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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">pulmo</journal-id><journal-title-group><journal-title xml:lang="ru">Пульмонология</journal-title><trans-title-group xml:lang="en"><trans-title>PULMONOLOGIYA</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0869-0189</issn><issn pub-type="epub">2541-9617</issn><publisher><publisher-name>Scientific and Practical Journal “PULMONOLOGIYA” LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18093/0869-0189-2013-0-4-87-94</article-id><article-id custom-type="elpub" pub-id-type="custom">pulmo-258</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Сочетание бронхиальной астмы и хронической обструктивной болезни легких</article-title><trans-title-group xml:lang="en"><trans-title>Co-morbidity of bronchial asthma and chronic obstructive pulmonary disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архипов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Arkhipov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., профессор кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>119991, Москва, ул. Трубецкая, 8, стр. 2. Тел.: (495) 915-59-89.</p></bio><email xlink:type="simple">arkhipov@gmx.us</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прозорова</surname><given-names>В. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Prozorova</surname><given-names>V. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., доцент кафедры клинической фармакологии и пропедевтики внутренних болезней</p><p>119991, Москва, ул. Трубецкая, 8, стр. 2. Тел.: (495) 915-59-89.</p></bio><email xlink:type="simple">prozorova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Архипова</surname><given-names>Д. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Arkhipova</surname><given-names>D. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., ассистент кафедры клинической фармакологии и пропедевтики внутренних болезней  </p><p>119991, Москва, ул. Трубецкая, 8, стр. 2. Тел.: (495) 915-59-89.</p></bio><email xlink:type="simple">d2414942@outlook.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГБОУ ВПО "Первый Московский государственный медицинский университет им. И.М.Сеченова" Минздрава России</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2013</year></pub-date><volume>0</volume><issue>4</issue><fpage>87</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Архипов В.В., Прозорова В.К., Архипова Д.Е., 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="ru">Архипов В.В., Прозорова В.К., Архипова Д.Е.</copyright-holder><copyright-holder xml:lang="en">Arkhipov V.V., Prozorova V.K., Arkhipova D.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.pulmonology.ru/pulm/article/view/258">https://journal.pulmonology.ru/pulm/article/view/258</self-uri><abstract><p>Сочетание бронхиальной астмы и хронической обструктивной болезни легких.</p></abstract><trans-abstract xml:lang="en"><p>Co-morbidity of bronchial asthma and chronic obstructive pulmonary disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>хроническая обструктивная болезнь легких</kwd><kwd>малые дыхательные пути</kwd><kwd>экстрамелкодисперсные аэрозоли</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>chronic obstructive pulmonary disease</kwd><kwd>small airways</kwd><kwd>extra-fine aerosols</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Han M.K., Agusti A., Calverley P.M. et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am. J. Respir. Crit. Care Med. 2010; 182 (5): 598–604.</mixed-citation><mixed-citation xml:lang="en">Han M.K., Agusti A., Calverley P.M. et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am. J. Respir. Crit. Care Med. 2010; 182 (5): 598–604.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cottini M., Asero R. Asthma phenotypes today. Eur. Ann. Allergy Clin. Immunol. 2013; 45 (1): 17–24.</mixed-citation><mixed-citation xml:lang="en">Cottini M., Asero R. Asthma phenotypes today. Eur. Ann. Allergy Clin. Immunol. 2013; 45 (1): 17–24.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Editorial. Asthma: still more questions than answers. Lancet 2008; 372 (9643): 1009.</mixed-citation><mixed-citation xml:lang="en">Editorial. Asthma: still more questions than answers. Lancet 2008; 372 (9643): 1009.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Miravitlles M., Soler3Cataluna J.J., Calle M. et al. Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. Arch. Bronconeumol. 2012; 48 (7): 247–257.</mixed-citation><mixed-citation xml:lang="en">Miravitlles M., Soler3Cataluna J.J., Calle M. et al. Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery. Arch. Bronconeumol. 2012; 48 (7): 247–257.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Global strategy for asthma management and prevention. Updated December 2012. http://www.ginasthma.org/documents/4</mixed-citation><mixed-citation xml:lang="en">Global strategy for asthma management and prevention. Updated December 2012. http://www.ginasthma.org/documents/4</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gallefoss F, Bakke P. Does smoking affect the outcome of patient education and self management in asthmatics? Patient Educ. Couns. 2003; 49: 91–97.</mixed-citation><mixed-citation xml:lang="en">Gallefoss F, Bakke P. Does smoking affect the outcome of patient education and self management in asthmatics? Patient Educ. Couns. 2003; 49: 91–97.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">van Schayck O.C., Haughney J., Aubier M. et al. Do asthmatic smokers benefit as much as non-smokers on budesonide / formoterol maintenance and reliever therapy? Results of an open label study. Respir. Med. 2012; 106 (2): 189–196.</mixed-citation><mixed-citation xml:lang="en">van Schayck O.C., Haughney J., Aubier M. et al. Do asthmatic smokers benefit as much as non-smokers on budesonide / formoterol maintenance and reliever therapy? Results of an open label study. Respir. Med. 2012; 106 (2): 189–196.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Aubier M., Buhl R., Ekstrom T. et al. Comparison of two twice-daily doses of budesonide / formoterol maintenance and reliever therapy. Eur. Respir. J. 2010; 36: 524–530.</mixed-citation><mixed-citation xml:lang="en">Aubier M., Buhl R., Ekstrom T. et al. Comparison of two twice-daily doses of budesonide / formoterol maintenance and reliever therapy. Eur. Respir. J. 2010; 36: 524–530.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Eisner M.D., Yelin E.H., Trupin L., Blanc P.D. Asthma and smoking status in a population-based study of California adults. Publ. Hlth Rep. 2001; 116 (2): 148–157.</mixed-citation><mixed-citation xml:lang="en">Eisner M.D., Yelin E.H., Trupin L., Blanc P.D. Asthma and smoking status in a population-based study of California adults. Publ. Hlth Rep. 2001; 116 (2): 148–157.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen S.E., Bateman E.D., Bousquet J. et al. Determinants of response to fluticasone propionate and salmeterol / fluticasone propionate combination in the Gaining Optimal Asthma controL study. J. Allergy Clin. Immunol. 2007; 120 (5): 1036–1042.</mixed-citation><mixed-citation xml:lang="en">Pedersen S.E., Bateman E.D., Bousquet J. et al. Determinants of response to fluticasone propionate and salmeterol / fluticasone propionate combination in the Gaining Optimal Asthma controL study. J. Allergy Clin. Immunol. 2007; 120 (5): 1036–1042.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhuri R., Livingston E., McMahon A.D. et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am. J. Respir. Crit. Care Med. 2003; 168 (11): 1308–1311.</mixed-citation><mixed-citation xml:lang="en">Chaudhuri R., Livingston E., McMahon A.D. et al. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am. J. Respir. Crit. Care Med. 2003; 168 (11): 1308–1311.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chalmers G.W., Macleod K.J., Little S.A. et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57 (3): 226–230.</mixed-citation><mixed-citation xml:lang="en">Chalmers G.W., Macleod K.J., Little S.A. et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57 (3): 226–230.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">O'Byrne P.M., Lamm C.J., Busse W.W. et al. The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma. Chest 2009; 136 (6): 1514–1520.</mixed-citation><mixed-citation xml:lang="en">O'Byrne P.M., Lamm C.J., Busse W.W. et al. The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma. Chest 2009; 136 (6): 1514–1520.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chaudhuri R., Livingston E., McMahon A.D. et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am. J. Respir. Crit. Care Med. 2006; 174 (2): 127–133.</mixed-citation><mixed-citation xml:lang="en">Chaudhuri R., Livingston E., McMahon A.D. et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am. J. Respir. Crit. Care Med. 2006; 174 (2): 127–133.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J., Adcock I.M., Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur. Respir. J. 2005; 25 (3): 552–563.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J., Adcock I.M., Ito K. Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur. Respir. J. 2005; 25 (3): 552–563.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Higenbottam T., Feyeraband C., Clark T. Cigarette smoking in asthma. Br. J. Dis. Chest 1980; 74: 279–284.</mixed-citation><mixed-citation xml:lang="en">Higenbottam T., Feyeraband C., Clark T. Cigarette smoking in asthma. Br. J. Dis. Chest 1980; 74: 279–284.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Dijkstra A., Vonk J.M., Jongepier H. et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex. Thorax 2006; 61 (2): 105–110.</mixed-citation><mixed-citation xml:lang="en">Dijkstra A., Vonk J.M., Jongepier H. et al. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex. Thorax 2006; 61 (2): 105–110.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., Edwards L.D., Scanlon P.D. et al. Changes in forced expiratory volume in 1 second over time in COPD. N. Engl. J. Med. 2011; 365 (13): 1184–1192.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., Edwards L.D., Scanlon P.D. et al. Changes in forced expiratory volume in 1 second over time in COPD. N. Engl. J. Med. 2011; 365 (13): 1184–1192.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Lange P., Scharling H., Ulrik C.S., Vestbo J. Inhaled corticosteroids and decline of lung function in community residents with asthma. Thorax 2006; 61 (2): 100–104.</mixed-citation><mixed-citation xml:lang="en">Lange P., Scharling H., Ulrik C.S., Vestbo J. Inhaled corticosteroids and decline of lung function in community residents with asthma. Thorax 2006; 61 (2): 100–104.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kerstjens H.A., Overbeek S.E., Schouten J.P. et al. Airways hyperresponsiveness, bronchodilator response, allergy and smoking predict improvement in FEV1 during long-term inhaled corticosteroid treatment. Dutch CNSLD Study Group. Eur. Respir. J. 1993; 6 (6): 868–876.</mixed-citation><mixed-citation xml:lang="en">Kerstjens H.A., Overbeek S.E., Schouten J.P. et al. Airways hyperresponsiveness, bronchodilator response, allergy and smoking predict improvement in FEV1 during long-term inhaled corticosteroid treatment. Dutch CNSLD Study Group. Eur. Respir. J. 1993; 6 (6): 868–876.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Chalmers G., MacLeod K., Thomson L. et al. Smoking and airway inflammation in patients with mild asthma. Chest 2001; 120: 1917–1922.</mixed-citation><mixed-citation xml:lang="en">Chalmers G., MacLeod K., Thomson L. et al. Smoking and airway inflammation in patients with mild asthma. Chest 2001; 120: 1917–1922.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Chalmers G.W., Macleod K.J., Little S.A. et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57 (3): 226–230.</mixed-citation><mixed-citation xml:lang="en">Chalmers G.W., Macleod K.J., Little S.A. et al. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57 (3): 226–230.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Green R.H., Brightling C.E., Woltmann G. et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875–879.</mixed-citation><mixed-citation xml:lang="en">Green R.H., Brightling C.E., Woltmann G. et al. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax 2002; 57: 875–879.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Dima E., Rovina N., Gerassimou C. et al. Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int. J. Chron. Obstruct. Pulm. Dis. 2010; 5: 287–296.</mixed-citation><mixed-citation xml:lang="en">Dima E., Rovina N., Gerassimou C. et al. Pulmonary function tests, sputum induction, and bronchial provocation tests: diagnostic tools in the challenge of distinguishing asthma and COPD phenotypes in clinical practice. Int. J. Chron. Obstruct. Pulm. Dis. 2010; 5: 287–296.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Wenzel S.E. Asthma phenotypes: the evolution from clinical to molecular approaches. Nature Med. 2012; 18 (5): 716–725.</mixed-citation><mixed-citation xml:lang="en">Wenzel S.E. Asthma phenotypes: the evolution from clinical to molecular approaches. Nature Med. 2012; 18 (5): 716–725.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Федосеев Г.Б., Хлопотова Г.П. Бронхиальная астма. Л.: Медицина; 1988.</mixed-citation><mixed-citation xml:lang="en">Федосеев Г.Б., Хлопотова Г.П. Бронхиальная астма. Л.: Медицина; 1988.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J., Woolcock A.J. Difficult asthma. Eur. Respir. J. 1998; 12 (5): 1209–1218.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J., Woolcock A.J. Difficult asthma. Eur. Respir. J. 1998; 12 (5): 1209–1218.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Fahy J.V. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc. Am. Thorac. Soc. 2009; 6 (3): 256–259.</mixed-citation><mixed-citation xml:lang="en">Fahy J.V. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc. Am. Thorac. Soc. 2009; 6 (3): 256–259.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Lange P., Parner J., Vestbo J. et al. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 1998; 339: 1194–1200.</mixed-citation><mixed-citation xml:lang="en">Lange P., Parner J., Vestbo J. et al. A 15-year follow-up study of ventilatory function in adults with asthma. N. Engl. J. Med. 1998; 339: 1194–1200.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Sorkness R., Bleecker E., Busse W. et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J. Appl. Physiol. 2008; 104: 394–403.</mixed-citation><mixed-citation xml:lang="en">Sorkness R., Bleecker E., Busse W. et al. Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J. Appl. Physiol. 2008; 104: 394–403.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Paganin F., Seneterre E., Chanez P. et al. Computed tomography of the lungs in asthma: influence of disease severity and etiology. Am. J. Respir. Crit. Care Med. 1996; 153: 110–114.</mixed-citation><mixed-citation xml:lang="en">Paganin F., Seneterre E., Chanez P. et al. Computed tomography of the lungs in asthma: influence of disease severity and etiology. Am. J. Respir. Crit. Care Med. 1996; 153: 110–114.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes P.J. Inhaled corticosteroids in COPD: a controversy. Respiration 2010; 80 (2): 89–95.</mixed-citation><mixed-citation xml:lang="en">Barnes P.J. Inhaled corticosteroids in COPD: a controversy. Respiration 2010; 80 (2): 89–95.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 1977; 1 (6077): 1645–1648.</mixed-citation><mixed-citation xml:lang="en">Fletcher C., Peto R. The natural history of chronic airflow obstruction. Br. Med. J. 1977; 1 (6077): 1645–1648.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kohansal R., Martinez3Camblor P., Agusti A. et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am. J. Respir. Crit. Care Med. 2009; 180 (1): 3–10.</mixed-citation><mixed-citation xml:lang="en">Kohansal R., Martinez3Camblor P., Agusti A. et al. The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort. Am. J. Respir. Crit. Care Med. 2009; 180 (1): 3–10.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178 (4): 332–338.</mixed-citation><mixed-citation xml:lang="en">Celli B.R., Thomas N.E., Anderson J.A. et al. Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study. Am. J. Respir. Crit. Care Med. 2008; 178 (4): 332–338.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Halpin D., Decramer M., Celli B. et al. Impact of a single chronic obstructive pulmonary disease (COPD) exacerbation on lung function decline: Analysis of UPLIFT. In: European Respiratory Society (ERS). 2012 Annual congress. 2012: Abstract 194OC. Presented September 2, 2012.</mixed-citation><mixed-citation xml:lang="en">Halpin D., Decramer M., Celli B. et al. Impact of a single chronic obstructive pulmonary disease (COPD) exacerbation on lung function decline: Analysis of UPLIFT. In: European Respiratory Society (ERS). 2012 Annual congress. 2012: Abstract 194OC. Presented September 2, 2012.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Vestbo J., Edwards L.D., Scanlon P.D. et al. Changes in forced expiratory volume in 1 second over time in COPD. N. Engl. J. Med. 2011; 365 (13): 1184–1192.</mixed-citation><mixed-citation xml:lang="en">Vestbo J., Edwards L.D., Scanlon P.D. et al. Changes in forced expiratory volume in 1 second over time in COPD. N. Engl. J. Med. 2011; 365 (13): 1184–1192.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir Crit. Care Med. 2002; 166 (8): 1084–1091.</mixed-citation><mixed-citation xml:lang="en">Mahler D.A., Wire P., Horstman D. et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am. J. Respir Crit. Care Med. 2002; 166 (8): 1084–1091.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Donohue J.F., Anderson W., Wisniewski M. et al. Demographics and bronchoreversibility of salmeterol and ipratropium in a large population of patients with mild-to-moderate COPD [abstract]. Am. J. Respir. Crit. Care Med.1997; 155: A227.</mixed-citation><mixed-citation xml:lang="en">Donohue J.F., Anderson W., Wisniewski M. et al. Demographics and bronchoreversibility of salmeterol and ipratropium in a large population of patients with mild-to-moderate COPD [abstract]. Am. J. Respir. Crit. Care Med.1997; 155: A227.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Dorinsky P.M., Reisner C., Ferguson G.T. et al. The combination of ipratropium and albuterol optimizes pulmonary function reversibility testing in patients with COPD. Chest 1999; 115: 966–971.</mixed-citation><mixed-citation xml:lang="en">Dorinsky P.M., Reisner C., Ferguson G.T. et al. The combination of ipratropium and albuterol optimizes pulmonary function reversibility testing in patients with COPD. Chest 1999; 115: 966–971.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Calverley P.M., Burge P.S., Spencer S. et al. Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax 2003; 58 (8): 659–664.</mixed-citation><mixed-citation xml:lang="en">Calverley P.M., Burge P.S., Spencer S. et al. Bronchodilator reversibility testing in chronic obstructive pulmonary disease. Thorax 2003; 58 (8): 659–664.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Watt A.P., Schock B.C., Ennis M. Neutrophils and eosinophils: clinical implications of their appearance, presence and disappearance in asthma and COPD. Curr. Drug Targets. Inflamm. Allergy 2005; 4 (4): 415–423.</mixed-citation><mixed-citation xml:lang="en">Watt A.P., Schock B.C., Ennis M. Neutrophils and eosinophils: clinical implications of their appearance, presence and disappearance in asthma and COPD. Curr. Drug Targets. Inflamm. Allergy 2005; 4 (4): 415–423.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Brightling C.E., Monteiro W., Ward R. et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2000; 356 (9240): 1480–1485.</mixed-citation><mixed-citation xml:lang="en">Brightling C.E., Monteiro W., Ward R. et al. Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2000; 356 (9240): 1480–1485.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Bafadhel M., McKenna S., Terry S. et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebocontrolled trial. Am. J. Respir. Crit. Care Med. 2012; 186 (1): 48–55.</mixed-citation><mixed-citation xml:lang="en">Bafadhel M., McKenna S., Terry S. et al. Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebocontrolled trial. Am. J. Respir. Crit. Care Med. 2012; 186 (1): 48–55.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Siva R., Green R., Briqthlinq C. et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomized controlled trial. Eur. Respir. J. 2007; 29: 906–913.</mixed-citation><mixed-citation xml:lang="en">Siva R., Green R., Briqthlinq C. et al. Eosinophilic airway inflammation and exacerbations of COPD: a randomized controlled trial. Eur. Respir. J. 2007; 29: 906–913.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Oraka E., Kim H.J., King M.E., Callahan D.B. Asthma prevalence among US elderly by age groups: age still matters. J. Asthma 2012; 49 (6): 593–599.</mixed-citation><mixed-citation xml:lang="en">Oraka E., Kim H.J., King M.E., Callahan D.B. Asthma prevalence among US elderly by age groups: age still matters. J. Asthma 2012; 49 (6): 593–599.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Sherrill D., Guerra S., Bobadilla A., Barbee R. The role of concomitant respiratory diseases on the rate of decline in FEV1 among adult asthmatics. Eur. Respir. J. 2003; 21 (1): 95–100.</mixed-citation><mixed-citation xml:lang="en">Sherrill D., Guerra S., Bobadilla A., Barbee R. The role of concomitant respiratory diseases on the rate of decline in FEV1 among adult asthmatics. Eur. Respir. J. 2003; 21 (1): 95–100.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Schneider A., Tilemann L., Schermer T. et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study: FENO &lt; or = 16 ppb better than FENO &lt; or =12 ppb to rule out mild and moderate to severe asthma [added]. Respir. Res. 2009; 10: 15.</mixed-citation><mixed-citation xml:lang="en">Schneider A., Tilemann L., Schermer T. et al. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study: FENO &lt; or = 16 ppb better than FENO &lt; or =12 ppb to rule out mild and moderate to severe asthma [added]. Respir. Res. 2009; 10: 15.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Cazzola M., Puxeddu E., Bettoncelli G. et al. The prevalence of asthma and COPD in Italy: a practice-based study. Respir. Med. 2011; 105 (3): 386–391.</mixed-citation><mixed-citation xml:lang="en">Cazzola M., Puxeddu E., Bettoncelli G. et al. The prevalence of asthma and COPD in Italy: a practice-based study. Respir. Med. 2011; 105 (3): 386–391.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Viegi G., Matteelli G., Angino A. et al. The proportional Venn diagram of obstructive lung disease in the Italian general population. Chest 2004; 126 (4): 1093–1101.</mixed-citation><mixed-citation xml:lang="en">Viegi G., Matteelli G., Angino A. et al. The proportional Venn diagram of obstructive lung disease in the Italian general population. Chest 2004; 126 (4): 1093–1101.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Soriano J.B., Davis K.J., Coleman B. et al. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003; 124 (2): 474–481.</mixed-citation><mixed-citation xml:lang="en">Soriano J.B., Davis K.J., Coleman B. et al. The proportional Venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 2003; 124 (2): 474–481.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Mannino D.M., Gagnon R.C., Petty T.L., Lydick E. Obstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988–1994. Arch. Intern. Med. 2000; 160 (11): 1683–1689.</mixed-citation><mixed-citation xml:lang="en">Mannino D.M., Gagnon R.C., Petty T.L., Lydick E. Obstructive lung disease and low lung function in adults in the United States: data from the National Health and Nutrition Examination Survey, 1988–1994. Arch. Intern. Med. 2000; 160 (11): 1683–1689.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Haahtela T., Tuomisto L.E., Pietinalho A. et al. A 10 year asthma programme in Finland: major change for the better. Thorax 2006; 61: 663–670.</mixed-citation><mixed-citation xml:lang="en">Haahtela T., Tuomisto L.E., Pietinalho A. et al. A 10 year asthma programme in Finland: major change for the better. Thorax 2006; 61: 663–670.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Kim T.B., Oh Y.M., Chang Y.S. et al. The reality of an intermediate type between asthma and COPD in practice. Respir. Care 2012; 57 (8): 1248–1253.</mixed-citation><mixed-citation xml:lang="en">Kim T.B., Oh Y.M., Chang Y.S. et al. The reality of an intermediate type between asthma and COPD in practice. Respir. Care 2012; 57 (8): 1248–1253.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Soler3Cataluna J.J., Cosio B., Izquierdo J.L. et al. Consensus document on the overlap phenotype COPD-asthma in COPD. Arch. Bronconeumol. 2012; 48 (9): 331–337.</mixed-citation><mixed-citation xml:lang="en">Soler3Cataluna J.J., Cosio B., Izquierdo J.L. et al. Consensus document on the overlap phenotype COPD-asthma in COPD. Arch. Bronconeumol. 2012; 48 (9): 331–337.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Duggal R., Menkes D.B. Evidence-based medicine in practice. Int. J. Clin. Pract. 2011; 65 (6): 639–644.</mixed-citation><mixed-citation xml:lang="en">Duggal R., Menkes D.B. Evidence-based medicine in practice. Int. J. Clin. Pract. 2011; 65 (6): 639–644.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Sethi S., Mahler D.A., Marcus P. et al. Inflammation in COPD: implications for management. Am. J. Med. 2012; 125 (12): 1162–1170.</mixed-citation><mixed-citation xml:lang="en">Sethi S., Mahler D.A., Marcus P. et al. Inflammation in COPD: implications for management. Am. J. Med. 2012; 125 (12): 1162–1170.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Lofdahl C.G., Postma D.S., Pride N.B. et al. Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD. Eur. Respir. J. 2007; 29 (6): 1115–1119.</mixed-citation><mixed-citation xml:lang="en">Lofdahl C.G., Postma D.S., Pride N.B. et al. Possible protection by inhaled budesonide against ischaemic cardiac events in mild COPD. Eur. Respir. J. 2007; 29 (6): 1115–1119.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Loke Y.K, Kwok C.S., Singh S. Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD. Eur. Respir. J. 2010; 35 (5):1003–1021. doi: 10.1183/09031936.00095909.</mixed-citation><mixed-citation xml:lang="en">Loke Y.K, Kwok C.S., Singh S. Risk of myocardial infarction and cardiovascular death associated with inhaled corticosteroids in COPD. Eur. Respir. J. 2010; 35 (5):1003–1021. doi: 10.1183/09031936.00095909.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Stallberg B., Selroos O., Vogelmeier C. et al. Budesonide / formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study. Respir. Res. 2009; 10: 11.</mixed-citation><mixed-citation xml:lang="en">Stallberg B., Selroos O., Vogelmeier C. et al. Budesonide / formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD. A double-blind, randomised, non-inferiority, parallel-group, multicentre study. Respir. Res. 2009; 10: 11.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Malmstrom K., Rodriguez3Gomez G., Guerra J. et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast / Beclomethasone Study Group. Ann. Intern. Med. 1999; 130 (6): 487–495.</mixed-citation><mixed-citation xml:lang="en">Malmstrom K., Rodriguez3Gomez G., Guerra J. et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast / Beclomethasone Study Group. Ann. Intern. Med. 1999; 130 (6): 487–495.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">van den Berge M., ten Hacken N.H., Cohen J. et al. Small airway disease in asthma and COPD: clinical implications. Chest 2011; 139 (2): 412–423.</mixed-citation><mixed-citation xml:lang="en">van den Berge M., ten Hacken N.H., Cohen J. et al. Small airway disease in asthma and COPD: clinical implications. Chest 2011; 139 (2): 412–423.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">To Y., Kharitonov S., Adcock I. et al. Corticosteroid sensitivity in patients with chronic obstructive pulmonary disease is restored by theophylline. In: Program and abstracts of the European Respiratory Society 15th Annual congress, September 17–21, 2005. Copenhagen, 2005. Abstr. 215.</mixed-citation><mixed-citation xml:lang="en">To Y., Kharitonov S., Adcock I. et al. Corticosteroid sensitivity in patients with chronic obstructive pulmonary disease is restored by theophylline. In: Program and abstracts of the European Respiratory Society 15th Annual congress, September 17–21, 2005. Copenhagen, 2005. Abstr. 215.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Dolovich M. New delivery systems and propellants. Can. Respir. J. 1999; 6 (3): 290–295.</mixed-citation><mixed-citation xml:lang="en">Dolovich M. New delivery systems and propellants. Can. Respir. J. 1999; 6 (3): 290–295.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">De Backer W., Devolder A., Poli G. et al. Lung deposition of BDP / formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients. J. Aerosol Med. Pulm. Drug Deliv. 2010; 23 (3): 137–148.</mixed-citation><mixed-citation xml:lang="en">De Backer W., Devolder A., Poli G. et al. Lung deposition of BDP / formoterol HFA pMDI in healthy volunteers, asthmatic, and COPD patients. J. Aerosol Med. Pulm. Drug Deliv. 2010; 23 (3): 137–148.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Brusselle G., Peche R., Van den Brande P. et al. Real-life effectiveness of extrafine beclometasone dipropionate / formoterol in adults with persistent asthma according to smoking status. Respir. Med. 2012; 106 (6): 811–819.</mixed-citation><mixed-citation xml:lang="en">Brusselle G., Peche R., Van den Brande P. et al. Real-life effectiveness of extrafine beclometasone dipropionate / formoterol in adults with persistent asthma according to smoking status. Respir. Med. 2012; 106 (6): 811–819.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">O'Connor B.J., Collarini S., Poli G. et al. Rapid effects of extrafine beclomethasone dipropionate / formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial. BMC Pulm. Med. 2011; 11: 60.</mixed-citation><mixed-citation xml:lang="en">O'Connor B.J., Collarini S., Poli G. et al. Rapid effects of extrafine beclomethasone dipropionate / formoterol fixed combination inhaler on airway inflammation and bronchoconstriction in asthma: a randomised controlled trial. BMC Pulm. Med. 2011; 11: 60.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Tzani P., Crisafulli E., Nicolini G. et al. Effects of beclomethasone / formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients. Int. J. Chron. Obstruct. Pulm. Dis. 2011; 6: 503–509.</mixed-citation><mixed-citation xml:lang="en">Tzani P., Crisafulli E., Nicolini G. et al. Effects of beclomethasone / formoterol fixed combination on lung hyperinflation and dyspnea in COPD patients. Int. J. Chron. Obstruct. Pulm. Dis. 2011; 6: 503–509.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Singh D., Kampschulte J., Wedzicha J.A. et al. A trial of beclomethasone / formoterol in COPD using EXACT-PRO to measure exacerbations. Eur. Respir. J. 2013; 41 (1): 12–17.</mixed-citation><mixed-citation xml:lang="en">Singh D., Kampschulte J., Wedzicha J.A. et al. A trial of beclomethasone / formoterol in COPD using EXACT-PRO to measure exacerbations. Eur. Respir. J. 2013; 41 (1): 12–17.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Spears M., Donnelly I., Jolly L. et al. Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. Eur. Respir. J. 2009; 33: 1010–1017.</mixed-citation><mixed-citation xml:lang="en">Spears M., Donnelly I., Jolly L. et al. Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. Eur. Respir. J. 2009; 33: 1010–1017.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Novelli F., Malagrino L., Dente F.L., Paggiaro P. Efficacy of anticholinergic drugs in asthma. Expert. Rev. Respir. Med. 2012; 6 (3): 309–319.</mixed-citation><mixed-citation xml:lang="en">Novelli F., Malagrino L., Dente F.L., Paggiaro P. Efficacy of anticholinergic drugs in asthma. Expert. Rev. Respir. Med. 2012; 6 (3): 309–319.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Kerstjens H.A., Engel M., Dahl R. et al. Tiotropium in asthma poorly controlled with standard combination therapy. N. Engl. J. Med. 2012; 367 (13): 1198–1207.</mixed-citation><mixed-citation xml:lang="en">Kerstjens H.A., Engel M., Dahl R. et al. Tiotropium in asthma poorly controlled with standard combination therapy. N. Engl. J. Med. 2012; 367 (13): 1198–1207.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
