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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2013-0-6-92-98</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-315</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Ранние и поздние легочные осложнения лучевой терапии лимфомы Ходжкина</article-title><trans-title-group xml:lang="en"><trans-title>Early and long-term pulmonary complications of radiotherapy of Hodgkin's lymphoma</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Даниленко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Danilenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., старший научный сотрудник отделения лучевой и лекарственной терапии гемобластозов</p><p>249036, Калужская обл., Обнинск, ул. Королева, 4. Тел.: 8-909-250-02-22.</p></bio><email xlink:type="simple">danilenko@mrrc.obninsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шахтарина</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakhtarina</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., ведущий научный сотрудник отделения лучевой и лекарственной терапии гемобластозов </p><p>249036, Калужская обл., Обнинск, ул. Королева, 4. Тел.: (48439) 9-31-01.</p></bio><email xlink:type="simple">danilenko@mrrc.obninsk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ФГБУ "Медицинский радиологический научный центр" Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2013</year></pub-date><volume>0</volume><issue>6</issue><fpage>92</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Даниленко А.А., Шахтарина С.В., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Даниленко А.А., Шахтарина С.В.</copyright-holder><copyright-holder xml:lang="en">Danilenko A.A., Shakhtarina S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/315">https://journal.pulmonology.ru/pulm/article/view/315</self-uri><abstract><p>Ранние и поздние легочные осложнения лучевой терапии лимфомы Ходжкина</p></abstract><trans-abstract xml:lang="en"><p>Early and long-term pulmonary complications of radiotherapy of Hodgkin's lymphoma.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лимфома Ходжкина</kwd><kwd>лучевые повреждения легких</kwd><kwd>пневмонит</kwd><kwd>пневмофиброз</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Hodgkin's lymphoma</kwd><kwd>lung radiation injury</kwd><kwd>pneumonitis</kwd><kwd>pulmonary fibrosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Williams J.P., Johnston C.J., Finkelstein J.N. Treatment for radiation-induced pulmonary late effects: Spoiled for choice or looking in the wrong direction? Curr. Drug Targets 2010; 11 (11): 1386–1394.</mixed-citation><mixed-citation xml:lang="en">Williams J.P., Johnston C.J., Finkelstein J.N. Treatment for radiation-induced pulmonary late effects: Spoiled for choice or looking in the wrong direction? Curr. Drug Targets 2010; 11 (11): 1386–1394.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Notter R.H., Finkelstein J.N., Holm B.A. Lung injury: mechanisms, pathophysiology, and therapy. New York: Taylor Fransis, 2005.</mixed-citation><mixed-citation xml:lang="en">Notter R.H., Finkelstein J.N., Holm B.A. Lung injury: mechanisms, pathophysiology, and therapy. New York: Taylor Fransis, 2005.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bentzen S.M. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nature Rev. Cancer. 2006; 6: 702–713.</mixed-citation><mixed-citation xml:lang="en">Bentzen S.M. Preventing or reducing late side effects of radiation therapy: Radiobiology meets molecular pathology. Nature Rev. Cancer. 2006; 6: 702–713.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Mikkelsen R.B., Wardman P. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 2003; 22: 5734–5754.</mixed-citation><mixed-citation xml:lang="en">Mikkelsen R.B., Wardman P. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 2003; 22: 5734–5754.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Fleckenstein K., Zgonjanin L., Chen L. et al. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2007; 68: 196–204.</mixed-citation><mixed-citation xml:lang="en">Fleckenstein K., Zgonjanin L., Chen L. et al. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2007; 68: 196–204.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ghafoori P., Marks L.B., Vujaskovic Z. et al. Radiationinduced lung injury: assessment, management, and prevention. Oncology 2008; 22 (1): 37–47.</mixed-citation><mixed-citation xml:lang="en">Ghafoori P., Marks L.B., Vujaskovic Z. et al. Radiationinduced lung injury: assessment, management, and prevention. Oncology 2008; 22 (1): 37–47.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Young B., Lowe J.S., Stevens A., Heath J.W. Wheather′s functional histology: a text and colour atlas. 5rd ed. London: Churchill Livingstone, 2006.</mixed-citation><mixed-citation xml:lang="en">Young B., Lowe J.S., Stevens A., Heath J.W. Wheather′s functional histology: a text and colour atlas. 5rd ed. London: Churchill Livingstone, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rubin P., Shapiro D.L., Finklestein J.N. et al. The early release of surfactant following lung irradiation of alveolar type II cells. Int. J. Radiat. Oncol. Biol. Phys.1980; 6: 75–77.</mixed-citation><mixed-citation xml:lang="en">Rubin P., Shapiro D.L., Finklestein J.N. et al. The early release of surfactant following lung irradiation of alveolar type II cells. Int. J. Radiat. Oncol. Biol. Phys.1980; 6: 75–77.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Allavena C., Conroy T., Aletti P. et al. Late cardiopulmonary toxicity after treatment for Hodgkin′s disease. Br. J. Cancer 1992; 65: 908–912.</mixed-citation><mixed-citation xml:lang="en">Allavena C., Conroy T., Aletti P. et al. Late cardiopulmonary toxicity after treatment for Hodgkin′s disease. Br. J. Cancer 1992; 65: 908–912.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Torrisi J.M., Schwartz L.H., Gollub M.J. CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology 2011; 258 (1): 41–56.</mixed-citation><mixed-citation xml:lang="en">Torrisi J.M., Schwartz L.H., Gollub M.J. CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity. Radiology 2011; 258 (1): 41–56.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Трахтенберг А.Х., Чиссов В.И. Клиническая онкопульмонология. М.: ГЭОТАР Медицина, 2000.</mixed-citation><mixed-citation xml:lang="en">Трахтенберг А.Х., Чиссов В.И. Клиническая онкопульмонология. М.: ГЭОТАР Медицина, 2000.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Marks L.B., Fan M., Clough R. et al. Radiation-induced pulmonary injury: Symptomatic versus subclinical endpoints. Int. J. Radiat. Biol. 2000; 76: 469–475.</mixed-citation><mixed-citation xml:lang="en">Marks L.B., Fan M., Clough R. et al. Radiation-induced pulmonary injury: Symptomatic versus subclinical endpoints. Int. J. Radiat. Biol. 2000; 76: 469–475.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Goethals I., Dierckx R., Meerleer G. et al. The role of nuclear medicine in the prediction and detection of radiation-associated normal pulmonary and cardiac damage. J. Nucl. Med. 2003; 44 (9): 1531–1539.</mixed-citation><mixed-citation xml:lang="en">Goethals I., Dierckx R., Meerleer G. et al. The role of nuclear medicine in the prediction and detection of radiation-associated normal pulmonary and cardiac damage. J. Nucl. Med. 2003; 44 (9): 1531–1539.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bria W.F., Kanarek D.J., Kazemi H. Prediction of postoperative pulmonary function following thoracic operations: value of ventilation-perfusion scanning. J. Thorac. Cardiovasc. Surg.1983; 86: 186–192.</mixed-citation><mixed-citation xml:lang="en">Bria W.F., Kanarek D.J., Kazemi H. Prediction of postoperative pulmonary function following thoracic operations: value of ventilation-perfusion scanning. J. Thorac. Cardiovasc. Surg.1983; 86: 186–192.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rubenstein J., Richter M., Moldofsky P. et al. Prospective prediction of post-radiation therapy lung function using quantitative lung scans and pulmonary function testing. Int. J. Radiat. Oncol. Biol. Phys.1988; 15: 83–87.</mixed-citation><mixed-citation xml:lang="en">Rubenstein J., Richter M., Moldofsky P. et al. Prospective prediction of post-radiation therapy lung function using quantitative lung scans and pulmonary function testing. Int. J. Radiat. Oncol. Biol. Phys.1988; 15: 83–87.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Choi N., Kanarek D., Grillo H. Effect of post-operative radiotherapy on changes in pulmonary function in patients with stage II and IIIa lung carcinoma. Int. J. Radiat. Oncol. Biol. Phys.1990; 18: 95–99.</mixed-citation><mixed-citation xml:lang="en">Choi N., Kanarek D., Grillo H. Effect of post-operative radiotherapy on changes in pulmonary function in patients with stage II and IIIa lung carcinoma. Int. J. Radiat. Oncol. Biol. Phys.1990; 18: 95–99.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Curran W., Moldofsky P., Solin L. Observations on the predictive value of perfusion lung scans on post-irradiation pulmonary function among 210 patients with bronchogenic carcinoma. Int. J. Radiat. Oncol. Biol. Phys.1992; 24: 31–36.</mixed-citation><mixed-citation xml:lang="en">Curran W., Moldofsky P., Solin L. Observations on the predictive value of perfusion lung scans on post-irradiation pulmonary function among 210 patients with bronchogenic carcinoma. Int. J. Radiat. Oncol. Biol. Phys.1992; 24: 31–36.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Boersma L., Damen.E., de Boer R. et al. A new method to determine dose-effect relations for local lung function changes using correlated SPECT and CT data. Radiother. Oncol.1993; 29: 110–116.</mixed-citation><mixed-citation xml:lang="en">Boersma L., Damen.E., de Boer R. et al. A new method to determine dose-effect relations for local lung function changes using correlated SPECT and CT data. Radiother. Oncol.1993; 29: 110–116.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Boersma L., Damen E., de Boer R.W. et al. Estimation of overall pulmonary function after irradiation using doseeffect relations for local functional injury. Radiother. Oncol. 1995; 36: 15–23.</mixed-citation><mixed-citation xml:lang="en">Boersma L., Damen E., de Boer R.W. et al. Estimation of overall pulmonary function after irradiation using doseeffect relations for local functional injury. Radiother. Oncol. 1995; 36: 15–23.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Boersma L., Damen E., de Boer R.W. et al. Recovery of overall and local function loss 18 monthsafter irradiation for malignant lymphoma. J. Clin. Oncol.1996; 14: 1431–1441.</mixed-citation><mixed-citation xml:lang="en">Boersma L., Damen E., de Boer R.W. et al. Recovery of overall and local function loss 18 monthsafter irradiation for malignant lymphoma. J. Clin. Oncol.1996; 14: 1431–1441.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Theuws J., Kwa S., Wagenaar A. et al. Prediction of overall pulmonary function loss in relation to 3-D dose distribution for patients with breast cancer and malignant lymphoma. Radiother. Oncol. 1998; 49: 233–243.</mixed-citation><mixed-citation xml:lang="en">Theuws J., Kwa S., Wagenaar A. et al. Prediction of overall pulmonary function loss in relation to 3-D dose distribution for patients with breast cancer and malignant lymphoma. Radiother. Oncol. 1998; 49: 233–243.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Robnett T.J., Machtay M., Vines E.P. et al. Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int. J. Radiat. Oncol. Biol. Phys.2000; 48: 89–94.</mixed-citation><mixed-citation xml:lang="en">Robnett T.J., Machtay M., Vines E.P. et al. Factors predicting severe radiation pneumonitis in patients receiving definitive chemoradiation for lung cancer. Int. J. Radiat. Oncol. Biol. Phys.2000; 48: 89–94.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kim T.H., Cho K.H., Pyo H.R. et al. Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimentional conformal radiation therapy for lung cancer. Radiology 2005; 235: 208–215.</mixed-citation><mixed-citation xml:lang="en">Kim T.H., Cho K.H., Pyo H.R. et al. Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimentional conformal radiation therapy for lung cancer. Radiology 2005; 235: 208–215.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kong F.M., Haymann J.A., Griffith K.A. et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 2006; 65: 1075–1086.</mixed-citation><mixed-citation xml:lang="en">Kong F.M., Haymann J.A., Griffith K.A. et al. Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 2006; 65: 1075–1086.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hua C., Hoth K.A., Wu S. et al. Incidence and correlates of radiation pneumonitis in pediatric patients with partial lung irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2012; 78 (1): 43–149.</mixed-citation><mixed-citation xml:lang="en">Hua C., Hoth K.A., Wu S. et al. Incidence and correlates of radiation pneumonitis in pediatric patients with partial lung irradiation. Int. J. Radiat. Oncol. Biol. Phys. 2012; 78 (1): 43–149.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Fox A.M., Dosoretz A.P., Mauch P.M. et al. Predictive factors for radiation pneumonitis in Hodgkin is lymphoma patients receiving combined modality therapy. Int. J. Radiat. Oncol. Biol. Phys. 2012; 83 (1): 277–283.</mixed-citation><mixed-citation xml:lang="en">Fox A.M., Dosoretz A.P., Mauch P.M. et al. Predictive factors for radiation pneumonitis in Hodgkin is lymphoma patients receiving combined modality therapy. Int. J. Radiat. Oncol. Biol. Phys. 2012; 83 (1): 277–283.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Koh E.S., Sun A., Tran T.H. et al. Clinical dose-volume histogram analysis in predicting radiation pneumonitis in Hodgkin′s lymphoma. Int. J. Radiat. Oncol. Biol. Phys. 2006; 66 (1): 223–228.</mixed-citation><mixed-citation xml:lang="en">Koh E.S., Sun A., Tran T.H. et al. Clinical dose-volume histogram analysis in predicting radiation pneumonitis in Hodgkin′s lymphoma. Int. J. Radiat. Oncol. Biol. Phys. 2006; 66 (1): 223–228.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Meadors M., Floyd J., Perry M.C. Pulmonary toxicity of chemotherapy. Semin. Oncol. 2006; 33: 98–105.</mixed-citation><mixed-citation xml:lang="en">Meadors M., Floyd J., Perry M.C. Pulmonary toxicity of chemotherapy. Semin. Oncol. 2006; 33: 98–105.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Байсоголов Г.Д., Афанасова Н.В., Шахтарина С.В. и др. Изменения в легких у больных лимфогранулематозом I–II клинической стадии после комбинированного лечения. Мед. радиол. 1985; 3: 18–22.</mixed-citation><mixed-citation xml:lang="en">Байсоголов Г.Д., Афанасова Н.В., Шахтарина С.В. и др. Изменения в легких у больных лимфогранулематозом I–II клинической стадии после комбинированного лечения. Мед. радиол. 1985; 3: 18–22.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Hirsch A., Van der Els N., Straus D.J. et al. Effect of ABVD chemotherapy with and without mantle or mediastinal irradiation on pulmonary function and symptoms in early-stage Hodgkin`s disease. J. Clin. Oncol. 1996; 14: 1297–1305.</mixed-citation><mixed-citation xml:lang="en">Hirsch A., Van der Els N., Straus D.J. et al. Effect of ABVD chemotherapy with and without mantle or mediastinal irradiation on pulmonary function and symptoms in early-stage Hodgkin`s disease. J. Clin. Oncol. 1996; 14: 1297–1305.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Macann A., Bredenfeld H., Muller R.P. et al. Radiotherapy does not influence the severe pulmonary toxicity observed with the administration of gemcitabine and bleomycin in patients with advanced-stage Hodgkin′s lymphoma treated with the BAGCOPP regimen: a report by the German Hodgkin′s Lymphoma Study Group. Int. J. Radiat. Oncol. Biol. Phys. 2008; 70 (1): 161–165.</mixed-citation><mixed-citation xml:lang="en">Macann A., Bredenfeld H., Muller R.P. et al. Radiotherapy does not influence the severe pulmonary toxicity observed with the administration of gemcitabine and bleomycin in patients with advanced-stage Hodgkin′s lymphoma treated with the BAGCOPP regimen: a report by the German Hodgkin′s Lymphoma Study Group. Int. J. Radiat. Oncol. Biol. Phys. 2008; 70 (1): 161–165.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Бардычев М.С., Цыб А.Ф. Местные лучевые повреждения. М.: Медицина, 1985.</mixed-citation><mixed-citation xml:lang="en">Бардычев М.С., Цыб А.Ф. Местные лучевые повреждения. М.: Медицина, 1985.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Park K.J., Chung J.Y., Chun M.S. et al. Radiation-induced lung disease and the impact of radiation methods on imaging features. Radiographics 2000; 20 (1): 83–98.</mixed-citation><mixed-citation xml:lang="en">Park K.J., Chung J.Y., Chun M.S. et al. Radiation-induced lung disease and the impact of radiation methods on imaging features. Radiographics 2000; 20 (1): 83–98.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Abratt R., Morgan G. Lung toxicity following chest irradiation in patients with lung cancer. Lung Cancer 2002; 35: 103–109.</mixed-citation><mixed-citation xml:lang="en">Abratt R., Morgan G. Lung toxicity following chest irradiation in patients with lung cancer. Lung Cancer 2002; 35: 103–109.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Rubin P., Finkelstein J., Shapiro D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 1992; 24: 93–101.</mixed-citation><mixed-citation xml:lang="en">Rubin P., Finkelstein J., Shapiro D. Molecular biology mechanisms in the radiation induction of pulmonary injury syndromes: interrelationship between the alveolar macrophage and the septal fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 1992; 24: 93–101.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Коврыжкина Т.А., Ильин Н.В., Акимов А.А. и др. Использование линейно-квадратичной модели для оценки поздних лучевых повреждений легких у больных лимфогранулематозом. Мед. радиол. 1997; 3: 59–63.</mixed-citation><mixed-citation xml:lang="en">Коврыжкина Т.А., Ильин Н.В., Акимов А.А. и др. Использование линейно-квадратичной модели для оценки поздних лучевых повреждений легких у больных лимфогранулематозом. Мед. радиол. 1997; 3: 59–63.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Villani F., Busia A., Villani M. et al. Cardiopulmonary response to exercise in patients with different degrees of lung toxicity after radio-chemotherapy for Hodgkin′s disease. Anticancer Res. 2009; 29 (2): 777–784.</mixed-citation><mixed-citation xml:lang="en">Villani F., Busia A., Villani M. et al. Cardiopulmonary response to exercise in patients with different degrees of lung toxicity after radio-chemotherapy for Hodgkin′s disease. Anticancer Res. 2009; 29 (2): 777–784.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Lund M.B., Kongerud J., Boe J. et al. Late complications after treatment of Hodgkin`s disease. Tidsskr. Norske Laegeforen. 1999; 119 (7): 933–937.</mixed-citation><mixed-citation xml:lang="en">Lund M.B., Kongerud J., Boe J. et al. Late complications after treatment of Hodgkin`s disease. Tidsskr. Norske Laegeforen. 1999; 119 (7): 933–937.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Enrichi R.M., Anselmo A.P., Donato V. et al. Relapse and late complications in early-stage Hodgkin′s disease patients with mediastinal involvement treated with radiotherapy alone or plus one cycle of ABVD. Haematologica 1999; 84 (10): 17–23.</mixed-citation><mixed-citation xml:lang="en">Enrichi R.M., Anselmo A.P., Donato V. et al. Relapse and late complications in early-stage Hodgkin′s disease patients with mediastinal involvement treated with radiotherapy alone or plus one cycle of ABVD. Haematologica 1999; 84 (10): 17–23.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Brusamolino E., Baio A., Orlandi E. et al. Long-term events in adult patients with clinical stage IA–IIA nonbulky Hodgkin`s lymphoma treated with four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine and adjuvant radiotherapy: a single-institution 15-year follow-up. Clin. Cancer Res. 2006; 12 (21): 6487–6493.</mixed-citation><mixed-citation xml:lang="en">Brusamolino E., Baio A., Orlandi E. et al. Long-term events in adult patients with clinical stage IA–IIA nonbulky Hodgkin`s lymphoma treated with four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine and adjuvant radiotherapy: a single-institution 15-year follow-up. Clin. Cancer Res. 2006; 12 (21): 6487–6493.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Andrieu J.M., Jais J.P., Colonna P. et al. Ten-year results of a strategy combining three cycles of ABVD and high-dose extended irradiation for treating Hodgkin′s disease at advanced stages. Ann. Oncol. 1998; 9 (2): 195–203.</mixed-citation><mixed-citation xml:lang="en">Andrieu J.M., Jais J.P., Colonna P. et al. Ten-year results of a strategy combining three cycles of ABVD and high-dose extended irradiation for treating Hodgkin′s disease at advanced stages. Ann. Oncol. 1998; 9 (2): 195–203.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Даниленко А.А., Шахтарина С.В., Афанасова Н.В., Павлов В.В. Изменения в легких у больных лимфомой Ходжкина после химиотерапии по схемам СОРР, ABVD, BEACOPP и облучения средостения в суммарной очаговой дозе 20–30 Гр. Клин. онкогематол. 2010; 3 (4): 354–358.</mixed-citation><mixed-citation xml:lang="en">Даниленко А.А., Шахтарина С.В., Афанасова Н.В., Павлов В.В. Изменения в легких у больных лимфомой Ходжкина после химиотерапии по схемам СОРР, ABVD, BEACOPP и облучения средостения в суммарной очаговой дозе 20–30 Гр. Клин. онкогематол. 2010; 3 (4): 354–358.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sasse A.D., Clark L.G., Sasse E.C., Clark O.A. Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis. Int. J. Radiat. Oncol. Biol. Phys. 2006; 64: 784–791.</mixed-citation><mixed-citation xml:lang="en">Sasse A.D., Clark L.G., Sasse E.C., Clark O.A. Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis. Int. J. Radiat. Oncol. Biol. Phys. 2006; 64: 784–791.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Levi M., Knol J.A., Ensminger W.D. et al. Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys. Drug Metabol. Disposit. 2002; 30: 1425–1430.</mixed-citation><mixed-citation xml:lang="en">Levi M., Knol J.A., Ensminger W.D. et al. Regional pharmacokinetics of amifostine in anesthetized dogs: role of the liver, gastrointestinal tract, lungs, and kidneys. Drug Metabol. Disposit. 2002; 30: 1425–1430.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberg J.S., Epperly M.W. Antioxidant gene therapeutic approaches to normal tissue protection and tumor radiosensitization. In Vitro 2007; 21: 141–146.</mixed-citation><mixed-citation xml:lang="en">Greenberg J.S., Epperly M.W. Antioxidant gene therapeutic approaches to normal tissue protection and tumor radiosensitization. In Vitro 2007; 21: 141–146.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Gauter7Fleckenstein B., Fleckenstein K., Owzar K. et al. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic. Biol. Med. 2008; 44: 982–989.</mixed-citation><mixed-citation xml:lang="en">Gauter7Fleckenstein B., Fleckenstein K., Owzar K. et al. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic. Biol. Med. 2008; 44: 982–989.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Williams J.P., Hernady E., Johnston C.J. et al. Effect of administration of lovastatin on the development of late pulmonary effects following whole lung irradiation in a murine model. Radiat. Res. 2004; 161: 560–567.</mixed-citation><mixed-citation xml:lang="en">Williams J.P., Hernady E., Johnston C.J. et al. Effect of administration of lovastatin on the development of late pulmonary effects following whole lung irradiation in a murine model. Radiat. Res. 2004; 161: 560–567.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Xie C.H., Zhang M.S., Zhou Y.F. et al. Chinese medicine Angelica sinensis supresses radiation-induced expression of TNF-α and TGF-β in mice. Oncol. Rep. 2006; 15: 1429–1436.</mixed-citation><mixed-citation xml:lang="en">Xie C.H., Zhang M.S., Zhou Y.F. et al. Chinese medicine Angelica sinensis supresses radiation-induced expression of TNF-α and TGF-β in mice. Oncol. Rep. 2006; 15: 1429–1436.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Kozaka Y., Mitsumori M., Araki N. et al. Avascular necrosis of bilateral femoral head as a result of long-term steroid administration for radiation pneumonitis after tangential irradiation of the breast. Int. J. Clin. Oncol. 2006; 11: 482–486.</mixed-citation><mixed-citation xml:lang="en">Kozaka Y., Mitsumori M., Araki N. et al. Avascular necrosis of bilateral femoral head as a result of long-term steroid administration for radiation pneumonitis after tangential irradiation of the breast. Int. J. Clin. Oncol. 2006; 11: 482–486.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
