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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2013-0-6-718-723</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-299</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group></article-categories><title-group><article-title></article-title><trans-title-group xml:lang="en"><trans-title></trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кадушкин</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kadushkin</surname><given-names>А. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант кафедры биологической химии </p><p>220116, Республика Беларусь, Минск, пр. Дзержинского, 83. Тел.: (37517) 272-67-88.</p></bio><email xlink:type="simple">kadushkyn@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таганович</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Taganovich</surname><given-names>А. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор, зав. Кафедрой биологической химии</p><p>220116, Республика Беларусь, Минск, пр. Дзержинского, 83. Тел.: (37517) 272-67-64.</p></bio><email xlink:type="simple">taganovich@bsmu.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Картун</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kartun</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ст. научный сотрудник лаборатории биохимических методов исследования</p><p>220116, Республика Беларусь, Минск, пр. Дзержинского, 83. Тел.: (37517) 278-77-34.</p></bio><email xlink:type="simple">lbmibgmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ходосовская</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Hodosovskaya</surname><given-names>Е. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник лаборатории биохимических методов исследования </p><p>220116, Республика Беларусь, Минск, пр. Дзержинского, 83. Тел.: (37517) 278-77-34.</p></bio><email xlink:type="simple">lbmibgmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чупик</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chupik</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>главный врач </p><p>220117, Республика Беларусь, Минск, ул. Голубева, 25. Тел.: (37517) 272-64-94.</p></bio><email xlink:type="simple">32poliklinika@mail.belpak.by</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО "Белорусский государственный медицинский университет"</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>УЗ "32 городская клиническая поликлиника"</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2013</year></pub-date><volume>0</volume><issue>6</issue><fpage>27</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кадушкин А.Г., Таганович А.Д., Картун Л.В., Ходосовская Е.В., Чупик В.Н., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Кадушкин А.Г., Таганович А.Д., Картун Л.В., Ходосовская Е.В., Чупик В.Н.</copyright-holder><copyright-holder xml:lang="en">Kadushkin А.G., Taganovich А.D., Kartun L.V., Hodosovskaya Е.V., Chupik V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/299">https://journal.pulmonology.ru/pulm/article/view/299</self-uri></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. global initiative for chronic obstructive lung disease (GOLD). 2011.</mixed-citation><mixed-citation xml:lang="en">Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. global initiative for chronic obstructive lung disease (GOLD). 2011.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Salvi S.S., Barnes P.J. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009; 374: 733–743.</mixed-citation><mixed-citation xml:lang="en">Salvi S.S., Barnes P.J. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009; 374: 733–743.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bai P., Sun Y., Jin J. et al. Disturbance of the OPG / RANK / RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis. Respir. Res. 2011; 12: 157.</mixed-citation><mixed-citation xml:lang="en">Bai P., Sun Y., Jin J. et al. Disturbance of the OPG / RANK / RANKL pathway and systemic inflammation in COPD patients with emphysema and osteoporosis. Respir. Res. 2011; 12: 157.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Tanni S.E., Pelegrino N.R., Angeleli A.Y. et al. Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients. J. Inflamm. 2010; 7: 29.</mixed-citation><mixed-citation xml:lang="en">Tanni S.E., Pelegrino N.R., Angeleli A.Y. et al. Smoking status and tumor necrosis factor-alpha mediated systemic inflammation in COPD patients. J. Inflamm. 2010; 7: 29.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lim S.C., Ju J.Y., Chi S.Y. et al. Apoptosis of T lymphocytes isolated from peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease. Yonsei Med. J. 2011; 52 (4): 581–587.</mixed-citation><mixed-citation xml:lang="en">Lim S.C., Ju J.Y., Chi S.Y. et al. Apoptosis of T lymphocytes isolated from peripheral blood of patients with acute exacerbation of chronic obstructive pulmonary disease. Yonsei Med. J. 2011; 52 (4): 581–587.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dickens J.A., Miller B.E., Edwards L.D. et al. COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir. Res. 2011; 12: 146.</mixed-citation><mixed-citation xml:lang="en">Dickens J.A., Miller B.E., Edwards L.D. et al. COPD association and repeatability of blood biomarkers in the ECLIPSE cohort. Respir. Res. 2011; 12: 146.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Schols A.M., Buurman W.A., Staal van den Brekel A.J. et al. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996; 51 (8): 819–824.</mixed-citation><mixed-citation xml:lang="en">Schols A.M., Buurman W.A., Staal van den Brekel A.J. et al. Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax 1996; 51 (8): 819–824.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Aaron S.D., Vandemheen K.L., Ramsay T. et al. Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD. Respir. Res. 2010; 11: 41.</mixed-citation><mixed-citation xml:lang="en">Aaron S.D., Vandemheen K.L., Ramsay T. et al. Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD. Respir. Res. 2010; 11: 41.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia7Rio F., Miravitlles M., Soriano J.B. et al. Systemic inflammation in chronic obstructive pulmonary disease: a population-based study. Respir. Res. 2010; 11: 63.</mixed-citation><mixed-citation xml:lang="en">Garcia7Rio F., Miravitlles M., Soriano J.B. et al. Systemic inflammation in chronic obstructive pulmonary disease: a population-based study. Respir. Res. 2010; 11: 63.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Serapinas D., Narbekovas A., Juskevicius J. et al. Systemic inflammation in COPD in relation to smoking status. Multidiscip. Respir. Med. 2011; 6 (4): 214–219.</mixed-citation><mixed-citation xml:lang="en">Serapinas D., Narbekovas A., Juskevicius J. et al. Systemic inflammation in COPD in relation to smoking status. Multidiscip. Respir. Med. 2011; 6 (4): 214–219.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">de Jong J.W., van der Belt7Gritter B., Koeter G.H. et al. Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. Respir. Med. 1997; 91 (2): 67–76.</mixed-citation><mixed-citation xml:lang="en">de Jong J.W., van der Belt7Gritter B., Koeter G.H. et al. Peripheral blood lymphocyte cell subsets in subjects with chronic obstructive pulmonary disease: association with smoking, IgE and lung function. Respir. Med. 1997; 91 (2): 67–76.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Guidelines for controlling and monitoring the tobacco epidemic. Genewa: WHO; 2008.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Guidelines for controlling and monitoring the tobacco epidemic. Genewa: WHO; 2008.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Jones P.W., Harding G., Berry P. et al. Development and first validation of the COPD Assessment Test. Eur. Respir. J. 2009; 34 (3): 648–654.</mixed-citation><mixed-citation xml:lang="en">Jones P.W., Harding G., Berry P. et al. Development and first validation of the COPD Assessment Test. Eur. Respir. J. 2009; 34 (3): 648–654.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Anthonisen N.R., Manfreda J., Warren C.P. et al. Antibiotic therapy in exacerbations of chronic obsructive pulmonary disease. Ann. Intern. Med. 1987; 106 (2): 196–204.</mixed-citation><mixed-citation xml:lang="en">Anthonisen N.R., Manfreda J., Warren C.P. et al. Antibiotic therapy in exacerbations of chronic obsructive pulmonary disease. Ann. Intern. Med. 1987; 106 (2): 196–204.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wanger J., Clausen J.L., Coates A. et al. Standartisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26 (3): 511–522.</mixed-citation><mixed-citation xml:lang="en">Wanger J., Clausen J.L., Coates A. et al. Standartisation of the measurement of lung volumes. Eur. Respir. J. 2005; 26 (3): 511–522.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy P.M. Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin. Hematol. 1997; 34 (4): 311–318.</mixed-citation><mixed-citation xml:lang="en">Murphy P.M. Neutrophil receptors for interleukin-8 and related CXC chemokines. Semin. Hematol. 1997; 34 (4): 311–318.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Rossi G.A. COPD patients or "healthy smokers": is IL-8 synthesis and release the borderline? Respiration 2003; 70 (5): 457–459.</mixed-citation><mixed-citation xml:lang="en">Rossi G.A. COPD patients or "healthy smokers": is IL-8 synthesis and release the borderline? Respiration 2003; 70 (5): 457–459.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Mediators of chronic obstructive pulmonary disease. Pharmacol. Rev. 2004; 56 (4): 515–548.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Mediators of chronic obstructive pulmonary disease. Pharmacol. Rev. 2004; 56 (4): 515–548.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Жестков А.В., Косарев В.В., Бабанов С.А. и др. Клинико-иммунологические особенности профессионального бронхита. Пульмонология 2008; 4: 31–35.</mixed-citation><mixed-citation xml:lang="en">Жестков А.В., Косарев В.В., Бабанов С.А. и др. Клинико-иммунологические особенности профессионального бронхита. Пульмонология 2008; 4: 31–35.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Petrescu F., Voican S.C., Silosi I. Tumor necrosis factor-α serum levels in healthy smokers and nonsmokers. Int. J. Chron. Obsruct. Pulm. Dis. 2010; 5: 217–222.</mixed-citation><mixed-citation xml:lang="en">Petrescu F., Voican S.C., Silosi I. Tumor necrosis factor-α serum levels in healthy smokers and nonsmokers. Int. J. Chron. Obsruct. Pulm. Dis. 2010; 5: 217–222.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Shirai T., Suda T., Inui N. et al. Correlation between peripheral blood T-cell profiles and clinical and inflammatory parameters in stable COPD. Allergol. Int. 2010; 59 (1): 75–82.</mixed-citation><mixed-citation xml:lang="en">Shirai T., Suda T., Inui N. et al. Correlation between peripheral blood T-cell profiles and clinical and inflammatory parameters in stable COPD. Allergol. Int. 2010; 59 (1): 75–82.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chung K.F. Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. 2001; 18 (34): 50s–59s.</mixed-citation><mixed-citation xml:lang="en">Chung K.F. Cytokines in chronic obstructive pulmonary disease. Eur. Respir. J. 2001; 18 (34): 50s–59s.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Torvinen M., Campwala H., Kilty I. The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures. Respir. Res. 2007; 8: 80.</mixed-citation><mixed-citation xml:lang="en">Torvinen M., Campwala H., Kilty I. The role of IFN-γ in regulation of IFN-γ-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures. Respir. Res. 2007; 8: 80.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
