Показано, что сдвиги в содержании нитрита в слюне больных бронхиальной астмой связаны с выраженностью бронхообструкции и изменениями в сердечно-сосудистой системе в условиях гипоксического стресса и формирования легочной гипертензии. Рекомендовано определение уровня нитрита в слюне для оценки выраженности бронхообструкции и корригирования схем противовоспалительной и противоастматической терапии при бронхиальной астме.
The involvement of nitric oxide in the formation of bronchial hyperresponsiveness and pulmonary hypertension in bronchial asthma was studied. Shifts of nitric oxide were assessed by measuring nitric anion content in saliva using Griess reaction in 67 patients with non-atopic bronchial asthma. We assessed a pulmonary hypertension level and a condition of left and right ventricles by echocardiography.It was shown that nitrite level in saliva depends on severity of airway limitation. Significant increase in nitrite content was revealed in mild bronchial asthma patients, especially during exacerbation. However, nitrite level in patients with status asthmaticus was significantly decreased. Based on data obtained we have suggested that changes in saliva nitric oxide reflect adaptive capacities of upper and lower airways and cardiovascular system in asthmatic patients with pulmonary hypertension. Nitric oxide produced in upper respiratory tract and oral cavity and self-inhaled thought to provide remarkable improvement in asthma and pulmonary hypertension course.The investigation findings allow us to conclude that measurement of nitrite saliva level in bronchial asthma patients could be used for diagnostic purpose and its results could constitute an alternative approach to antiasthmatic and hypotensive treatment.
The authors declare that there are no conflicts of interest present.