References

pulmo

Пульмонология

PULMONOLOGIYA

0869-01892541-9617

Scientific and Practical Journal “PULMONOLOGIYA” LLC

pulmo-2915

Research Article

ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ

ORIGINAL STUDIES

Полиморфизм генов ферментов биотрансформации ксенобиотиков и особенности бронхиальной астмы у детей

Gene polymorphism of xenobiotics transformation enzymes and childhood bronchial asthma peculiarities

Ляхович

В. В.

Lyakhovich

V. V.

Гавалов

С. М.

Gavalov

S. M.

Вавилин

В. А.

Vavilin

V. A.

Рябова

О. А.

Ryabova

O. A.

Макарова

С. И.

Makarova

S. I.

Гуткина

Н. И.

Gutkina

N. I.

Часовникова

О. Б.

Chasovnikova

O. B.

Суслякова

О. В.

Suslyakova

O. V.

Лиханов

А. В.

Likhanov

A. V.

Институт молекулярной биологии и биофизики СО РАМНRussian Federationкафедра педиатрии ФУВ Новосибирской государственной медицинской академииRussian Federation

2002

23102021

023138

2021

Ляхович В.В., Гавалов С.М., Вавилин В.А., Рябова О.А., Макарова С.И., Гуткина Н.И., Часовникова О.Б., Суслякова О.В., Лиханов А.В.

Lyakhovich V.V., Gavalov S.M., Vavilin V.A., Ryabova O.A., Makarova S.I., Gutkina N.I., Chasovnikova O.B., Suslyakova O.V., Likhanov A.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://journal.pulmonology.ru/pulm/article/view/2915

Исследована взаимосвязь клинических особенностей бронхиальной астмы с генетическим изолейцин-валиновым полиморфизмом цитохрома Р-4501А1 (CYP1A1 lle/Val), нуль-полиморфизмом глютатион-Б-трансферазы M1 (GSTM1«-») и фенотипическим полиморфизмом N-ацетилтрансферазы (медленные (МА) и быстрые (БА) ацетиляторы) и цитохрома Р-4501А (быстрые, промежуточные и медленные метаболизеры — БМ, ПМ и ММ) и пассивным курением у детей (/7=100). У некурящих (п=40) риск поливалентной аллергии ассоциирован со статусом МА (отношение шансов (ОЯ=1,63; CI: 0,27-11,87) и нормальным генотипом GSTM1 (OR=3,73; Cl: 0,38-10,73), риск раннего развития астмы — со статусом МА (ОЯ=2,48; CI: 0,45-17,25), тяжелое течение заболевания — с генотипом CYP1A1 lle/Val (OR=2,75; Cl: 0,27-36,24) и статусом МА (OR=1,9; Cl: 0,38-10,73). Фактор курения модифицирует их функциональную значимость. У пассивных курильщиков (/7=60) с этими клиническими особенностями ассоциирован генотип GSTM1«-» (ОЯ=1,98; CI: 0,46-9,95); 9,0 (CI: 1,07-409,9); 1,23 (0,36-4,27) и ММфенотипом (ОЯ=1,7 (CI: 0,28-9,25); 2,6 (CI: 0,29-22,31) и 2,88 (CI: 0,57-14,24).

An association was investigated between clinical sighs of child’s asthma with gene isoleucine/valine polymorphism of cytochrome P-4501A1 (CYP1A1 lle/Val), null-polymorphism of glutatione-S-transferase M1 (GSTM1”-”), phenotypic N-acetyltransferase (rapid and slow acetylators — RA and SA) and CYP1A (rapid, intermediate and slow metabolizers of theophylline — RM, IM and SM) polymorphism and passive smoking (/7=100). Polyvalent allergy In non-smokers (/7=40) was associated with SA (odds ratio (ОЯ)=1.63; Ci: 0.27-11.87) and normal GSTM1 genotype (OR=3.73; Cl: 0.38-10.73). Early occurrence of asthma was associated with SA (ОЯ=2.48; Cl: 0.45-17.25). Severe asthma course correlated with CYP1A1 lle/Val genotype (OR=2.75; Cl: 0.27-36.24) and SA (ОЯ=1.9; Cl: 0.38-10.73). Smoking modified the functional significance of the polymorph traits. GSTM1 -genotype and SM-phenotype in passive smokers (л=60) were associated with these clinical features of asthma: OR for GSTM1 genotype was 1.98; Cl: 0.46-9.95); 9.0 (Cl: 1.07-409.9); 1.23 (0.36-4.27) for polyvalent allergy, early asthma occurrence and severe course respectively. The values for SM-phenotype were 1.7 (Cl: 0.28-9.25); 2.6 (Cl: 0.29-22.31) and 2.88 (Cl: 0.57-14.24) respectively.

Работа выполнена при финансовой поддержке Государственной научно-технической программы "Здоровье населения России" по направлению 06.04, грант 06.04.01.04.

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The authors declare that there are no conflicts of interest present.