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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pulmo-3184</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title>Эффективность и безопасность ингаляционных глюкокортикоидов у больных бронхиальной астмой</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy and safety of inhaled glucocorticoids in bronchial asthma patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Емельянов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Emelianov</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шевелев</surname><given-names>С. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Shevelev</surname><given-names>S. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амосов</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Amosov</surname><given-names>V. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурзин</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mursin</surname><given-names>B. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шубин</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shubin</surname><given-names>S. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Кафедра госпитальной терапии;&#13;
Кафедра рентгенологии и радиологии Санкт-Петербургского государственного медицинского университета им. акад. И.П.Павлова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>1999</year></pub-date><pub-date pub-type="epub"><day>30</day><month>03</month><year>1999</year></pub-date><volume>0</volume><issue>1</issue><fpage>39</fpage><lpage>42</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Емельянов А.В., Шевелев С.Э., Амосов В.И., Мурзин Б.А., Шубин С.А., 1999</copyright-statement><copyright-year>1999</copyright-year><copyright-holder xml:lang="ru">Емельянов А.В., Шевелев С.Э., Амосов В.И., Мурзин Б.А., Шубин С.А.</copyright-holder><copyright-holder xml:lang="en">Emelianov A.V., Shevelev S.E., Amosov V.I., Mursin B.A., Shubin S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/3184">https://journal.pulmonology.ru/pulm/article/view/3184</self-uri><abstract><p>Целью настоящей работы явилось исследование эффективности и безопасности ингаляционных глюкокортикоидов (будесонида и беклометазона дипропионата) у больных бронхиальной астмой (БА). Под наблюдением находилось 19 пациентов (8 мужчин, 11 женщин) с БА средней тяжести течения, получавших эти препараты в течение 9 месяцев. В процессе лечения у обследованных отмечалось существенное снижение частоты приступов удушья и потребности в ингаляциях β2-адреномиметиков короткого действия. Достоверный прирост показателей бронхиальной проходимости отмечался лишь через 3 месяца после начала терапии и сохранялся до конца периода наблюдения. Уровень кортизола в крови, концентрация  магния, кальция и калия в сыворотке крови,эритроцитах и суточной моче, содержание остеокальцина всыворотке, плотность костной ткани поясничных позвонков (L2-L4) через 3, 6 и 9 месяцев лечения существенно не отличались от исходных.Таким образом, ингаляционные глюкокортикоиды обладают высокой клинической эффективностью при лечении больных БА. Их следует назначать больным в течение как минимум 3 месяцев. Использованные топические стероиды в средних терапевтических дозах не обладают отрицательным влиянием на уровень кортизола, минеральный обмен и костную ткань.</p></abstract><trans-abstract xml:lang="en"><p>The aim of this study was to investigate efficacy and safety of inhaled glucocorticoids (budesonide and beclometazone dipropionate) in bronchial asthma (BA) patients. Nineteen patients (8 males and 11 females) with moderate BA were observed. They have received these drugs for 9 months. The patients demonstrated significantreduction in asthmatic attacks frequency and in need for short-acting β2-agonists inhalations during the treatment. The reliable increase of bronchial passability parameters was registered only over 3 months after the starting of the therapy and was maintained up to the end of the observation period. Cortizol blood level, magnesium, calcium and potassium concentrations in serum, erythrocytes and in daily urine, serum osteocalcine content, lumbar vertebra density (L2-L4) did not differ significantly after 3, 6 and 9 months of treatment compared with the initial parameters.Thus, the inhaled glucocorticoids possess high clinical activity in asthmatic patients’ treatment. These drugs should be prescribed for at least 3 months. The inhaled glucocorticoids used in average therapeutic doses do not effect negatively on cortizol blood level, mineral metabolism and osseous tissue.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Agertoff L., Pedersen S. Bone mineral density in children with asthma receiving long term treatment with inhaled budesonide / / Am. J. Respir. Crit. 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