pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2022-32-5-745-754pulmo-2760Research ArticleОБЗОРЫREVIEWРоль микробиома верхних дыхательных путей в здоровье человека: биотопы и изменчивостьThe upper respiratory tract microbiome and its role in human health: biotopes and variabilityhttps://orcid.org/0000-0001-6582-210XСтариковаЕ. В.StarikovaE. V.

Старикова Елизавета Валентиновна – младший научный сотрудник лаборатории геномных исследований и вычислительной биологии

119435, Москва, ул. Малая Пироговская, 1а

Elizaveta V. Starikova, Researcher, Laboratory of Genomic Research and Computational Biology

ul. Malaya Pirogovskaya 1a, Moscow, 119435

estarikova@rcpcm.orghttps://orcid.org/0000-0001-6304-4607ГалееваЮ. С.GaleevaJu. S.

Галеева Юлия Сергеевна – лаборант-исследователь лаборатории геномных исследований и вычислительной биологии

119435, Москва, ул. Малая Пироговская, 1а

Yuliya S. Galeeva, Research Assistant at Laboratory of Genomic Research and Computational Biology

ul. Malaya Pirogovskaya 1a, Moscow, 119435

galeeva.yu@rcpcm.orghttps://orcid.org/0000-0003-0130-5079ИльинаЕ. Н.IlinaE. N.

Ильина Елена Николаевна – доктор биологических наук, профессор, член-корр. Российской академии наук, заведующая лабораторией геномных исследований и вычислительной биологии, заместитель директора по науке

119435, Москва, ул. Малая Пироговская, 1а

Elena N. Ilina, Doctor of Biology Science, Professor, Corresponding Member of Russian Academy of Sciences, Head of Laboratory of Genomic Studies and Computational Biology, Deputy Director for Science

ul. Malaya Pirogovskaya 1a, Moscow, 119435

ilinaen@gmail.comФедеральное государственное бюджетное учреждение «Федеральный научно-клинический центр физико-химической медицины» Федерального медико-биологического агентстваРоссияFederal Research & Clinical Center of Physical-Chemical Medicine of Federal Medical Biological AgencyRussian Federation202210102022325745754Copyright © Старикова Е.В., Галеева Ю.С., Ильина Е.Н., 20222022Старикова Е.В., Галеева Ю.С., Ильина Е.Н.Starikova E.V., Galeeva J.S., Ilina E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/2760

Дыхательные пути (ДП) человека представляют собой сложную систему, обладающую собственным микробным профилем. До недавнего времени основной интерес научного сообщества вызывали микробные сообщества легких, ассоциированные с различными заболеваниями. В период пандемии COVID-19 внимание специалистов сосредоточилось на микробиоте верхних ДП (ВДП), которая, предположительно, является одним из факторов, оказывающих влияние на течение вирусных инфекций. Целью работы явились систематизация и оценка известной к настоящему моменту информации о микробных сообществах каждого из отделов ВДП, однако особое внимание уделено предположительной барьерной функции респираторной микробиоты. Заключение. Приводятся данные, обобщающие известную информацию о микробных сообществах каждого из отделов ВДП и факторах, оказывающих влияние на состав респираторной микробиоты.

Human respiratory tract is a complex system with a specific microbiological profile. Until recently, researchers were mostly interested in lung microbial communities associated with acute and chronic infections. The upper respiratory tract microbiota has gained attention during COVID-19 pandemic as it was proposed to be one of the factors affecting the course and the outcome of viral infections. The aim. In this review, we summarized the current knowledge about microbial communities in each section of the upper respiratory tract, considering the proposed barrier function of the respiratory microbiome. Conclusion. The facts provided in the first part of this review give a modern perspective on the structure of microbial communities of each part of the upper respiratory tract and factors that affect their variability.

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The authors declare that there are no conflicts of interest present.