., Norel X. et al. A second cysteinyl leukotriene receptor in human lung / / J. Pharmacol. Exp. Ther.— 1992.— Vol.63.— P.800—805.</mixed-citation><mixed-citation xml:lang="en">Labat C., Ortiz J.L., Norel X. et al. A second cysteinyl leukotriene receptor in human lung / / J. Pharmacol. Exp. Ther.— 1992.— Vol.63.— P.800—805.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Laitinen L.A., Laitinen A., Haahtela T. et al. Leukotriene E4 and granulocytic infiltration into asthm atic airways / / Lancet.— 1993.— Vol.341.— P.989—990.</mixed-citation><mixed-citation xml:lang="en">Laitinen L.A., Laitinen A., Haahtela T. et al. Leukotriene E4 and granulocytic infiltration into asthm atic airways / / Lancet.— 1993.— Vol.341.— P.989—990.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Lam S., Chan H., LeRiche J.C. et al. Realese of leukotrienes in patients with bronchial asthm a / / J. Allergy Clin. Immunol.— 1988,— Vol.81.— P.1711 — 1717.</mixed-citation><mixed-citation xml:lang="en">Lam S., Chan H., LeRiche J.C. et al. Realese of leukotrienes in patients with bronchial asthm a / / J. Allergy Clin. Immunol.— 1988,— Vol.81.— P.1711 — 1717.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Lammers J.W., Cheng J.B. Early efficacy data with a newer generation of LTD4 antagonists in anti-asthma trials / / Pulmon. Pharmacol.— 1992.— Vol.5.— P.121 — 125.</mixed-citation><mixed-citation xml:lang="en">Lammers J.W., Cheng J.B. Early efficacy data with a newer generation of LTD4 antagonists in anti-asthma trials / / Pulmon. Pharmacol.— 1992.— Vol.5.— P.121 — 125.</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Lay S.R., Barden J.M ., Easley C.B. et al. Effect of the oral leukotriene antagonist JC J 204219 on antigen-induced bronchoconstriction in subjects with asthm a / / J. Allergy Clin. Im munol.— 1992.— Vol.89.— P.1040— 1045.</mixed-citation><mixed-citation xml:lang="en">Lay S.R., Barden J.M ., Easley C.B. et al. Effect of the oral leukotriene antagonist JC J 204219 on antigen-induced bronchoconstriction in subjects with asthm a / / J. Allergy Clin. Im munol.— 1992.— Vol.89.— P.1040— 1045.</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Larsen J.S. Leukotriene — receptor antagonists and 5 — lipoxygenase inhibitors in asthm a / / Ann. Pharm acother.— 1993.— Vol.27.— P.898—903.</mixed-citation><mixed-citation xml:lang="en">Larsen J.S. Leukotriene — receptor antagonists and 5 — lipoxygenase inhibitors in asthm a / / Ann. Pharm acother.— 1993.— Vol.27.— P.898—903.</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Lazarus S.T., Lavins B.J., Wong H., Watts M.J., Minkwitz M.C. Effect of oral ‘Accolate’ on sulfur dioxide (S02) — induced bronchoconstriction in patients with asthm a / / Am. J. Respir. Crit. Care M ed.— 1995.— V ol.151, Pt 2.— P.A41.</mixed-citation><mixed-citation xml:lang="en">Lazarus S.T., Lavins B.J., Wong H., Watts M.J., Minkwitz M.C. Effect of oral ‘Accolate’ on sulfur dioxide (S02) — induced bronchoconstriction in patients with asthm a / / Am. J. Respir. Crit. Care M ed.— 1995.— V ol.151, Pt 2.— P.A41.</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Maclouf J., Fitzpatrick F.A., Murphy R.C. Transcellular biosynthesis of eicosanoids / / Pharmacol. Res.— 1989.— Vol.21.— P .l—7.</mixed-citation><mixed-citation xml:lang="en">Maclouf J., Fitzpatrick F.A., Murphy R.C. Transcellular biosynthesis of eicosanoids / / Pharmacol. Res.— 1989.— Vol.21.— P .l—7.</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Makker H.K., Lau L.C., Thomson H.W. et al. The protective effect of inhaled leucotriene D4 receptor antagonist ICI 204219 against exercise — induced asthm a / / Am. Rev. Respir. Dis.— 1993.— V ol.147, Pt 1.— P.1413—1418.</mixed-citation><mixed-citation xml:lang="en">Makker H.K., Lau L.C., Thomson H.W. et al. The protective effect of inhaled leucotriene D4 receptor antagonist ICI 204219 against exercise — induced asthm a / / Am. Rev. Respir. Dis.— 1993.— V ol.147, Pt 1.— P.1413—1418.</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Manning P.J., Rokach J., Malo J.-L. et al. Urinary leukotriene E4 levels during early and late asthm atic responses / / J. Allergy Clin. Immunol.— 1990.— Vol.86.— P .211—220.</mixed-citation><mixed-citation xml:lang="en">Manning P.J., Rokach J., Malo J.-L. et al. Urinary leukotriene E4 levels during early and late asthm atic responses / / J. Allergy Clin. Immunol.— 1990.— Vol.86.— P .211—220.</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Manning P.J., Watson R.M., Morgolskee D.J. et al. Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4 receptor antagonist / / N. Engl. J. M ed.— 1990.— Vol.323.— P. 1736—1739.</mixed-citation><mixed-citation xml:lang="en">Manning P.J., Watson R.M., Morgolskee D.J. et al. Inhibition of exercise-induced bronchoconstriction by MK-571, a potent leukotriene D4 receptor antagonist / / N. Engl. J. M ed.— 1990.— Vol.323.— P. 1736—1739.</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Margolskee D., Bodtnan S., Dockhorn R. et al. The therapeutic effects of MK-571, a potent and selective leukotriene D4, receptor antagonist in patients with chronic asthm a / / J. Allergy Clin. Immunol.— 1991.— Vol.87.— P.309.</mixed-citation><mixed-citation xml:lang="en">Margolskee D., Bodtnan S., Dockhorn R. et al. The therapeutic effects of MK-571, a potent and selective leukotriene D4, receptor antagonist in patients with chronic asthm a / / J. Allergy Clin. Immunol.— 1991.— Vol.87.— P.309.</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Marom Z.V.L., Shelhamer J.H., Bach M.K. et al. Slow-reacting substance, leukotrienes C4 and D4, icrease the realease of mucus from human airways in vitro / / Am. Rev. Respir. Dis.— 1982.— Vol.126.— P.449—451.</mixed-citation><mixed-citation xml:lang="en">Marom Z.V.L., Shelhamer J.H., Bach M.K. et al. Slow-reacting substance, leukotrienes C4 and D4, icrease the realease of mucus from human airways in vitro / / Am. Rev. Respir. Dis.— 1982.— Vol.126.— P.449—451.</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Miller D.K., Gillard J.W., Vickers P.J. et al. Indentification and isolation of a membrane protein necessary for leukotriene production / / N ature.— 1990.— Vol.343.— P.278—281.</mixed-citation><mixed-citation xml:lang="en">Miller D.K., Gillard J.W., Vickers P.J. et al. Indentification and isolation of a membrane protein necessary for leukotriene production / / N ature.— 1990.— Vol.343.— P.278—281.</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Morris H.R., Taylor G.W., Piper P.J., Tippins J.R. Structure of slow reacting substance of anaphylaxis from guinea-pig lung / / Ibid.— 1980.— Vol.285.— P.104—106.</mixed-citation><mixed-citation xml:lang="en">Morris H.R., Taylor G.W., Piper P.J., Tippins J.R. Structure of slow reacting substance of anaphylaxis from guinea-pig lung / / Ibid.— 1980.— Vol.285.— P.104—106.</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy R.C., Hammarstrom S., Samuelsson B. Leukotriene C: a slow-reacting substance from murine mastocytoma cells / / Proc. Natl. Acad. Sei. USA.— 1979.— Vol.76.— P.4275—4279.</mixed-citation><mixed-citation xml:lang="en">Murphy R.C., Hammarstrom S., Samuelsson B. Leukotriene C: a slow-reacting substance from murine mastocytoma cells / / Proc. Natl. Acad. Sei. USA.— 1979.— Vol.76.— P.4275—4279.</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Nakai H., Konno M., Kosuge S. et al. New potent antagonist of leukotrienes C4 and D4 1. Synthesis and structure-activity relationships / / J. Med. Chem.— 1988.— Vol.34.— P.84.</mixed-citation><mixed-citation xml:lang="en">Nakai H., Konno M., Kosuge S. et al. New potent antagonist of leukotrienes C4 and D4 1. Synthesis and structure-activity relationships / / J. Med. Chem.— 1988.— Vol.34.— P.84.</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Nakagawa N., Obata T. Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthm a / / Eur. J. Pharmacol.— 1993.— Vol.235.— P .211—219.</mixed-citation><mixed-citation xml:lang="en">Nakagawa N., Obata T. Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthm a / / Eur. J. Pharmacol.— 1993.— Vol.235.— P .211—219.</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Obata T., Okada Y., Motoishi M. et al. In vitro antagonism ONO-1078, a newly developed antiasthm a agent, against peptide leukotrienes in isolated guinea pig tissues / / Jap. J. Pharm acol.— 1992.— Vol.60.— P.227—230.</mixed-citation><mixed-citation xml:lang="en">Obata T., Okada Y., Motoishi M. et al. In vitro antagonism ONO-1078, a newly developed antiasthm a agent, against peptide leukotrienes in isolated guinea pig tissues / / Jap. J. Pharm acol.— 1992.— Vol.60.— P.227—230.</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">O’Hickey S.P., Hawksworth J., Fong C.V. et al. Leukotrienes C4D4-E4 enhance histamine responsiveness in asthm atic airways / / Am. Rev. Respir. Dis.— 1991.— V ol.144.— P .1053—1057.</mixed-citation><mixed-citation xml:lang="en">O’Hickey S.P., Hawksworth J., Fong C.V. et al. Leukotrienes C4D4-E4 enhance histamine responsiveness in asthm atic airways / / Am. Rev. Respir. Dis.— 1991.— V ol.144.— P .1053—1057.</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Ohmi Naoko, Tani C., Yamada K., Fukui M. Pharmacological profile of a novel, orally active leukotriene B4 antagonist, SM-15178 / / Iflammation.— 1994.— V ol.18.— P.129—140.</mixed-citation><mixed-citation xml:lang="en">Ohmi Naoko, Tani C., Yamada K., Fukui M. Pharmacological profile of a novel, orally active leukotriene B4 antagonist, SM-15178 / / Iflammation.— 1994.— V ol.18.— P.129—140.</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Picado C., Ramis I., Rosello J. et al. Release of peptide leukotriene in to nasal secretions after local instillation of aspirin in aspirin sensitive asthm atic patients / / Am. Rev. Respir. Dis.— 1991.— Vol.145.— P.65—69.</mixed-citation><mixed-citation xml:lang="en">Picado C., Ramis I., Rosello J. et al. Release of peptide leukotriene in to nasal secretions after local instillation of aspirin in aspirin sensitive asthm atic patients / / Am. Rev. Respir. Dis.— 1991.— Vol.145.— P.65—69.</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Piper P.J. Formation and actions of leukotrienes / / Pharmacol. Rev.— 1984.— Vol.64.— P.744—761.</mixed-citation><mixed-citation xml:lang="en">Piper P.J. Formation and actions of leukotrienes / / Pharmacol. Rev.— 1984.— Vol.64.— P.744—761.</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Piper P.J. Leukotriene in airways and blood vessels / / Arzneim.- Forsch.— 1989.— Bd 39.— S. 1005—1009.</mixed-citation><mixed-citation xml:lang="en">Piper P.J. Leukotriene in airways and blood vessels / / Arzneim.- Forsch.— 1989.— Bd 39.— S. 1005—1009.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Piper P.J. Leukotrienes: potent mediators of airway constriction / / Int. Arch. Allergy Appl. Immunol.— 1985.— Vol.76, Suppl. 1.— P.43—48.</mixed-citation><mixed-citation xml:lang="en">Piper P.J. Leukotrienes: potent mediators of airway constriction / / Int. Arch. Allergy Appl. Immunol.— 1985.— Vol.76, Suppl. 1.— P.43—48.</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Rasmussen J.B., Morgolskee D.J., Eriksson L.O. et al. Leukotriene (LT) D4 is involved in antigen— induced asthma: a study with the LTD4 receptor antagonist MR— 571 / / Ann. N. Y. Acad. Sei.— 1991.— Vol.629.— P.436.</mixed-citation><mixed-citation xml:lang="en">Rasmussen J.B., Morgolskee D.J., Eriksson L.O. et al. Leukotriene (LT) D4 is involved in antigen— induced asthma: a study with the LTD4 receptor antagonist MR— 571 / / Ann. N. Y. Acad. Sei.— 1991.— Vol.629.— P.436.</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Roquet A., Dahlen B., Ihre E. et al. Cysteinyl-leukotriens and histamine account for predominant components of early and late phase airway obstruction evoked by allergene-challenge of asthmatics / / Am. J. Respir. Crit. Care Med.— 1996.— Vol. 154, № 4.— Pt 2.— P.A214.</mixed-citation><mixed-citation xml:lang="en">Roquet A., Dahlen B., Ihre E. et al. Cysteinyl-leukotriens and histamine account for predominant components of early and late phase airway obstruction evoked by allergene-challenge of asthmatics / / Am. J. Respir. Crit. Care Med.— 1996.— Vol. 154, № 4.— Pt 2.— P.A214.</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Rouzer C.A., Ford-IJutchinson A.W., Morten H.E. MK-886, a potent and specific leukotriene biosynthesis inhibitor, blocks and reverses the membrane association of 5-lipoxygenase in ionophore challenged leukocytes / / J. Biol. Chem.— 1990.— Vol.265.— P.1436—1442.</mixed-citation><mixed-citation xml:lang="en">Rouzer C.A., Ford-IJutchinson A.W., Morten H.E. MK-886, a potent and specific leukotriene biosynthesis inhibitor, blocks and reverses the membrane association of 5-lipoxygenase in ionophore challenged leukocytes / / J. Biol. Chem.— 1990.— Vol.265.— P.1436—1442.</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Rouzer C.A., Kargman S. Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187 / / Ibid.— 1988.— Vol.263.— P.10980—10988.</mixed-citation><mixed-citation xml:lang="en">Rouzer C.A., Kargman S. Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187 / / Ibid.— 1988.— Vol.263.— P.10980—10988.</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Sakakibara H., Hirose K., Okawara S. Peptidoleukotriene receptor antagonists / / Nippon Rinsho.— 1996.— Vol.54.— P.3049—3055.</mixed-citation><mixed-citation xml:lang="en">Sakakibara H., Hirose K., Okawara S. Peptidoleukotriene receptor antagonists / / Nippon Rinsho.— 1996.— Vol.54.— P.3049—3055.</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Salari H., Borgeat P., Fournier M. et al. Studies of the release of leukotrienes and histamine by human lung parenchymal and bronchial frafments upon immunologic and nonimmunologic stim ulation / / J. Exp. M ed.— 1985.— Vol.162.— P.1904—1915.</mixed-citation><mixed-citation xml:lang="en">Salari H., Borgeat P., Fournier M. et al. Studies of the release of leukotrienes and histamine by human lung parenchymal and bronchial frafments upon immunologic and nonimmunologic stim ulation / / J. Exp. M ed.— 1985.— Vol.162.— P.1904—1915.</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reaction and inflammation / / Science.— 1983.— Vol.220.— P.568.</mixed-citation><mixed-citation xml:lang="en">Samuelsson B. Leukotrienes: mediators of immediate hypersensitivity reaction and inflammation / / Science.— 1983.— Vol.220.— P.568.</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Satoh Y., Stanton J.L., Hutchinson A.J. et al. Substituted Chromenes as potent, orally active 5-lipoxigenase inhibitors / / J. Med. Chem.— 1993.— Vol.36.— P.3580—3594.</mixed-citation><mixed-citation xml:lang="en">Satoh Y., Stanton J.L., Hutchinson A.J. et al. Substituted Chromenes as potent, orally active 5-lipoxigenase inhibitors / / J. Med. Chem.— 1993.— Vol.36.— P.3580—3594.</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Schroer K. Pharmacology of allergic inflammation: new approaches to drug treatm ent by selective modulation of the formation and action of aicosanoids / / Allergologie.— 1992.— Vol. 15.— P.330—335.</mixed-citation><mixed-citation xml:lang="en">Schroer K. Pharmacology of allergic inflammation: new approaches to drug treatm ent by selective modulation of the formation and action of aicosanoids / / Allergologie.— 1992.— Vol. 15.— P.330—335.</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw A., Krell R.D. Peptide leukotriens: current status of research / / J. Med. Chem.— 1991.— Vol.34, № 4.— P.1235—1242.</mixed-citation><mixed-citation xml:lang="en">Shaw A., Krell R.D. Peptide leukotriens: current status of research / / J. Med. Chem.— 1991.— Vol.34, № 4.— P.1235—1242.</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Smith M.J.H., Ford-Hutchinson A.W., Bray M.A. Leukotriene B: a potencial mediator of inflammation / / J. Pharm. Pharmacol.— 1980.— Vol.32.— P.517—518.</mixed-citation><mixed-citation xml:lang="en">Smith M.J.H., Ford-Hutchinson A.W., Bray M.A. Leukotriene B: a potencial mediator of inflammation / / J. Pharm. Pharmacol.— 1980.— Vol.32.— P.517—518.</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Smith L.J., Geller S., Edright L. et al. Inhibition of leukotriene (LT) D4-induced bronchoconstriction in asthm atic subjects by the oral LTD4 receptor antagonist ICI 204219 / / Am. Rev. Respir. Dis.— 1990.— Vol.141.— P.A33.</mixed-citation><mixed-citation xml:lang="en">Smith L.J., Geller S., Edright L. et al. Inhibition of leukotriene (LT) D4-induced bronchoconstriction in asthm atic subjects by the oral LTD4 receptor antagonist ICI 204219 / / Am. Rev. Respir. Dis.— 1990.— Vol.141.— P.A33.</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Tagari P., Becker A.B., Brideau C. et al. Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591 / / J. Pharmacol. Exp. Their.— 1993.— Vol.265.— P.416—425.</mixed-citation><mixed-citation xml:lang="en">Tagari P., Becker A.B., Brideau C. et al. Leukotriene generation and metabolism in dogs: inhibition of biosynthesis by MK-0591 / / J. Pharmacol. Exp. Their.— 1993.— Vol.265.— P.416—425.</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Tagari P., Rasmussen J.B., Delore D. et al. Comparison of urinary leukotriene E4 and 16-carboxytetranordihydroleukotriene E4 excretion in allergic asthm atics after inhaled antigen / / Eicosanoids.— 1990.— Vol.3.— P.75—80.</mixed-citation><mixed-citation xml:lang="en">Tagari P., Rasmussen J.B., Delore D. et al. Comparison of urinary leukotriene E4 and 16-carboxytetranordihydroleukotriene E4 excretion in allergic asthm atics after inhaled antigen / / Eicosanoids.— 1990.— Vol.3.— P.75—80.</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Taniguchi Y., Tamura G., Honma M. et al. The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthm atic subjects / / J. Allergy Clin. Immunol.— 1993.— Vol.92.— P.507—512.</mixed-citation><mixed-citation xml:lang="en">Taniguchi Y., Tamura G., Honma M. et al. The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthm atic subjects / / J. Allergy Clin. Immunol.— 1993.— Vol.92.— P.507—512.</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor I.K. Cysteinyl leukotriene in asthma: current state of therapeutic evalution / / Thorax.— 1995.— Vol.50.— P. 1005—1010.</mixed-citation><mixed-citation xml:lang="en">Taylor I.K. Cysteinyl leukotriene in asthma: current state of therapeutic evalution / / Thorax.— 1995.— Vol.50.— P. 1005—1010.</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor G.W., Black P., Turner N. et al. Urinary leukotriene E4 after antigen challenge in acute asthma and allergic rhinitis / / Lancet.— 1989.— V ol.l.— P.584—588.</mixed-citation><mixed-citation xml:lang="en">Taylor G.W., Black P., Turner N. et al. Urinary leukotriene E4 after antigen challenge in acute asthma and allergic rhinitis / / Lancet.— 1989.— V ol.l.— P.584—588.</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor I.K., O’Shaughnessy K.M., Choudry N.B. et al. A comparative stady in atopic subjects with asthma of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity and increase in urinary leukotriene E4 excretion / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P.575—583.</mixed-citation><mixed-citation xml:lang="en">Taylor I.K., O’Shaughnessy K.M., Choudry N.B. et al. A comparative stady in atopic subjects with asthma of the effects of salmeterol and salbutamol on allergen-induced bronchoconstriction, increase in airway reactivity and increase in urinary leukotriene E4 excretion / / J. Allergy Clin. Immunol.— 1992.— Vol.89.— P.575—583.</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor W.A. Eicosanoids in asthma: the therapeutic options / / Perspectives in Medicinal Chemistry / Ed. B. Testa, E. Kuburz et al.— Weinheim, 1993.— P.445—458.</mixed-citation><mixed-citation xml:lang="en">Taylor W.A. Eicosanoids in asthma: the therapeutic options / / Perspectives in Medicinal Chemistry / Ed. B. Testa, E. Kuburz et al.— Weinheim, 1993.— P.445—458.</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Virchow J.C., Kroegel C., Luttman W. et al. Leukotriene-receptor-antagonists, 5-lipoxygenase-activating-protein inhibitors — a new form of therapy in bronchial asthma / / Allergologie.— 1996.— Vol.19, № 1.— P.3—14.</mixed-citation><mixed-citation xml:lang="en">Virchow J.C., Kroegel C., Luttman W. et al. Leukotriene-receptor-antagonists, 5-lipoxygenase-activating-protein inhibitors — a new form of therapy in bronchial asthma / / Allergologie.— 1996.— Vol.19, № 1.— P.3—14.</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Wardlaw A.J., Hay H., Cromwell O. et al. Leukotrienes, LTC4 and LTD4 in bronchoalveolar lavage in bronchial asthma and respiratory diseases / / J. Allergy Clin. Immunol.— 1989.— Vol.84.— P. 19—26.</mixed-citation><mixed-citation xml:lang="en">Wardlaw A.J., Hay H., Cromwell O. et al. Leukotrienes, LTC4 and LTD4 in bronchoalveolar lavage in bronchial asthma and respiratory diseases / / J. Allergy Clin. Immunol.— 1989.— Vol.84.— P. 19—26.</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">WEI Er-Qing, XIN Xiao-Hua et al. Effects of ONO-1078, a lekotriene antagonist, on cardiovascular responses induced by vagal stimulation, capsaicin, and substance P in guinea pigs / / Acta Pharmacol. Sin.— 1995.— Vol.16.— P.485—488.</mixed-citation><mixed-citation xml:lang="en">WEI Er-Qing, XIN Xiao-Hua et al. Effects of ONO-1078, a lekotriene antagonist, on cardiovascular responses induced by vagal stimulation, capsaicin, and substance P in guinea pigs / / Acta Pharmacol. Sin.— 1995.— Vol.16.— P.485—488.</mixed-citation></citation-alternatives></ref><ref id="cit117"><label>117</label><citation-alternatives><mixed-citation xml:lang="ru">Weiss J.W., Drazen J.M., Coles H. Bronchoconstrictor effects of leukotriene C in humans / / Science.— 1982.— Vol.216.— P.196—198.</mixed-citation><mixed-citation xml:lang="en">Weiss J.W., Drazen J.M., Coles H. Bronchoconstrictor effects of leukotriene C in humans / / Science.— 1982.— Vol.216.— P.196—198.</mixed-citation></citation-alternatives></ref><ref id="cit118"><label>118</label><citation-alternatives><mixed-citation xml:lang="ru">Whealan C.J. Prospects for the development of new drags for the therapy of respiratory diseases / / Drugs Today.— 1996.— Vol.32.— P.295—311.</mixed-citation><mixed-citation xml:lang="en">Whealan C.J. Prospects for the development of new drags for the therapy of respiratory diseases / / Drugs Today.— 1996.— Vol.32.— P.295—311.</mixed-citation></citation-alternatives></ref><ref id="cit119"><label>119</label><citation-alternatives><mixed-citation xml:lang="ru">Woodward D.F., Weichman B.M., Gill C.A., Wasserman M.A. The effect of synthetic leukotrienes on tracheal microvascular permeability / / Prostaglandins.— 1983.— Vol.25.— P.131—142.</mixed-citation><mixed-citation xml:lang="en">Woodward D.F., Weichman B.M., Gill C.A., Wasserman M.A. The effect of synthetic leukotrienes on tracheal microvascular permeability / / Prostaglandins.— 1983.— Vol.25.— P.131—142.</mixed-citation></citation-alternatives></ref><ref id="cit120"><label>120</label><citation-alternatives><mixed-citation xml:lang="ru">Zakrzewski J.T., Barnes H.C., Piper P.J. Quantitation of leukotrienes in asthmatic sputum / / Br. J. Pharmacol.— 1985.— Vol.19.— P.574.</mixed-citation><mixed-citation xml:lang="en">Zakrzewski J.T., Barnes H.C., Piper P.J. Quantitation of leukotrienes in asthmatic sputum / / Br. J. Pharmacol.— 1985.— Vol.19.— P.574.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
