pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLC10.18093/0869-0189-2013-0-4-131-134pulmo-267Research ArticleКЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯCLINICAL PHARMACOLOGYОт ХандиХалера к Респимату: пути доставки тиотропияFrom Handihaler to Respimat: tiotropium delivery systemsВизельА. А.VizelA. A.

д. м. н., профессор, зав. кафедрой фтизиопульмонологии 

420012, Республика Татарстан, Казань, ул. Бутлерова, 49. Тел.: (987) 296-25-99.

lordara@inbox.ruВизельИ. Ю.VizelI. Yu.

к. м. н., профессор РАЕ, ассистент кафедры фтизиопульмонологии 

420012, Республика Татарстан, Казань, ул. Бутлерова, 49. Тел.: (843) 279-80-03.

tatpulmo@mail.ruГБОУ ВПО "Казанский государственный медицинский университет" Минздрава РоссииRussian Federation20132808201304131134Copyright © Визель А.А., Визель И.Ю., 20132013Визель А.А., Визель И.Ю.Vizel A.A., Vizel I.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/267

От ХандиХалера к Респимату: пути доставки тиотропия.

From Handihaler to Respimat: tiotropium delivery systems.

тиотропия бромидхроническая обструктивная болезнь легкихбезопасностьtiotropium bromidechronic obstructive pulmonary diseasesafetyReferencesCelli B., Decramer M., Kesten S. et al. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med 2009; 180 (10): 948–955.Celli B., Decramer M., Kesten S. et al. Mortality in the 4-year trial of tiotropium (UPLIFT) in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med 2009; 180 (10): 948–955.Ichinose M., Fujimoto T., Fukuchi Y. Tiotropium 5 mcg via Respimat and 18 mg via HandiHaler1; efficacy and safety in Japanese COPD patients. Respir. Med. 2010; 104 (2): 228–236.Ichinose M., Fujimoto T., Fukuchi Y. Tiotropium 5 mcg via Respimat and 18 mg via HandiHaler1; efficacy and safety in Japanese COPD patients. Respir. Med. 2010; 104 (2): 228–236.Bateman E.D., Singh D., Smith D. et al. Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies. Int. J. Chron. Obstruct. Pulm. Dis. 2010; 5: 197–208.Bateman E.D., Singh D., Smith D. et al. Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies. Int. J. Chron. Obstruct. Pulm. Dis. 2010; 5: 197–208.Ram F.S., Carvallho C.R., White J. Clinical effectiveness of the Respimat inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices. Int. J. Chron. Obstruct. Pulm. Dis. 2011; 6: 129–139.Ram F.S., Carvallho C.R., White J. Clinical effectiveness of the Respimat inhaler device in managing chronic obstructive pulmonary disease: evidence when compared with other handheld inhaler devices. Int. J. Chron. Obstruct. Pulm. Dis. 2011; 6: 129–139.Singh S., Loke Y.K., Furberg C.D. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J.A.M.A. 2008; 300 (12): 1439–1450.Singh S., Loke Y.K., Furberg C.D. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. J.A.M.A. 2008; 300 (12): 1439–1450.Ram F.S. Spiriva (Respimat) increases mortality by 52 % in patients with COPD: time to take action. N. Z. Med. J. 2011; 124 (1337): 117–118.Ram F.S. Spiriva (Respimat) increases mortality by 52 % in patients with COPD: time to take action. N. Z. Med. J. 2011; 124 (1337): 117–118.Beasley R. Tiotropium Respimat increases the risk of mortality: pro. Eur. Respir. J. 2013; 42 (3): 584–589.Beasley R. Tiotropium Respimat increases the risk of mortality: pro. Eur. Respir. J. 2013; 42 (3): 584–589.Stewart H.J. The effect of increased heart rate due to the injection of atropine on the oxygen saturation of the arterial and venous blood of patients with heart disease. J. Clin. Invest. 1926; 3 (2): 241–251.Stewart H.J. The effect of increased heart rate due to the injection of atropine on the oxygen saturation of the arterial and venous blood of patients with heart disease. J. Clin. Invest. 1926; 3 (2): 241–251.Peters N.L. Snipping the thread of life. Antimuscarinic side effects of medications in the elderly. Arch. Intern. Med. 1989; 149 (11): 2414–2420.Peters N.L. Snipping the thread of life. Antimuscarinic side effects of medications in the elderly. Arch. Intern. Med. 1989; 149 (11): 2414–2420.Bateman E.D. Tiotropium Respimat increases the risk of mortality: con. Eur. Respir. J. 2013; 42: 590–593.Bateman E.D. Tiotropium Respimat increases the risk of mortality: con. Eur. Respir. J. 2013; 42: 590–593.Beier J., Kirsten A.M., Mruz R. et al. Efficacy and safety of aclidinium bromide compared with placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease: Results from a 6-week, randomized, controlled phase iiib study. COPD 2013; 10 (4): 511–522.Beier J., Kirsten A.M., Mruz R. et al. Efficacy and safety of aclidinium bromide compared with placebo and tiotropium in patients with moderate-to-severe chronic obstructive pulmonary disease: Results from a 6-week, randomized, controlled phase iiib study. COPD 2013; 10 (4): 511–522.D'Urzo A. Role of once-daily glycopyrronium bromide (NVA237) in the management of COPD. Ther. Clin. Risk. Manag. 2013; 9: 341–353.D'Urzo A. Role of once-daily glycopyrronium bromide (NVA237) in the management of COPD. Ther. Clin. Risk. Manag. 2013; 9: 341–353.Singh S., Loke Y.K., Enright P.L. et al. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and metaanalysis of randomized controlled trials. Br. Med. J. 2011; 342: d3215.Singh S., Loke Y.K., Enright P.L. et al. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and metaanalysis of randomized controlled trials. Br. Med. J. 2011; 342: d3215.US National Institutes of Health. ClinicalTrials.gov. Tiotropium Respimat pharmacokinetic study in COPD. 2010. www.clinicaltrials.gov/ct2/show/results/NCT01222533US National Institutes of Health. ClinicalTrials.gov. Tiotropium Respimat pharmacokinetic study in COPD. 2010. www.clinicaltrials.gov/ct2/show/results/NCT01222533Khorfan F.M., Smith P., Watt S., Barber K.R. Effects of nebulized bronchodilator therapy on heart rate and arrhythmias in critically ill adult patients. Chest. 2011; 140 (6): 1466–1472.Khorfan F.M., Smith P., Watt S., Barber K.R. Effects of nebulized bronchodilator therapy on heart rate and arrhythmias in critically ill adult patients. Chest. 2011; 140 (6): 1466–1472.Abrahams R., Moroni3Zentgraf P., Ramsdell J. et al. Safety and efficacy of the once-daily anticholinergic BEA2180 compared to tiotropium in patients with COPD. Respir. Med. 2013; 107 (6): 854–862.Abrahams R., Moroni3Zentgraf P., Ramsdell J. et al. Safety and efficacy of the once-daily anticholinergic BEA2180 compared to tiotropium in patients with COPD. Respir. Med. 2013; 107 (6): 854–862.Wise R.A., Anzueto A., Cotton D. et al. Tiotropium Respimat inhaler and the risk of death in COPD. N. Engl. J. Med. 2013 Aug 30 [Epub ahead of print].Wise R.A., Anzueto A., Cotton D. et al. Tiotropium Respimat inhaler and the risk of death in COPD. N. Engl. J. Med. 2013 Aug 30 [Epub ahead of print].

The authors declare that there are no conflicts of interest present.