<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">pulmo-2840</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTIONS</subject></subj-group></article-categories><title-group><article-title>100 лет заместительной панкреатической терапии; история создания препарата Pankreon (Панкреон)</article-title><trans-title-group xml:lang="en"><trans-title>A hundred years of replacing pancreatic therapy; the history of Pankreon development</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Rudmann</surname><given-names>M. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudmann</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Hannover</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Отдел международного сотрудничества; Solvay Pharmaceuticals Gm bH</institution><country>Germany</country></aff><pub-date pub-type="collection"><year>2001</year></pub-date><pub-date pub-type="epub"><day>30</day><month>09</month><year>2001</year></pub-date><volume>0</volume><issue>3</issue><fpage>120</fpage><lpage>124</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Rudmann M.A., 2001</copyright-statement><copyright-year>2001</copyright-year><copyright-holder xml:lang="ru">Rudmann M.A.</copyright-holder><copyright-holder xml:lang="en">Rudmann M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/2840">https://journal.pulmonology.ru/pulm/article/view/2840</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kuhlmann Н. In: Rudmann M.A., ed. The magic potions in the belly gland. Hannover: Solvay Pharmaceuticals GmbH; 2000.</mixed-citation><mixed-citation xml:lang="en">Kuhlmann Н. In: Rudmann M.A., ed. The magic potions in the belly gland. Hannover: Solvay Pharmaceuticals GmbH; 2000.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rapaille M. Solvay. Ein Mann und sein Werk. Brussels: Didier Hatier; 1991.</mixed-citation><mixed-citation xml:lang="en">Rapaille M. Solvay. Ein Mann und sein Werk. Brussels: Didier Hatier; 1991.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gockel M. Uber Erfolge mit ’Pankreon’, einem neuen, gegen Magensaft widerstandsfähigen Pankreaspraparat. Cbl. Stoffwechsel- и. Verdauungskrankheit. 1900; 11: 251—256.</mixed-citation><mixed-citation xml:lang="en">Gockel M. Uber Erfolge mit ’Pankreon’, einem neuen, gegen Magensaft widerstandsfähigen Pankreaspraparat. Cbl. Stoffwechsel- и. Verdauungskrankheit. 1900; 11: 251—256.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Von Noorden C. Zur Diagnostik der Pankreaserkrankungen. Klin.-ther. Wschr. 1908; 35: 929—934.</mixed-citation><mixed-citation xml:lang="en">Von Noorden C. Zur Diagnostik der Pankreaserkrankungen. Klin.-ther. Wschr. 1908; 35: 929—934.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Peschke G. Solvay Pharmaceuticals GmbH (data on file), 2000.</mixed-citation><mixed-citation xml:lang="en">Peschke G. Solvay Pharmaceuticals GmbH (data on file), 2000.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Smyth R.L. et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet 1995; 346: 1247—1251.</mixed-citation><mixed-citation xml:lang="en">Smyth R.L. et al. Fibrosing colonopathy in cystic fibrosis: results of a case-control study. Lancet 1995; 346: 1247—1251.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Prescott P., Bakowski M.T. Pathogenesis of fibrosing colonopathy: the role of methacrylic acid copolymer. Pharmacoepidemiol. Drug Saf. 1999; 8: 377—384.</mixed-citation><mixed-citation xml:lang="en">Prescott P., Bakowski M.T. Pathogenesis of fibrosing colonopathy: the role of methacrylic acid copolymer. Pharmacoepidemiol. Drug Saf. 1999; 8: 377—384.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bansi D.S. et al. Fibrosing colonopathy in an adult owing to overuse of pancreatic enzyme supplements. Gut 2000; 46: 283—285.</mixed-citation><mixed-citation xml:lang="en">Bansi D.S. et al. Fibrosing colonopathy in an adult owing to overuse of pancreatic enzyme supplements. Gut 2000; 46: 283—285.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Littlewood J.M., Wolfe S.P. Control of malabsorption in cystic fibrosis. Paediatr. Drugs 2000; 3: 205—222.</mixed-citation><mixed-citation xml:lang="en">Littlewood J.M., Wolfe S.P. Control of malabsorption in cystic fibrosis. Paediatr. Drugs 2000; 3: 205—222.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Apte M.V. et al. Chronic pancreatitis: complications and management. J. Clin. Gastroenterol. 1999; 29: 225—240.</mixed-citation><mixed-citation xml:lang="en">Apte M.V. et al. Chronic pancreatitis: complications and management. J. Clin. Gastroenterol. 1999; 29: 225—240.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mohan V. et al. Oral pancreatic enzyme therapy in the control of diabetes mellitus in tropical calculous pancreatitis. Int. J. Pancreatol. 1998; 24: 19—22.</mixed-citation><mixed-citation xml:lang="en">Mohan V. et al. Oral pancreatic enzyme therapy in the control of diabetes mellitus in tropical calculous pancreatitis. Int. J. Pancreatol. 1998; 24: 19—22.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Van Hoozen C.M. et al. Efficacy of enzyme supplementation after surgery for chronic pancreatitis. Pancreas 1997; 14: 174—180.</mixed-citation><mixed-citation xml:lang="en">Van Hoozen C.M. et al. Efficacy of enzyme supplementation after surgery for chronic pancreatitis. Pancreas 1997; 14: 174—180.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Neoptolemos J.P. et al. T rea tm en t of pancreatic exocrine insufficiency after pancreatic resection. Int. J. Pancreatol. 1999; 25: 171—180.</mixed-citation><mixed-citation xml:lang="en">Neoptolemos J.P. et al. T rea tm en t of pancreatic exocrine insufficiency after pancreatic resection. Int. J. Pancreatol. 1999; 25: 171—180.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bragelmann R. et al. The effect of pancreatic enzyme supplementation in patients with steatorhoea after gastrectomy. Eur. J. Gastroenterol. Hepatol. 1999; 11: 231—237.</mixed-citation><mixed-citation xml:lang="en">Bragelmann R. et al. The effect of pancreatic enzyme supplementation in patients with steatorhoea after gastrectomy. Eur. J. Gastroenterol. Hepatol. 1999; 11: 231—237.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kitagawa M. et al. Evaluating exocrine function te s ts for diagnosing chronic pancreatitis. Pancreas 1997; 15: 402—408.</mixed-citation><mixed-citation xml:lang="en">Kitagawa M. et al. Evaluating exocrine function te s ts for diagnosing chronic pancreatitis. Pancreas 1997; 15: 402—408.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Rathmann W. et al. Pancreatic exocrine insufficiency and type 2 diabetes are strongly associated. Diabetologia 1999; 42 (suppl.lA): 297.</mixed-citation><mixed-citation xml:lang="en">Rathmann W. et al. Pancreatic exocrine insufficiency and type 2 diabetes are strongly associated. Diabetologia 1999; 42 (suppl.lA): 297.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">George D.E. et al. Comparison of two pancreatic enzyme supplements in pa tien ts with cystic fibrosis. Adv. Ther. 1990; 7: 109—118.</mixed-citation><mixed-citation xml:lang="en">George D.E. et al. Comparison of two pancreatic enzyme supplements in pa tien ts with cystic fibrosis. Adv. Ther. 1990; 7: 109—118.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Friesen C., Prestidge С. Comparison of a high-strength pancreatic enzyme preparation and a standard-strength preparation in cystic fibrosis. Ibid. 1995; 12: 236—244.</mixed-citation><mixed-citation xml:lang="en">Friesen C., Prestidge С. Comparison of a high-strength pancreatic enzyme preparation and a standard-strength preparation in cystic fibrosis. Ibid. 1995; 12: 236—244.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Braden B. et al. Monitoring pancreatin supplementation in cystic fibrosis patients with the 13C-Hiolein® breath test: evidence of normalized fat assimilation with high dose pancreatin therapy. Z. Gastroenterol. 1997; 35: 123—129.</mixed-citation><mixed-citation xml:lang="en">Braden B. et al. Monitoring pancreatin supplementation in cystic fibrosis patients with the 13C-Hiolein® breath test: evidence of normalized fat assimilation with high dose pancreatin therapy. Z. Gastroenterol. 1997; 35: 123—129.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lankisch P.G. Conservative trea tm en t of chronic pancreatitis. Digestion 1987; 37 (supp l.l): 47—55.</mixed-citation><mixed-citation xml:lang="en">Lankisch P.G. Conservative trea tm en t of chronic pancreatitis. Digestion 1987; 37 (supp l.l): 47—55.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Vyas H. et al. A comparison of enteric coated microspheres with enteric coated tablet pancreatic enzyme preparations in cystic fibrosis: A controlled study. Eur. J. Pediatr. 1990; 149: 241—243.</mixed-citation><mixed-citation xml:lang="en">Vyas H. et al. A comparison of enteric coated microspheres with enteric coated tablet pancreatic enzyme preparations in cystic fibrosis: A controlled study. Eur. J. Pediatr. 1990; 149: 241—243.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Layer P., Holtmann G. Pancreatic enzymes in chronic pancreatitis. Int. J. Pancreatol. 1994; 15: 1—11.</mixed-citation><mixed-citation xml:lang="en">Layer P., Holtmann G. Pancreatic enzymes in chronic pancreatitis. Int. J. Pancreatol. 1994; 15: 1—11.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer J.H. et al. Human postprandial g astric emptying of 1—3 millimeter spheres. Gastroenterology 1988; 94: 1315—1325.</mixed-citation><mixed-citation xml:lang="en">Meyer J.H. et al. Human postprandial g astric emptying of 1—3 millimeter spheres. Gastroenterology 1988; 94: 1315—1325.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Kuhnelt P., Mundlos S., Adler G. Einfluss der Pelletgosse eines Pankreasenzympraparates auf die duodenale lipolytische Aktivität. Z. Gastroenterol. 1991; 29: 417—421.</mixed-citation><mixed-citation xml:lang="en">Kuhnelt P., Mundlos S., Adler G. Einfluss der Pelletgosse eines Pankreasenzympraparates auf die duodenale lipolytische Aktivität. Z. Gastroenterol. 1991; 29: 417—421.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mundlos S., Kuhnelt P., Adler G. Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Gut 1991; 31: 1324—1328.</mixed-citation><mixed-citation xml:lang="en">Mundlos S., Kuhnelt P., Adler G. Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Gut 1991; 31: 1324—1328.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Layer P. et al. Enzyme pellet size and luminal n u trient digestion in pancreatic insufficiency. Digestion 1992; 52: 100.</mixed-citation><mixed-citation xml:lang="en">Layer P. et al. Enzyme pellet size and luminal n u trient digestion in pancreatic insufficiency. Digestion 1992; 52: 100.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Norregard P. et al. Gastric emptying of pancreatin granules and dietary lipids in pancreatic insufficiency. Aliment. Pharmacol. Ther. 1996; 10: 427—432.</mixed-citation><mixed-citation xml:lang="en">Norregard P. et al. Gastric emptying of pancreatin granules and dietary lipids in pancreatic insufficiency. Aliment. Pharmacol. Ther. 1996; 10: 427—432.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lippold B.C. What is the ideal size for enteric-coated pancreatic preparations? Drugs made in Germany 1998; 41: 52—56.</mixed-citation><mixed-citation xml:lang="en">Lippold B.C. What is the ideal size for enteric-coated pancreatic preparations? Drugs made in Germany 1998; 41: 52—56.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Beverley D.W. et al. Comparison of four different pancreatic extracts in cystic fibrosis. Arch. Dis. Child. 1987; 62: 564—568.</mixed-citation><mixed-citation xml:lang="en">Beverley D.W. et al. Comparison of four different pancreatic extracts in cystic fibrosis. Arch. Dis. Child. 1987; 62: 564—568.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Stead R.J. et al. Treatment of ste ato rrh o ea in cystic fibrosis: A comparison of enteric coated microspheres of pancreatin versus non-enteric coated pancreatin and adjuvant cimetidine. Aliment. Pharmacol. Ther. 1988; 2: 471—482.</mixed-citation><mixed-citation xml:lang="en">Stead R.J. et al. Treatment of ste ato rrh o ea in cystic fibrosis: A comparison of enteric coated microspheres of pancreatin versus non-enteric coated pancreatin and adjuvant cimetidine. Aliment. Pharmacol. Ther. 1988; 2: 471—482.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Whitehead A.M. Stu d y to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations. Pharm. Weekbl. (Sei.) 1988; 10: 12—16.</mixed-citation><mixed-citation xml:lang="en">Whitehead A.M. Stu d y to compare the enzyme activity, acid resistance and dissolution characteristics of currently available pancreatic enzyme preparations. Pharm. Weekbl. (Sei.) 1988; 10: 12—16.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Atkinson S.N. A comparative study of enzyme activity, acid resistance and dissolution characteris tics of four enteric coated microsphere preparations of pancreatin. Eur. J. Clin. Res. 1991; 1: 37—45.</mixed-citation><mixed-citation xml:lang="en">Atkinson S.N. A comparative study of enzyme activity, acid resistance and dissolution characteris tics of four enteric coated microsphere preparations of pancreatin. Eur. J. Clin. Res. 1991; 1: 37—45.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Huwel S., Behrens R., Spener F. Pankreasenzyme: Präparate im Vergleich. Pharm. Ztg. 1996; 37: 33—42.</mixed-citation><mixed-citation xml:lang="en">Huwel S., Behrens R., Spener F. Pankreasenzyme: Präparate im Vergleich. Pharm. Ztg. 1996; 37: 33—42.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
